{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T02:32:31Z","timestamp":1791772351008,"version":"4.3.4"},"reference-count":41,"publisher":"Elsevier BV","issue":"15","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100005010","name":"Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","award":["21963"],"award-info":[{"award-number":["21963"]}],"id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006692","name":"Universit\u00e0 degli Studi di Torino","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006692","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002809","name":"Generalitat de Catalunya","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013941","name":"Centro de Investigaci\u00c3\u00b3n Biom\u00c3\u00a9dica en Red Diabetes y Enfermedades Metab\u00c3\u00b3licas Asociadas","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013941","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["2014SGR48"],"award-info":[{"award-number":["2014SGR48"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["SAF2016-75246R"],"award-info":[{"award-number":["SAF2016-75246R"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003741","name":"Instituci\u00c3\u00b3 Catalana de Recerca i Estudis Avan\u00c3\u00a7ats","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003741","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Molecular Biology"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1016\/j.jmb.2019.05.032","type":"journal-article","created":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T11:12:41Z","timestamp":1559041961000},"page":"2674-2686","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":112,"title":["Autophagy Exacerbates Muscle Wasting in Cancer Cachexia and Impairs Mitochondrial Function"],"prefix":"10.1016","volume":"431","author":[{"given":"Fabio","family":"Penna","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Ballar\u00f2","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Martinez-Cristobal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Sala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Sebastian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Busquets","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Muscaritoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep M.","family":"Argil\u00e9s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Costelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Zorzano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jmb.2019.05.032_bb0005","article-title":"Cancer-associated cachexia","volume":"4","author":"Baracos","year":"2018","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.jmb.2019.05.032_bb0010","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1038\/nrc3829","article-title":"Cancer cachexia: understanding the molecular basis","volume":"14","author":"Argil\u00e9s","year":"2014","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.jmb.2019.05.032_bb0015","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1097\/SPC.0b013e328359e6dd","article-title":"Muscle protein kinetics in cancer cachexia","volume":"6","author":"Johns","year":"2012","journal-title":"Curr. Opin. Support. Palliat. Care."},{"key":"10.1016\/j.jmb.2019.05.032_bb0020","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1002\/jcsm.12050","article-title":"Effect of the specific proteasome inhibitor bortezomib on cancer-related muscle wasting","author":"Penna","year":"2016","journal-title":"J. Cachexia. Sarcopenia Muscle"},{"key":"10.1016\/j.jmb.2019.05.032_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajpath.2012.12.023","article-title":"Autophagic degradation contributes to muscle wasting in cancer cachexia","volume":"182","author":"Penna","year":"2013","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.jmb.2019.05.032_bb0030","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.3945\/ajcn.113.063859","article-title":"Autophagic-lysosomal pathway is the main proteolytic system modified in the skeletal muscle of esophageal cancer patients","volume":"98","author":"Tardif","year":"2013","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.jmb.2019.05.032_bb0035","doi-asserted-by":"crossref","DOI":"10.1038\/srep30340","article-title":"Autophagy is induced in the skeletal muscle of cachectic cancer patients","volume":"6","author":"Aversa","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jmb.2019.05.032_bb0040","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.cmet.2009.10.008","article-title":"Autophagy is required to maintain muscle mass","volume":"10","author":"Masiero","year":"2009","journal-title":"Cell Metab."},{"key":"10.1016\/j.jmb.2019.05.032_bb0045","doi-asserted-by":"crossref","DOI":"10.1038\/srep26991","article-title":"Aerobic exercise and pharmacological treatments counteract cachexia by modulating autophagy in colon cancer","volume":"6","author":"Pigna","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jmb.2019.05.032_bb0050","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1172\/JCI72327","article-title":"Autophagy-regulating TP53INP2 mediates muscle wasting and is repressed in diabetes","volume":"124","author":"Sala","year":"2014","journal-title":"J. Clin. Invest."},{"issue":"80","key":"10.1016\/j.jmb.2019.05.032_bb0055","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1126\/science.1065874","article-title":"Identification of ubiquitin ligases required for skeletal muscle atrophy","volume":"294","author":"Bodine","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.jmb.2019.05.032_bb0060","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.yjmcc.2012.08.001","article-title":"Mitochondrial biogenesis and fragmentation as regulators of protein degradation in striated muscles","volume":"55","author":"Romanello","year":"2013","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.jmb.2019.05.032_bb0065","doi-asserted-by":"crossref","unstructured":"R. He, J. Peng, P. Yuan, F. Xu, W. Wei, Divergent roles of BECN1 in LC3 lipidation and autophagosomal function, (n.d.). doi:https:\/\/doi.org\/10.1080\/15548627.2015.1034404.","DOI":"10.1080\/15548627.2015.1034404"},{"key":"10.1016\/j.jmb.2019.05.032_bb0070","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/nature10758","article-title":"Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis","volume":"481","author":"He","year":"2012","journal-title":"Nature."},{"key":"10.1016\/j.jmb.2019.05.032_bb0075","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1002\/ijc.29930","article-title":"Complete reversal of muscle wasting in experimental cancer cachexia: additive effects of activin type II receptor inhibition and \u03b2-2 agonist","volume":"138","author":"Toledo","year":"2016","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.jmb.2019.05.032_bb0080","first-page":"1269","article-title":"Phase I\/II trial of formoterol fumarate combined with megestrol acetate in cachectic patients with advanced malignancy","volume":"22","author":"Greig","year":"2014","journal-title":"Support Care Cancer"},{"key":"10.1016\/j.jmb.2019.05.032_bb0085","first-page":"234","article-title":"Is TP53INP2 a critical regulator of muscle mass?","volume":"18","author":"Sala","year":"2015","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care."},{"key":"10.1016\/j.jmb.2019.05.032_bb0090","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.molmed.2017.01.003","article-title":"Mitochondrial dynamics: coupling mitochondrial fitness with healthy aging","volume":"23","author":"Sebasti\u00e1n","year":"2017","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.jmb.2019.05.032_bb0095","doi-asserted-by":"crossref","first-page":"5482","DOI":"10.1096\/fj.201801862R","article-title":"Moderate exercise in mice improves cancer plus chemotherapy-induced muscle wasting and mitochondrial alterations","volume":"33","author":"Ballar\u00f2","year":"2019","journal-title":"FASEB J."},{"key":"10.1016\/j.jmb.2019.05.032_bb0100","first-page":"897","article-title":"Emerging paradigm of crosstalk between autophagy and the ubiquitin\u2013proteasome system","volume":"40","author":"Nam","year":"2017","journal-title":"Mol. Cell"},{"key":"10.1016\/j.jmb.2019.05.032_bb0105","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.4161\/auto.25573","article-title":"A novel crosstalk between two major protein degradation systems","volume":"9","author":"Wang","year":"2013","journal-title":"Autophagy."},{"key":"10.1016\/j.jmb.2019.05.032_bb0110","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2017.00213","article-title":"Interference with Ca2+-dependent proteolysis does not alter the course of muscle wasting in experimental cancer cachexia","volume":"8","author":"Pin","year":"2017","journal-title":"Front. Physiol."},{"key":"10.1016\/j.jmb.2019.05.032_bb0115","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.4161\/auto.29264","article-title":"Combined autophagy and proteasome inhibition: a phase 1 trial of hydroxychloroquine and bortezomib in patients with relapsed\/refractory myeloma","volume":"10","author":"Vogl","year":"2014","journal-title":"Autophagy."},{"key":"10.1016\/j.jmb.2019.05.032_bb0120","doi-asserted-by":"crossref","first-page":"2444","DOI":"10.1016\/j.biocel.2013.07.019","article-title":"Regulation of Akt\u2013mTOR, ubiquitin\u2013proteasome and autophagy-lysosome pathways in response to formoterol administration in rat skeletal muscle","volume":"45","author":"Joassard","year":"2013","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.jmb.2019.05.032_bb0125","doi-asserted-by":"crossref","first-page":"6725","DOI":"10.1158\/0008-5472.CAN-04-0425","article-title":"Anticachectic effects of formoterol: a drug for potential treatment of muscle wasting","volume":"64","author":"Busquets","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.jmb.2019.05.032_bb0130","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.biochi.2018.04.009","article-title":"Effects of the beta 2 agonist formoterol on atrophy signaling, autophagy, and muscle phenotype in respiratory and limb muscles of rats with cancer-induced cachexia","volume":"149","author":"Salazar-Degracia","year":"2018","journal-title":"Biochimie."},{"key":"10.1016\/j.jmb.2019.05.032_bb0135","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/1743-7075-9-86","article-title":"Extrinsic and intrinsic regulation of DOR\/TP53INP2 expression in mice: effects of dietary fat content, tissue type and sex in adipose and muscle tissues","volume":"9","author":"Fromm-Dornieden","year":"2012","journal-title":"Nutr. Metab. (Lond.)"},{"key":"10.1016\/j.jmb.2019.05.032_bb0140","doi-asserted-by":"crossref","DOI":"10.1371\/annotation\/f2e121d7-0878-44b1-a5c2-994231626fe1","article-title":"Dor\/tp53inp2 and tp53inp1 constitute a metazoan gene family encoding dual regulators of autophagy and transcription","volume":"7","author":"Sancho","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jmb.2019.05.032_bb0145","doi-asserted-by":"crossref","first-page":"3179","DOI":"10.1016\/j.febslet.2012.06.032","article-title":"DOR undergoes nucleo-cytoplasmic shuttling, which involves passage through the nucleolus","volume":"586","author":"Mauvezin","year":"2012","journal-title":"FEBS Lett."},{"key":"10.1016\/j.jmb.2019.05.032_bb0150","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1146\/annurev-pathol-020712-163918","article-title":"Autophagy as a stress-response and quality-control mechanism: implications for cell injury and human disease","volume":"8","author":"Murrow","year":"2013","journal-title":"Annu. Rev. Pathol. Mech. Dis."},{"key":"10.1016\/j.jmb.2019.05.032_bb0155","doi-asserted-by":"crossref","first-page":"300","DOI":"10.15252\/embr.201541486","article-title":"The ubiquitin signal and autophagy: an orchestrated dance leading to mitochondrial degradation","volume":"17","author":"Yamano","year":"2016","journal-title":"EMBO Rep."},{"key":"10.1016\/j.jmb.2019.05.032_bb0160","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1002\/jcsm.12232","article-title":"Mitochondrial degeneration precedes the development of muscle atrophy in progression of cancer cachexia in tumor-bearing mice","volume":"8","author":"Brown","year":"2017","journal-title":"J. Cachexia. Sarcopenia Muscle"},{"key":"10.1016\/j.jmb.2019.05.032_bb0165","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.15252\/embj.201593084","article-title":"Mfn2 deficiency links age-related sarcopenia and impaired autophagy to activation of an adaptive mitophagy pathway","volume":"35","author":"Sebasti\u00e1n","year":"2016","journal-title":"EMBO J."},{"key":"10.1016\/j.jmb.2019.05.032_bb0170","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1016\/j.cmet.2017.04.021","article-title":"Age-associated loss of OPA1 in muscle impacts muscle mass, metabolic homeostasis, systemic inflammation, and epithelial senescence","volume":"25","author":"Tezze","year":"2017","journal-title":"Cell Metab."},{"key":"10.1016\/j.jmb.2019.05.032_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.semcdb.2015.09.002","article-title":"Experimental cancer cachexia: evolving strategies for getting closer to the human scenario","volume":"54","author":"Penna","year":"2016","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.jmb.2019.05.032_bb0180","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.molcel.2008.06.001","article-title":"JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy","volume":"30","author":"Wei","year":"2008","journal-title":"Mol. Cell"},{"key":"10.1016\/j.jmb.2019.05.032_bb0185","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/S0092-8674(04)00400-3","article-title":"Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy","volume":"117","author":"Sandri","year":"2004","journal-title":"Cell."},{"key":"10.1016\/j.jmb.2019.05.032_bb0190","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1007\/s00216-003-2224-3","article-title":"Quantitative magnetic resonance (QMR) method for bone and whole-body-composition analysis","volume":"377","author":"Taicher","year":"2003","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.jmb.2019.05.032_bb0195","doi-asserted-by":"crossref","DOI":"10.1007\/s13539-011-0028-4","article-title":"Combined approach to counteract experimental cancer cachexia: eicosapentaenoic acid and training exercise","volume":"2","author":"Penna","year":"2011","journal-title":"J. Cachexia. Sarcopenia Muscle"},{"key":"10.1016\/j.jmb.2019.05.032_bb0200","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S1470-2045(10)70218-7","article-title":"Definition and classification of cancer cachexia: an international consensus","volume":"12","author":"Fearon","year":"2011","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.jmb.2019.05.032_bb0205","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/0005-2728(87)90174-5","article-title":"Mitochondrial respiratory parameters in cardiac tissue: a novel method of assessment by using saponin-skinned fibers","volume":"892","author":"Veksler","year":"1987","journal-title":"Biochim. Biophys. Acta"}],"container-title":["Journal of Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002228361930316X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002228361930316X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T06:17:07Z","timestamp":1762669027000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002228361930316X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":41,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["S002228361930316X"],"URL":"https:\/\/doi.org\/10.1016\/j.jmb.2019.05.032","relation":{},"ISSN":["0022-2836"],"issn-type":[{"value":"0022-2836","type":"print"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Autophagy Exacerbates Muscle Wasting in Cancer Cachexia and Impairs Mitochondrial Function","name":"articletitle","label":"Article Title"},{"value":"Journal of Molecular Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jmb.2019.05.032","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}