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Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jmb.2019.10.004_bib70","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1006793","article-title":"MeCP2 recognizes cytosine methylated tri-nucleotide and di-nucleotide sequences to tune transcription in the mammalian brain","volume":"13","author":"Lagger","year":"2017","journal-title":"PLoS Genet."},{"key":"10.1016\/j.jmb.2019.10.004_bib71","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/nature14319","article-title":"Disruption of DNA-methylation-dependent long gene repression in Rett syndrome","volume":"522","author":"Gabel","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.jmb.2019.10.004_bib72","doi-asserted-by":"crossref","first-page":"14995","DOI":"10.1073\/pnas.1903549116","article-title":"Quantitative modelling predicts the impact of DNA methylation on RNA polymerase II traffic","volume":"116","author":"Cholewa-waclaw","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jmb.2019.10.004_bib73","doi-asserted-by":"crossref","first-page":"28237","DOI":"10.1074\/jbc.M704304200","article-title":"MeCP2-Chromatin interactions include the formation of chromatosome-like structures and are altered in mutations causing Rett syndrome","volume":"282","author":"Nikitina","year":"2007","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jmb.2019.10.004_bib74","doi-asserted-by":"crossref","first-page":"1237905","DOI":"10.1126\/science.1237905","article-title":"Global epigenomic reconfiguration during mammalian brain development","volume":"341","author":"Lister","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.jmb.2019.10.004_bib75","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1101\/gr.147942.112","article-title":"Dynamic DNA methylation across diverse human cell lines and tissues Dynamic DNA methylation across diverse human cell lines and tissues","volume":"23","author":"Varley","year":"2013","journal-title":"Genome Res."},{"key":"10.1016\/j.jmb.2019.10.004_bib76","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/nn.3607","article-title":"Distribution, recognition and regulation of non-CpG methylation in the adult mammalian brain","volume":"17","author":"Guo","year":"2014","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.jmb.2019.10.004_bib77","doi-asserted-by":"crossref","first-page":"5237","DOI":"10.1073\/pnas.97.10.5237","article-title":"Non-CpG methylation is prevalent in embryonic stem cells and may be mediated by DNA methyltransferase 3a.","volume":"97","author":"Ramsahoye","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jmb.2019.10.004_bib78","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1016\/j.neuron.2015.05.018","article-title":"Epigenomic signatures of neuronal diversity in the mammalian brain","volume":"86","author":"Mo","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.jmb.2019.10.004_bib79","doi-asserted-by":"crossref","DOI":"10.1038\/s41593-018-0270-6","article-title":"Characterization of human mosaic Rett syndrome brain tissue by single-nucleus RNA sequencing","volume":"21","author":"Renthal","year":"2018","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.jmb.2019.10.004_bib80","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/j.cell.2017.09.047","article-title":"Early-life gene expression in neurons modulates lasting epigenetic states","volume":"171","author":"Stroud","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.jmb.2019.10.004_bib81","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0015367","article-title":"Tissue distribution of 5-hydroxymethylcytosine and search for active demethylation intermediates","volume":"5","author":"Globisch","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.jmb.2019.10.004_bib82","first-page":"929","article-title":"The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain","volume":"325","author":"Kriaucionis","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.jmb.2019.10.004_bib83","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.molcel.2007.12.028","article-title":"MeCP2 binding to DNA depends upon hydration at methyl-CpG","volume":"29","author":"Ho","year":"2008","journal-title":"Mol. 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Neurosci."},{"key":"10.1016\/j.jmb.2019.10.004_bib87","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1038\/nm.4406","article-title":"Biotin tagging of MeCP2 in mice reveals contextual insights into the Rett syndrome transcriptome","volume":"23","author":"Johnson","year":"2017","journal-title":"Nat. Med."},{"key":"10.1016\/j.jmb.2019.10.004_bib88","doi-asserted-by":"crossref","first-page":"4838","DOI":"10.1007\/s12035-018-1412-2","article-title":"A\u00a0novel Mecp2Y120D knock-in model displays similar behavioral traits but distinct molecular features compared to the Mecp2-null mouse implying precision medicine for the treatment of Rett syndrome","volume":"56","author":"Gandaglia","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.jmb.2019.10.004_bib89","doi-asserted-by":"crossref","first-page":"6357","DOI":"10.1021\/acs.biochem.5b00790","article-title":"Impact of Rett syndrome mutations on MeCP2 MBD stability","volume":"54","author":"Kucukkal","year":"2015","journal-title":"Biochemistry"},{"key":"10.1016\/j.jmb.2019.10.004_bib90","doi-asserted-by":"crossref","first-page":"2706","DOI":"10.1021\/acschembio.6b00450","article-title":"Binding analysis of methyl-CpG binding domain of MeCP2 and Rett syndrome mutations","volume":"11","author":"Yang","year":"2016","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.jmb.2019.10.004_bib91","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1093\/hmg\/ddn061","article-title":"Defective body-weight regulation, motor control and abnormal social interactions in Mecp2 hypomorphic mice","volume":"17","author":"Kerr","year":"2008","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.jmb.2019.10.004_bib92","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1093\/hmg\/ddn062","article-title":"A\u00a0partial loss of function allele of Methyl-CpG-binding protein 2 predicts a human neurodevelopmental syndrome","volume":"17","author":"Samaco","year":"2008","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.jmb.2019.10.004_bib93","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1172\/JCI90967","article-title":"Elevating expression of MeCP2 T158M rescues DNA binding and Rett syndrome-like phenotypes","volume":"127","author":"Lamonica","year":"2017","journal-title":"J.\u00a0Clin. Investig."},{"key":"10.1016\/j.jmb.2019.10.004_bib94","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1101\/gad.320325.118","article-title":"Toxicity of overexpressed MeCP2 is independent of HDAC3 activity","volume":"32","author":"V Koerner","year":"2018","journal-title":"Genes Dev."},{"key":"10.1016\/j.jmb.2019.10.004_bib95","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.02676.011","article-title":"Rett-causing mutations reveal two domains critical for MeCP2 function and for toxicity in MECP2 duplication syndrome mice","author":"Heckman","year":"2014","journal-title":"Elife"},{"key":"10.1016\/j.jmb.2019.10.004_bib96","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1136\/jmedgenet-2013-102113","article-title":"Methyl-CpG-binding protein 2 (MECP2) mutation type is associated with disease severity in Rett syndrome","volume":"51","author":"Cuddapah","year":"2014","journal-title":"J.\u00a0Med. 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Neurosci."},{"key":"10.1016\/j.jmb.2019.10.004_bib99","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.neuron.2011.08.022","article-title":"Genome-wide activity-dependent MeCP2 phosphorylation regulates nervous system development and function","volume":"72","author":"Cohen","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.jmb.2019.10.004_bib100","first-page":"420","article-title":"MECP2 , a multi-talented modulator of chromatin architecture","volume":"15","author":"Della Ragione","year":"2016","journal-title":"Brief. Funct. Genom."},{"key":"10.1016\/j.jmb.2019.10.004_bib101","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/nrg3897","article-title":"Rett syndrome: a complex disorder with simple roots","volume":"16","author":"Lyst","year":"2015","journal-title":"Nat. Rev. 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Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jmb.2019.10.004_bib105","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1126\/science.1153252","article-title":"MeCP2, a key contributor to neurological disease, activates and represses transcription","volume":"320","author":"Chahrour","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.jmb.2019.10.004_bib106","doi-asserted-by":"crossref","first-page":"34115","DOI":"10.1074\/jbc.M105747200","article-title":"The Ski protein family is required for MeCP2-mediated transcriptional repression","volume":"276","author":"Kokura","year":"2001","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jmb.2019.10.004_bib107","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1038\/nn.3434","article-title":"Rett syndrome mutations abolish the interaction of MeCP2 with the NCoR\/SMRT co-repressor","volume":"16","author":"Lyst","year":"2013","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.jmb.2019.10.004_bib108","doi-asserted-by":"crossref","first-page":"8688","DOI":"10.1038\/sj.onc.1207182","article-title":"Direct association between PU.1 and MeCP2 that recruits mSin3A-HDAC complex for PU.1-mediated transcriptional repression","volume":"22","author":"Suzuki","year":"2003","journal-title":"Oncogene"},{"key":"10.1016\/j.jmb.2019.10.004_bib109","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/sj.cdd.4401979","article-title":"Regulation of myofibroblast transdifferentiation by DNA methylation and MeCP2: implications for wound healing and fibrogenesis","volume":"14","author":"Mann","year":"2007","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.jmb.2019.10.004_bib110","doi-asserted-by":"crossref","first-page":"3114","DOI":"10.1093\/hmg\/ddq214","article-title":"The MeCP2\/YY1 interaction regulates ANT1 expression at 4q35: novel hints for Rett syndrome pathogenesis","volume":"19","author":"Forlani","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.jmb.2019.10.004_bib111","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1083\/jcb.200908151","article-title":"Cross talk between microRNA and epigenetic regulation in adult neurogenesis","volume":"189","author":"Szulwach","year":"2010","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.jmb.2019.10.004_bib112","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1124\/mol.110.064311","article-title":"Up-regulation of the mu-opioid receptor gene is mediated through chromatin remodeling and transcriptional factors in differentiated neuronal cells","volume":"78","author":"Hwang","year":"2010","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.jmb.2019.10.004_bib113","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.devcel.2011.03.012","article-title":"Pancreatic beta cell identity is maintained by DNA methylation-mediated repression of Arx","volume":"20","author":"Dhawan","year":"2011","journal-title":"Dev. 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Genet."},{"key":"10.1016\/j.jmb.2019.10.004_bib117","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1093\/nar\/28.9.1921","article-title":"MeCP2 driven transcriptional repression in vitro: selectivity for methylated DNA, action at a distance and contacts with the basal transcription machinery","volume":"28","author":"Kaludov","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jmb.2019.10.004_bib118","doi-asserted-by":"crossref","first-page":"9407","DOI":"10.1073\/pnas.95.16.9407","article-title":"Evolutionary parameters of the transcribed mammalian genome\u202f: an analysis of 2,820 orthologous rodent and human sequences","volume":"95","author":"Maka\u0142owski","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jmb.2019.10.004_bib119","doi-asserted-by":"crossref","first-page":"E3243","DOI":"10.1073\/pnas.1700731114","article-title":"Structure of the MeCP2\u2013TBLR1 complex reveals a molecular basis for Rett syndrome and related disorders","volume":"114","author":"Kruusvee","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jmb.2019.10.004_bib120","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1093\/hmg\/ddy159","article-title":"A\u00a0mutation-led search for novel functional domains in MeCP2","volume":"27","author":"Guy","year":"2018","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.jmb.2019.10.004_bib121","doi-asserted-by":"crossref","first-page":"2927","DOI":"10.1002\/1873-3468.12328","article-title":"Sequence-specific DNA binding by AT-hook motifs in MeCP2","volume":"590","author":"Lyst","year":"2016","journal-title":"FEBS Lett."},{"key":"10.1016\/j.jmb.2019.10.004_bib122","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.bbadis.2017.10.022","article-title":"Disruption of AT-hook 1 domain in MeCP2 protein caused behavioral abnormality in mice","volume":"1864","author":"Xu","year":"2018","journal-title":"Biochim. Biophys. Acta (BBA) - Mol. Basis Dis."},{"key":"10.1016\/j.jmb.2019.10.004_bib123","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1016\/j.cell.2013.01.038","article-title":"An AT-hook domain in MeCP2 determines the clinical course of Rett syndrome and related disorders","volume":"152","author":"Baker","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.jmb.2019.10.004_bib124","doi-asserted-by":"crossref","first-page":"32181","DOI":"10.1074\/jbc.M305308200","article-title":"Chromatin compaction by human MeCP2. Assembly of novel secondary chromatin structures in the absence of DNA methylation","volume":"278","author":"Georgel","year":"2003","journal-title":"J.\u00a0Biol. 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