{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T01:40:48Z","timestamp":1783561248198,"version":"3.55.0"},"reference-count":65,"publisher":"Elsevier BV","issue":"14","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,4,13]],"date-time":"2020-04-13T00:00:00Z","timestamp":1586736000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100001906","name":"Washington Research Foundation","doi-asserted-by":"publisher","award":["T32AG00005740"],"award-info":[{"award-number":["T32AG00005740"]}],"id":[{"id":"10.13039\/100001906","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NCI\/5 R01 CA223674-02"],"award-info":[{"award-number":["NCI\/5 R01 CA223674-02"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32AG00005740"],"award-info":[{"award-number":["T32AG00005740"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Molecular Biology"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1016\/j.jmb.2020.04.002","type":"journal-article","created":{"date-parts":[[2020,4,15]],"date-time":"2020-04-15T19:19:06Z","timestamp":1586978346000},"page":"3989-4009","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"title":["A TfR-Binding Cystine-Dense Peptide Promotes Blood\u2013Brain Barrier Penetration of Bioactive Molecules"],"prefix":"10.1016","volume":"432","author":[{"given":"Zachary R.","family":"Crook","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Girard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory P.","family":"Sevilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgan","family":"Merrill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Della","family":"Friend","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter B.","family":"Rupert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona","family":"Pakiam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunfeng","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond O.","family":"Ruff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gene","family":"Hopping","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew D.","family":"Strand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn A.K.","family":"Finton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margo","family":"Coxon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Mhyre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland K.","family":"Strong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James M.","family":"Olson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jmb.2020.04.002_bb0005","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.neuron.2015.11.024","article-title":"Discovery of novel blood\u2013brain barrier targets to enhance brain uptake of therapeutic antibodies","volume":"89","author":"Zuchero","year":"2016","journal-title":"Neuron."},{"key":"10.1016\/j.jmb.2020.04.002_bb0010","doi-asserted-by":"crossref","first-page":"5705","DOI":"10.1073\/pnas.91.12.5705","article-title":"Macromolecular permeability across the blood\u2013nerve and blood\u2013brain barriers","volume":"91","author":"Poduslo","year":"1994","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.jmb.2020.04.002_bb0015","first-page":"1","article-title":"Drug delivery systems, CNS protection, and the blood brain barrier","volume":"2014","author":"Upadhyay","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.jmb.2020.04.002_bb0020","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1146\/annurev-pharmtox-010814-124852","article-title":"Targeting receptor-mediated transport for delivery of biologics across the blood\u2013brain barrier","volume":"55","author":"Lajoie","year":"2015","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.jmb.2020.04.002_bb0025","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/S1476-5586(03)80034-9","article-title":"The transferrin receptor: a potential molecular imaging marker for human cancer","volume":"5","author":"H\u00f6gemann-Savellano","year":"2003","journal-title":"Neoplasia."},{"key":"10.1016\/j.jmb.2020.04.002_bb0030","doi-asserted-by":"crossref","first-page":"4515","DOI":"10.1073\/pnas.78.7.4515","article-title":"Ubiquitous cell-surface glycoprotein on tumor cells is proliferation-associated receptor for transferrin","volume":"78","author":"Sutherland","year":"1981","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jmb.2020.04.002_bb0035","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.bbagen.2011.07.016","article-title":"The transferrin receptor and the targeted delivery of therapeutic agents against cancer","volume":"1820","author":"Daniels","year":"2012","journal-title":"Biochim. Biophys. Acta - Gen. Subj."},{"key":"10.1016\/j.jmb.2020.04.002_bb0040","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.3389\/fimmu.2017.01001","article-title":"Therapeutic antibodies against intracellular tumor antigens","volume":"8","author":"Trenevska","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jmb.2020.04.002_bb0045","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1080\/19420862.2015.1111497","article-title":"Influence of molecular size on tissue distribution of antibody fragments","volume":"8","author":"Li","year":"2016","journal-title":"MAbs."},{"key":"10.1016\/j.jmb.2020.04.002_bb0050","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1208\/s12248-009-9157-5","article-title":"Biodistribution mechanisms of therapeutic monoclonal antibodies in health and disease","volume":"12","author":"Tabrizi","year":"2010","journal-title":"AAPS J."},{"key":"10.1016\/j.jmb.2020.04.002_bb0055","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.3389\/fimmu.2017.01751","article-title":"Progress and challenges in the design and clinical development of antibodies for cancer therapy","volume":"8","author":"Almagro","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jmb.2020.04.002_bb0060","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s00005-014-0322-x","article-title":"Human antibody production in transgenic animals","volume":"63","author":"Br\u00fcggemann","year":"2015","journal-title":"Arch. Immunol. Ther. Exp."},{"key":"10.1016\/j.jmb.2020.04.002_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.tibs.2019.12.008","article-title":"Miniproteins as a powerful modality in drug development","author":"Crook","year":"2020","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.jmb.2020.04.002_bb0070","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s13238-017-0386-6","article-title":"In vitro-engineered non-antibody protein therapeutics","volume":"9","author":"Simeon","year":"2018","journal-title":"Protein Cell."},{"key":"10.1016\/j.jmb.2020.04.002_bb0075","doi-asserted-by":"crossref","first-page":"4366","DOI":"10.3390\/toxins7104366","article-title":"The cystine knot is responsible for the exceptional stability of the insecticidal spider toxin \u03c9-hexatoxin-Hv1a","volume":"7","author":"Herzig","year":"2015","journal-title":"Toxins (Basel)."},{"key":"10.1016\/j.jmb.2020.04.002_bb0080","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/537508","article-title":"High proteolytic resistance of spider-derived inhibitor cystine knots","volume":"2015","author":"Kikuchi","year":"2015","journal-title":"Int. J. Pept."},{"key":"10.1016\/j.jmb.2020.04.002_bb0085","doi-asserted-by":"crossref","DOI":"10.1038\/s41594-018-0033-9","article-title":"Screening, large-scale production and structure-based classification of cystine-dense peptides","author":"Correnti","year":"2018","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.jmb.2020.04.002_bb0090","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1517\/13543784.16.5.595","article-title":"Potential therapeutic applications of the cyclotides and related cystine knot mini-proteins","volume":"16","author":"Craik","year":"2007","journal-title":"Expert Opin. Investig. Drugs"},{"key":"10.1016\/j.jmb.2020.04.002_bb0095","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/0041-0101(94)00186-C","article-title":"Immunogenicity of a disulphide-containing neurotoxin: presentation to T-cells requires a reduction step","volume":"33","author":"Maill\u00e8re","year":"1995","journal-title":"Toxicon."},{"key":"10.1016\/j.jmb.2020.04.002_bb0100","doi-asserted-by":"crossref","first-page":"2244","DOI":"10.1038\/s41467-017-02098-8","article-title":"Mammalian display screening of diverse cystine-dense peptides for difficult to drug targets","volume":"8","author":"Crook","year":"2017","journal-title":"Nat. Commun."},{"issue":"21","key":"10.1016\/j.jmb.2020.04.002_bb0105","doi-asserted-by":"crossref","first-page":"e143","DOI":"10.1093\/nar\/gkr706","article-title":"Daedalus: a robust, turnkey platform for rapid production of decigram quantities of active recombinant proteins in human cell lines using novel lentiviral vectors","volume":"39","author":"Bandaranayake","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jmb.2020.04.002_bb0110","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/nature05539","article-title":"Transferrin receptor 1 is a cellular receptor for New World haemorrhagic fever arenaviruses","volume":"446","author":"Radoshitzky","year":"2007","journal-title":"Nature."},{"key":"10.1016\/j.jmb.2020.04.002_bb0115","article-title":"I-TASSER Server for Protein 3D Structure Prediction","author":"Zhang","year":"2008","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.jmb.2020.04.002_bb0120","doi-asserted-by":"crossref","first-page":"10345","DOI":"10.1016\/j.bmc.2008.10.030","article-title":"The role of molecular modeling in the design of analogues of the fungicidal natural products crocacins A and D","volume":"16","author":"Crowley","year":"2008","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.jmb.2020.04.002_bb0125","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1002\/pro.2230","article-title":"Protein\u2013protein interactions: general trends in the relationship between binding affinity and interfacial buried surface area","volume":"22","author":"Chen","year":"2013","journal-title":"Protein Sci."},{"key":"10.1016\/j.jmb.2020.04.002_bb0130","doi-asserted-by":"crossref","first-page":"13089","DOI":"10.1073\/pnas.1105786108","article-title":"How the binding of human transferrin primes the transferrin receptor potentiating iron release at endosomal pH","volume":"108","author":"Eckenroth","year":"2011","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.jmb.2020.04.002_bb0135","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1136\/jcp.21.5.603","article-title":"Serum iron, total iron-binding capacity, and percentage saturation in normal subjects","volume":"21","author":"Sinniah","year":"1968","journal-title":"J. Clin. Pathol."},{"key":"10.1016\/j.jmb.2020.04.002_bb0140","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0092-8674(00)81151-4","article-title":"Crystal structure of the hemochromatosis protein HFE and characterization of its interaction with transferrin receptor","volume":"93","author":"Lebr\u00f3n","year":"1998","journal-title":"Cell."},{"key":"10.1016\/j.jmb.2020.04.002_bb0145","doi-asserted-by":"crossref","first-page":"4359","DOI":"10.1016\/S0021-9258(17)30016-9","article-title":"Labeling of proteins by reductive methylation using sodium cyanoborohydride","volume":"254","author":"Jentoft","year":"1979","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jmb.2020.04.002_bb0150","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.3892\/or.2017.5412","article-title":"Uptake of111In-labeled fully human monoclonal antibody TSP-A18 reflects transferrin receptor expression in normal organs and tissues of mice","volume":"37","author":"Sugyo","year":"2017","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.jmb.2020.04.002_bb0155","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.clim.2006.06.010","article-title":"The transferrin receptor part I: biology and targeting with cytotoxic antibodies for the treatment of cancer","volume":"121","author":"Daniels","year":"2006","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.jmb.2020.04.002_bb0160","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1177\/074823379701300401","article-title":"Physiological parameter values for physiologically based pharmacokinetic models","volume":"13","author":"Brown","year":"1997","journal-title":"Toxicol. Ind. Health"},{"key":"10.1016\/j.jmb.2020.04.002_bb0165","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1016\/j.neuroimage.2009.03.083","article-title":"Measurement of cerebral blood volume in mouse brain regions using micro-computed tomography","volume":"47","author":"Chugh","year":"2009","journal-title":"Neuroimage"},{"key":"10.1016\/j.jmb.2020.04.002_bb0170","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1021\/mp400748t","article-title":"Comparative physiology of mice and rats: radiometric measurement of vascular parameters in rodent tissues","volume":"11","author":"Boswell","year":"2014","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.jmb.2020.04.002_bb0175","doi-asserted-by":"crossref","first-page":"84ra44","DOI":"10.1126\/scitranslmed.3002230","article-title":"Boosting brain uptake of a therapeutic antibody by reducing its affinity for a transcytosis target","volume":"3","author":"Yu","year":"2011","journal-title":"Sci. Transl. Med"},{"key":"10.1016\/j.jmb.2020.04.002_bb0180","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1074\/jbc.M110.145664","article-title":"Characterization of promoter elements regulating the expression of the human neurotensin\/neuromedin N gene","volume":"286","author":"Wang","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jmb.2020.04.002_bb0185","doi-asserted-by":"crossref","first-page":"526","DOI":"10.3390\/nu10040526","article-title":"Neurotensin is a lipid-induced gastrointestinal peptide associated with visceral adipose tissue inflammation in obesity","volume":"10","author":"Capoccia","year":"2018","journal-title":"Nutrients."},{"key":"10.1016\/j.jmb.2020.04.002_bb0190","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/0306-4522(87)90350-2","article-title":"Distribution of neurotensin binding sites in rat brain: a light microscopic radioautographic study using monoiodo [125I]Tyr3-neurotensin","volume":"22","author":"Moyse","year":"1987","journal-title":"Neuroscience."},{"key":"10.1016\/j.jmb.2020.04.002_bb0195","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/S0165-6147(99)01357-7","article-title":"Neurotensin and neurotensin receptors","volume":"20","author":"Vincent","year":"1999","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.jmb.2020.04.002_bb0200","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0306-4522(99)00597-7","article-title":"Neurotensin regulates intracellular calcium in ventral tegmental area astrocytes: evidence for the involvement of multiple receptors","volume":"97","author":"Trudeau","year":"2000","journal-title":"Neuroscience."},{"key":"10.1016\/j.jmb.2020.04.002_bb0205","doi-asserted-by":"crossref","first-page":"130B","DOI":"10.1097\/00002826-199202001-00249","article-title":"Phospholipase C activation by rat neurotensin receptor expressed in Chinese hamster ovary cells","volume":"15","author":"Hermans","year":"2012","journal-title":"Clin. Neuropharmacol."},{"key":"10.1016\/j.jmb.2020.04.002_bb0210","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1097\/MED.0b013e3283419052","article-title":"The role of neurotensin in physiologic and pathologic processes","volume":"18","author":"Mustain","year":"2011","journal-title":"Curr. Opin. Endocrinol. Diabetes Obes."},{"key":"10.1016\/j.jmb.2020.04.002_bb0215","first-page":"1","article-title":"Knock-in luciferase reporter mice for in vivo monitoring of CREB activity","volume":"11","author":"Akhmedov","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.jmb.2020.04.002_bb0220","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/S0959-440X(98)80090-0","article-title":"The structure, catalytic mechanism and regulation of adenylyl cyclase","volume":"8","author":"Tesmer","year":"1998","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.1016\/j.jmb.2020.04.002_bb0225","doi-asserted-by":"crossref","first-page":"15020","DOI":"10.1073\/pnas.95.25.15020","article-title":"Rolipram, a type IV-specific phosphodiesterase inhibitor, facilitates the establishment of long-lasting long-term potentiation and improves memory","volume":"95","author":"Barad","year":"1998","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.jmb.2020.04.002_bb0230","doi-asserted-by":"crossref","first-page":"2993","DOI":"10.1093\/jn\/136.12.2993","article-title":"Accelerated transferrin degradation in HFE-deficient mice is associated with increased transferrin saturation","volume":"136","author":"Chaudhury","year":"2006","journal-title":"J. Nutr."},{"key":"10.1016\/j.jmb.2020.04.002_bb0235","doi-asserted-by":"crossref","first-page":"711","DOI":"10.3390\/ph8040711","article-title":"Antimicrobial peptides from plants","volume":"8","author":"Tam","year":"2015","journal-title":"Pharmaceuticals."},{"key":"10.1016\/j.jmb.2020.04.002_bb0240","doi-asserted-by":"crossref","first-page":"101665","DOI":"10.1016\/j.pneurobio.2019.101665","article-title":"Targeting the transferrin receptor for brain drug delivery","volume":"181","author":"Johnsen","year":"2019","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.jmb.2020.04.002_bb0245","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.bbrep.2017.07.003","article-title":"A novel LRP1-binding peptide L57 that crosses the blood brain barrier","volume":"12","author":"Sakamoto","year":"2017","journal-title":"Biochem. Biophys. Reports."},{"key":"10.1016\/j.jmb.2020.04.002_bb0250","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1002\/jcb.240230111","article-title":"Sorting and recycling of cell surface receptors and endocytosed ligands: the asialoglycoprotein and transferrin receptors","volume":"23","author":"Ciechanover","year":"1983","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.jmb.2020.04.002_bb0255","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1242\/jcs.1985.Supplement_3.17","article-title":"Receptor-mediated endocytosis of transferrin and epidermal growth factor receptors: a comparison of constitutive and ligand-induced uptake","volume":"3","author":"Hopkins","year":"1985","journal-title":"J. Cell Sci. Suppl."},{"key":"10.1016\/j.jmb.2020.04.002_bb0260","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1021\/ci700178w","article-title":"Molecular mechanism of the sea anemone toxin ShK recognizing the Kv1.3 channel explored by docking and molecular dynamic simulations","volume":"47","author":"Ling","year":"2007","journal-title":"J. Chem. Inf. Model"},{"key":"10.1016\/j.jmb.2020.04.002_bb0265","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/srep04509","article-title":"A potent and Kv1.3-selective analogue of the scorpion toxin HsTX1 as a potential therapeutic for autoimmune diseases","volume":"4","author":"Rashid","year":"2014","journal-title":"Sci. Rep"},{"key":"10.1016\/j.jmb.2020.04.002_bb0270","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1021\/mp500809f","article-title":"Toward oral delivery of biopharmaceuticals: an assessment of the gastrointestinal stability of 17 peptide drugs","volume":"12","author":"Wang","year":"2015","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.jmb.2020.04.002_bb0275","doi-asserted-by":"crossref","DOI":"10.1021\/ed086p969","article-title":"Using proteins in a bioinorganic laboratory experiment: iron loading and removal from transferrin","author":"Hamilton","year":"2009","journal-title":"J. Chem. Educ"},{"key":"10.1016\/j.jmb.2020.04.002_bb0280","doi-asserted-by":"crossref","first-page":"D204","DOI":"10.1093\/nar\/gku989","article-title":"UniProt: a hub for protein information","volume":"43","author":"UniProt Consortium","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jmb.2020.04.002_bb0285","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/978-1-4939-9853-1_21","article-title":"Mammalian surface display screening of diverse cystine-dense peptide libraries for difficult-to-drug targets","volume":"2070","author":"Crook","year":"2020","journal-title":"Methods Mol. Biol"},{"key":"10.1016\/j.jmb.2020.04.002_bb0290","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1002\/(SICI)1099-1352(199909\/10)12:5<279::AID-JMR473>3.0.CO;2-3","article-title":"Improving biosensor analysis","volume":"12","author":"Myszka","year":"1999","journal-title":"J. Mol. Recognit."},{"key":"10.1016\/j.jmb.2020.04.002_bb0295","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.ab.2005.09.034","article-title":"Analyzing a kinetic titration series using affinity biosensors","volume":"349","author":"Karlsson","year":"2006","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.jmb.2020.04.002_bb0300","doi-asserted-by":"crossref","DOI":"10.1016\/S0076-6879(97)76066-X","article-title":"Processing of X-ray diffraction data collected in oscillation mode","author":"Otwinowski","year":"1997","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.jmb.2020.04.002_bb0305","doi-asserted-by":"crossref","DOI":"10.1107\/S0907444996012255","article-title":"Refinement of macromolecular structures by the maximum-likelihood method","author":"Murshudov","year":"1997","journal-title":"Acta Crystallogr. Sect. D Biol. Crystallogr."},{"key":"10.1016\/j.jmb.2020.04.002_bb0310","doi-asserted-by":"crossref","DOI":"10.1107\/S0021889807021206","article-title":"Phaser crystallographic software","author":"McCoy","year":"2007","journal-title":"J. Appl. Crystallogr."},{"key":"10.1016\/j.jmb.2020.04.002_bb0315","doi-asserted-by":"crossref","DOI":"10.1107\/S0907444903008126","article-title":"A graphical user interface to the CCP4 program suite","author":"Potterton","year":"2003","journal-title":"Acta Crystallogr. - Sect. D Biol. Crystallogr"},{"key":"10.1016\/j.jmb.2020.04.002_bb0320","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1107\/S0907444994003112","article-title":"The CCP4 suite: programs for protein crystallography","volume":"50","year":"1994","journal-title":"Acta Crystallogr. Sect. D Biol. Crystallogr"},{"key":"10.1016\/j.jmb.2020.04.002_bb0325","doi-asserted-by":"crossref","DOI":"10.1107\/S0907444904019158","article-title":"Coot: model-building tools for molecular graphics","author":"Emsley","year":"2004","journal-title":"Acta Crystallogr. Sect. D Biol. Crystallogr."}],"container-title":["Journal of Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022283620302795?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022283620302795?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:25:57Z","timestamp":1777418757000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022283620302795"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6]]},"references-count":65,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["S0022283620302795"],"URL":"https:\/\/doi.org\/10.1016\/j.jmb.2020.04.002","relation":{},"ISSN":["0022-2836"],"issn-type":[{"value":"0022-2836","type":"print"}],"subject":[],"published":{"date-parts":[[2020,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A TfR-Binding Cystine-Dense Peptide Promotes Blood\u2013Brain Barrier Penetration of Bioactive Molecules","name":"articletitle","label":"Article Title"},{"value":"Journal of Molecular Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jmb.2020.04.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}