{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T04:46:50Z","timestamp":1758343610525,"version":"3.44.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"19","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,9,14]],"date-time":"2021-09-14T00:00:00Z","timestamp":1631577600000},"content-version":"am","delay-in-days":378,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","award":["JPMJPR19G4"],"award-info":[{"award-number":["JPMJPR19G4"]}],"id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009952","name":"Gatan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009952","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["18H03986","18\u202fK14662"],"award-info":[{"award-number":["18H03986","18\u202fK14662"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Molecular Biology"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.jmb.2020.08.006","type":"journal-article","created":{"date-parts":[[2020,8,11]],"date-time":"2020-08-11T02:20:15Z","timestamp":1597112415000},"page":"5378-5389","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Disruption of Hydrogen-Bond Network in Rhodopsin Mutations Cause Night Blindness"],"prefix":"10.1016","volume":"432","author":[{"given":"Kota","family":"Katayama","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuri","family":"Takeyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiko","family":"Enomoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroo","family":"Imai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Kandori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jmb.2020.08.006_bb0005","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1146\/annurev.biochem.75.103004.142743","article-title":"G protein-coupled receptor rhodopsin","volume":"75","author":"Palczewski","year":"2006","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.jmb.2020.08.006_bb0010","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1021\/cr4003769","article-title":"Microbial and animal rhodopsins: structures, functions, and molecular mechanisms","volume":"114","author":"Ernst","year":"2014","journal-title":"Chem. Rev."},{"key":"10.1016\/j.jmb.2020.08.006_bb0015","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1016\/S0006-3495(98)77625-8","article-title":"Origin of reproducibility in the responses of retinal rods to single photons","volume":"75","author":"Rieke","year":"1998","journal-title":"Biophys. J."},{"key":"10.1016\/j.jmb.2020.08.006_bb0020","first-page":"10000","article-title":"Maximal rate and nucleotide dependence of rhodopsin-catalyzed transducin activation: initial rate analysis based on a double displacement mechanism","volume":"276","author":"Heck","year":"2001","journal-title":"J. Mol. Chem."},{"key":"10.1016\/j.jmb.2020.08.006_bb0025","doi-asserted-by":"crossref","first-page":"5982","DOI":"10.1073\/pnas.082666399","article-title":"Functional role of internal water molecules in rhodopsin revealed by X-ray crystallography","volume":"99","author":"Okada","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jmb.2020.08.006_bb0030","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1039\/C7FD00207F","article-title":"The role of water molecules in phototransduction of retinal proteins and G protein-coupled receptors","volume":"207","author":"Lesca","year":"2018","journal-title":"Faraday Discuss."},{"key":"10.1016\/j.jmb.2020.08.006_bb0035","doi-asserted-by":"crossref","first-page":"3288","DOI":"10.1073\/pnas.1809251116","article-title":"Diverese GPCRs exhibit conserved water networks for stabilization and activation","volume":"116","author":"Venkatakrishnan","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jmb.2020.08.006_bb0040","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1038\/343364a0","article-title":"A point mutation of the rhodopsin gene in one form of retinitis pigmentosa","volume":"343","author":"Dryja","year":"1990","journal-title":"Nature"},{"key":"10.1016\/j.jmb.2020.08.006_bb0045","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1073\/pnas.92.3.880","article-title":"Dark-light: model for nightblindness from the human rhodopsin Gly-90 \u2192 Asp mutation","volume":"92","author":"Sieving","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jmb.2020.08.006_bb0050","doi-asserted-by":"crossref","first-page":"39993","DOI":"10.1074\/jbc.M110.201517","article-title":"Molecular mechanims of disease for mutations at Gly-90 in rhodopsin","volume":"286","author":"Toledo","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jmb.2020.08.006_bb0055","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1002\/(SICI)1098-1004(1999)13:1<75::AID-HUMU9>3.0.CO;2-4","article-title":"A novel mutation within the rhodopsin gene (Thr-94-Ile) causing autosomal dominant congenital stationary night blindness","volume":"13","author":"al-Jandal, N., Farrar, G. J., Kiang, A. S., Humphries, M. M., Bannon, N., Findlay, J. B., Humphries, P. & Kenna, P. F.","year":"1999","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.jmb.2020.08.006_bb0060","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/ng0793-280","article-title":"Heterozygous missese mutation in the rhodopsin gene as a cause of congenital stationary night blindness","volume":"4","author":"Dryja","year":"1993","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jmb.2020.08.006_bb0065","doi-asserted-by":"crossref","first-page":"4105","DOI":"10.1167\/iovs.08-1717","article-title":"Identification and functional characterization of a novel rhodopsin mutation associated with autosomal dominant CSNB","volume":"49","author":"Zeitz","year":"2008","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.jmb.2020.08.006_bb0070","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/B978-0-12-417197-8.00001-8","article-title":"Constitutively active rhodopsin and retinal disease","volume":"70","author":"Park","year":"2014","journal-title":"Adv. Pharmacol."},{"key":"10.1016\/j.jmb.2020.08.006_bb0075","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1021\/bi020612r","article-title":"Slow binding of retinal to rhodopsin mutants G90D and T94D","volume":"42","author":"Gross","year":"2003","journal-title":"Biochemistry"},{"key":"10.1016\/j.jmb.2020.08.006_bb0080","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/367639a0","article-title":"Rhodposin mutation G90D and a molecular mechanism for congenital night blindness","volume":"367","author":"Rao","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.jmb.2020.08.006_bb0085","doi-asserted-by":"crossref","first-page":"5449","DOI":"10.1523\/JNEUROSCI.21-15-05449.2001","article-title":"Constitutive \u201clight\u201d adaptation in rods from G90D rhodopsin: a mechanism for human congenital nightblindness without rod cell loss","volume":"21","author":"Sieving","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jmb.2020.08.006_bb0090","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1021\/bi020613j","article-title":"Characterization of rhodopsin congenital night blindness mutant T94I","volume":"42","author":"Gross","year":"2003","journal-title":"Biochemistry"},{"key":"10.1016\/j.jmb.2020.08.006_bb0095","doi-asserted-by":"crossref","first-page":"6427","DOI":"10.1074\/jbc.M210929200","article-title":"Unusual thermal and conformational properties of the rhodopsin congenital night blindness mutant Thr-94->Ile","volume":"278","author":"Ramon","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jmb.2020.08.006_bb0100","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1038\/embor.2013.44","article-title":"Insights into congenital stationary night blindness based on the structure of G90D rhodopsin","volume":"14","author":"Singhal","year":"2013","journal-title":"EMBO Rep."},{"key":"10.1016\/j.jmb.2020.08.006_bb0105","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.15252\/embr.201642671","article-title":"Structural role of the T94I rhodopsin mutation in congenital stationary night blindness","volume":"17","author":"Singhal","year":"2016","journal-title":"EMBO Rep."},{"key":"10.1016\/j.jmb.2020.08.006_bb0110","doi-asserted-by":"crossref","first-page":"2544","DOI":"10.1021\/bi00383a021","article-title":"Assignment of fingerprint vibrations in the resonance Raman spectra of rhodopsin, isorhodopsin, and bathorhodopsin: implications for chromophore structure and environment","volume":"26","author":"Palings","year":"1987","journal-title":"Biochemistry"},{"key":"10.1016\/j.jmb.2020.08.006_bb0115","doi-asserted-by":"crossref","first-page":"14220","DOI":"10.1021\/bi00043a029","article-title":"FTIR spectroscopy reveals microscopic changes of the protein around the rhodopsin chromophore upon photoisomerization","volume":"34","author":"Kandori","year":"1995","journal-title":"Biochemistry"},{"key":"10.1016\/j.jmb.2020.08.006_bb0120","series-title":"Handbook of Biological Physics, Volume 3","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S1383-8121(00)80005-6","article-title":"Molecular mechanisms in visual transduction","author":"Mathies","year":"2000"},{"key":"10.1016\/j.jmb.2020.08.006_bb0125","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/j.1432-1033.1983.tb07714.x","article-title":"Fourier-transform infrared spectroscopy applied to rhodopsin. The problem of the protonation state of the retinylidene Schiff base re-investigated","volume":"136","author":"Siebert","year":"1983","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.jmb.2020.08.006_bb0130","doi-asserted-by":"crossref","first-page":"17216","DOI":"10.1021\/bi9810149","article-title":"The hydrogen-bonding network of water molecules and the peptide backbone in the region connecting Asp83, Gly120, and Glu113 in bovine rhodopsin","volume":"37","author":"Nagata","year":"1998","journal-title":"Biochemistry"},{"key":"10.1016\/j.jmb.2020.08.006_bb0135","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.bbabio.2013.10.007","article-title":"Amino acid conservation and interactions in rhodopsin: probing receptor activation by NMR spectroscopy","volume":"1837","author":"Pope","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jmb.2020.08.006_bb0140","doi-asserted-by":"crossref","first-page":"10206","DOI":"10.1073\/pnas.90.21.10206","article-title":"Protonation states of membrane-embedded carboxylic acid groups in rhodopsin and metarhodopsin II: a Fourier-transform infrared spectroscopy study of site-directed mutants","volume":"90","author":"Fahmy","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jmb.2020.08.006_bb0145","doi-asserted-by":"crossref","first-page":"10277","DOI":"10.1021\/bi00090a001","article-title":"Fourier transform infrared difference spectroscopy of rhodopsin mutants: light activation of rhodopsin causes hydrogen-bonding change in residue aspartic acid-83 during meta II formation","volume":"32","author":"Rath","year":"1993","journal-title":"Biochemistry"},{"key":"10.1016\/j.jmb.2020.08.006_bb0150","doi-asserted-by":"crossref","first-page":"15065","DOI":"10.1021\/bi961486s","article-title":"Spectroscopic evidence for altered chromophore-protein interactions in low-temperature photoproducts of the visual pigment responsible for congenital night blindness","volume":"35","author":"Fahmy","year":"1996","journal-title":"Biochemistry"},{"key":"10.1016\/j.jmb.2020.08.006_bb0155","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1021\/jp0124488","article-title":"Isomer-specific interaction of the retinal chromophore with threonine-118 in rhodopsin","volume":"106","author":"Nagata","year":"2002","journal-title":"J. Phys. Chem. A"},{"key":"10.1016\/j.jmb.2020.08.006_bb0160","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1126\/science.289.5480.739","article-title":"Crystal structure of rhodopsin: a G protein-coupled receptor","volume":"289","author":"Palczewski","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.jmb.2020.08.006_bb0165","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1016\/j.jmb.2004.08.090","article-title":"Structure of bovine rhodopsin in a trigonal crystal form","volume":"343","author":"Li","year":"2004","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.jmb.2020.08.006_bb0170","doi-asserted-by":"crossref","first-page":"8895","DOI":"10.1021\/bi000852b","article-title":"The molecular origin of the inhibition of transducin activation in rhodopsin lacking the 9-methyl group of the retinal chromophore: a UV\u2013Vis and FTIR spectroscopic study","volume":"39","author":"Vogel","year":"2000","journal-title":"Biochemistry"},{"key":"10.1016\/j.jmb.2020.08.006_bb0175","doi-asserted-by":"crossref","first-page":"9619","DOI":"10.1021\/bi034592k","article-title":"Structural changes of water molecules during the photoactivation processes in bovine rhodopsin","volume":"42","author":"Furutani","year":"2003","journal-title":"Biochemistry"},{"key":"10.1016\/j.jmb.2020.08.006_bb0180","doi-asserted-by":"crossref","first-page":"5693","DOI":"10.1021\/ja907756e","article-title":"Protein fluctuations as the possible origin of the thermal activation of rod photoreceptors in the dark","volume":"132","author":"L\u00f3renz-Fonfr\u00eda","year":"2010","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.jmb.2020.08.006_bb0185","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/S0006-3495(88)83114-X","article-title":"The nature of the priary photochemical events in rhodopsin and isorhodopsin","volume":"53","author":"Birge","year":"1988","journal-title":"Biophys. J."},{"key":"10.1016\/j.jmb.2020.08.006_bb0190","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1021\/ja00266a020","article-title":"Comparative investigation of the photoisomerization of the protonated and unprotonated n-butylamine Schiff base of 9-cis-, 11-cis-, 13-cis-, and all-trans-retinals","volume":"108","author":"Freedman","year":"1986","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.jmb.2020.08.006_bb0195","doi-asserted-by":"crossref","first-page":"6028","DOI":"10.1073\/pnas.1701088114","article-title":"Evolutionary steps involving counterion displacement in a tunicate opsin","volume":"114","author":"Kojima","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jmb.2020.08.006_bb0200","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1038\/nsmb731","article-title":"Counterion displacement in the molecular evolution of the rhodopsin family","volume":"11","author":"Terakita","year":"2004","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.jmb.2020.08.006_bb0205","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1039\/c0pp00168f","article-title":"Diversity and functional properties of bistable pigments","volume":"9","author":"Tsukamoto","year":"2010","journal-title":"Photochem. Photobiol. Sci."},{"key":"10.1016\/j.jmb.2020.08.006_bb0210","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1016\/j.bpj.2019.02.025","article-title":"The two-photon reversible reaction of the bistable jumping spider rhodopsin-1","volume":"116","author":"Ehrenberg","year":"2019","journal-title":"Biophys. J."},{"key":"10.1016\/j.jmb.2020.08.006_bb0215","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/s42003-019-0409-3","article-title":"The counterion-retinylidene Schiff base interaction of an invertebrate rhodopsin rearranges upon light activation","volume":"2","author":"Nagata","year":"2019","journal-title":"Commun. Biol."},{"key":"10.1016\/j.jmb.2020.08.006_bb0220","doi-asserted-by":"crossref","first-page":"14547","DOI":"10.1073\/pnas.1902192116","article-title":"Crystal structure of jumping spider rhodopsin-1 as a light sensitive GPCR","volume":"116","author":"Varma","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jmb.2020.08.006_bb0225","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.bbabio.2013.09.002","article-title":"Relevance of rhodopsin studies for GPCR activation","volume":"1837","author":"Deupi","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jmb.2020.08.006_bb0230","doi-asserted-by":"crossref","first-page":"12508","DOI":"10.1073\/pnas.0404519101","article-title":"Structural origins of constitutive activation in rhodopsin: role of the K296\/E113 salt bridge","volume":"101","author":"Kim","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jmb.2020.08.006_bb0235","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/j.1751-1097.1989.tb04094.x","article-title":"Dependency of photon density on primary process of cattle rhodopsin","volume":"49","author":"Kandori","year":"1989","journal-title":"Photochem. Photobiol."},{"key":"10.1016\/j.jmb.2020.08.006_bb0240","doi-asserted-by":"crossref","first-page":"2944","DOI":"10.1021\/acs.biochem.9b00340","article-title":"Role of Gln114 in spectral tuning of a long-wavelength sensitive visual pigment","volume":"58","author":"Katayama","year":"2019","journal-title":"Biochemistry"},{"key":"10.1016\/j.jmb.2020.08.006_bb0245","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1021\/bi201676y","article-title":"Protein-bound water molecules in primate red- and green-sensitive visual pigments","volume":"51","author":"Katayama","year":"2012","journal-title":"Biochemistry"}],"container-title":["Journal of Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022283620304903?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022283620304903?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T21:36:34Z","timestamp":1758317794000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022283620304903"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":49,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["S0022283620304903"],"URL":"https:\/\/doi.org\/10.1016\/j.jmb.2020.08.006","relation":{},"ISSN":["0022-2836"],"issn-type":[{"type":"print","value":"0022-2836"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Disruption of Hydrogen-Bond Network in Rhodopsin Mutations Cause Night Blindness","name":"articletitle","label":"Article Title"},{"value":"Journal of Molecular Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jmb.2020.08.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}