{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T07:33:16Z","timestamp":1783409596720,"version":"3.54.6"},"reference-count":30,"publisher":"Elsevier BV","issue":"21","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100009192","name":"Alberta Innovates","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009192","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000046","name":"National Research Council Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000046","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Molecular Biology"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.jmb.2020.09.006","type":"journal-article","created":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T21:25:14Z","timestamp":1599773114000},"page":"5843-5847","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":50,"title":["Anti-Frameshifting Ligand Active against SARS Coronavirus-2 Is Resistant to Natural Mutations of the Frameshift-Stimulatory Pseudoknot"],"prefix":"10.1016","volume":"432","author":[{"given":"Krishna","family":"Neupane","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sneha","family":"Munshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dustin B.","family":"Ritchie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandaru M.","family":"Ileperuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael T.","family":"Woodside","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jmb.2020.09.006_bb0005","doi-asserted-by":"crossref","first-page":"10741","DOI":"10.1074\/jbc.AC120.013449","article-title":"Structural and functional conservation of the programmed \u22121 ribosomal frameshift signal of SARS coronavirus 2 (SARS-CoV-2)","volume":"295","author":"Kelly","year":"2020","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jmb.2020.09.006_bb0010","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.virusres.2008.06.008","article-title":"Frameshifting RNA pseudoknots: structure and mechanism","volume":"139","author":"Giedroc","year":"2009","journal-title":"Virus Res."},{"key":"10.1016\/j.jmb.2020.09.006_bb0015","series-title":"Recoding: Expansion of Decoding Rules Enriches Gene Expression","first-page":"149","article-title":"Pseudoknot-dependent programmed \u22121 ribosomal frameshifting: structures, mechanisms and models","author":"Brierley","year":"2010"},{"key":"10.1016\/j.jmb.2020.09.006_bb0020","doi-asserted-by":"crossref","first-page":"e172","DOI":"10.1371\/journal.pbio.0030172","article-title":"A three-stemmed mRNA pseudoknot in the SARS coronavirus frameshift signal","volume":"3","author":"Plant","year":"2005","journal-title":"PLoS Biol."},{"key":"10.1016\/j.jmb.2020.09.006_bb0025","doi-asserted-by":"crossref","first-page":"4330","DOI":"10.1128\/JVI.02480-09","article-title":"Achieving a golden mean: mechanisms by which coronaviruses ensure synthesis of the correct stoichiometric ratios of viral proteins","volume":"84","author":"Plant","year":"2010","journal-title":"J. Virol."},{"key":"10.1016\/j.jmb.2020.09.006_bb0030","doi-asserted-by":"crossref","first-page":"279","DOI":"10.3390\/v5010279","article-title":"Altering SARS coronavirus frameshift efficiency affects genomic and subgenomic RNA production","volume":"5","author":"Plant","year":"2013","journal-title":"Viruses"},{"key":"10.1016\/j.jmb.2020.09.006_bb0035","doi-asserted-by":"crossref","first-page":"3669","DOI":"10.1128\/jvi.66.6.3669-3676.1992","article-title":"Ribosomal frameshifting efficiency and gag\/gag-pol ratio are critical for yeast M1 double-stranded RNA virus propagation","volume":"66","author":"Dinman","year":"1992","journal-title":"J. Virol."},{"key":"10.1016\/j.jmb.2020.09.006_bb0040","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.virol.2005.08.048","article-title":"Decreasing the frameshift efficiency translates into an equivalent reduction of the replication of the human immunodeficiency virus type 1","volume":"345","author":"Dulude","year":"2006","journal-title":"Virology"},{"key":"10.1016\/j.jmb.2020.09.006_bb0045","doi-asserted-by":"crossref","first-page":"10094","DOI":"10.1021\/ja1098325","article-title":"Identification of RNA pseudoknot-binding ligand that inhibits the \u22121 ribosomal frameshifting of SARS-coronavirus by structure-based virtual screening","volume":"133","author":"Park","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.jmb.2020.09.006_bb0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.antiviral.2011.04.009","article-title":"Interference of ribosomal frameshifting by antisense peptide nucleic acids suppresses SARS coronavirus replication","volume":"91","author":"Ahn","year":"2011","journal-title":"Antivir. Res."},{"key":"10.1016\/j.jmb.2020.09.006_bb0055","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.1021\/ja410344b","article-title":"Anti-frameshifting ligand reduces the conformational plasticity of the SARS virus pseudoknot","volume":"136","author":"Ritchie","year":"2014","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.jmb.2020.09.006_bb0060","doi-asserted-by":"crossref","first-page":"172","DOI":"10.4161\/15384101.2014.989123","article-title":"Cell cycle control (and more) by programmed \u22121 ribosomal frameshifting: implications for disease and therapeutics","volume":"14","author":"Belew","year":"2015","journal-title":"Cell Cycle"},{"key":"10.1016\/j.jmb.2020.09.006_bb0065","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1021\/jm401438g","article-title":"High-affinity recognition of HIV-1 frameshift-stimulating RNA alters frameshifting in vitro and interferes with HIV-1 infectivity","volume":"57","author":"Ofori","year":"2014","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.jmb.2020.09.006_bb0070","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1021\/acschembio.5b00682","article-title":"N-methylation as a strategy for enhancing the affinity and selectivity of RNA-binding peptides: application to the HIV-1 frameshift-stimulating RNA","volume":"11","author":"Hilimire","year":"2016","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.jmb.2020.09.006_bb0075","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1021\/acschembio.7b00052","article-title":"HIV-1 frameshift RNA-targeted triazoles inhibit propagation of replication-competent and multi-drug-resistant HIV in human cells","volume":"12","author":"Hilimire","year":"2017","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.jmb.2020.09.006_bb0080","doi-asserted-by":"crossref","first-page":"2972","DOI":"10.1016\/j.bmc.2019.05.009","article-title":"Enhancing the ligand efficiency of anti-HIV compounds targeting frameshift-stimulating RNA","volume":"27","author":"Anokhina","year":"2019","journal-title":"Biorg. Med. Chem."},{"key":"10.1016\/j.jmb.2020.09.006_bb0085","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1517\/14728222.2012.665879","article-title":"Targeting frameshifting in the human immunodeficiency virus","volume":"16","author":"Brakier-Gingras","year":"2012","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.jmb.2020.09.006_bb0090","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1021\/cb200082d","article-title":"Structure of the HIV-1 frameshift site RNA bound to a small molecule inhibitor of viral replication","volume":"6","author":"Marcheschi","year":"2011","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.jmb.2020.09.006_bb0095","doi-asserted-by":"crossref","first-page":"4873","DOI":"10.2741\/3046","article-title":"The role of programmed \u22121 ribosomal frameshifting in coronavirus propagation","volume":"13","author":"Plant","year":"2008","journal-title":"Front. Biosci."},{"key":"10.1016\/j.jmb.2020.09.006_bb0100","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1261\/rna.076141.120","article-title":"RNA genome conservation and secondary structure in SARS-CoV-2 and SARS-related viruses: a first look","volume":"26","author":"Rangan","year":"2020","journal-title":"RNA"},{"key":"10.1016\/j.jmb.2020.09.006_bb0105","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1002\/gch2.1018","article-title":"Data, disease and diplomacy: GISAID\u2019s innovative contribution to global health","volume":"1","author":"Elbe","year":"2017","journal-title":"Global Chall."},{"key":"10.1016\/j.jmb.2020.09.006_bb0110","doi-asserted-by":"crossref","first-page":"2594","DOI":"10.1093\/nar\/gks1361","article-title":"RNA dimerization plays a role in ribosomal frameshifting of the SARS coronavirus","volume":"41","author":"Ishimaru","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jmb.2020.09.006_bb0115","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1261\/rna.199006","article-title":"The global structures of a wild-type and poorly functional plant luteoviral mRNA pseudoknot are essentially identical","volume":"12","author":"Cornish","year":"2006","journal-title":"RNA"},{"key":"10.1016\/j.jmb.2020.09.006_bb0120","article-title":"Modeling the structure of the frameshift stimulatory pseudoknot in SARS-CoV-2 reveals multiple possible conformers","author":"Omar","year":"2020","journal-title":"bioRxiv"},{"key":"10.1016\/j.jmb.2020.09.006_bb0125","doi-asserted-by":"crossref","unstructured":"Zhang, K., Zheludev, I. N., Hagey, R. J., Wu, M. T.-P., Haslecker, R., Hou, Y. J., Kretsch, R., Pintilie, G. D., Rangan, R., Kladwang, W., Li, S., Pham, E. A., Bernardin-Souibgui, C., Baric, R. S., Sheahean, T. P., D'Souza, V., Glenn, J. S., Chiu, W., and Das, R. (2020) Cryo-electron microscopy and exploratory antisense targeting of the 28-kDa frameshift stimulation element from the SARS-CoV-2 RNA genome. bioRxiv 2020.07.18.209270.","DOI":"10.1101\/2020.07.18.209270"},{"key":"10.1016\/j.jmb.2020.09.006_bb0130","doi-asserted-by":"crossref","first-page":"19500","DOI":"10.1073\/pnas.1905258116","article-title":"Complex dynamics under tension in a high-efficiency frameshift stimulatory structure","volume":"116","author":"Halma","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jmb.2020.09.006_bb0135","doi-asserted-by":"crossref","first-page":"16167","DOI":"10.1073\/pnas.1204114109","article-title":"Programmed \u22121 frameshifting efficiency correlates with RNA pseudoknot conformational plasticity, not resistance to mechanical unfolding","volume":"109","author":"Ritchie","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jmb.2020.09.006_bb0140","doi-asserted-by":"crossref","first-page":"12706","DOI":"10.1073\/pnas.0905046106","article-title":"Triplex structures in an RNA pseudoknot enhance mechanical stability and increase efficiency of \u22121 ribosomal frameshifting","volume":"106","author":"Chen","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jmb.2020.09.006_bb0145","first-page":"479","article-title":"A dual-luciferase reporter system for studying recoding signals","volume":"4","author":"Grentzmann","year":"1998","journal-title":"RNA"},{"key":"10.1016\/j.jmb.2020.09.006_bb0150","doi-asserted-by":"crossref","first-page":"e160","DOI":"10.1093\/nar\/gnh157","article-title":"Systematic analysis of bicistronic reporter assay data","volume":"32","author":"Jacobs","year":"2004","journal-title":"Nucleic Acids Res."}],"container-title":["Journal of Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022283620305374?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022283620305374?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T21:37:01Z","timestamp":1758317821000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022283620305374"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":30,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["S0022283620305374"],"URL":"https:\/\/doi.org\/10.1016\/j.jmb.2020.09.006","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.06.29.178707","asserted-by":"object"}]},"ISSN":["0022-2836"],"issn-type":[{"value":"0022-2836","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anti-Frameshifting Ligand Active against SARS Coronavirus-2 Is Resistant to Natural Mutations of the Frameshift-Stimulatory Pseudoknot","name":"articletitle","label":"Article Title"},{"value":"Journal of Molecular Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jmb.2020.09.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}