{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T04:42:33Z","timestamp":1790656953715,"version":"4.1.0"},"reference-count":80,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T00:00:00Z","timestamp":1671494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000866","name":"International AIDS Vaccine Initiative","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000866","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001602","name":"Science Foundation Ireland","doi-asserted-by":"publisher","award":["20\/FFP-P\/8809"],"award-info":[{"award-number":["20\/FFP-P\/8809"]}],"id":[{"id":"10.13039\/501100001602","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002081","name":"Irish Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002081","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["INV-008352\/OPP1153692"],"award-info":[{"award-number":["INV-008352\/OPP1153692"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Molecular Biology"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1016\/j.jmb.2022.167928","type":"journal-article","created":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T11:22:16Z","timestamp":1671621736000},"page":"167928","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":54,"title":["Variations within the Glycan Shield of SARS-CoV-2 Impact Viral Spike Dynamics"],"prefix":"10.1016","volume":"435","author":[{"given":"Maddy L.","family":"Newby","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl A.","family":"Fogarty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel D.","family":"Allen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Butler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Fadda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max","family":"Crispin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jmb.2022.167928_b0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2021.103539","article-title":"B and T cell response to SARS-CoV-2 vaccination in health care professionals with and without previous COVID-19","volume":"70","author":"Zollner","year":"2021","journal-title":"EBioMedicine"},{"key":"10.1016\/j.jmb.2022.167928_b0010","doi-asserted-by":"crossref","first-page":"3751","DOI":"10.3389\/fimmu.2021.740708","article-title":"Evidence of SARS-CoV-2-Specific Memory B Cells Six Months After Vaccination With the BNT162b2 mRNA Vaccine","volume":"12","author":"Ciabattini","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jmb.2022.167928_b0015","doi-asserted-by":"crossref","first-page":"eabi6950","DOI":"10.1126\/sciimmunol.abi6950","article-title":"Distinct antibody and memory B cell responses in SARS-CoV-2 na\u00efve and recovered individuals after mRNA vaccination","volume":"6","author":"Goel","year":"2021","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.jmb.2022.167928_b0020","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1056\/NEJMc2101667","article-title":"Antibody Responses in Seropositive Persons after a Single Dose of SARS-CoV-2 mRNA Vaccine","volume":"384","author":"Krammer","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jmb.2022.167928_b0025","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.chom.2022.01.003","article-title":"Persistent B cell memory after SARS-CoV-2 vaccination is functional during breakthrough infections","volume":"30","author":"Terreri","year":"2022","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.jmb.2022.167928_b0030","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/s41590-021-01122-w","article-title":"The T cell immune response against SARS-CoV-2","volume":"23","author":"Moss","year":"2022","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jmb.2022.167928_b0035","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.jinf.2021.12.003","article-title":"SARS-CoV-2 antibody and T cell responses one year after COVID-19 and the booster effect of vaccination: A prospective cohort study","volume":"84","author":"Mak","year":"2022","journal-title":"J. Infect."},{"key":"10.1016\/j.jmb.2022.167928_b0040","doi-asserted-by":"crossref","first-page":"e0251021","DOI":"10.1128\/mBio.02510-21","article-title":"Neutralization of SARS-CoV-2 Variants of Concern Harboring Q677H","volume":"12","author":"Zeng","year":"2021","journal-title":"MBio"},{"key":"10.1016\/j.jmb.2022.167928_b0045","doi-asserted-by":"crossref","first-page":"e1010022","DOI":"10.1371\/journal.ppat.1010022","article-title":"Reduced neutralisation of the Delta (B.1.617.2) SARS-CoV-2 variant of concern following vaccination","volume":"17","author":"Davis","year":"2021","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.jmb.2022.167928_b0050","doi-asserted-by":"crossref","first-page":"eabj1750","DOI":"10.1126\/sciimmunol.abj1750","article-title":"SARS-CoV-2 variants of concern partially escape humoral but not T cell responses in COVID-19 convalescent donors and vaccine recipients","volume":"6","author":"Geers","year":"2021","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.jmb.2022.167928_b0055","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/s41586-020-2179-y","article-title":"Structural basis of receptor recognition by SARS-CoV-2","volume":"581","author":"Shang","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.jmb.2022.167928_b0060","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.cell.2020.02.058","article-title":"Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein","volume":"181","author":"Walls","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.jmb.2022.167928_b0065","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/s41586-020-2380-z","article-title":"Human neutralizing antibodies elicited by SARS-CoV-2 infection","volume":"584","author":"Ju","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.jmb.2022.167928_b0070","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1126\/science.abc7520","article-title":"Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model","volume":"369","author":"Rogers","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.jmb.2022.167928_b0075","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1126\/science.abd2321","article-title":"Structural basis of a shared antibody response to SARS-CoV-2","volume":"369","author":"Yuan","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.jmb.2022.167928_b0080","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/s41586-020-2456-9","article-title":"Convergent antibody responses to SARS-CoV-2 in convalescent individuals","volume":"584","author":"Robbiani","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.jmb.2022.167928_b0085","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1126\/science.abc5902","article-title":"Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability","volume":"369","author":"Brouwer","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.jmb.2022.167928_b0090","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1126\/science.abc2241","article-title":"A noncompeting pair of human neutralizing antibodies block COVID-19 virus binding to its receptor ACE2","volume":"368","author":"Wu","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.jmb.2022.167928_b0095","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/s41586-020-2349-y","article-title":"Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody","volume":"583","author":"Pinto","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.jmb.2022.167928_b0100","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.immuni.2020.06.001","article-title":"Analysis of a SARS-CoV-2-Infected Individual Reveals Development of Potent Neutralizing Antibodies with Limited Somatic Mutation","volume":"53","author":"Seydoux","year":"2020","journal-title":"Immunity"},{"key":"10.1016\/j.jmb.2022.167928_b0105","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1038\/s41586-020-2381-y","article-title":"A human neutralizing antibody targets the receptor-binding site of SARS-CoV-2","volume":"584","author":"Shi","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.jmb.2022.167928_b0110","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1016\/j.cell.2020.06.025","article-title":"Structures of Human Antibodies Bound to SARS-CoV-2 Spike Reveal Common Epitopes and Recurrent Features of Antibodies","volume":"182","author":"Barnes","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.jmb.2022.167928_b0115","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1038\/s41579-021-00573-0","article-title":"SARS-CoV-2 variants, spike mutations and immune escape","volume":"19","author":"Harvey","year":"2021","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.jmb.2022.167928_b0120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7554\/eLife.61312","article-title":"Escape from neutralizing antibodies by SARS-CoV-2 spike protein variants","volume":"9","author":"Weisblum","year":"2020","journal-title":"Elife"},{"key":"10.1016\/j.jmb.2022.167928_b0125","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1126\/scitranslmed.abm0899","article-title":"Vaccination with SARS-CoV-2 spike protein lacking glycan shields elicits enhanced protective responses in animal models","volume":"14","author":"Huang","year":"2022","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.jmb.2022.167928_b0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.compbiomed.2022.105735","article-title":"Insights into the structural peculiarities of the N-terminal and receptor binding domains of the spike protein from the SARS-CoV-2 Omicron variant","volume":"147","author":"Bayani","year":"2022","journal-title":"Comput. Biol. Med."},{"key":"10.1016\/j.jmb.2022.167928_b0135","article-title":"Glycosite-deleted mRNA of SARS-CoV-2 spike protein as a broad-spectrum vaccine","volume":"119","author":"Wu","year":"2022","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.jmb.2022.167928_b0140","doi-asserted-by":"crossref","first-page":"E1059","DOI":"10.1503\/cmaj.1095949","article-title":"Alpha, Beta, Delta, Gamma: What\u2019s important to know about SARS-CoV-2 variants of concern?","volume":"193","author":"Duong","year":"2021","journal-title":"Can. Med. Assoc. J."},{"key":"10.1016\/j.jmb.2022.167928_b0145","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1126\/science.abe8499","article-title":"SARS-CoV-2 D614G variant exhibits efficient replication ex vivo and transmission in vivo","volume":"370","author":"Hou","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.jmb.2022.167928_b0150","doi-asserted-by":"crossref","first-page":"e283","DOI":"10.1016\/S2666-5247(21)00068-9","article-title":"SARS-CoV-2 spike E484K mutation reduces antibody neutralisation","volume":"2","author":"Jangra","year":"2021","journal-title":"Lancet Microbe"},{"key":"10.1016\/j.jmb.2022.167928_b0155","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1038\/s41586-021-04245-0","article-title":"The N501Y spike substitution enhances SARS-CoV-2 infection and transmission","volume":"602","author":"Liu","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.jmb.2022.167928_b0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmb.2021.167058","article-title":"Experimental Evidence for Enhanced Receptor Binding by Rapidly Spreading SARS-CoV-2 Variants","volume":"433","author":"Laffeber","year":"2021","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.jmb.2022.167928_b0165","doi-asserted-by":"crossref","first-page":"6013","DOI":"10.1038\/s41467-020-19808-4","article-title":"SARS-CoV-2 spike-protein D614G mutation increases virion spike density and infectivity","volume":"11","author":"Zhang","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jmb.2022.167928_b0170","doi-asserted-by":"crossref","first-page":"2384","DOI":"10.1016\/j.cell.2021.03.036","article-title":"SARS-CoV-2 variants B.1.351 and P.1 escape from neutralizing antibodies","volume":"184","author":"Hoffmann","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.jmb.2022.167928_b0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.108424","article-title":"E484K and N501Y SARS-CoV 2 spike mutants Increase ACE2 recognition but reduce affinity for neutralizing antibody","volume":"102","author":"Chakraborty","year":"2022","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.jmb.2022.167928_b0180","doi-asserted-by":"crossref","first-page":"5638","DOI":"10.1002\/jmv.27062","article-title":"Preliminary report on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Spike mutation T478K","volume":"93","author":"Di Giacomo","year":"2021","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.jmb.2022.167928_b0185","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1016\/j.cell.2020.09.037","article-title":"Mapping Neutralizing and Immunodominant Sites on the SARS-CoV-2 Spike Receptor-Binding Domain by Structure-Guided High-Resolution Serology","volume":"183","author":"Piccoli","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.jmb.2022.167928_b0190","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1016\/j.str.2022.05.006","article-title":"Uncovering cryptic pockets in the SARS-CoV-2 spike glycoprotein","author":"Zuzic","year":"2022","journal-title":"Structure"},{"key":"10.1016\/j.jmb.2022.167928_b0195","doi-asserted-by":"crossref","first-page":"eabi6226","DOI":"10.1126\/science.abi6226","article-title":"Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity","volume":"373","author":"Gobeil","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.jmb.2022.167928_b0200","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1126\/science.abi9745","article-title":"Structural basis for enhanced infectivity and immune evasion of SARS-CoV-2 variants","volume":"373","author":"Cai","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.jmb.2022.167928_b0205","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.chom.2021.04.007","article-title":"Increased resistance of SARS-CoV-2 variant P.1 to antibody neutralization","volume":"29","author":"Wang","year":"2021","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.jmb.2022.167928_b0210","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.1016\/j.molcel.2022.03.028","article-title":"Structural Diversity of the SARS-CoV-2 Omicron Spike","volume":"82","author":"Gobeil","year":"2022","journal-title":"Mol. Cell"},{"key":"10.1016\/j.jmb.2022.167928_b0215","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1126\/science.abb9983","article-title":"Site-specific glycan analysis of the SARS-CoV-2 spike","volume":"369","author":"Watanabe","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.jmb.2022.167928_b0220","doi-asserted-by":"crossref","first-page":"14991","DOI":"10.1038\/s41598-020-71748-7","article-title":"Analysis of the SARS-CoV-2 spike protein glycan shield reveals implications for immune recognition","volume":"10","author":"Grant","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jmb.2022.167928_b0225","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.chom.2020.08.004","article-title":"Virus-Receptor Interactions of Glycosylated SARS-CoV-2 Spike and Human ACE2 Receptor","volume":"28","author":"Zhao","year":"2020","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.jmb.2022.167928_b0230","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/s41392-021-00809-8","article-title":"The glycosylation in SARS-CoV-2 and its receptor ACE2","volume":"6","author":"Gong","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.jmb.2022.167928_b0235","doi-asserted-by":"crossref","first-page":"11132","DOI":"10.1128\/JVI.01542-16","article-title":"HIV-1 Glycan Density Drives the Persistence of the Mannose Patch within an Infected Individual","volume":"90","author":"Coss","year":"2016","journal-title":"J. Virol."},{"key":"10.1016\/j.jmb.2022.167928_b0240","doi-asserted-by":"crossref","first-page":"e00204","DOI":"10.1128\/mBio.00204-19","article-title":"Human Influenza A Virus Hemagglutinin Glycan Evolution Follows a Temporal Pattern to a Glycan Limit","volume":"10","author":"Altman","year":"2019","journal-title":"mBio."},{"key":"10.1016\/j.jmb.2022.167928_b0245","doi-asserted-by":"crossref","first-page":"2911","DOI":"10.1126\/sciadv.abn2911","article-title":"Structural mapping of antibody landscapes to human betacoronavirus spike proteins","volume":"8","author":"Bangaru","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.jmb.2022.167928_b0250","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1021\/acscentsci.0c01056","article-title":"Beyond Shielding: The Roles of Glycans in the SARS-CoV-2 Spike Protein","volume":"6","author":"Casalino","year":"2020","journal-title":"ACS Cent. Sci."},{"key":"10.1016\/j.jmb.2022.167928_b0255","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.03718-21","article-title":"Inhibition of Protein N- Glycosylation Blocks SARS-CoV-2 Infection","volume":"13","author":"Casas-Sanchez","year":"2022","journal-title":"MBio"},{"key":"10.1016\/j.jmb.2022.167928_b0260","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1093\/glycob\/cws110","article-title":"Site-specific glycoproteomics confirms that protein structure dictates formation of N-glycan type, core fucosylation and branching","volume":"22","author":"Thaysen-Andersen","year":"2012","journal-title":"Glycobiology"},{"key":"10.1016\/j.jmb.2022.167928_b0265","doi-asserted-by":"crossref","first-page":"7479","DOI":"10.1038\/ncomms8479","article-title":"Glycan clustering stabilizes the mannose patch of HIV-1 and preserves vulnerability to broadly neutralizing antibodies","volume":"6","author":"Pritchard","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jmb.2022.167928_b0270","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.1021\/acs.biochem.1c00279","article-title":"Site-Specific Steric Control of SARS-CoV-2 Spike Glycosylation","volume":"60","author":"Allen","year":"2021","journal-title":"Biochemistry"},{"key":"10.1016\/j.jmb.2022.167928_b0275","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.sbi.2017.03.008","article-title":"Structural principles controlling HIV envelope glycosylation","volume":"44","author":"Behrens","year":"2017","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.1016\/j.jmb.2022.167928_b0280","doi-asserted-by":"crossref","DOI":"10.1016\/j.sbi.2022.102402","article-title":"Principles of SARS-CoV-2 glycosylation","volume":"75","author":"Chawla","year":"2022","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.1016\/j.jmb.2022.167928_b0285","doi-asserted-by":"crossref","first-page":"14730","DOI":"10.1021\/acs.analchem.0c03301","article-title":"Comprehensive Analysis of the Glycan Complement of SARS-CoV-2 Spike Proteins Using Signature Ions-Triggered Electron-Transfer\/Higher-Energy Collisional Dissociation (EThcD) Mass Spectrometry","volume":"92","author":"Wang","year":"2020","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jmb.2022.167928_b0290","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.virol.2009.12.020","article-title":"Identification of N-linked carbohydrates from severe acute respiratory syndrome (SARS) spike glycoprotein","volume":"399","author":"Ritchie","year":"2010","journal-title":"Virology"},{"key":"10.1016\/j.jmb.2022.167928_b0295","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1126\/science.abd0826","article-title":"Structure-based design of prefusion-stabilized SARS-CoV-2 spikes","volume":"369","author":"Hsieh","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.jmb.2022.167928_b0300","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abg7607","article-title":"SARS-CoV-2 can recruit a heme metabolite to evade antibody immunity","volume":"7","author":"Rosa","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.jmb.2022.167928_b0305","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmb.2021.167332","article-title":"Glycosylation and Serological Reactivity of an Expression-enhanced SARS-CoV-2 Viral Spike Mimetic","volume":"434","author":"Chawla","year":"2022","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.jmb.2022.167928_b0310","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1021\/acscentsci.1c00058","article-title":"Assessing Antigen Structural Integrity through Glycosylation Analysis of the SARS-CoV-2 Viral Spike","volume":"7","author":"Brun","year":"2021","journal-title":"ACS Cent. Sci."},{"key":"10.1016\/j.jmb.2022.167928_b0315","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1021\/acscentsci.1c00080","article-title":"Native-like SARS-CoV-2 Spike Glycoprotein Expressed by ChAdOx1 nCoV-19\/AZD1222 Vaccine","volume":"7","author":"Watanabe","year":"2021","journal-title":"ACS Cent. Sci."},{"key":"10.1016\/j.jmb.2022.167928_b0320","doi-asserted-by":"crossref","first-page":"28014","DOI":"10.1073\/pnas.2000260117","article-title":"Visualization of the HIV-1 Env glycan shield across scales","volume":"117","author":"Berndsen","year":"2020","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.jmb.2022.167928_b0325","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.108933","article-title":"Enhancing glycan occupancy of soluble HIV-1 envelope trimers to mimic the native viral spike","volume":"35","author":"Derking","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.jmb.2022.167928_b0330","first-page":"5513","article-title":"Glycosylation of closely spaced acceptor sites in human glycoproteins","volume":"126","author":"Shrimal","year":"2013","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.jmb.2022.167928_b0335","doi-asserted-by":"crossref","first-page":"4884","DOI":"10.1021\/bi500681p","article-title":"The Middle X Residue Influences Cotranslational N-Glycosylation Consensus Site Skipping","volume":"53","author":"Malaby","year":"2014","journal-title":"Biochemistry"},{"key":"10.1016\/j.jmb.2022.167928_b0340","doi-asserted-by":"crossref","first-page":"13800","DOI":"10.1073\/pnas.1006498107","article-title":"Envelope glycans of immunodeficiency virions are almost entirely oligomannose antigens","volume":"107","author":"Doores","year":"2010","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.jmb.2022.167928_b0345","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1126\/science.abl9463","article-title":"Membrane fusion and immune evasion by the spike protein of SARS-CoV-2 Delta variant","volume":"374","author":"Zhang","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.jmb.2022.167928_b0350","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1039\/D1SC04832E","article-title":"Fine-tuning the spike: role of the nature and topology of the glycan shield in the structure and dynamics of the SARS-CoV-2 S","volume":"13","author":"Harbison","year":"2022","journal-title":"Chem. Sci."},{"key":"10.1016\/j.jmb.2022.167928_bib396","doi-asserted-by":"crossref","first-page":"4696","DOI":"10.1038\/s41467-022-32262-8","article-title":"SARS-CoV-2 variants of concern: spike protein mutational analysis and epitope for broad neutralization","volume":"13","author":"Mannar","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jmb.2022.167928_b0355","first-page":"816702","article-title":"PyVOL: A PyMOL plugin for visualization, comparison, and volume calculation of drug-binding sites","author":"Smith","year":"2019","journal-title":"BioRxiv"},{"key":"10.1016\/j.jmb.2022.167928_b0360","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1126\/science.abh2644","article-title":"Sabino, Genomics and epidemiology of the P.1 SARS-CoV-2 lineage in Manaus, Brazil","volume":"372","author":"Faria","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.jmb.2022.167928_b0365","article-title":"A pseudovirus system enables deep mutational scanning of the full SARS-CoV-2 spike","author":"Dadonaite","year":"2022","journal-title":"BioRxiv"},{"key":"10.1016\/j.jmb.2022.167928_b0370","doi-asserted-by":"crossref","first-page":"2332","DOI":"10.1016\/j.cell.2021.03.028","article-title":"N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2","volume":"184","author":"McCallum","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.jmb.2022.167928_b0375","doi-asserted-by":"crossref","first-page":"2688","DOI":"10.1038\/s41467-020-16567-0","article-title":"Vulnerabilities in coronavirus glycan shields despite extensive glycosylation","volume":"11","author":"Watanabe","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jmb.2022.167928_b0380","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1038\/nsmb.3293","article-title":"Glycan shield and epitope masking of a coronavirus spike protein observed by cryo-electron microscopy","volume":"23","author":"Walls","year":"2016","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.jmb.2022.167928_b0385","doi-asserted-by":"crossref","first-page":"3696","DOI":"10.1021\/acs.jctc.5b00255","article-title":"ff14SB: Improving the Accuracy of Protein Side Chain and Backbone Parameters from ff99SB","volume":"11","author":"Maier","year":"2015","journal-title":"J. Chem. Theory Comput."},{"key":"10.1016\/j.jmb.2022.167928_b0390","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1002\/jcc.20820","article-title":"GLYCAM06: A generalizable biomolecular force field. Carbohydrates","volume":"29","author":"Kirschner","year":"2008","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.jmb.2022.167928_b0395","unstructured":"D.A. Case, I.Y. Ben-Shalom, S.R. Brozell, D.S. Cerutti, T.E. Cheatham, V.W.D.C. III, T.A. Darden, R.E. Duke, et al., AMBER 2018, 2018. http:\/\/ambermd.org\/contributors.html (accessed August 12, 2022)."}],"container-title":["Journal of Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022283622005551?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022283622005551?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T06:25:06Z","timestamp":1762669506000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022283622005551"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":80,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["S0022283622005551"],"URL":"https:\/\/doi.org\/10.1016\/j.jmb.2022.167928","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2022.08.17.504157","asserted-by":"object"}]},"ISSN":["0022-2836"],"issn-type":[{"value":"0022-2836","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Variations within the Glycan Shield of SARS-CoV-2 Impact Viral Spike Dynamics","name":"articletitle","label":"Article Title"},{"value":"Journal of Molecular Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jmb.2022.167928","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"167928"}}