{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:51:28Z","timestamp":1786668688043,"version":"build-2736575974"},"reference-count":52,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T00:00:00Z","timestamp":1708387200000},"content-version":"am","delay-in-days":325,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100006151","name":"Basic Energy Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006151","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["ACB-12002"],"award-info":[{"award-number":["ACB-12002"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006224","name":"Argonne National Laboratory","doi-asserted-by":"publisher","award":["DE-AC02-06CH11357"],"award-info":[{"award-number":["DE-AC02-06CH11357"]}],"id":[{"id":"10.13039\/100006224","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["AGM-12006"],"award-info":[{"award-number":["AGM-12006"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["P30GM138396"],"award-info":[{"award-number":["P30GM138396"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006228","name":"Oak Ridge National Laboratory","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006228","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000161","name":"National Institute of Standards and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000161","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000190","name":"U.S. Department of Commerce","doi-asserted-by":"publisher","award":["70NANB17H299"],"award-info":[{"award-number":["70NANB17H299"]}],"id":[{"id":"10.13039\/100000190","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006132","name":"Office of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006132","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000015","name":"U.S. Department of Energy","doi-asserted-by":"publisher","award":["DE-AC05-00OR22725"],"award-info":[{"award-number":["DE-AC05-00OR22725"]}],"id":[{"id":"10.13039\/100000015","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI152677"],"award-info":[{"award-number":["AI152677"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Molecular Biology"],"published-print":{"date-parts":[[2023,4]]},"DOI":"10.1016\/j.jmb.2023.168009","type":"journal-article","created":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T05:34:07Z","timestamp":1676007247000},"page":"168009","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Neutron Reflectometry and Molecular Simulations Demonstrate HIV-1 Nef Homodimer Formation on Model Lipid Bilayers"],"prefix":"10.1016","volume":"435","author":[{"given":"Frank","family":"Heinrich","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine E.","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"Alvarado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Eells","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyssa","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu","family":"Doucet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kindra N.","family":"Whitlatch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manish","family":"Aryal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"L\u00f6sche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas E.","family":"Smithgall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jmb.2023.168009_b0005","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.mam.2010.05.003","article-title":"Human immunodeficiency virus (HIV) type-1, HIV-2 and simian immunodeficiency virus Nef proteins","volume":"31","author":"Laguette","year":"2010","journal-title":"Mol. Aspects Med."},{"key":"10.1016\/j.jmb.2023.168009_b0010","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0092-8674(00)81748-1","article-title":"Nef harbors a major determinant of pathogenicity for an AIDS-like disease induced by HIV-1 in transgenic mice","volume":"95","author":"Hanna","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.jmb.2023.168009_b0015","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1126\/science.270.5238.988","article-title":"Genomic structure of an attenuated quasi species of HIV-1 from a blood transfusion donor and recipients","volume":"270","author":"Deacon","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.jmb.2023.168009_b0020","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1056\/NEJM199501263320405","article-title":"Absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection","volume":"332","author":"Kirchhoff","year":"1995","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jmb.2023.168009_b0025","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/0092-8674(91)90097-I","article-title":"Importance of the nef gene for maintenance of high viral loads and for development of AIDS","volume":"65","author":"Kestler","year":"1991","journal-title":"Cell"},{"key":"10.1016\/j.jmb.2023.168009_b0030","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1006\/jmbi.1999.2740","article-title":"Structure of the anchor-domain of myristoylated and non-myristoylated HIV-1 Nef protein","volume":"289","author":"Geyer","year":"1999","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.jmb.2023.168009_b0035","doi-asserted-by":"crossref","first-page":"5970","DOI":"10.1021\/bi9629945","article-title":"Solution structure of a polypeptide from the N terminus of the HIV protein Nef","volume":"36","author":"Barnham","year":"1997","journal-title":"Biochemistry"},{"key":"10.1016\/j.jmb.2023.168009_b0040","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/nchembio.268","article-title":"HIV-1 Nef membrane association depends on charge, curvature, composition and sequence","volume":"6","author":"Gerlach","year":"2010","journal-title":"Nature Chem. Biol."},{"key":"10.1016\/j.jmb.2023.168009_b0045","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.virol.2006.07.003","article-title":"Specific and distinct determinants mediate membrane binding and lipid raft incorporation of HIV-1(SF2) Nef","volume":"355","author":"Giese","year":"2006","journal-title":"Virology"},{"key":"10.1016\/j.jmb.2023.168009_b0050","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1099\/vir.0.81200-0","article-title":"Role of myristoylation and N-terminal basic residues in membrane association of the human immunodeficiency virus type 1 Nef protein","volume":"87","author":"Bentham","year":"2006","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.jmb.2023.168009_b0055","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/1742-4690-4-70","article-title":"Human immunodeficiency virus type 1 Nef protein modulates the lipid composition of virions and host cell membrane microdomains","volume":"4","author":"Brugger","year":"2007","journal-title":"Retrovirology"},{"key":"10.1016\/j.jmb.2023.168009_b0060","doi-asserted-by":"crossref","first-page":"15158","DOI":"10.1074\/jbc.REV120.012317","article-title":"Structure, function, and inhibitor targeting of HIV-1 Nef-effector kinase complexes","volume":"295","author":"Staudt","year":"2020","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jmb.2023.168009_b0065","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1021\/acsinfecdis.1c00288","article-title":"Inhibitors of HIV-1 Nef-Mediated Activation of the Myeloid Src-Family Kinase Hck Block HIV-1 Replication in Macrophages and Disrupt MHC-I Downregulation","volume":"8","author":"Emert-Sedlak","year":"2022","journal-title":"ACS Infect. Dis."},{"key":"10.1016\/j.jmb.2023.168009_b0070","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.chembiol.2012.11.005","article-title":"Effector Kinase Coupling Enables High-Throughput Screens for Direct HIV-1 Nef Antagonists with Antiretroviral Activity","volume":"20","author":"Emert-Sedlak","year":"2013","journal-title":"Chem. Biol."},{"key":"10.1016\/j.jmb.2023.168009_b0075","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1021\/cb900195c","article-title":"Chemical library screens targeting an HIV-1 accessory factor\/host cell kinase complex identify novel antiretroviral compounds","volume":"4","author":"Emert-Sedlak","year":"2009","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.jmb.2023.168009_b0080","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/nm0396-338","article-title":"Endocytosis of major histocompatibility complex class I molecules is induced by the HIV-1 Nef protein","volume":"2","author":"Schwartz","year":"1996","journal-title":"Nature Med."},{"key":"10.1016\/j.jmb.2023.168009_b0085","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/1742-4690-7-44","article-title":"Expression of Nef from unintegrated HIV-1 DNA downregulates cell surface CXCR4 and CCR5 on T-lymphocytes","volume":"7","author":"Sloan","year":"2010","journal-title":"Retrovirology"},{"key":"10.1016\/j.jmb.2023.168009_b0090","doi-asserted-by":"crossref","first-page":"11141","DOI":"10.1128\/JVI.01556-06","article-title":"Expression of Nef Downregulates CXCR4, the Major Coreceptor of Human Immunodeficiency Virus, From the Surface of Target Cells and Thereby Enhances Resistance to Superinfection","volume":"80","author":"Venzke","year":"2006","journal-title":"J. Virol."},{"key":"10.1016\/j.jmb.2023.168009_b0095","doi-asserted-by":"crossref","first-page":"3578","DOI":"10.1091\/mbc.e06-02-0117","article-title":"The Nef protein of human immunodeficiency virus is a broad-spectrum modulator of chemokine receptor cell surface levels that acts independently of classical motifs for receptor endocytosis and Galphai signaling","volume":"17","author":"Michel","year":"2006","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.jmb.2023.168009_b0100","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1111\/tra.12412","article-title":"HIV-1 Nef: Taking Control of Protein Trafficking","volume":"17","author":"Pereira","year":"2016","journal-title":"Traffic"},{"key":"10.1016\/j.jmb.2023.168009_b0105","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.bbagen.2015.01.003","article-title":"HIV-1 Nef: a master manipulator of the membrane trafficking machinery mediating immune evasion","volume":"1850","author":"Pawlak","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jmb.2023.168009_b0110","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/S0092-8674(00)81276-3","article-title":"Crystal structure of the conserved core of HIV-1 Nef complexed with a Src family SH3 domain","volume":"85","author":"Lee","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.jmb.2023.168009_b0115","doi-asserted-by":"crossref","first-page":"28539","DOI":"10.1074\/jbc.M114.600031","article-title":"Interaction with the Src homology (SH3-SH2) region of the Src-family kinase Hck structures the HIV-1 Nef dimer for kinase activation and effector recruitment","volume":"289","author":"Alvarado","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jmb.2023.168009_b0120","doi-asserted-by":"crossref","first-page":"5163","DOI":"10.1074\/jbc.RA120.012536","article-title":"HIV-1 Nef dimers short-circuit immune receptor signaling by activating Tec-family kinases at the host cell membrane","volume":"295","author":"Li","year":"2020","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jmb.2023.168009_b0125","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.jmb.2009.09.047","article-title":"HIV-1 Nef dimerization is required for Nef-mediated receptor downregulation and viral replication","volume":"394","author":"Poe","year":"2009","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.jmb.2023.168009_b0130","doi-asserted-by":"crossref","first-page":"15540","DOI":"10.1074\/jbc.RA120.014668","article-title":"Nef homodimers down-regulate SERINC5 by AP-2-mediated endocytosis to promote HIV-1 infectivity","volume":"295","author":"Staudt","year":"2020","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jmb.2023.168009_b0135","doi-asserted-by":"crossref","first-page":"2670","DOI":"10.1074\/jbc.M116.770016","article-title":"Cell-based Fluorescence Complementation Reveals a Role for HIV-1 Nef Protein Dimerization in AP-2 Adaptor Recruitment and CD4 Co-receptor Down-regulation","volume":"292","author":"Shu","year":"2017","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jmb.2023.168009_b0140","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/nsmb.2328","article-title":"Structural basis of evasion of cellular adaptive immunity by HIV-1 Nef","volume":"19","author":"Jia","year":"2012","journal-title":"Nature Struct. Mol. Biol."},{"key":"10.1016\/j.jmb.2023.168009_b0145","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.jmb.2017.12.008","article-title":"Remodeling of HIV-1 Nef Structure by Src-Family Kinase Binding","volume":"430","author":"Moroco","year":"2018","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.jmb.2023.168009_b0150","doi-asserted-by":"crossref","first-page":"4544","DOI":"10.1128\/JVI.02820-15","article-title":"Membrane Binding of HIV-1 Matrix Protein: Dependence on Bilayer Composition and Protein Lipidation","volume":"90","author":"Barros","year":"2016","journal-title":"J. Virol."},{"key":"10.1016\/j.jmb.2023.168009_b0155","doi-asserted-by":"crossref","first-page":"2339","DOI":"10.1021\/bi052052c","article-title":"Biochemical indication for myristoylation-dependent conformational changes in HIV-1 Nef","volume":"45","author":"Breuer","year":"2006","journal-title":"Biochemistry"},{"key":"10.1016\/j.jmb.2023.168009_b0160","doi-asserted-by":"crossref","first-page":"e0192512","DOI":"10.1371\/journal.pone.0192512","article-title":"A single beta-octyl glucoside molecule induces HIV-1 Nef dimer formation in the absence of partner protein binding","volume":"13","author":"Wu","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.jmb.2023.168009_b0165","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1016\/j.str.2013.08.008","article-title":"Conformational transition of membrane-associated terminally acylated HIV-1 Nef","volume":"21","author":"Akgun","year":"2013","journal-title":"Structure"},{"key":"10.1016\/j.jmb.2023.168009_b0170","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/S0968-0004(01)01846-1","article-title":"Dynamic Nef and Nef dynamics: how structure could explain the complex activities of this small HIV protein","volume":"26","author":"Arold","year":"2001","journal-title":"Trends Biochem. Sci"},{"key":"10.1016\/j.jmb.2023.168009_b0175","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0014-5793(01)02394-8","article-title":"Domain assembly, surface accessibility and sequence conservation in full length HIV-1 Nef","volume":"496","author":"Geyer","year":"2001","journal-title":"FEBS Letter"},{"key":"10.1016\/j.jmb.2023.168009_b0180","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1021\/acsinfecdis.9b00382","article-title":"Tight-Binding Hydroxypyrazole HIV-1 Nef Inhibitors Suppress Viral Replication in Donor Mononuclear Cells and Reverse Nef-Mediated MHC-I Downregulation","volume":"6","author":"Shi","year":"2020","journal-title":"ACS Infect. Dis."},{"key":"10.1016\/j.jmb.2023.168009_b0185","doi-asserted-by":"crossref","first-page":"7030","DOI":"10.1021\/acs.analchem.5b01725","article-title":"Membrane-Associated Conformation of HIV-1 Nef Investigated with Hydrogen Exchange Mass Spectrometry at a Langmuir Monolayer","volume":"87","author":"Pirrone","year":"2015","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jmb.2023.168009_b0190","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1107\/S0907444909047337","article-title":"Xds","volume":"66","author":"Kabsch","year":"2010","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.jmb.2023.168009_b0195","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1107\/S0907444909052925","article-title":"PHENIX: a comprehensive Python-based system for macromolecular structure solution","volume":"66","author":"Adams","year":"2010","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.jmb.2023.168009_b0200","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1107\/S0021889892009944","article-title":"PROCHECK - a program to check the stereochemical quality of protein structures","volume":"26","author":"Lakowski","year":"1993","journal-title":"J. App. Cryst."},{"key":"10.1016\/j.jmb.2023.168009_b0205","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1002\/prot.10286","article-title":"Structure validation by C-alpha geometry: phi, psi and C-beta deviation","volume":"50","author":"Lovell","year":"2003","journal-title":"Proteins"},{"key":"10.1016\/j.jmb.2023.168009_b0210","doi-asserted-by":"crossref","first-page":"8645","DOI":"10.1021\/la401132c","article-title":"Structure and properties of tethered bilayer lipid membranes with unsaturated anchor molecules","volume":"29","author":"Budvytyte","year":"2013","journal-title":"Langmuir"},{"key":"10.1016\/j.jmb.2023.168009_b0215","doi-asserted-by":"crossref","first-page":"74301","DOI":"10.1063\/1.2219744","article-title":"AND\/R: Advanced neutron diffractometer\/reflectometer for investigation of thin films and multilayers for the life sciences","volume":"77","author":"Dura","year":"2006","journal-title":"Rev. Sci. Instrum."},{"key":"10.1016\/j.jmb.2023.168009_b0220","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.cocis.2011.11.001","article-title":"Phase-sensitive specular neutron reflectometry for imaging the nanometer scale composition depth profile of thin-film materials","volume":"17","author":"Kirby","year":"2012","journal-title":"Curr. Opin. Colloid Interface Sci."},{"key":"10.1016\/j.jmb.2023.168009_b0225","doi-asserted-by":"crossref","first-page":"10018","DOI":"10.1021\/acsami.9b22382","article-title":"The Study of the Binder Poly(acrylic acid) and Its Role in Concomitant Solid-Electrolyte Interphase Formation on Si Anodes","volume":"12","author":"Browning","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.jmb.2023.168009_b0230","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1016\/j.bbamem.2014.03.007","article-title":"Zooming in on disordered systems: neutron reflection studies of proteins associated with fluid membranes","volume":"1838","author":"Heinrich","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jmb.2023.168009_b0235","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.cpc.2011.09.010","article-title":"SASSIE: a program to study intrinsically disordered biological molecules and macromolecular assemblies using experimental scattering restraints","volume":"183","author":"Curtis","year":"2012","journal-title":"Comput. Phys. Commun."},{"key":"10.1016\/j.jmb.2023.168009_b0240","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1107\/S160057671601517X","article-title":"Atomistic modelling of scattering data in the Collaborative Computational Project for Small Angle Scattering (CCP-SAS)","volume":"49","author":"Perkins","year":"2016","journal-title":"J. Appl. Cryst."},{"key":"10.1016\/j.jmb.2023.168009_b0245","doi-asserted-by":"crossref","first-page":"e01754","DOI":"10.7554\/eLife.01754","article-title":"How HIV-1 Nef hijacks the AP-2 clathrin adaptor to downregulate CD4","volume":"3","author":"Ren","year":"2014","journal-title":"Elife"},{"key":"10.1016\/j.jmb.2023.168009_b0250","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1002\/prot.340230306","article-title":"Evaluation of comparative protein modeling by MODELLER","volume":"23","author":"Sali","year":"1995","journal-title":"Proteins"},{"key":"10.1016\/j.jmb.2023.168009_b0255","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1002\/jcc.21287","article-title":"CHARMM: the biomolecular simulation program","volume":"30","author":"Brooks","year":"2009","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.jmb.2023.168009_b0260","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.1002\/jcc.21787","article-title":"MDAnalysis: a toolkit for the analysis of molecular dynamics simulations","volume":"32","author":"Michaud-Agrawal","year":"2011","journal-title":"J. Comput. Chem."}],"container-title":["Journal of Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022283623000657?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022283623000657?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T06:26:05Z","timestamp":1762669565000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022283623000657"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4]]},"references-count":52,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["S0022283623000657"],"URL":"https:\/\/doi.org\/10.1016\/j.jmb.2023.168009","relation":{},"ISSN":["0022-2836"],"issn-type":[{"value":"0022-2836","type":"print"}],"subject":[],"published":{"date-parts":[[2023,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neutron Reflectometry and Molecular Simulations Demonstrate HIV-1 Nef Homodimer Formation on Model Lipid Bilayers","name":"articletitle","label":"Article Title"},{"value":"Journal of Molecular Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jmb.2023.168009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"168009"}}