{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T06:15:41Z","timestamp":1789107341629,"version":"build-2803163510"},"reference-count":56,"publisher":"Elsevier BV","issue":"22","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Shandong Province Natural Science Foundation","doi-asserted-by":"publisher","award":["ZR2020QC006"],"award-info":[{"award-number":["ZR2020QC006"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012580","name":"Natural Science Foundation of Tianjin Science and Technology Correspondent Project","doi-asserted-by":"publisher","award":["22JCYBJC01060"],"award-info":[{"award-number":["22JCYBJC01060"]}],"id":[{"id":"10.13039\/501100012580","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006606","name":"Natural Science Foundation of Tianjin Municipality","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32170110"],"award-info":[{"award-number":["32170110"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Molecular Biology"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.jmb.2024.168798","type":"journal-article","created":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T12:24:32Z","timestamp":1726748672000},"page":"168798","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Shigella Senses the Environmental Cue Leucine to Promote its Virulence Gene Expression in the Colon"],"prefix":"10.1016","volume":"436","author":[{"given":"Huiying","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongyao","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqi","family":"Teng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jmb.2024.168798_b0005","doi-asserted-by":"crossref","first-page":"S580","DOI":"10.1093\/cid\/ciz892","article-title":"Consensus report on Shigella controlled human infection model: conduct of studies","volume":"69","author":"Talaat","year":"2019","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.jmb.2024.168798_b0010","doi-asserted-by":"crossref","first-page":"e101","DOI":"10.1016\/S2214-109X(19)30456-5","article-title":"Heterogeneity in enterotoxigenic Escherichia coli and shigella infections in children under 5 years of age from 11 African countries: a subnational approach quantifying risk, mortality, morbidity, and stunting","volume":"8","author":"Bagamian","year":"2020","journal-title":"Lancet Glob. Health"},{"key":"10.1016\/j.jmb.2024.168798_b0015","doi-asserted-by":"crossref","first-page":"9929","DOI":"10.1073\/pnas.1406694111","article-title":"Shigella reroutes host cell central metabolism to obtain high-flux nutrient supply for vigorous intracellular growth","volume":"111","author":"Kentner","year":"2014","journal-title":"PNAS"},{"key":"10.1016\/j.jmb.2024.168798_b0020","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1080\/10408390500295458","article-title":"Shigella as a foodborne pathogen and current methods for detection in food","volume":"46","author":"Warren","year":"2006","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.jmb.2024.168798_b0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodcont.2023.110111","article-title":"Establishment of a dual-signal sandwich sensor for detection of shigella sonnei based on truncated aptamers","volume":"156","author":"He","year":"2024","journal-title":"Food Control"},{"key":"10.1016\/j.jmb.2024.168798_b0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodcont.2024.110305","article-title":"A DNA walker-driven SERS-fluorescent dual-mode aptasensor based on optimized aptamers to detect Shigella flexneri","volume":"160","author":"He","year":"2024","journal-title":"Food Control"},{"key":"10.1016\/j.jmb.2024.168798_b0035","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/s41564-021-01054-z","article-title":"Pathogenomic analyses of Shigella isolates inform factors limiting shigellosis prevention and control across LMICs","volume":"7","author":"Bengtsson","year":"2022","journal-title":"Nature Microbiol."},{"key":"10.1016\/j.jmb.2024.168798_b0040","doi-asserted-by":"crossref","DOI":"10.1128\/microbiolspec.BAI-0023-2019","article-title":"Shigella pathogenesis: new insights through advanced methodologies","volume":"7","author":"Schnupf","year":"2019","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.jmb.2024.168798_b0045","doi-asserted-by":"crossref","first-page":"6362","DOI":"10.1002\/fsn3.2603","article-title":"Genetic diversity and antibiotic resistance of Shigella spp. isolates from food products","volume":"9","author":"Pakbin","year":"2021","journal-title":"Food Sci. Nutr."},{"key":"10.1016\/j.jmb.2024.168798_b0050","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1128\/CMR.00032-07","article-title":"Molecular pathogenesis of Shigella spp.: controlling host cell signaling, invasion, and death by type III secretion","volume":"21","author":"Schroeder","year":"2008","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.jmb.2024.168798_b0055","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.mib.2008.12.002","article-title":"Shigella type III secretion effectors: how, where, when, for what purposes?","volume":"12","author":"Parsot","year":"2009","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.jmb.2024.168798_b0060","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.mib.2012.11.010","article-title":"Tips and tricks about Shigella invasion of epithelial cells","volume":"16","author":"Carayol","year":"2013","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.jmb.2024.168798_b0065","doi-asserted-by":"crossref","first-page":"219","DOI":"10.3389\/fimmu.2015.00219","article-title":"Shigella manipulates host immune responses by delivering effector proteins with specific roles","volume":"6","author":"Ashida","year":"2015","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jmb.2024.168798_b0070","doi-asserted-by":"crossref","first-page":"61","DOI":"10.3389\/fmolb.2016.00061","article-title":"The multifaceted activity of the VirF regulatory protein in the Shigella Lifestyle","volume":"3","author":"Di Martino","year":"2016","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.jmb.2024.168798_b0075","doi-asserted-by":"crossref","first-page":"650","DOI":"10.3389\/fmicb.2017.00650","article-title":"VirF relieves the transcriptional attenuation of the virulence gene icsA of Shigella flexneri affecting the icsA mRNA-RnaG complex formation","volume":"8","author":"Giangrossi","year":"2017","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.jmb.2024.168798_b0080","doi-asserted-by":"crossref","DOI":"10.1128\/jb.00143-22","article-title":"Elucidation of key interactions between VirF and the virB promoter in Shigella flexneri using E. coli MarA- and GadX-based homology models and in vitro analysis of the DNA-binding domains of VirF and MarA","volume":"204","author":"Ragazzone","year":"2022","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.jmb.2024.168798_b0085","doi-asserted-by":"crossref","first-page":"3522","DOI":"10.1128\/JB.180.14.3522-3528.1998","article-title":"Identification of cpxR as a positive regulator essential for expression of the Shigella sonnei virF gene","volume":"180","author":"Nakayama","year":"1998","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.jmb.2024.168798_b0090","doi-asserted-by":"crossref","first-page":"5062","DOI":"10.1128\/jb.177.17.5062-5069.1995","article-title":"Involvement of cpxA, a sensor of a two-component regulatory system, in the pH-dependent regulation of expression of Shigella sonnei virF gene","volume":"177","author":"Nakayama","year":"1995","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.jmb.2024.168798_b0095","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1046\/j.1365-2958.2001.02646.x","article-title":"Involvement of FIS in the H-NS-mediated regulation of virF gene of Shigella and enteroinvasive Escherichia coli","volume":"42","author":"Falconi","year":"2001","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.jmb.2024.168798_b0100","doi-asserted-by":"crossref","first-page":"6537","DOI":"10.1128\/jb.179.21.6537-6550.1997","article-title":"Positive regulation of Shigella flexneri virulence genes by integration host factor","volume":"179","author":"Porter","year":"1997","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.jmb.2024.168798_b0105","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1128\/JB.187.1.107-113.2005","article-title":"A sensor of the two-component system CpxA affects expression of the type III secretion system through posttranscriptional processing of InvE","volume":"187","author":"Mitobe","year":"2005","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.jmb.2024.168798_b0110","doi-asserted-by":"crossref","first-page":"7033","DOI":"10.1093\/emboj\/17.23.7033","article-title":"Thermoregulation of Shigella and Escherichia coli EIEC pathogenicity. A temperature-dependent structural transition of DNA modulates accessibility of virF promoter to transcriptional repressor H-NS","volume":"17","author":"Falconi","year":"1998","journal-title":"EMBO J."},{"key":"10.1016\/j.jmb.2024.168798_b0115","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01064-15","article-title":"Vibrio cholerae CsrA regulates ToxR levels in response to amino acids and is essential for virulence","volume":"6","author":"Mey","year":"2015","journal-title":"MBio"},{"key":"10.1016\/j.jmb.2024.168798_b0120","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/1471-2180-9-110","article-title":"Involvement of RNA-binding protein Hfq in the osmotic-response regulation of invE gene expression in Shigella sonnei","volume":"9","author":"Mitobe","year":"2009","journal-title":"BMC Microbiol."},{"key":"10.1016\/j.jmb.2024.168798_b0125","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2021.661026","article-title":"RNA regulated toxin-antitoxin systems in pathogenic bacteria","volume":"11","author":"Sarpong","year":"2021","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.jmb.2024.168798_b0130","article-title":"Small RNA regulation of virulence in pathogenic Escherichia coli","volume":"10","author":"Sy","year":"2020","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.jmb.2024.168798_b0135","doi-asserted-by":"crossref","first-page":"fuac017","DOI":"10.1093\/femsre\/fuac017","article-title":"An overview of gene regulation in bacteria by small RNAs derived from mRNA 3' ends","volume":"46","author":"Ponath","year":"2022","journal-title":"FEMS Microbiol. Rev."},{"key":"10.1016\/j.jmb.2024.168798_b0140","doi-asserted-by":"crossref","first-page":"2","DOI":"10.3389\/fcimb.2016.00002","article-title":"Riboregulators: fine-tuning virulence in Shigella","volume":"6","author":"Fris","year":"2016","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.jmb.2024.168798_b0145","doi-asserted-by":"crossref","first-page":"e00439","DOI":"10.1128\/mSystems.00439-20","article-title":"Benchmarking bacterial promoter prediction tools: potentialities and limitations","volume":"5","author":"Cassiano","year":"2020","journal-title":"mSystems"},{"key":"10.1016\/j.jmb.2024.168798_b0150","doi-asserted-by":"crossref","first-page":"2476","DOI":"10.4049\/jimmunol.178.4.2476","article-title":"New animal model of shigellosis in the Guinea pig: its usefulness for protective efficacy studies","volume":"178","author":"Shim","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.jmb.2024.168798_b0155","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.bbrc.2010.09.100","article-title":"Defensins play a crucial role in protecting mice against oral Shigella flexneri infection","volume":"401","author":"Shim","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jmb.2024.168798_b0160","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1128\/jcm.26.2.261-266.1988","article-title":"Development and testing of invasion-associated DNA probes for detection of Shigella spp. and enteroinvasive Escherichia coli","volume":"26","author":"Venkatesan","year":"1988","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.jmb.2024.168798_b0165","doi-asserted-by":"crossref","first-page":"2849","DOI":"10.1093\/bioinformatics\/btn544","article-title":"IntaRNA: efficient prediction of bacterial sRNA targets incorporating target site accessibility and seed regions","volume":"24","author":"Busch","year":"2008","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jmb.2024.168798_b0170","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1006\/jmbi.2001.4955","article-title":"Leucine-regulated self-association of leucine-responsive regulatory protein (Lrp) from Escherichia coli","volume":"312","author":"Chen","year":"2001","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.jmb.2024.168798_b0175","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1111\/j.1574-6941.1998.tb00487.x","article-title":"Enumeration of amino acid fermenting bacteria in the human large intestine: effects of pH and starch on peptide metabolism and dissimilation of amino acids","volume":"25","author":"Smith","year":"1998","journal-title":"FEMS Microbiol. Ecol."},{"key":"10.1016\/j.jmb.2024.168798_b0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijfoodmicro.2019.108252","article-title":"Prevalence and molecular characterization of multidrug-resistant Shigella species of food origins and their inactivation by specific lytic bacteriophages","volume":"305","author":"Shahin","year":"2019","journal-title":"Int. J. Food Microbiol."},{"key":"10.1016\/j.jmb.2024.168798_b0185","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1093\/femsre\/fuv016","article-title":"Target activation by regulatory RNAs in bacteria","volume":"39","author":"Papenfort","year":"2015","journal-title":"FEMS Microbiol. Rev."},{"key":"10.1016\/j.jmb.2024.168798_b0190","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1128\/JB.01419-10","article-title":"Accessibility and evolutionary conservation mark bacterial small-rna target-binding regions","volume":"193","author":"Peer","year":"2011","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.jmb.2024.168798_b0195","doi-asserted-by":"crossref","first-page":"4674","DOI":"10.1128\/IAI.00589-10","article-title":"CsrA and Cra influence Shigella flexneri pathogenesis","volume":"78","author":"Gore","year":"2010","journal-title":"Infect. Immun."},{"key":"10.1016\/j.jmb.2024.168798_b0200","doi-asserted-by":"crossref","first-page":"3362","DOI":"10.1093\/nar\/gkq025","article-title":"A novel antisense RNA regulates at transcriptional level the virulence gene icsA of Shigella flexneri","volume":"38","author":"Giangrossi","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jmb.2024.168798_b0205","doi-asserted-by":"crossref","first-page":"4543","DOI":"10.1128\/IAI.05340-11","article-title":"The iron-responsive Fur\/RyhB regulatory cascade modulates the Shigella outer membrane protease IcsP","volume":"79","author":"Africa","year":"2011","journal-title":"Infect. Immun."},{"key":"10.1016\/j.jmb.2024.168798_b0210","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1111\/mmi.13656","article-title":"Activation of leuO by LrhA in Escherichia coli","volume":"104","author":"Breddermann","year":"2017","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.jmb.2024.168798_b0215","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1046\/j.1365-2958.2002.03032.x","article-title":"LrhA as a new transcriptional key regulator of flagella, motility and chemotaxis genes in Escherichia coli","volume":"45","author":"Lehnen","year":"2002","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.jmb.2024.168798_b0220","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1111\/j.1365-2958.2009.06937.x","article-title":"LrhA positively controls the expression of the locus of enterocyte effacement genes in enterohemorrhagic Escherichia coli by differential regulation of their master regulators PchA and PchB","volume":"74","author":"Honda","year":"2009","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.jmb.2024.168798_b0225","doi-asserted-by":"crossref","first-page":"E3282","DOI":"10.1073\/pnas.1509091112","article-title":"Bioimage analysis of Shigella infection reveals targeting of colonic crypts","volume":"112","author":"Arena","year":"2015","journal-title":"PNAS"},{"key":"10.1016\/j.jmb.2024.168798_b0230","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/S0022-2836(02)00187-0","article-title":"Leucine-induced dissociation of Lrp hexadecamers to octamers","volume":"318","author":"Chen","year":"2002","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.jmb.2024.168798_b0235","doi-asserted-by":"crossref","first-page":"2448","DOI":"10.3390\/ijms24032448","article-title":"Molecular mechanisms of Shigella pathogenesis; recent advances","volume":"24","author":"Pakbin","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jmb.2024.168798_b0240","doi-asserted-by":"crossref","first-page":"6640","DOI":"10.1073\/pnas.120163297","article-title":"One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products","volume":"97","author":"Datsenko","year":"2000","journal-title":"PNAS"},{"key":"10.1016\/j.jmb.2024.168798_b0245","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0378-1119(95)00193-A","article-title":"Gene disruption in Escherichia coli: TcR and KmR cassettes with the option of Flp-catalyzed excision of the antibiotic-resistance determinant","volume":"158","author":"Cherepanov","year":"1995","journal-title":"Gene"},{"key":"10.1016\/j.jmb.2024.168798_b0250","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.chom.2014.03.001","article-title":"IcsA is a Shigella flexneri adhesin regulated by the type III secretion system and required for pathogenesis","volume":"15","author":"Brotcke Zumsteg","year":"2014","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.jmb.2024.168798_b0255","doi-asserted-by":"crossref","first-page":"3249","DOI":"10.1093\/emboj\/18.12.3249","article-title":"IpaC induces actin polymerization and filopodia formation during Shigella entry into epithelial cells","volume":"18","author":"Tran Van Nhieu","year":"1999","journal-title":"EMBO J."},{"key":"10.1016\/j.jmb.2024.168798_b0260","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1002788","article-title":"Control of virulence by small RNAs in Streptococcus pneumoniae","volume":"8","author":"Mann","year":"2012","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.jmb.2024.168798_b0265","doi-asserted-by":"crossref","first-page":"21764","DOI":"10.1038\/srep21764","article-title":"Succinyl-proteome profiling of a high taxol containing hybrid Taxus species (Taxus x media) revealed involvement of succinylation in multiple metabolic pathways","volume":"6","author":"Shen","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jmb.2024.168798_b0270","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1111\/j.1365-2958.2009.06950.x","article-title":"Competitive activation of the Escherichia coli argO gene coding for an arginine exporter by the transcriptional regulators Lrp and ArgP","volume":"74","author":"Peeters","year":"2009","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.jmb.2024.168798_b0275","doi-asserted-by":"crossref","first-page":"7918","DOI":"10.1128\/JB.187.23.7918-7930.2005","article-title":"A positive regulatory loop controls expression of the locus of enterocyte effacement-encoded regulators Ler and GrlA","volume":"187","author":"Barba","year":"2005","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.jmb.2024.168798_b0280","doi-asserted-by":"crossref","first-page":"6592","DOI":"10.1038\/ncomms7592","article-title":"Enterohemorrhagic Escherichia coli senses low biotin status in the large intestine for colonization and infection","volume":"6","author":"Yang","year":"2015","journal-title":"Nature Commun."}],"container-title":["Journal of Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022283624004200?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022283624004200?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T04:34:43Z","timestamp":1731472483000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022283624004200"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":56,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["S0022283624004200"],"URL":"https:\/\/doi.org\/10.1016\/j.jmb.2024.168798","relation":{},"ISSN":["0022-2836"],"issn-type":[{"value":"0022-2836","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Shigella Senses the Environmental Cue Leucine to Promote its Virulence Gene Expression in the Colon","name":"articletitle","label":"Article Title"},{"value":"Journal of Molecular Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jmb.2024.168798","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"168798"}}