{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T03:59:49Z","timestamp":1782791989116,"version":"3.54.5"},"reference-count":59,"publisher":"Elsevier BV","issue":"13","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T00:00:00Z","timestamp":1744070400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003246","name":"Dutch Research Council","doi-asserted-by":"publisher","award":["16433"],"award-info":[{"award-number":["16433"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Molecular Biology"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.jmb.2025.169135","type":"journal-article","created":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T02:48:10Z","timestamp":1744339690000},"page":"169135","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Membrane Modification and Adaptation of Metabolism by Acinetobacter baumannii Prompts Resistance to Antimicrobial Activity of Outer Membrane Perturbing Peptide L8"],"prefix":"10.1016","volume":"437","author":[{"given":"Gina","family":"Schouten","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Paulussen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom N.","family":"Grossmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilbert","family":"Bitter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"van Ulsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jmb.2025.169135_b0005","first-page":"271","article-title":"Pandrug-resistant Gram-negative bacteria: a systematic review of current epidemiology, prognosis and treatment options","volume":"75","author":"Karakonstantis","year":"2020","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.jmb.2025.169135_b0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.micres.2022.127069","article-title":"Acinetobacter baumannii: more ways to die","volume":"261","author":"Oyejobi","year":"2022","journal-title":"Microbial Research"},{"key":"10.1016\/j.jmb.2025.169135_b0015","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1146\/annurev.micro.50.1.553","article-title":"The \u03b2-ketoadipate pathway and the biology of self-identity","volume":"50","author":"Harwood","year":"1996","journal-title":"Annu. Rev. Microbiol."},{"issue":"4","key":"10.1016\/j.jmb.2025.169135_b0020","first-page":"1","article-title":"CsrA-controlled proteins reveal new dimensions of Acinetobacter baumannii desiccation tolerance","volume":"204","author":"Oda","year":"2021","journal-title":"J. Bacteriol."},{"issue":"4","key":"10.1016\/j.jmb.2025.169135_b0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/mBio.01295-21","article-title":"Homeoviscous adaptation of the Acinetobacter baumannii outer membrane: alteration of lipooligosaccharide during cold stress","volume":"12","author":"Herrera","year":"2021","journal-title":"mBio"},{"key":"10.1016\/j.jmb.2025.169135_b0030","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1146\/annurev-micro-020518-115714","article-title":"Acinetobacter baumannii: envelope determinants that control drug resistance, virulence and surface variability","volume":"73","author":"Geisinger","year":"2019","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.jmb.2025.169135_b0035","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1021\/pr400603f","article-title":"Molecular mechanisms involved in response to desiccation stress and persistence in Acinetobacter baumannii","volume":"13","author":"Gayoso","year":"2013","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.jmb.2025.169135_b0040","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.jhin.2020.09.009","article-title":"Excess mortality due to pandrug-resistant Acinetobacter baumannii infections in hospitalized patients","volume":"106","author":"Karakonstantis","year":"2020","journal-title":"J. Hosp. Infect."},{"issue":"640981","key":"10.1016\/j.jmb.2025.169135_b0045","first-page":"1","article-title":"Developing antimicrobial synergy with AMPs","volume":"3","author":"Duong","year":"2021","journal-title":"Front. Med. Technol."},{"issue":"1","key":"10.1016\/j.jmb.2025.169135_b0050","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1124\/pr.55.1.2","article-title":"Mechanisms of antimicrobial peptide action and resistance","volume":"55","author":"Yeaman","year":"2003","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.jmb.2025.169135_b0055","first-page":"1","article-title":"Positive charge patterning and hydrophobicity of membrane active antimicrobial peptides as determinants of activity, toxicity, and pharmacokinetic stability","author":"Stone","year":"2019","journal-title":"Am. Chem. Soc."},{"issue":"620","key":"10.1016\/j.jmb.2025.169135_b0060","first-page":"1","article-title":"Synergies with and resistance to membrane-active peptides","volume":"9","author":"Kmeck","year":"2020","journal-title":"Antibiotics"},{"issue":"10","key":"10.1016\/j.jmb.2025.169135_b0065","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1021\/cb1001558","article-title":"Describing the mechanism of antimicrobial peptide action with the interfacial activity model","volume":"5","author":"Wimley","year":"2010","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.jmb.2025.169135_b0070","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1002\/bip.10260","article-title":"Mode of action of membrane active antimicrobial peptides","volume":"66","author":"Shai","year":"2002","journal-title":"Biopolymers (Peptide Science)"},{"issue":"1","key":"10.1016\/j.jmb.2025.169135_b0075","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/AAC.47.1.1-6.2003","article-title":"Transcriptional profile of the Escherichia coli response to the antimicrobial insect peptide cecropin A","volume":"47","author":"Hong","year":"2003","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.jmb.2025.169135_b0080","first-page":"1","article-title":"Antimicrobial host defence peptides: functions and clinical potential","author":"Mookherjee","year":"2020","journal-title":"Nature Rev. Drug Discov."},{"key":"10.1016\/j.jmb.2025.169135_b0085","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.coph.2006.04.006","article-title":"Antibacterial peptides for therapeutic use: obstacles and realistic outlook","volume":"6","author":"Marr","year":"2006","journal-title":"Curr. Opin. Pharmacol."},{"issue":"7","key":"10.1016\/j.jmb.2025.169135_b0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0068875","article-title":"Mechanisms and fitness costs of resistance to antimicrobial peptides LL-37, CNY100HL and wheat germ histones","volume":"8","author":"Lofton","year":"2013","journal-title":"PLoS One"},{"issue":"103","key":"10.1016\/j.jmb.2025.169135_b0095","article-title":"Resistance evolution against antimicrobial peptides in Staphylococcus aureus alters pharmacodynamics beyond the MIC","volume":"11","author":"El Shazely","year":"2020","journal-title":"Front. Microbiol."},{"issue":"273","key":"10.1016\/j.jmb.2025.169135_b0100","first-page":"1","article-title":"Stapling of peptides potentiates the antibiotic treatment of Acinetobacter baumannii in vivo","volume":"11","author":"Schouten","year":"2022","journal-title":"Antibiotics"},{"issue":"1","key":"10.1016\/j.jmb.2025.169135_b0105","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/s42003-020-01511-1","article-title":"Outer-membrane-acting peptides and lipid II-targeting antibiotics cooperatively kill Gram-negative pathogens","volume":"4","author":"Li","year":"2021","journal-title":"Commun. Biol."},{"issue":"3","key":"10.1016\/j.jmb.2025.169135_b0110","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.bbamem.2015.11.003","article-title":"The human cathelicidin LL-37 \u2013 a pore-forming antibacterial peptide and host-cell modulator","volume":"1858","author":"Xhindoli","year":"2016","journal-title":"BBA"},{"issue":"33","key":"10.1016\/j.jmb.2025.169135_b0115","doi-asserted-by":"crossref","first-page":"15303","DOI":"10.1021\/jacs.2c06304","article-title":"Covalent proteomimetic inhibitor of the bacterial FtsQB divisome complex","volume":"144","author":"Paulussen","year":"2022","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.jmb.2025.169135_b0120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/antibiotics9110808","article-title":"Stress-based high-throughput screening assays to identify inhibitors of cell envelope biogenesis","volume":"9","author":"Steenhuis","year":"2020","journal-title":"Antibiotics"},{"issue":"8","key":"10.1016\/j.jmb.2025.169135_b0125","doi-asserted-by":"crossref","first-page":"5232","DOI":"10.1016\/S0021-9258(19)67791-4","article-title":"Sequence and inactivation of the pss gene of Escherichia coli phosphatidylethanolamine may not be essential for cell viability","volume":"266","author":"DeChavigny","year":"1991","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.jmb.2025.169135_b0130","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/0732-8893(93)90087-N","article-title":"Synergy assessed by checkerboard a critical analysis","volume":"16","author":"Hsieh","year":"1993","journal-title":"Diagn. Microbiol. Infect. Dis."},{"issue":"7","key":"10.1016\/j.jmb.2025.169135_b0135","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/nmeth.2089","article-title":"NIH image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nature Methods"},{"issue":"586","key":"10.1016\/j.jmb.2025.169135_b0140","first-page":"1","article-title":"Cell age dependent concentration of Escherichia coli divisome proteins analyzed with ImageJ and ObjectJ","volume":"6","author":"Vischer","year":"2015","journal-title":"Front. Microbiol."},{"issue":"1","key":"10.1016\/j.jmb.2025.169135_b0145","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/0003-2697(82)90673-X","article-title":"A sensitive silver stain for detecting lipopolysaccharides in polyacrylamide gels","volume":"119","author":"Tsai","year":"1982","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.jmb.2025.169135_b0150","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/978-1-4939-9118-1_15","article-title":"A simple static biofilm assay for Acinetobacter baumannii","volume":"1946","author":"Biswas","year":"1946","journal-title":"Methods Mol. Biol."},{"issue":"103937","key":"10.1016\/j.jmb.2025.169135_b0155","first-page":"1","article-title":"Pal depletion results in hypervesiculation and affects cell morphology and outer-membrane lipid asymmetry in bordetellae","volume":"173","author":"De Jonge","year":"2022","journal-title":"Res. Microbiol."},{"issue":"1","key":"10.1016\/j.jmb.2025.169135_b0160","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/mmi.14255","article-title":"Inhibition of autotransporter biogenesis by small molecules","volume":"112","author":"Steenhuis","year":"2019","journal-title":"Mol. Microbiol."},{"issue":"313","key":"10.1016\/j.jmb.2025.169135_b0165","first-page":"1","article-title":"Maintaining integrity under stress: Envelope stress response regulation of pathogenesis in Gram-Negative bacteria","volume":"9","author":"Hews","year":"2019","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.jmb.2025.169135_b0170","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1146\/annurev-micro-090817-062640","article-title":"The complex Rcs regulatory cascade","volume":"72","author":"Wall","year":"2018","journal-title":"Annu. Rev. Microbiol."},{"issue":"3","key":"10.1016\/j.jmb.2025.169135_b0175","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1128\/CMR.00006-08","article-title":"Polymyxins revisited","volume":"21","author":"Landman","year":"2008","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.jmb.2025.169135_b0180","article-title":"\u201cAerosporin\u201d, an antibiotic produced by Bacillus aerosporus Greer","volume":"4060","author":"Ainsworth","year":"1947","journal-title":"Nature"},{"issue":"22","key":"10.1016\/j.jmb.2025.169135_b0185","doi-asserted-by":"crossref","first-page":"7040","DOI":"10.1128\/jb.179.22.7040-7045.1997","article-title":"Regulation of polymyxin resistance and adaptation to low-Mg2+ environments","volume":"179","author":"Groisman","year":"1997","journal-title":"J. Bacteriol."},{"issue":"1","key":"10.1016\/j.jmb.2025.169135_b0190","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/0014-5793(88)80811-1","article-title":"The fluorescence intensity of the lipophilic probe N \u2010phenyl\u20101\u2010naphthylamine responds to the oxidation\u2010reduction state of purified Escherichia coli cytochrome o incorporated into phospholipid vesicles","volume":"229","author":"Sedgwick","year":"1988","journal-title":"FEBS Lett."},{"key":"10.1016\/j.jmb.2025.169135_b0195","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1046\/j.1365-2672.2000.00971.x","article-title":"Fluorometric assessment of Gram-negative bacterial permeabilization","volume":"88","author":"Helander","year":"2000","journal-title":"J. Appl. Microbiol."},{"key":"10.1016\/j.jmb.2025.169135_b0200","first-page":"401","article-title":"An evaluation of N-phenyl-1-naphthylamine as a probe of membrane energy state in Escherichia coli","volume":"499","author":"Cramer","year":"1976","journal-title":"BBA"},{"issue":"36","key":"10.1016\/j.jmb.2025.169135_b0205","first-page":"1","article-title":"Critical aspects of using bacterial cell viability assays with the fluorophores SYTO9 and propidium iodide","volume":"15","author":"Stiefel","year":"2015","journal-title":"BMC Microbiol."},{"issue":"2","key":"10.1016\/j.jmb.2025.169135_b0210","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.bpj.2014.11.819","article-title":"Living E. coli is permeable to propidium iodide: a study by time resolved second-harmonic scattering and fluorescence microscopy","volume":"108","author":"Wilhelm","year":"2015","journal-title":"Biophys. J."},{"issue":"10755","key":"10.1016\/j.jmb.2025.169135_b0215","first-page":"1","article-title":"An integrative, multi-omics approach towards the prioritization of Klebsiella pneumoniae drug targets","volume":"8","author":"Pereira Ramos","year":"2018","journal-title":"Nature Sci. Rep."},{"issue":"16","key":"10.1016\/j.jmb.2025.169135_b0220","doi-asserted-by":"crossref","first-page":"5038","DOI":"10.1016\/S0021-9258(19)42325-9","article-title":"Partial purification and properties of phosphatidylserine synthase from Escherichia coli","volume":"249","author":"Raetz","year":"1974","journal-title":"J. Biol. Chem."},{"issue":"24","key":"10.1016\/j.jmb.2025.169135_b0225","doi-asserted-by":"crossref","first-page":"5212","DOI":"10.1021\/bi00669a003","article-title":"Ribosomal-associated phosphatidylserine synthetase from Escherichia coli: Purification by substrate-specific elution from phosphocellulose using cytidine 5\u2019-diphospho-1,2-diacyl-sn-glycerol","volume":"15","author":"Larson","year":"1976","journal-title":"Biochemistry"},{"key":"10.1016\/j.jmb.2025.169135_b0230","first-page":"222","article-title":"Membrane lipid homeostasis in bacteria","volume":"6","author":"Zhang","year":"2008","journal-title":"Nature Rev."},{"issue":"28","key":"10.1016\/j.jmb.2025.169135_b0235","first-page":"1","article-title":"PS, it\u2019s complicated: the roles of phosphatidylserine and phosphatidylethanolamine in pathogenesis of Candida albicans and other microbial pathogens","volume":"4","author":"Cassilly","year":"2018","journal-title":"Journal of Fungi"},{"issue":"4545","key":"10.1016\/j.jmb.2025.169135_b0240","first-page":"1","article-title":"The role of phosphatidylethanolamine adducts in modification of the activity of membrane proteins under oxidative stress","volume":"24","author":"Pohl","year":"2019","journal-title":"MDPI Molecules"},{"key":"10.1016\/j.jmb.2025.169135_b0245","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1529\/biophysj.104.048835","article-title":"Phosphatidylethanolamine-phosphatidylglycerol bilayer as a model of the inner bacterial membrane","volume":"88","author":"Murzyn","year":"2005","journal-title":"Biophys. J."},{"issue":"4","key":"10.1016\/j.jmb.2025.169135_b0250","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1128\/MMBR.67.4.593-656.2003","article-title":"Molecular basis of bacterial outer membrane permeability revisited","volume":"67","author":"Nikaido","year":"2003","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"10.1016\/j.jmb.2025.169135_b0255","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.plipres.2015.02.003","article-title":"The increasing role of phosphatidylethanolamine as a lipid receptor in the action of host defence peptides","volume":"59","author":"Phoenix","year":"2014","journal-title":"Prog. Lipid Res."},{"issue":"1","key":"10.1016\/j.jmb.2025.169135_b0260","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1111\/1758-2229.13042","article-title":"The \u00df-ketoadipate pathway of Acinetobacter baumannii is involved in complement resistance and affects resistance against aromatic antibiotics","volume":"14","author":"Breisch","year":"2022","journal-title":"Environ. Microbiol. Rep."},{"issue":"3","key":"10.1016\/j.jmb.2025.169135_b0265","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1002\/mbo3.33","article-title":"Evidence for the involvement of the anthranilate degradation pathway in Pseudomonas aeruginosa biofilm formation","volume":"1","author":"Costaglioli","year":"2012","journal-title":"Microbiol. Open"},{"key":"10.1016\/j.jmb.2025.169135_b0270","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s12551-021-00912-8","article-title":"Lipid-mediated antimicrobial resistance: a phantom menace or a new hope?","volume":"14","author":"MacDermott-Opeskin","year":"2022","journal-title":"Biophys. Rev."},{"key":"10.1016\/j.jmb.2025.169135_b0275","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.jhin.2018.03.037","article-title":"Pseudomonas aeruginosa adapts to octenidine in the laboratory and a simulated clinical setting, leading to increased tolerance to chlorhexidine and other biocides","volume":"100","author":"Shepherd","year":"2018","journal-title":"J. Hosp. Infect."},{"issue":"1058","key":"10.1016\/j.jmb.2025.169135_b0280","first-page":"1","article-title":"Pseudomonas aeruginosa adapts to octenidine via a combination of efflux and membrane remodelling","volume":"4","author":"Bock","year":"2021","journal-title":"Commun. Biol."},{"issue":"6","key":"10.1016\/j.jmb.2025.169135_b0285","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1128\/JB.180.6.1512-1524.1998","article-title":"PcaU, a transcriptional activator of genes for protocatechuate utilization in Acinetobacter","volume":"180","author":"Gerischer","year":"1998","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.jmb.2025.169135_b0290","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.cmet.2019.06.009","article-title":"Bacterial metabolism and antibiotic efficacy","volume":"30","author":"Stokes","year":"2019","journal-title":"Cell Metab."},{"issue":"27","key":"10.1016\/j.jmb.2025.169135_b0295","doi-asserted-by":"crossref","first-page":"8173","DOI":"10.1073\/pnas.1509743112","article-title":"Antibiotic efficacy is linked to bacterial cellular respiration","volume":"112","author":"Lobritz","year":"2015","journal-title":"PNAS"}],"container-title":["Journal of Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022283625002013?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022283625002013?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T22:03:08Z","timestamp":1762207388000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022283625002013"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":59,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["S0022283625002013"],"URL":"https:\/\/doi.org\/10.1016\/j.jmb.2025.169135","relation":{},"ISSN":["0022-2836"],"issn-type":[{"value":"0022-2836","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Membrane Modification and Adaptation of Metabolism by Acinetobacter baumannii Prompts Resistance to Antimicrobial Activity of Outer Membrane Perturbing Peptide L8","name":"articletitle","label":"Article Title"},{"value":"Journal of Molecular Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jmb.2025.169135","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"169135"}}