{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T22:43:41Z","timestamp":1791326621358,"version":"4.3.1"},"reference-count":44,"publisher":"Elsevier BV","issue":"18","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","award":["PAPD 2023007"],"award-info":[{"award-number":["PAPD 2023007"]}],"id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073767"],"award-info":[{"award-number":["82073767"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273834"],"award-info":[{"award-number":["82273834"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Molecular Biology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.jmb.2026.169628","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:13:16Z","timestamp":1767658396000},"page":"169628","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["DRAVP 2.0: A Curated and Genomically Annotated Database of Antiviral Peptides and Proteins"],"prefix":"10.1016","volume":"438","author":[{"given":"Maryam","family":"Nawaz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiyuan","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3627-0400","authenticated-orcid":false,"given":"Hongyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fahad","family":"Akhtar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyue","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunhao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zichun","family":"Hua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1810-5842","authenticated-orcid":false,"given":"Heng","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jmb.2026.169628_b0005","first-page":"1","article-title":"A great ape perspective on the origins and evolution of human viruses","volume":"110","author":"Calvignac-Spencer","year":"2021","journal-title":"Adv. Virus Res."},{"key":"10.1016\/j.jmb.2026.169628_b0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2021.339338","article-title":"Toward a next-generation diagnostic tool: a review on emerging isothermal nucleic acid amplification techniques for the detection of SARS-CoV-2 and other infectious viruses","volume":"1209","author":"Islam","year":"2022","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.jmb.2026.169628_b0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.meegid.2020.104260","article-title":"Genetic diversity and evolution of SARS-CoV-2","volume":"81","author":"Phan","year":"2020","journal-title":"Infect. Genet. Evol."},{"issue":"7","key":"10.1016\/j.jmb.2026.169628_b0020","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0022572","article-title":"Broad-spectrum antiviral therapeutics","volume":"6","author":"Rider","year":"2011","journal-title":"PLOS ONE"},{"issue":"1","key":"10.1016\/j.jmb.2026.169628_b0025","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s10989-020-10072-0","article-title":"Antiviral peptides: identification and validation","volume":"27","author":"Agarwal","year":"2021","journal-title":"Int. J. Pept. Res. Ther."},{"issue":"1","key":"10.1016\/j.jmb.2026.169628_b0030","doi-asserted-by":"crossref","DOI":"10.1128\/CMR.00162-20","article-title":"Remdesivir against COVID-19 and other viral diseases","volume":"34","author":"Malin","year":"2020","journal-title":"Clin. Microbiol. Rev."},{"issue":"6575","key":"10.1016\/j.jmb.2026.169628_b0035","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1126\/science.abl4784","article-title":"An oral SARS-CoV-2 Mpro inhibitor clinical candidate for the treatment of COVID-19","volume":"374","author":"Owen","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.jmb.2026.169628_b0040","doi-asserted-by":"crossref","DOI":"10.3389\/fddsv.2022.898035","article-title":"Developing small-molecule inhibitors of protein-protein interactions involved in viral entry as potential antivirals for COVID-19","volume":"2","author":"Buchwald","year":"2022","journal-title":"Front. Drug Discovery"},{"issue":"18","key":"10.1016\/j.jmb.2026.169628_b0045","doi-asserted-by":"crossref","first-page":"3525","DOI":"10.1007\/s00018-019-03138-w","article-title":"Antiviral peptides as promising therapeutic drugs","volume":"76","author":"Vilas Boas","year":"2019","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.jmb.2026.169628_b0050","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s40409-016-0089-0","article-title":"Antiviral activity of animal venom peptides and related compounds","volume":"23","author":"da Mata","year":"2017","journal-title":"J. Venom. Anim. Toxins Incl. Trop. Dis."},{"issue":"10","key":"10.1016\/j.jmb.2026.169628_b0055","doi-asserted-by":"crossref","first-page":"5428","DOI":"10.3390\/v7102883","article-title":"Perspective of use of antiviral peptides against influenza virus","volume":"7","author":"Skalickova","year":"2015","journal-title":"Viruses"},{"issue":"5","key":"10.1016\/j.jmb.2026.169628_b0060","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1021\/acscentsci.0c00489","article-title":"Remdesivir: a review of its discovery and development leading to emergency use authorization for treatment of COVID-19","volume":"6","author":"Eastman","year":"2020","journal-title":"ACS Cent. Sci."},{"issue":"4","key":"10.1016\/j.jmb.2026.169628_b0065","doi-asserted-by":"crossref","first-page":"3753","DOI":"10.1007\/s11030-025-11173-y","article-title":"Deep learning in the discovery of antiviral peptides and peptidomimetics: databases and prediction tools","volume":"29","author":"Nawaz","year":"2025","journal-title":"Mol. Divers."},{"key":"10.1016\/j.jmb.2026.169628_b0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.peptides.2021.170570","article-title":"Review of antiviral peptides for use against zoonotic and selected non-zoonotic viruses","volume":"142","author":"Hollmann","year":"2021","journal-title":"Peptides"},{"key":"10.1016\/j.jmb.2026.169628_b0075","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2020.582779","article-title":"Antimicrobial peptides: classification, design, application and research progress in multiple fields","volume":"11","author":"Huan","year":"2020","journal-title":"Front. Microbiol."},{"issue":"3","key":"10.1016\/j.jmb.2026.169628_b0080","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.bbrc.2019.07.088","article-title":"Envelope-deforming antiviral peptide derived from influenza virus M2 protein","volume":"517","author":"Jung","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jmb.2026.169628_b0085","first-page":"414","article-title":"Inhibition of virus multiplication by immunoactive peptides","volume":"179","author":"Imanishi","year":"1985","journal-title":"CR Seances Soc. Biol. Fil."},{"key":"10.1016\/j.jmb.2026.169628_b0090","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1134\/S1068162020040044","article-title":"Antimicrobial peptide engineering: rational design, synthesis, and synergistic effect","volume":"46","author":"Ajingi","year":"2020","journal-title":"Russ. J. Bioorg. Chem."},{"issue":"6575","key":"10.1016\/j.jmb.2026.169628_b0095","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1126\/science.abl4784","article-title":"An oral SARS-CoV-2 M(pro) inhibitor clinical candidate for the treatment of COVID-19","volume":"374","author":"Owen","year":"2021","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.jmb.2026.169628_b0100","doi-asserted-by":"crossref","first-page":"77","DOI":"10.3390\/v11010077","article-title":"Comparison of anti-viral activity of frog skin anti-microbial peptides temporin-Sha and [K3]SHa to LL-37 and temporin-Tb against herpes simplex virus type 1","volume":"11","author":"Roy","year":"2019","journal-title":"Viruses"},{"issue":"13","key":"10.1016\/j.jmb.2026.169628_b0105","doi-asserted-by":"crossref","first-page":"7194","DOI":"10.3390\/ijms23137194","article-title":"The inhibition of DNA viruses by the amphibian antimicrobial peptide temporin G: a virological study addressing HSV-1 and JPCyV","volume":"23","author":"Marcocci","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.jmb.2026.169628_b0110","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202001885RR","article-title":"Temporin G, an amphibian antimicrobial peptide against influenza and parainfluenza respiratory viruses: Insights into biological activity and mechanism of action","volume":"35","author":"De Angelis","year":"2021","journal-title":"FASEB J."},{"issue":"5","key":"10.1016\/j.jmb.2026.169628_b0115","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1002\/hep.24542","article-title":"The antiviral protein viperin inhibits hepatitis C virus replication via interaction with nonstructural protein 5A","volume":"54","author":"Helbig","year":"2011","journal-title":"Hepatology"},{"issue":"26","key":"10.1016\/j.jmb.2026.169628_b0120","doi-asserted-by":"crossref","first-page":"15125","DOI":"10.1073\/pnas.011593298","article-title":"Viperin (cig5), an IFN-inducible antiviral protein directly induced by human cytomegalovirus","volume":"98","author":"Chin","year":"2001","journal-title":"PNAS"},{"issue":"1","key":"10.1016\/j.jmb.2026.169628_b0125","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1021\/acs.jmedchem.2c01708","article-title":"Structure-based rational design of small \u03b1-helical peptides with broad-spectrum activity against multidrug-resistant pathogens","volume":"66","author":"Lohan","year":"2023","journal-title":"J. Med. Chem."},{"issue":"1","key":"10.1016\/j.jmb.2026.169628_b0130","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1038\/s41467-024-45766-2","article-title":"Design of target specific peptide inhibitors using generative deep learning and molecular dynamics simulations","volume":"15","author":"Chen","year":"2024","journal-title":"Nature Commun."},{"issue":"9","key":"10.1016\/j.jmb.2026.169628_b0135","doi-asserted-by":"crossref","first-page":"3349","DOI":"10.1128\/AAC.48.9.3349-3357.2004","article-title":"De novo design of potent antimicrobial peptides","volume":"48","author":"Frecer","year":"2004","journal-title":"Antimicrob. Agents Chemother."},{"issue":"Database issue","key":"10.1016\/j.jmb.2026.169628_b0140","doi-asserted-by":"crossref","first-page":"D1147","DOI":"10.1093\/nar\/gkt1191","article-title":"AVPdb: a database of experimentally validated antiviral peptides targeting medically important viruses","volume":"42","author":"Qureshi","year":"2014","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.jmb.2026.169628_b0145","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0054908","article-title":"HIPdb: a database of experimentally validated HIV inhibiting peptides","volume":"8","author":"Qureshi","year":"2013","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.jmb.2026.169628_b0150","doi-asserted-by":"crossref","first-page":"820","DOI":"10.3390\/v15040820","article-title":"DRAVP: a comprehensive database of antiviral peptides and proteins","volume":"15","author":"Liu","year":"2023","journal-title":"Viruses"},{"issue":"D1","key":"10.1016\/j.jmb.2026.169628_b0155","doi-asserted-by":"crossref","first-page":"D10","DOI":"10.1093\/nar\/gkaa892","article-title":"Database resources of the National Center for Biotechnology Information","volume":"49","author":"Sayers","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jmb.2026.169628_b0160","unstructured":"Web of science. https:\/\/clarivate.com\/academia-government\/scientific-and-academic-research\/research-discovery-and-referencing\/web-of-science\/?utm_medium=Referral&utm_source=mjl-clarivate-com."},{"key":"10.1016\/j.jmb.2026.169628_b0165","unstructured":"CNKI. https:\/\/www.cnki.net."},{"key":"10.1016\/j.jmb.2026.169628_b0170","unstructured":"Drug Bank. https:\/\/go.drugbank.com."},{"key":"10.1016\/j.jmb.2026.169628_b0175","unstructured":"Clinical Trials.gov. https:\/\/clinicaltrials.gov."},{"key":"10.1016\/j.jmb.2026.169628_b0180","unstructured":"Chinese Clinical Trial Registry. https:\/\/www.chictr.org.cn\/indexEN.html."},{"key":"10.1016\/j.jmb.2026.169628_b0185","unstructured":"The lens. https:\/\/www.lens.org."},{"issue":"1","key":"10.1016\/j.jmb.2026.169628_b0190","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/s41597-019-0154-y","article-title":"DRAMP 2.0, an updated data repository of antimicrobial peptides","volume":"6","author":"Kang","year":"2019","journal-title":"Sci. Data"},{"issue":"D1","key":"10.1016\/j.jmb.2026.169628_b0195","doi-asserted-by":"crossref","first-page":"D488","DOI":"10.1093\/nar\/gkab651","article-title":"DRAMP 3.0: an enhanced comprehensive data repository of antimicrobial peptides","volume":"50","author":"Shi","year":"2022","journal-title":"Nucleic Acids Res."},{"issue":"D1","key":"10.1016\/j.jmb.2026.169628_b0200","doi-asserted-by":"crossref","first-page":"D403","DOI":"10.1093\/nar\/gkae1046","article-title":"DRAMP 4.0: an open-access data repository dedicated to the clinical translation of antimicrobial peptides","volume":"53","author":"Ma","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jmb.2026.169628_b0205","doi-asserted-by":"crossref","first-page":"24482","DOI":"10.1038\/srep24482","article-title":"DRAMP: a comprehensive data repository of antimicrobial peptides","volume":"6","author":"Fan","year":"2016","journal-title":"Sci. Rep."},{"issue":"D1","key":"10.1016\/j.jmb.2026.169628_b0210","doi-asserted-by":"crossref","first-page":"D288","DOI":"10.1093\/nar\/gkaa991","article-title":"DBAASP v3: database of antimicrobial\/cytotoxic activity and structure of peptides as a resource for development of new therapeutics","volume":"49","author":"Pirtskhalava","year":"2021","journal-title":"Nucleic Acids Res."},{"issue":"D1","key":"10.1016\/j.jmb.2026.169628_b0215","doi-asserted-by":"crossref","first-page":"D377","DOI":"10.1093\/nar\/gkac933","article-title":"CAMPR4: a database of natural and synthetic antimicrobial peptides","volume":"51","author":"Gawde","year":"2022","journal-title":"Nucleic Acids Res."},{"issue":"D1","key":"10.1016\/j.jmb.2026.169628_b0220","doi-asserted-by":"crossref","first-page":"D460","DOI":"10.1093\/nar\/gkab1080","article-title":"dbAMP 2.0: updated resource for antimicrobial peptides with an enhanced scanning method for genomic and proteomic data","volume":"50","author":"Jhong","year":"2022","journal-title":"Nucleic Acids Res."}],"container-title":["Journal of Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002228362600001X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002228362600001X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T06:19:40Z","timestamp":1784528380000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002228362600001X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":44,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S002228362600001X"],"URL":"https:\/\/doi.org\/10.1016\/j.jmb.2026.169628","relation":{},"ISSN":["0022-2836"],"issn-type":[{"value":"0022-2836","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"DRAVP 2.0: A Curated and Genomically Annotated Database of Antiviral Peptides and Proteins","name":"articletitle","label":"Article Title"},{"value":"Journal of Molecular Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jmb.2026.169628","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"169628"}}