{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T18:26:57Z","timestamp":1793644017181,"version":"4.5.1"},"reference-count":51,"publisher":"Elsevier BV","issue":"22","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003977","name":"Israel Science Foundation","doi-asserted-by":"publisher","award":["587\/19"],"award-info":[{"award-number":["587\/19"]}],"id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003977","name":"Israel Science Foundation","doi-asserted-by":"publisher","award":["1969\/24"],"award-info":[{"award-number":["1969\/24"]}],"id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Molecular Biology"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.jmb.2026.169997","type":"journal-article","created":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T14:15:09Z","timestamp":1787926509000},"page":"169997","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["An Interaction Domain Drives Heme Exchange in the C. albicans CFEM Hemophores Cascade"],"prefix":"10.1016","volume":"438","author":[{"given":"Udita","family":"Roy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elian","family":"Far","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1578-7331","authenticated-orcid":false,"given":"Soham","family":"Chattopadhyay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziva","family":"Weissman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5062-2735","authenticated-orcid":false,"given":"Daniel","family":"Kornitzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jmb.2026.169997_b0005","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1001\/jama.1975.03240130021018","article-title":"Nutritional immunity","volume":"231","author":"Weinberg","year":"1975","journal-title":"JAMA"},{"key":"10.1016\/j.jmb.2026.169997_b0010","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/s41579-022-00745-6","article-title":"Nutritional immunity: the battle for nutrient metals at the host\u2013pathogen interface","volume":"20","author":"Murdoch","year":"2022","journal-title":"Nature Rev. Microbiol."},{"key":"10.1016\/j.jmb.2026.169997_b0015","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1128\/MMBR.00012-07","article-title":"Siderophore-based iron acquisition and pathogen control","volume":"71","author":"Miethke","year":"2007","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"10.1016\/j.jmb.2026.169997_b0020","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1002777","article-title":"Candida albicans scavenges host zinc via Pra1 during endothelial invasion","volume":"8","author":"Citiulo","year":"2012","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.jmb.2026.169997_b0025","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01281-17","article-title":"The metallophore staphylopine enables staphylococcus aureus to compete with the host for zinc and overcome nutritional immunity","volume":"8","author":"Grim","year":"2017","journal-title":"MBio"},{"key":"10.1016\/j.jmb.2026.169997_b0030","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1146\/annurev.micro.58.030603.123811","article-title":"Bacterial iron sources: from siderophores to hemophores","volume":"58","author":"Wandersman","year":"2004","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.jmb.2026.169997_b0035","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1038\/9281","article-title":"The crystal structure of HasA, a hemophore secreted by Serratia marcescens","volume":"6","author":"Arnoux","year":"1999","journal-title":"Nature Struct. Biol."},{"key":"10.1016\/j.jmb.2026.169997_b0040","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1000132","article-title":"Bacillus anthracis secretes proteins that mediate heme acquisition from hemoglobin","volume":"4","author":"Maresso","year":"2008","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.jmb.2026.169997_b0045","doi-asserted-by":"crossref","first-page":"21714","DOI":"10.1074\/jbc.M113.453076","article-title":"The Mycobacterium tuberculosis secreted protein Rv0203 transfers heme to membrane proteins MmpL3 and MmpL11","volume":"288","author":"Owens","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jmb.2026.169997_b0050","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1111\/j.1365-2958.2004.04199.x","article-title":"A family of Candida cell surface haem-binding proteins involved in haemin and haemoglobin-iron utilization","volume":"53","author":"Weissman","year":"2004","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.jmb.2026.169997_b0055","doi-asserted-by":"crossref","first-page":"16156","DOI":"10.1038\/nmicrobiol.2016.156","article-title":"Structural basis of haem-iron acquisition by fungal pathogens","volume":"1","author":"Nasser","year":"2016","journal-title":"Nature Microbiol."},{"key":"10.1016\/j.jmb.2026.169997_b0060","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1056\/NEJMra1315399","article-title":"Invasive candidiasis","volume":"373","author":"Kullberg","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jmb.2026.169997_b0065","doi-asserted-by":"crossref","first-page":"549","DOI":"10.2147\/CLEP.S459600","article-title":"Epidemiology of invasive candidiasis","volume":"16","author":"Bays","year":"2024","journal-title":"Clin. Epidemiol."},{"key":"10.1016\/j.jmb.2026.169997_b0070","doi-asserted-by":"crossref","first-page":"20-","DOI":"10.1038\/s41572-024-00503-3","article-title":"Invasive candidiasis","volume":"10","author":"Lass-Fl\u00f6rl","year":"2024","journal-title":"Nature Rev. Dis. Prim."},{"key":"10.1016\/j.jmb.2026.169997_b0075","doi-asserted-by":"crossref","first-page":"5154","DOI":"10.1128\/iai.62.11.5154-5156.1994","article-title":"Production of a hemolytic factor by Candida albicans","volume":"62","author":"Manns","year":"1994","journal-title":"Infect. Immun."},{"key":"10.1016\/j.jmb.2026.169997_b0080","doi-asserted-by":"crossref","DOI":"10.3390\/toxins14120874","article-title":"Candidalysin is the hemolytic factor of Candida albicans","volume":"14","author":"Mogavero","year":"2022","journal-title":"Toxins (Basel)"},{"key":"10.1016\/j.jmb.2026.169997_b0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1472-6807-3-6","article-title":"Crystal structural analysis of human serum albumin complexed with hemin and fatty acid","volume":"3","author":"Zunszain","year":"2003","journal-title":"BMC Struct. Biol."},{"key":"10.1016\/j.jmb.2026.169997_b0090","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00607-20","article-title":"Human serum albumin facilitates heme-iron utilization by fungi","volume":"11","author":"Pinsky","year":"2020","journal-title":"MBio"},{"key":"10.1016\/j.jmb.2026.169997_b0095","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1004407","article-title":"A relay network of extracellular heme-binding proteins drives C. albicans iron acquisition from hemoglobin","volume":"10","author":"Kuznets","year":"2014","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.jmb.2026.169997_b0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamcr.2020.118817","article-title":"Pathways of heme utilization in fungi","volume":"1867","author":"Kornitzer","year":"2020","journal-title":"Biochim. Biophys. Acta \u2013 Mol. Cell Res."},{"key":"10.1016\/j.jmb.2026.169997_b0105","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.80604","article-title":"Ferric reductase-related proteins mediate fungal heme acquisition","volume":"11","author":"Roy","year":"2022","journal-title":"Elife"},{"key":"10.1016\/j.jmb.2026.169997_b0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.jinorgbio.2026.113246","article-title":"Ferric reductase related proteins Frp1 and Frp2 mediate reductive heme uptake in the opportunistic pathogen Candida albicans","volume":"278","author":"Fu","year":"2026","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.jmb.2026.169997_b0115","doi-asserted-by":"crossref","first-page":"25541","DOI":"10.1074\/jbc.M603698200","article-title":"The heme transfer from the soluble HasA hemophore to its membrane-bound receptor HasR is driven by protein-protein interaction from a high to a lower affinity binding site","volume":"281","author":"Izadi-Pruneyre","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jmb.2026.169997_b0120","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1073\/pnas.0809406106","article-title":"Heme uptake across the outer membrane as revealed by crystal structures of the receptor\u2013hemophore complex","volume":"106","author":"Krieg","year":"2009","journal-title":"PNAS"},{"key":"10.1016\/j.jmb.2026.169997_b0125","doi-asserted-by":"crossref","first-page":"6668","DOI":"10.1074\/jbc.M708372200","article-title":"Direct hemin transfer from IsdA to IsdC in the Isd heme acquisition system of S. aureus","volume":"283","author":"Liu","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jmb.2026.169997_b0130","doi-asserted-by":"crossref","first-page":"8421","DOI":"10.1128\/JB.01335-06","article-title":"S. aureus IsdB is a hemoglobin receptor required for heme iron utilization","volume":"188","author":"Torres","year":"2006","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.jmb.2026.169997_b0135","doi-asserted-by":"crossref","first-page":"18450","DOI":"10.1074\/jbc.M801466200","article-title":"Pathway for heme uptake from human methemoglobin by the iron-regulated surface determinants system of S. aureus","volume":"283","author":"Zhu","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jmb.2026.169997_b0140","doi-asserted-by":"crossref","first-page":"6646","DOI":"10.1021\/bi100692f","article-title":"Kinetic and spectroscopic studies of hemin acquisition in the hemophore HasAp from P. aeruginosa","volume":"49","author":"Yukl","year":"2010","journal-title":"Biochemistry"},{"key":"10.1016\/j.jmb.2026.169997_b0145","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/S0003-2697(03)00096-4","article-title":"A novel protein-based heme sensor consisting of green fluorescent protein and apocytochrome b562","volume":"317","author":"Takeda","year":"2003","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.jmb.2026.169997_b0150","doi-asserted-by":"crossref","first-page":"7539","DOI":"10.1073\/pnas.1523802113","article-title":"Heme dynamics and trafficking factors revealed by genetically encoded fluorescent heme sensors","volume":"113","author":"Hanna","year":"2016","journal-title":"PNAS"},{"key":"10.1016\/j.jmb.2026.169997_b0155","doi-asserted-by":"crossref","first-page":"13632","DOI":"10.1021\/ja301987h","article-title":"Structural basis for efficient chromophore communication and energy transfer in a constructed didomain protein scaffold","volume":"134","author":"Arpino","year":"2012","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.jmb.2026.169997_b0160","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1128\/EC.00327-09","article-title":"A photostable green fluorescent protein variant for analysis of protein localization in Candida albicans","volume":"9","author":"Zhang","year":"2010","journal-title":"Eukaryot. Cell"},{"key":"10.1016\/j.jmb.2026.169997_b0165","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1016\/j.celrep.2019.07.062","article-title":"Secretory vesicle clustering in fungal filamentous cells does not require directional growth","volume":"28","author":"Silva","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.jmb.2026.169997_b0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.fbr.2022.09.002","article-title":"Heme sensing and trafficking in fungi","volume":"43","author":"Xue","year":"2023","journal-title":"Fungal Biol. Rev."},{"key":"10.1016\/j.jmb.2026.169997_b0175","first-page":"1","article-title":"Machinery for fungal heme acquisition","author":"Labb\u00e9","year":"2020","journal-title":"Curr. Genet."},{"key":"10.1016\/j.jmb.2026.169997_b0180","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.mib.2019.05.006","article-title":"Heme-iron acquisition in fungi","volume":"52","author":"Roy","year":"2019","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.jmb.2026.169997_b0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.jinorgbio.2023.112368","article-title":"Development and atomic structure of a new fluorescence-based sensor to probe heme transfer in bacterial pathogens","volume":"249","author":"Mahoney","year":"2023","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.jmb.2026.169997_b0190","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1042\/bj0190338","article-title":"A note on the kinetics of enzyme action","volume":"19","author":"Briggs","year":"1925","journal-title":"Biochem. J."},{"key":"10.1016\/j.jmb.2026.169997_b0195","doi-asserted-by":"crossref","first-page":"4207","DOI":"10.1016\/S0021-9258(17)41764-9","article-title":"His64(E7)\u00a0\u2192\u00a0Tyr apomyoglobin as a reagent for measuring rates of hemin dissociation","volume":"269","author":"Hargrove","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jmb.2026.169997_b0200","doi-asserted-by":"crossref","first-page":"17385","DOI":"10.1074\/jbc.272.28.17385","article-title":"Quaternary structure regulates hemin dissociation from human hemoglobin","volume":"272","author":"Hargrove","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jmb.2026.169997_b0205","doi-asserted-by":"crossref","first-page":"10130","DOI":"10.1074\/jbc.271.17.10130","article-title":"Stability of the heme-globin linkage in \u03b1\u03b2 dimers and isolated chains of human hemoglobin: a study of the heme transfer reaction from the immobilized proteins to albumin","volume":"271","author":"Gattoni","year":"1996","journal-title":"J. Biol. Chem."},{"issue":"Suppl 1","key":"10.1016\/j.jmb.2026.169997_b0210","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/mmy.39.1.1.8-0","article-title":"Molecular organization of the cell wall of Candida albicans","volume":"39","author":"Klis","year":"2001","journal-title":"Med. Mycol."},{"key":"10.1016\/j.jmb.2026.169997_b0215","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1128\/EC.00250-13","article-title":"Cell wall-related bionumbers and bioestimates of Saccharomyces cerevisiae and Candida albicans","volume":"13","author":"Klis","year":"2014","journal-title":"Eukaryot. Cell"},{"key":"10.1016\/j.jmb.2026.169997_b0220","doi-asserted-by":"crossref","first-page":"6799","DOI":"10.1016\/S0021-9258(18)32293-2","article-title":"Separate physiological roles and subcellular compartments for two tetrapyrrole biosynthetic pathways in Euglena gracilis","volume":"258","author":"Weinstein","year":"1983","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jmb.2026.169997_b0225","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1093\/bioinformatics\/btu097","article-title":"ZDOCK server: interactive docking prediction of protein\u2013protein complexes and symmetric multimers","volume":"30","author":"Pierce","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jmb.2026.169997_b0230","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/nprot.2016.169","article-title":"The ClusPro web server for protein\u2013protein docking","volume":"12","author":"Kozakov","year":"2017","journal-title":"Nature Protoc."},{"key":"10.1016\/j.jmb.2026.169997_b0235","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1021\/ja026939x","article-title":"HADDOCK: a protein\u2013protein docking approach based on biochemical or biophysical information","volume":"125","author":"Dominguez","year":"2003","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.jmb.2026.169997_b0240","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1093\/bioinformatics\/btt038","article-title":"SwarmDock: a server for flexible protein\u2013protein docking","volume":"29","author":"Torchala","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jmb.2026.169997_b0245","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1002\/prot.21495","article-title":"FireDock: fast interaction refinement in molecular docking","volume":"69","author":"Andrusier","year":"2007","journal-title":"Proteins Struct. Funct. Bioinform."},{"key":"10.1016\/j.jmb.2026.169997_b0250","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1002\/prot.21419","article-title":"PyDock: electrostatics and desolvation for effective scoring of rigid-body protein-protein docking","volume":"68","author":"Cheng","year":"2007","journal-title":"Proteins Struct. Funct. Genet."},{"key":"10.1016\/j.jmb.2026.169997_b0255","doi-asserted-by":"crossref","first-page":"447-","DOI":"10.1186\/1471-2105-9-447","article-title":"Identification of hot-spot residues in protein-protein interactions by computational docking","volume":"9","author":"Grosdidier","year":"2008","journal-title":"BMC Bioinf."}],"container-title":["Journal of Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022283626003700?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022283626003700?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T17:30:04Z","timestamp":1793640604000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022283626003700"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":51,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["S0022283626003700"],"URL":"https:\/\/doi.org\/10.1016\/j.jmb.2026.169997","relation":{},"ISSN":["0022-2836"],"issn-type":[{"value":"0022-2836","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An Interaction Domain Drives Heme Exchange in the C. albicans CFEM Hemophores Cascade","name":"articletitle","label":"Article Title"},{"value":"Journal of Molecular Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jmb.2026.169997","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"169997"}}