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Soc."},{"key":"10.1016\/j.jmb.2026.170026_b0310","doi-asserted-by":"crossref","first-page":"5007","DOI":"10.1093\/nar\/gkl575","article-title":"ZBP1 subcellular localization and association with stress granules is controlled by its Z-DNA binding domains","volume":"34","author":"Deigendesch","year":"2006","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jmb.2026.170026_b0315","doi-asserted-by":"crossref","first-page":"14367","DOI":"10.1073\/pnas.0405586101","article-title":"A poxvirus protein forms a complex with left-handed Z-DNA: crystal structure of a Yatapoxvirus Zalpha bound to DNA","volume":"101","author":"Ha","year":"2004","journal-title":"PNAS"},{"key":"10.1016\/j.jmb.2026.170026_b0320","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1073\/pnas.0308260100","article-title":"Evidence that vaccinia virulence factor E3L binds to Z-DNA in vivo: implications for development of a therapy for poxvirus infection","volume":"101","author":"Kim","year":"2004","journal-title":"PNAS"},{"key":"10.1016\/j.jmb.2026.170026_b0325","doi-asserted-by":"crossref","first-page":"7714","DOI":"10.1093\/nar\/gkm748","article-title":"Characterization of DNA-binding activity of Z alpha domains from poxviruses and the importance of the beta-wing regions in converting B-DNA to Z-DNA","volume":"35","author":"Quyen","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jmb.2026.170026_b0330","doi-asserted-by":"crossref","first-page":"12957","DOI":"10.1093\/nar\/gkaa1115","article-title":"Dual conformational recognition by Z-DNA binding protein is important for the B-Z transition process","volume":"48","author":"Park","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jmb.2026.170026_b0335","doi-asserted-by":"crossref","first-page":"13532","DOI":"10.1073\/pnas.240464097","article-title":"The zalpha domain of the editing enzyme dsRNA adenosine deaminase binds left-handed Z-RNA as well as Z-DNA","volume":"97","author":"Brown","year":"2000","journal-title":"PNAS"},{"key":"10.1016\/j.jmb.2026.170026_b0340","article-title":"ZBP1's inability to convert unmodified RNAs to the Z-form underlies a balanced mechanism of RNA recognition with ADAR1","author":"Krall","year":"2026","journal-title":"bioRxiv"},{"key":"10.1016\/j.jmb.2026.170026_b0345","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.cell.2020.03.040","article-title":"Caspase-6 is a key regulator of innate immunity, inflammasome activation, and host defense","volume":"181","author":"Zheng","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.jmb.2026.170026_b0350","doi-asserted-by":"crossref","DOI":"10.1038\/s41586-025-09705-5","article-title":"Host cell Z-RNAs activate ZBP1 during virus infections","author":"Yin","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.jmb.2026.170026_b0355","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.113377","article-title":"Triggering endogenous Z-RNA sensing for anti-tumor therapy through ZBP1-dependent necroptosis","volume":"42","author":"Yang","year":"2023","journal-title":"Cell Rep."},{"key":"10.1016\/j.jmb.2026.170026_b0360","doi-asserted-by":"crossref","first-page":"9505","DOI":"10.1074\/jbc.M109488200","article-title":"Identification of a novel homotypic interaction motif required for the phosphorylation of receptor-interacting protein (RIP) by RIP3","volume":"277","author":"Sun","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jmb.2026.170026_b0365","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/ni1061","article-title":"RIP1 is an essential mediator of toll-like receptor 3-induced NF-kappa B activation","volume":"5","author":"Meylan","year":"2004","journal-title":"Nature Immunol."},{"key":"10.1016\/j.jmb.2026.170026_b0370","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.cell.2012.06.019","article-title":"The RIP1\/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis","volume":"150","author":"Li","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.jmb.2026.170026_b0375","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/s41556-022-00854-7","article-title":"Mosaic composition of RIP1-RIP3 signalling hub and its role in regulating cell death","volume":"24","author":"Chen","year":"2022","journal-title":"Nature Cell Biol."},{"key":"10.1016\/j.jmb.2026.170026_b0380","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1016\/j.cell.2018.03.032","article-title":"The structure of the necrosome RIPK1-RIPK3 core, a human hetero-amyloid signaling complex","volume":"173","author":"Mompean","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.jmb.2026.170026_b0385","doi-asserted-by":"crossref","first-page":"6975","DOI":"10.1038\/s41467-024-51303-y","article-title":"The structure of mouse RIPK1 RHIM-containing domain as a homo-amyloid and in RIPK1\/RIPK3 complex","volume":"15","author":"Liu","year":"2024","journal-title":"Nature Commun."},{"key":"10.1016\/j.jmb.2026.170026_b0390","doi-asserted-by":"crossref","DOI":"10.3390\/molecules27113382","article-title":"The RHIM of the immune adaptor protein TRIF forms hybrid amyloids with other necroptosis-associated proteins","volume":"27","author":"Baker","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.jmb.2026.170026_b0395","article-title":"The structure of a minimum amyloid fibril core formed by necroptosis-mediating RHIM of human RIPK3","volume":"118","author":"Wu","year":"2021","journal-title":"PNAS"},{"key":"10.1016\/j.jmb.2026.170026_b0400","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/s41418-020-0598-9","article-title":"RIP3-mediated necroptosis is regulated by inter-filament assembly of RIP homotypic interaction motif","volume":"28","author":"Hu","year":"2021","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.jmb.2026.170026_b0405","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1038\/s41467-021-21881-2","article-title":"The amyloid structure of mouse RIPK3 (receptor interacting protein kinase 3) in cell necroptosis","volume":"12","author":"Wu","year":"2021","journal-title":"Nature Commun."},{"key":"10.1016\/j.jmb.2026.170026_b0410","doi-asserted-by":"crossref","first-page":"9607","DOI":"10.1038\/s41467-025-64621-6","article-title":"Structural basis for amyloid fibril assembly by the master cell-signaling regulator receptor-interacting protein kinase 1","volume":"16","author":"Polonio","year":"2025","journal-title":"Nature Commun."},{"key":"10.1016\/j.jmb.2026.170026_b0415","doi-asserted-by":"crossref","first-page":"4857","DOI":"10.1016\/j.cell.2021.08.013","article-title":"The expanding amyloid family: structure, stability, function, and pathogenesis","volume":"184","author":"Sawaya","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.jmb.2026.170026_b0420","doi-asserted-by":"crossref","first-page":"7436","DOI":"10.1038\/srep07436","article-title":"Evolutionary link between metazoan RHIM motif and prion-forming domain of fungal heterokaryon incompatibility factor HET-s\/HET-s","volume":"4","author":"Kajava","year":"2014","journal-title":"Sci. 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Immunol."},{"key":"10.1016\/j.jmb.2026.170026_b0460","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2023.104568","article-title":"NMR characterization of an assembling RHIM (RIP homotypic interaction motif) amyloid reveals a cryptic region for self-recognition","volume":"299","author":"Pham","year":"2023","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jmb.2026.170026_b0465","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2026.153513","article-title":"Solution NMR reveals micelle-stabilized alpha-helical segments flanking the RIPK1 RHIM amyloid core","volume":"809","author":"Polonio","year":"2026","journal-title":"Biochem. Biophys. Res. 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Comp. Immunol."},{"key":"10.1016\/j.jmb.2026.170026_b0535","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.tcb.2016.06.004","article-title":"An evolutionary perspective on the necroptotic pathway","volume":"26","author":"Dondelinger","year":"2016","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.jmb.2026.170026_b0540","doi-asserted-by":"crossref","first-page":"5059","DOI":"10.1128\/JVI.80.10.5059-5064.2006","article-title":"Double-stranded RNA is produced by positive-strand RNA viruses and DNA viruses but not in detectable amounts by negative-strand RNA viruses","volume":"80","author":"Weber","year":"2006","journal-title":"J. Virol."},{"key":"10.1016\/j.jmb.2026.170026_b0545","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.biochi.2007.03.001","article-title":"The dsRNA protein kinase PKR: virus and cell control","volume":"89","author":"Garcia","year":"2007","journal-title":"Biochimie"},{"key":"10.1016\/j.jmb.2026.170026_b0550","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1111\/j.1742-4658.2007.06188.x","article-title":"The Atlantic salmon Z-DNA binding protein kinase phosphorylates translation initiation factor 2 alpha and constitutes a unique orthologue to the mammalian dsRNA-activated protein kinase R","volume":"275","author":"Bergan","year":"2008","journal-title":"FEBS J."},{"key":"10.1016\/j.jmb.2026.170026_b0555","doi-asserted-by":"crossref","DOI":"10.1016\/j.dci.2024.105226","article-title":"The involvement of CgRHIM-containing protein in regulating haemocyte apoptosis after high temperature stress in Pacific oyster Crassostrea gigas","volume":"159","author":"Liu","year":"2024","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.jmb.2026.170026_b0560","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.dci.2017.05.025","article-title":"The oyster immunity","volume":"80","author":"Wang","year":"2018","journal-title":"Dev. Comp. 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Organ."},{"key":"10.1016\/j.jmb.2026.170026_b0580","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1006\/viro.2001.1186","article-title":"French scallops: a new host for ostreid herpesvirus-1","volume":"290","author":"Arzul","year":"2001","journal-title":"Virology"},{"key":"10.1016\/j.jmb.2026.170026_b0585","doi-asserted-by":"crossref","DOI":"10.3389\/fmars.2023.1159754","article-title":"Tracing the invertebrate herpesviruses in the global sequence datasets","volume":"10","author":"Rosani","year":"2023","journal-title":"Front. Mar. Sci."},{"key":"10.1016\/j.jmb.2026.170026_b0590","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.747737","article-title":"Convergent loss of the necroptosis pathway in disparate mammalian lineages shapes viruses countermeasures","volume":"12","author":"Agueda-Pinto","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jmb.2026.170026_b0595","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.virol.2015.03.016","article-title":"Necroptosis: the Trojan horse in cell autonomous antiviral host defense","volume":"479\u2013480","author":"Mocarski","year":"2015","journal-title":"Virology"},{"key":"10.1016\/j.jmb.2026.170026_b0600","doi-asserted-by":"crossref","first-page":"2779","DOI":"10.1099\/0022-1317-83-11-2779","article-title":"The R1 subunit of herpes simplex virus ribonucleotide reductase protects cells against apoptosis at, or upstream of, caspase-8 activation","volume":"83","author":"Langelier","year":"2002","journal-title":"J. Gen. 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