{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:59:04Z","timestamp":1788872344810,"version":"build-2803163510"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"FAPESP and CNPq","award":["04\/04386-1"],"award-info":[{"award-number":["04\/04386-1"]}]},{"name":"FAPESP and CNPq","award":["07\/50681-3"],"award-info":[{"award-number":["07\/50681-3"]}]},{"name":"FAPESP and CNPq","award":["07\/50510-4"],"award-info":[{"award-number":["07\/50510-4"]}]},{"name":"FAPESP and CNPq","award":["304544\/2010-8"],"award-info":[{"award-number":["304544\/2010-8"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Mechanical Behavior of Biomedical Materials"],"published-print":{"date-parts":[[2012,10]]},"DOI":"10.1016\/j.jmbbm.2012.04.024","type":"journal-article","created":{"date-parts":[[2012,5,14]],"date-time":"2012-05-14T21:15:26Z","timestamp":1337030126000},"page":"78-88","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"special_numbering":"C","title":["Effect of partial crystallization on the mechanical properties and cytotoxicity of bioactive glass from the 3CaO.P2O5\u2013SiO2\u2013MgO system"],"prefix":"10.1016","volume":"14","author":[{"given":"J.K.M.F.","family":"Daguano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Strecker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.C.","family":"Ziemath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.O.","family":"Rogero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.H.V.","family":"Fernandes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jmbbm.2012.04.024_bib1","first-page":"145","article-title":"Evaluation of the acceptance of glass in bone","volume":"3","author":"Andersson","year":"1992","journal-title":"Journal of Materials Science: Materials in Medicine"},{"key":"10.1016\/j.jmbbm.2012.04.024_bib2","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0022-3093(99)00072-1","article-title":"Solubility and film formation of phosphate and alumina containing silicate glasses","volume":"246","author":"Andersson","year":"1999","journal-title":"Journal of Non-Crystalline Solids"},{"key":"10.1016\/j.jmbbm.2012.04.024_bib3","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.jmbbm.2007.11.005","article-title":"Phenomena and mechanisms of crack propagation in glass-ceramics","author":"Apel","year":"2008","journal-title":"Journal of Mechanical Behavior of Biomedical Materials I"},{"key":"10.1016\/j.jmbbm.2012.04.024_bib4","first-page":"284","article-title":"Bioactive glass compositions suitable for repeated heat-treatments","volume":"925","author":"Arstila","year":"2005","journal-title":"Key Engineering Materials"},{"key":"10.1016\/j.jmbbm.2012.04.024_bib5","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1016\/j.jeurceramsoc.2006.04.017","article-title":"Factors affecting crystallization of bioactive glasses","volume":"27","author":"Arstila","year":"2007","journal-title":"Journal of the European Ceramic Society"},{"key":"10.1016\/j.jmbbm.2012.04.024_bib6","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.jnoncrysol.2007.06.092","article-title":"Influence of heat treatment on crystallization of bioactive glasses","volume":"354","author":"Arstila","year":"2008","journal-title":"Journal of Non-Crystalline Solids"},{"key":"10.1016\/j.jmbbm.2012.04.024_bib7","unstructured":"ASTM C1161-02c, 2002. Standard test method for determination for flexural strength of advanced ceramics at ambient temperature. Annual Book of ASTM Standards, USA."},{"key":"10.1016\/j.jmbbm.2012.04.024_bib8","unstructured":"ASTM C1327-08, 2008. Standard Test Method for Vickers Indentation Hardness of Advanced Ceramics. 2008. Annual Book of ASTM Standards, USA."},{"key":"10.1016\/j.jmbbm.2012.04.024_bib9","unstructured":"ASTM C1421-10, 2010. Standard Test Methods for Determination of Fracture Toughness of Advanced Ceramics at Ambient Temperature, Annual Book of ASTM Standards, USA."},{"key":"10.1016\/j.jmbbm.2012.04.024_bib10","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1146\/annurev.ms.22.080192.000515","article-title":"Design and properties of Glass-ceramics","volume":"22","author":"Beall","year":"1992","journal-title":"Annual Reviews Materials Science"},{"key":"10.1016\/j.jmbbm.2012.04.024_bib11","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.msea.2011.10.117","article-title":"Evaluation of the micro-hardness and fracture toughness of amorphous and partially crystallized 3CaO.P2O5\u2013SiO2\u2013MgO bioglasses","volume":"533","author":"Daguano","year":"2012","journal-title":"Materials Science and Engineering: A"},{"key":"10.1016\/j.jmbbm.2012.04.024_bib12","series-title":"Biomechanics and biomaterials in orthopedics","first-page":"208","article-title":"Rational utilization of the stress shielding effect of implants","author":"Dai","year":"2004"},{"key":"10.1016\/j.jmbbm.2012.04.024_bib13","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.jmbbm.2011.12.014","article-title":"Part II: Fracture strength and elastic modulus as a function of porosity for hydroxyapatite and other brittle materials","volume":"8","author":"Fan","year":"2012","journal-title":"Journal of the Mechanical Behavior of Biomedical Materials"},{"key":"10.1016\/j.jmbbm.2012.04.024_bib14","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.dental.2003.05.003","article-title":"Strength, fracture toughness and microstructure of a selection of all-ceramic materials. Part I. Pressable and alumina glass-infiltrated ceramics","volume":"20","author":"Guazzato","year":"2004","journal-title":"Dental Materials"},{"key":"10.1016\/j.jmbbm.2012.04.024_bib15","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1016\/S0142-9612(98)00133-1","article-title":"A forcast for the future","volume":"19","author":"Hench","year":"1998","journal-title":"Biomaterials"},{"key":"10.1016\/j.jmbbm.2012.04.024_bib16","first-page":"187","article-title":"Biological applications of bioactive glasses","volume":"13","author":"Hench","year":"1996","journal-title":"Life Chemistry Reports"},{"key":"10.1016\/j.jmbbm.2012.04.024_bib17","series-title":"Glass-Ceramic Technology","author":"Holand","year":"2002"},{"key":"10.1016\/j.jmbbm.2012.04.024_bib18","unstructured":"ISO 10993-5, 2009. International Organization for Standardization, Biological Evaluation of Medical Devices. Part 1: Guidance on Selection of Tests."},{"key":"10.1016\/j.jmbbm.2012.04.024_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0022-3093(94)00515-X","article-title":"Glass ceramics: new composition and uses","volume":"181","author":"James","year":"1995","journal-title":"Journal of Non-Crystalline Solids"},{"key":"10.1016\/j.jmbbm.2012.04.024_bib20","doi-asserted-by":"crossref","first-page":"4578","DOI":"10.1016\/j.polymer.2007.05.048","article-title":"Fabrication and characterization of chitosan\/gelatin porous scaffolds with predefined internal microstructures","volume":"48","author":"Jiankang","year":"2007","journal-title":"Polymer"},{"key":"10.1016\/j.jmbbm.2012.04.024_bib21","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.jnoncrysol.2007.06.100","article-title":"Thirty-five years of guided tissue engineering","volume":"354","author":"Karlsson","year":"2008","journal-title":"Journal of Non-Crystalline Solids"},{"key":"10.1016\/j.jmbbm.2012.04.024_bib22","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.1016\/j.ceramint.2009.05.023","article-title":"Effect of some rare-earth oxides on structure, devitrification and properties of diopside based glasses","volume":"35","author":"Kansal","year":"2009","journal-title":"Ceramics International"},{"key":"10.1016\/j.jmbbm.2012.04.024_bib23","doi-asserted-by":"crossref","first-page":"2511","DOI":"10.1016\/j.jeurceramsoc.2005.06.042","article-title":"Sinter-crystallisation in the diopside\u2013albite system. Part I. Formation of induced crystallisation porosity","volume":"26","author":"Karamanov","year":"2006","journal-title":"Journal of the European Ceramic Society"},{"key":"10.1016\/j.jmbbm.2012.04.024_bib24","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.jeurceramsoc.2007.08.001","article-title":"Induced crystallization porosity and properties of sintereds diopside and wollastonite glass-ceramics","volume":"28","author":"Karamanov","year":"2008","journal-title":"Journal of the European Ceramic Society"},{"key":"10.1016\/j.jmbbm.2012.04.024_bib25","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/j.msec.2010.06.019","article-title":"Crystallization kinetics, mineralization and crack propagation in partially crystallized bioactive glass 45S5","volume":"31","author":"Kashyap","year":"2011","journal-title":"Materials Science and Engineering C"},{"key":"10.1016\/j.jmbbm.2012.04.024_bib26","series-title":"Introduction to Ceramics. 2\u00aa Edition","article-title":"Phase transformation","author":"Kingery","year":"1975"},{"key":"10.1016\/j.jmbbm.2012.04.024_bib27","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1016\/S0142-9612(03)00044-9","article-title":"Novel bioactive materials with different mechanical properties","volume":"24","author":"Kokubo","year":"2003","journal-title":"Biomaterials"},{"key":"10.1016\/j.jmbbm.2012.04.024_bib28","series-title":"An Introduction to Bioceramics","first-page":"75","article-title":"A\/W glass-ceramic: processing and properties","author":"Kokubo","year":"1993"},{"key":"10.1016\/j.jmbbm.2012.04.024_bib29","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1002\/pol.1951.120070105","article-title":"Quantitative X-ray studies of order in amorphous and crystalline polymers. Quantitative X-ray determination of crystallinity in polyethylene","volume":"7","author":"Krimm","year":"1951","journal-title":"Journal of Polymer Science"},{"key":"10.1016\/j.jmbbm.2012.04.024_bib30","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1002\/adma.200803322","article-title":"On the fracture toughness of advanced materials","volume":"21","author":"Launey","year":"2009","journal-title":"Advance Materials"},{"key":"10.1016\/j.jmbbm.2012.04.024_bib31","first-page":"452","article-title":"The effect of residual glassy phase in a bioactive glass-ceramic on the formation of its surface apatite layer in vitro","volume":"3","author":"Li","year":"1992","journal-title":"Journal of Materials Science: Materials in Medicine"},{"key":"10.1016\/j.jmbbm.2012.04.024_bib32","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1002\/jbm.a.31165","article-title":"In vitro osteogenesis on a highly bioactive glass-ceramic (Biosilicate\u00ae)","volume":"82A","author":"Moura","year":"2007","journal-title":"Journal of Biomedical Materials Research"},{"key":"10.1016\/j.jmbbm.2012.04.024_bib33","first-page":"7","article-title":"Development of a New Glass Ceramic in the System MgO\u20133CaO.P2O5\u2013SiO2","volume":"5","author":"Oliveira","year":"1997","journal-title":"Bioceramics"},{"issue":"5","key":"10.1016\/j.jmbbm.2012.04.024_bib34","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1111\/j.1151-2916.2000.tb01374.x","article-title":"Formation of Convoluted Silica Precipitates during Amorphous Phase Separation in the Ca3(PO4)\u2013SiO2\u2013MgO System","volume":"83","author":"Oliveira","year":"2000","journal-title":"Journal of American Ceramics Society"},{"key":"10.1016\/j.jmbbm.2012.04.024_bib35","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0022-3093(00)00144-7","article-title":"Effect of SiO2 on amorphous phase separation of CaO\u2013P2O5\u2013SiO2\u2013MgO glasses","volume":"273","author":"Oliveira","year":"2000","journal-title":"Journal of Non-Crystalline Solids"},{"key":"10.1016\/j.jmbbm.2012.04.024_bib36","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.actbio.2011.10.014","article-title":"Compositional and microstructural design of highly bioactive P2O5\u2013Na2O\u2013CaO\u2013SiO2 glass-ceramics","volume":"8","author":"Peitl","year":"2012","journal-title":"Acta Biomaterialia"},{"issue":"3","key":"10.1016\/j.jmbbm.2012.04.024_bib37","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1111\/j.1551-2916.2007.02129.x","article-title":"Microstructural evolution in some silicate glass-ceramics: a review","volume":"91","author":"Pinckney","year":"2008","journal-title":"Journal of American Ceramics Society"},{"key":"10.1016\/j.jmbbm.2012.04.024_bib38","first-page":"2005","article-title":"Cristaliza\u00e7\u00e3o de biomateriais vitrocer\u00e2micos e mineraliza\u00e7\u00e3o em meio fisiol\u00f3gico simulado. 2005. 170f","author":"Queiroz","year":"2005","journal-title":"Disserta\u00e7\u00e3o (Doutorado em Ci\u00eancias e Tecnologia dos Materiais)\u2014Departamento de Engenharia Cer\u00e2mica e do Vidro, Universidade de Aveiro, Aveiro"},{"key":"10.1016\/j.jmbbm.2012.04.024_bib39","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1080\/14786430902915388","article-title":"Resonant ultrasound spectroscopy measurement of Young's modulus, shear modulus and Poisson's ratio as a function of porosity for alumina and hydroxyapatite","volume":"89","author":"Ren","year":"2009","journal-title":"Philosophical Magazine"},{"key":"10.1016\/j.jmbbm.2012.04.024_bib40","series-title":"Fundamentals of Inorganic Glasses","article-title":"Elastic properties and Microhardness of Glass","author":"Varshneya","year":"2006"},{"key":"10.1016\/j.jmbbm.2012.04.024_bib41","series-title":"Glass Chemistry","article-title":"Chapter 10: Crystallization of glasses","author":"Vogel","year":"1994"},{"key":"10.1016\/j.jmbbm.2012.04.024_bib42","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.dental.2006.10.008","article-title":"Preparation of mica-based glass-ceramics with need-like fluorapatite","volume":"23","author":"Xiang","year":"2007","journal-title":"Dental Materials"},{"key":"10.1016\/j.jmbbm.2012.04.024_bib43","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/S0272-8842(02)00219-5","article-title":"Effect of the microstructure on the mechanical properties of CaO\u2013P2O5\u2013SiO2\u2013MgO\u2013F- glass ceramics","volume":"29","author":"Yu","year":"2003","journal-title":"Ceramics International"},{"key":"10.1016\/j.jmbbm.2012.04.024_bib44","doi-asserted-by":"crossref","first-page":"481","DOI":"10.4028\/www.scientific.net\/KEM.284-286.481","article-title":"InVitro characterization of Bioactive Glasses","volume":"284-286","author":"Zhang","year":"2005","journal-title":"Key Engineering Materials"}],"container-title":["Journal of the Mechanical Behavior of Biomedical Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1751616112001506?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1751616112001506?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T21:59:13Z","timestamp":1761688753000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1751616112001506"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10]]},"references-count":44,"alternative-id":["S1751616112001506"],"URL":"https:\/\/doi.org\/10.1016\/j.jmbbm.2012.04.024","relation":{},"ISSN":["1751-6161"],"issn-type":[{"value":"1751-6161","type":"print"}],"subject":[],"published":{"date-parts":[[2012,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of partial crystallization on the mechanical properties and cytotoxicity of bioactive glass from the 3CaO.P2O5\u2013SiO2\u2013MgO system","name":"articletitle","label":"Article Title"},{"value":"Journal of the Mechanical Behavior of Biomedical Materials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jmbbm.2012.04.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}