{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:38:20Z","timestamp":1791409100403,"version":"4.3.3"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100012125","name":"Agricultural Research Foundation","doi-asserted-by":"publisher","award":["R221000039133"],"award-info":[{"award-number":["R221000039133"]}],"id":[{"id":"10.13039\/100012125","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012125","name":"Agricultural Research Foundation","doi-asserted-by":"publisher","award":["R221000052112"],"award-info":[{"award-number":["R221000052112"]}],"id":[{"id":"10.13039\/100012125","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001352","name":"National University of Singapore","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001352","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001459","name":"Ministry of Education - Singapore","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001459","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Mechanical Behavior of Biomedical Materials"],"published-print":{"date-parts":[[2013,1]]},"DOI":"10.1016\/j.jmbbm.2012.09.008","type":"journal-article","created":{"date-parts":[[2012,9,28]],"date-time":"2012-09-28T17:31:00Z","timestamp":1348853460000},"page":"278-289","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":43,"special_numbering":"C","title":["Chitosan\/Riboflavin-modified demineralized dentin as a potential substrate for bonding"],"prefix":"10.1016","volume":"17","author":[{"given":"Amr S.","family":"Fawzy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorraine I.","family":"Nitisusanta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kulsum","family":"Iqbal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umer","family":"Daood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu Thong","family":"Beng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Neo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jmbbm.2012.09.008_bib1","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.jmbbm.2011.08.006","article-title":"Nano and micro mechanical properties of uncross-linked and cross-linked chitosan films","volume":"5","author":"Aryaei","year":"2012","journal-title":"Journal of the Mechanical Behavior of Biomedical Materials"},{"key":"10.1016\/j.jmbbm.2012.09.008_bib2","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.jsb.2008.02.010","article-title":"Mechanical properties of mineralized collagen fibrils as influenced by demineralization","volume":"162","author":"Balooch","year":"2008","journal-title":"Journal of Structural Biology"},{"key":"10.1016\/j.jmbbm.2012.09.008_bib3","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1002\/jbm.b.30593","article-title":"Application of crosslinkers to dentin collagen enhances the ultimate tensile strength","volume":"80","author":"Bedran-Russo","year":"2007","journal-title":"Journal of Biomedical Materials Research Part B, Applied Biomaterials"},{"key":"10.1016\/j.jmbbm.2012.09.008_bib4","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1002\/jbm.b.31022","article-title":"Changes in stiffness of demineralized dentin following application of collagen crosslinkers","volume":"86","author":"Bedran-Russo","year":"2008","journal-title":"Journal of Biomedical Materials Research Part B, Applied Biomaterials"},{"key":"10.1016\/j.jmbbm.2012.09.008_bib5","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1177\/0022034509342556","article-title":"Mechanical properties of tannic-acid-treated dentin matrix","volume":"88","author":"Bedran-Russo","year":"2009","journal-title":"Journal of Dental Research"},{"key":"10.1016\/j.jmbbm.2012.09.008_bib6","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1016\/j.actbio.2010.12.013","article-title":"Characterization of biomodified dentin matrices for potential preventive and reparative therapies","volume":"7","author":"Bedran-Russo","year":"2011","journal-title":"Acta Biomaterialia"},{"key":"10.1016\/j.jmbbm.2012.09.008_bib7","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0939-6411(03)00161-9","article-title":"Structure and interactions in covalently and ionically crosslinked chitosan hydrogels for biomedical applications","volume":"57","author":"Berger","year":"2004","journal-title":"European Journal of Pharmaceuticals and Biopharmaceuticals"},{"key":"10.1016\/j.jmbbm.2012.09.008_bib8","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.jbiomech.2010.09.005","article-title":"Mechanical recovery of dentin following remineralization in vitro-an indentation study","volume":"44","author":"Bertassoni","year":"2011","journal-title":"Journal of Biomechanics"},{"key":"10.1016\/j.jmbbm.2012.09.008_bib9","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.dental.2007.02.009","article-title":"Dental adhesion review: aging and stability of the bonded interface","volume":"24","author":"Breschi","year":"2008","journal-title":"Dental Materials : Official Publication of the Academy of Dental Materials"},{"key":"10.1016\/j.jmbbm.2012.09.008_bib10","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.jdent.2010.02.002","article-title":"Solubility study of phytochemical cross-linking agents on dentin stiffness","volume":"38","author":"Castellan","year":"2010","journal-title":"Journal of Dentistry"},{"key":"10.1016\/j.jmbbm.2012.09.008_bib11","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1177\/0022034511423397","article-title":"Effect of UVA-activated riboflavin on dentin bonding","volume":"90","author":"Cova","year":"2011","journal-title":"Journal of Dental Research"},{"key":"10.1016\/j.jmbbm.2012.09.008_bib12","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.progpolymsci.2011.02.001","article-title":"Chitosan-A versatile semi-synthetic polymer in biomedical applications","volume":"36","author":"Dash","year":"2011","journal-title":"Progress in Polymer Science"},{"key":"10.1016\/j.jmbbm.2012.09.008_bib13","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/0142-9612(95)94149-F","article-title":"Collagen and its interaction with chitosan: II. Influence of the physicochemical characteristics of collagen","volume":"16","author":"Domard","year":"1995","journal-title":"Biomaterials"},{"key":"10.1016\/j.jmbbm.2012.09.008_bib14","first-page":"135","article-title":"Sodium hypochlorite as dentin pretreatment etch-and-rinse single-bottle and two-step self-etching adhesives: atomic force microscope and tensile bond strength evaluation","volume":"10","author":"Fawzy","year":"2008","journal-title":"The Journal of Adhesive Dentistry"},{"key":"10.1016\/j.jmbbm.2012.09.008_bib15","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1016\/j.jdent.2010.08.004","article-title":"Grape seed proanthocyanidins increase collagen biodegradation resistance in the dentin\/adhesive interface when included in an adhesive","volume":"38","author":"Green","year":"2010","journal-title":"Journal of Dentistry"},{"key":"10.1016\/j.jmbbm.2012.09.008_bib16","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1016\/j.actbio.2009.10.052","article-title":"Changes in stiffness of resin-infiltrated demineralized dentin after remineralization by a bottom-up biomimetic approach","volume":"6","author":"Gu","year":"2010","journal-title":"Acta Biomaterialia"},{"key":"10.1016\/j.jmbbm.2012.09.008_bib17","first-page":"7","article-title":"Quantitative contribution of resin infiltration\/hybridization to dentin bonding","volume":"6","author":"Gwinnett","year":"1993","journal-title":"American Journal of Dentistry"},{"key":"10.1016\/j.jmbbm.2012.09.008_bib18","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1002\/jbm.b.31535","article-title":"A review-micromorphological evidence of degradation in resin-dentin bonds and potential preventional solutions","volume":"92","author":"Hashimoto","year":"2010","journal-title":"Journal of Biomedical Materials Research Part B, Applied Biomaterials"},{"key":"10.1016\/j.jmbbm.2012.09.008_bib19","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1002\/jbm.820240905","article-title":"Biochemical changes and cytotoxicity associated with the degradation of polymeric glutaraldehyde derived cross-links","volume":"24","author":"Huang","year":"1990","journal-title":"Journal of Biomedical Materials Research"},{"key":"10.1016\/j.jmbbm.2012.09.008_bib20","doi-asserted-by":"crossref","first-page":"97","DOI":"10.2147\/OPTH.S27170","article-title":"Long term results of a prospective randomized bilateral eye comparison trial of higher fluence, shorter duration ultraviolet A radiation, and riboflavin collagen cross linking for progressive keratoconus","volume":"6","author":"Kanellopoulos","year":"2012","journal-title":"Clinics Ophthalmology"},{"key":"10.1016\/j.jmbbm.2012.09.008_bib21","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1177\/154405910308201204","article-title":"The importance of intrafibrillar mineralization of collagen on the mechanical properties of dentin","volume":"82","author":"Kinney","year":"2003","journal-title":"Journal of Dental Research"},{"key":"10.1016\/j.jmbbm.2012.09.008_bib22","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.jcrs.2005.12.092","article-title":"Biomechanical evidence of the distribution of cross-links in corneas treated with riboflavin and ultraviolet A light","volume":"32","author":"Kohlhaas","year":"2006","journal-title":"Journal of Cataract and Refractive Surgery"},{"key":"10.1016\/j.jmbbm.2012.09.008_bib23","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1016\/j.actbio.2009.09.028","article-title":"Evaluation of composition and crosslinking effects on collagen-based composite constructs","volume":"6","author":"Madhavan","year":"2010","journal-title":"Acta Biomaterialia"},{"key":"10.1016\/j.jmbbm.2012.09.008_bib24","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.archoralbio.2009.11.002","article-title":"The effect of cationic polymer treatment on dye staining and on the adhesion of charged particles to dentin","volume":"55","author":"Markowitz","year":"2010","journal-title":"Archives of Oral Biology"},{"key":"10.1016\/j.jmbbm.2012.09.008_bib25","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1167\/iovs.09-3738","article-title":"Mechanisms of corneal tissue cross-linking in response to treatment with topical riboflavin and long-wavelength ultraviolet radiation (UVA)","volume":"51","author":"McCall","year":"2010","journal-title":"Investigative Ophthalmology and Visual Science"},{"key":"10.1016\/j.jmbbm.2012.09.008_bib26","doi-asserted-by":"crossref","first-page":"3960","DOI":"10.1016\/j.biomaterials.2008.06.017","article-title":"PEG-stabilized carbodiimide crosslinked collagen-chitosan hydrogels for corneal tissue engineering","volume":"29","author":"Mehrdad","year":"2008","journal-title":"Biomaterials"},{"key":"10.1016\/j.jmbbm.2012.09.008_bib27","series-title":"Hybridization of dental hard tissues","author":"Nakabayashi","year":"1998"},{"key":"10.1016\/j.jmbbm.2012.09.008_bib28","volume":"Vol. 1","author":"Nielsen","year":"1974"},{"key":"10.1016\/j.jmbbm.2012.09.008_bib29","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1557\/JMR.1992.1564","article-title":"An improved technique for determining hardness and elastic modulus using load and displacement sensing indentation experiments","volume":"7","author":"Oliver","year":"1992","journal-title":"Journal of Materials Research"},{"key":"10.1016\/j.jmbbm.2012.09.008_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.dental.2010.10.016","article-title":"State of art etch-and-rinse adhesives","volume":"27","author":"Pashley","year":"2011","journal-title":"Dental Materials: Official Publication of the Academy of Dental Materials"},{"key":"10.1016\/j.jmbbm.2012.09.008_bib32","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.cden.2007.01.001","article-title":"New development in dental adhesion","volume":"51","author":"Perdigao","year":"2007","journal-title":"Dental Clinics of North America"},{"key":"10.1016\/j.jmbbm.2012.09.008_bib33","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1021\/bm034130m","article-title":"Chitosan as antimicrobial agent: applications and mode of action","volume":"4","author":"Rabea","year":"2003","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.jmbbm.2012.09.008_bib34","doi-asserted-by":"crossref","first-page":"3960","DOI":"10.1016\/j.biomaterials.2008.06.017","article-title":"PEG-stabilized carbodiimide crosslinked collagen-chitosan hydrogels for corneal tissue engineering","volume":"29","author":"Rafat","year":"2008","journal-title":"Biomaterials"},{"key":"10.1016\/j.jmbbm.2012.09.008_bib35","doi-asserted-by":"crossref","first-page":"7029","DOI":"10.1016\/S0032-3861(99)00056-7","article-title":"Influence of acetic acid concentration on the solubilization of chitosan","volume":"40","author":"Rinaudo","year":"1999","journal-title":"Polymer"},{"key":"10.1016\/j.jmbbm.2012.09.008_bib36","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1177\/0022034511421928","article-title":"Photodynamically Crosslinked and Chitosan-incorporated Dentin Collagen","volume":"90","author":"Shrestha","year":"2011","journal-title":"Journal of Dental Research"},{"key":"10.1016\/j.jmbbm.2012.09.008_bib37","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1097\/ICO.0b013e3180334f78","article-title":"Safety of UVA-riboflavin cross-linking of the cornea","volume":"26","author":"Spoerl","year":"2007","journal-title":"Cornea"},{"key":"10.1016\/j.jmbbm.2012.09.008_bib38","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/j.1442-9071.2010.02228.x","article-title":"Collagen cross-linking: a new treatment paradigm in corneal disease\u2014a review.","volume":"38","author":"Snibson","year":"2010","journal-title":"Clinical and Experimental Ophthalmology"},{"key":"10.1016\/j.jmbbm.2012.09.008_bib39","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/j.jdent.2010.06.004","article-title":"Chitosan effect on dental enamel de-remineralization: an in vitro evaluation","volume":"38","author":"Stamford Arnaud","year":"2010","journal-title":"Journal of Dentistry"},{"key":"10.1016\/j.jmbbm.2012.09.008_bib40","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1111\/j.1439-0434.1984.tb04244.x","article-title":"Effect of chitosan, chitin and some aminosugars on growth of various soilbome phytopathogenic fungi","volume":"111","author":"Stossel","year":"1984","journal-title":"Phytopathologische Zeitschrift"},{"key":"10.1016\/j.jmbbm.2012.09.008_bib41","first-page":"37","article-title":"Properties of collagen\/chitosan scaffolds for skin tissue engineering","volume":"16","author":"Tangsadthakun","year":"2006","journal-title":"Journal of the Metals, Materials and Minerals"},{"key":"10.1016\/j.jmbbm.2012.09.008_bib42","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1177\/00220345930720020501","article-title":"Comparative SEM and TEM examination of ultrastructure of resin\u2013dentin interdiffusion zone","volume":"72","author":"Van Meerbeek","year":"1993","journal-title":"Journal of Dental Research"},{"key":"10.1016\/j.jmbbm.2012.09.008_bib43","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1016\/j.addr.2003.08.004","article-title":"Collagen gel systems for sustained delivery and tissue engineering","volume":"55","author":"Wallace","year":"2003","journal-title":"Advanced Drug Delivery Reviews"},{"key":"10.1016\/j.jmbbm.2012.09.008_bib44","doi-asserted-by":"crossref","first-page":"3213","DOI":"10.1016\/S0142-9612(03)00170-4","article-title":"Crosslinked collagen\/chitosan matrix for artificial livers","volume":"24","author":"Wang","year":"2003","journal-title":"Biomaterials"},{"key":"10.1016\/j.jmbbm.2012.09.008_bib45","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/S0002-9394(02)02220-1","article-title":"Riboflavin\/ultraviolet-A-induced collagen crosslinking for the treatment of keratoconus","volume":"135","author":"Wollensak","year":"2003","journal-title":"American Journal of Ophthalmology"},{"key":"10.1016\/j.jmbbm.2012.09.008_bib46","first-page":"242","article-title":"Cross-linked demineralized dentin maintains its mechanical stability when challenged by bacterial collagenase","volume":"96","author":"Xu","year":"2010","journal-title":"Journal of Biomedical Materials Research Part B, Applied Biomaterials"},{"key":"10.1016\/j.jmbbm.2012.09.008_bib47","first-page":"455","article-title":"Collagen biochemistry: an overview","volume":"Vol 6","author":"Yamauchi","year":"2000"},{"key":"10.1016\/j.jmbbm.2012.09.008_bib48","doi-asserted-by":"crossref","first-page":"5021","DOI":"10.1016\/j.biomaterials.2005.01.024","article-title":"Effect of structural change of collagen fibrils on the durability of dentin bonding","volume":"26","author":"Yang","year":"2005","journal-title":"Biomaterials"},{"key":"10.1016\/j.jmbbm.2012.09.008_bib49","doi-asserted-by":"crossref","first-page":"163","DOI":"10.4248\/IJOS.09044","article-title":"The role of host-derived dentinal matrix metalloproteinases in reducing dentin bonding of resin adhesives","volume":"1","author":"Zhang","year":"2009","journal-title":"International Journal of Oral Science"},{"key":"10.1016\/j.jmbbm.2012.09.008_bib50","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1111\/j.1365-2818.2010.03412.x","article-title":"Real-time enzymatic degradation of human dentin collagen fibrils exposed to exogenous collagenase: an AFM study in situ","volume":"241","author":"Zheng","year":"2010","journal-title":"Journal of Microscopy"},{"key":"10.1016\/j.jmbbm.2012.09.008_bib51","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.jsb.2010.09.010","article-title":"Young's modulus of peritubular and intertubular human dentin by nano-indentation tests","volume":"174","author":"Ziskind","year":"2010","journal-title":"Journal of Structural Biology"}],"container-title":["Journal of the Mechanical Behavior of Biomedical Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1751616112002524?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1751616112002524?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T22:01:15Z","timestamp":1761688875000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1751616112002524"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1]]},"references-count":50,"alternative-id":["S1751616112002524"],"URL":"https:\/\/doi.org\/10.1016\/j.jmbbm.2012.09.008","relation":{},"ISSN":["1751-6161"],"issn-type":[{"value":"1751-6161","type":"print"}],"subject":[],"published":{"date-parts":[[2013,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chitosan\/Riboflavin-modified demineralized dentin as a potential substrate for bonding","name":"articletitle","label":"Article Title"},{"value":"Journal of the Mechanical Behavior of Biomedical Materials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jmbbm.2012.09.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}