{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T11:09:27Z","timestamp":1790507367488,"version":"4.1.0"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"IVTV ANR-10-EQPX-06-01, ANR OMBIOS and the AOI (Association de l\u2019Ost\u00e9og\u00e9n\u00e8se Imparfaite)"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Mechanical Behavior of Biomedical Materials"],"published-print":{"date-parts":[[2015,6]]},"DOI":"10.1016\/j.jmbbm.2014.12.020","type":"journal-article","created":{"date-parts":[[2015,2,16]],"date-time":"2015-02-16T03:49:52Z","timestamp":1424058592000},"page":"261-270","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":44,"special_numbering":"C","title":["Microstructure and compressive mechanical properties of cortical bone in children with osteogenesis imperfecta treated with bisphosphonates compared with healthy children"],"prefix":"10.1016","volume":"46","author":[{"given":"Laurianne","family":"Imbert","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Charles","family":"Aur\u00e9gan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K\u00e9lig","family":"Pernelle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Hoc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jmbbm.2014.12.020_bib34","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.clinbiomech.2012.10.003","article-title":"Bone properties by nanoindentation in mild and severe osteogenesis imperfecta","volume":"28","author":"Albert","year":"2013","journal-title":"Clin. Biomech."},{"key":"10.1016\/j.jmbbm.2014.12.020_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2014.05.022","article-title":"Reduced diaphyseal strength associated with high intracortical vascular porosity within long bones of children with Osteogenesis Imperfecta","author":"Albert","year":"2014","journal-title":"Bone"},{"key":"10.1016\/j.jmbbm.2014.12.020_bib43","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1002\/jbmr.1501","article-title":"Bone micromechanical properties are compromised during long-term alendronate therapy independently of mineralization","volume":"27","author":"Bala","year":"2012","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.jmbbm.2014.12.020_bib54","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0021-9290(03)00257-4","article-title":"Comparison of the elastic and yield properties of human femoral trabecular and cortical bone tissue","volume":"37","author":"Bayraktar","year":"2004","journal-title":"J. Biomech."},{"issue":"5","key":"10.1016\/j.jmbbm.2014.12.020_bib52","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1016\/j.ultras.2013.09.014","article-title":"In vitro ultrasonic and mechanic characterization of the modulus of elasticity of children cortical bone","volume":"54","author":"Berteau","year":"2014","journal-title":"Ultrasonics"},{"key":"10.1016\/j.jmbbm.2014.12.020_bib27","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s002239900600","article-title":"The mineralization density of iliac crest bone from children with osteogenesis imperfecta","volume":"64","author":"Boyde","year":"1999","journal-title":"Calcif. Tissue Int."},{"issue":"6","key":"10.1016\/j.jmbbm.2014.12.020_bib36","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.bone.2004.02.023","article-title":"Bone turnover markers in patients with osteogenesis imperfecta","volume":"34","author":"Braga","year":"2004","journal-title":"Bone"},{"key":"10.1016\/j.jmbbm.2014.12.020_bib20","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1007\/s00223-002-1038-1","article-title":"Fourier transform infrared imaging spectroscopy (FT-IRIS) of mineralization in bisphosphonate-treated oim\/oim mice","volume":"72","author":"Camacho","year":"2003","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.jmbbm.2014.12.020_bib51","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.bone.2013.12.020","article-title":"Altered lacunar and vascular porosity in osteogenesis imperfecta mouse bone as revealed by synchrotron tomography contributes to bone fragility","volume":"61","author":"Carriero","year":"2014","journal-title":"Bone"},{"issue":"1","key":"10.1016\/j.jmbbm.2014.12.020_bib50","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.bone.2012.09.010","article-title":"Cooper DML. Variation in osteocyte lacunar morphology and density in the human femur\u2014a synchrotron radiation micro-CT study","volume":"52","author":"Carter","year":"2013","journal-title":"Bone"},{"key":"10.1016\/j.jmbbm.2014.12.020_bib8","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s002239900670","article-title":"Osteogenesis imperfecta: bone turnover, bone density, and ultrasound parameters","volume":"65","author":"Cepollaro","year":"1999","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.jmbbm.2014.12.020_bib39","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.bone.2008.02.019","article-title":"Side-to-side and within-side variability of 3D bone microarchitecture by conventional micro-computed tomography of paired iliac crest biopsies","volume":"43","author":"Chappard","year":"2008","journal-title":"Bone"},{"key":"10.1016\/j.jmbbm.2014.12.020_bib18","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/j.bone.2012.08.110","article-title":"Comparison of bone tissue properties in mouse models with collagenous and non-collagenous genetic mutations using FTIRI","volume":"51","author":"Coleman","year":"2012","journal-title":"Bone"},{"key":"10.1016\/j.jmbbm.2014.12.020_bib6","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s00223-012-9588-3","article-title":"Recent advances in osteogenesis imperfecta","volume":"90","author":"Cundy","year":"2012","journal-title":"Calcif. Tissue Int."},{"issue":"6","key":"10.1016\/j.jmbbm.2014.12.020_bib49","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/j.bone.2010.08.013","article-title":"Collagen mutation causes changes of the microdamage morphology in bone of an OI mouse model","volume":"47","author":"Dong","year":"2010","journal-title":"Bone"},{"key":"10.1016\/j.jmbbm.2014.12.020_bib11","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.bone.2011.03.774","article-title":"The relationship between the chemistry and biological activity of the bisphosphonates","volume":"49","author":"Ebetino","year":"2011","journal-title":"Bone"},{"key":"10.1016\/j.jmbbm.2014.12.020_bib35","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.compositesb.2006.08.006","article-title":"Nanoindentation as a means for distinguishing clinical type of osteogenesis imperfecta","volume":"38","author":"Fan","year":"2007","journal-title":"Composites Part B: Eng."},{"key":"10.1016\/j.jmbbm.2014.12.020_bib4","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1006\/mgme.2000.3039","article-title":"Osteogenesis imperfecta: prospects for molecular therapeutics","volume":"71","author":"Forlino","year":"2000","journal-title":"Mol. Gen. Metab."},{"key":"10.1016\/j.jmbbm.2014.12.020_bib21","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1172\/JCI118428","article-title":"Bone mineralization in an osteogenesis imperfecta mouse model studied by small-angle x-ray scattering","volume":"97","author":"Fratzl","year":"1996","journal-title":"J. Clin. Invest."},{"issue":"6","key":"10.1016\/j.jmbbm.2014.12.020_bib41","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/j.bone.2009.02.021","article-title":"Normative data on mineralization density distribution in iliac bone biopsies of children, adolescents and young adults","volume":"44","author":"Fratzl-Zelman","year":"2009","journal-title":"Bone"},{"key":"10.1016\/j.jmbbm.2014.12.020_bib32","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.bone.2013.11.023","article-title":"Mineral particle size in children with osteogenesis imperfecta type I is not increased independently of specific collagen mutations","volume":"60","author":"Fratzl-Zelman","year":"2014","journal-title":"Bone"},{"key":"10.1016\/j.jmbbm.2014.12.020_bib38","unstructured":"GE Sensing and Inspection Technologies GmbH, Phoenix|x-ray, Datos|x Reconstruction, CT Data Optimization and Reconstruction Software, 2010."},{"key":"10.1016\/j.jmbbm.2014.12.020_bib3","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.berh.2007.12.012","article-title":"Osteogenesis imperfecta","volume":"22","author":"Glorieux","year":"2008","journal-title":"Best Pract. Res. Clin. Rheumatol."},{"key":"10.1016\/j.jmbbm.2014.12.020_bib22","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/S8756-3282(01)00594-4","article-title":"Age-and genotype-dependence of bone material properties in the osteogenesis imperfecta murine model (oim)","volume":"29","author":"Grabner","year":"2001","journal-title":"Bone"},{"key":"10.1016\/j.jmbbm.2014.12.020_bib33","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.bone.2014.04.030","article-title":"Mechanical and mineral properties of osteogenesis imperfecta human bones at the tissue level","volume":"65","author":"Imbert","year":"2014","journal-title":"Bone"},{"key":"10.1016\/j.jmbbm.2014.12.020_bib25","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1007\/s002239900571","article-title":"The microscopic structure of bone in normal children and patients with osteogenesis imperfecta: a survey using backscattered electron imaging","volume":"64","author":"Jones","year":"1999","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.jmbbm.2014.12.020_bib56","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.jmbbm.2012.09.009","article-title":"Micromechanical modeling of R-curve behaviors in human cortical bone","volume":"16","author":"Ks","year":"2012","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"10.1016\/j.jmbbm.2014.12.020_bib55","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.jmbbm.2013.02.021","article-title":"Variability and anisotropy of mechanical behavior of cortical bone in tension and compression","volume":"21","author":"Li","year":"2013","journal-title":"J. Mech. Behav. Biomed. Mater."},{"issue":"1","key":"10.1016\/j.jmbbm.2014.12.020_bib10","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s10238-012-0218-1","article-title":"Therapeutic application of mesenchymal stem cells in bone and joint diseases","volume":"14","author":"Liu","year":"2014","journal-title":"Clin. Exp. Med."},{"issue":"6","key":"10.1016\/j.jmbbm.2014.12.020_bib46","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1016\/j.jbiomech.2008.01.017","article-title":"Quantitative associations between osteocyte density and biomechanics, microcrack and microstructure in OVX rats vertebral trabeculae","volume":"41","author":"Ma","year":"2008","journal-title":"J. Biomech."},{"key":"10.1016\/j.jmbbm.2014.12.020_bib5","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1007\/s00198-005-1905-5","article-title":"Musculoskeletal manifestations of mild osteogenesis imperfecta in the adult","volume":"16","author":"McKiernan","year":"2005","journal-title":"Osteoporos. Int."},{"issue":"9","key":"10.1016\/j.jmbbm.2014.12.020_bib45","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1016\/j.jbiomech.2005.04.032","article-title":"Osteocyte lacunae tissue strain in cortical bone","volume":"39","author":"Nicolella","year":"2006","journal-title":"J. Biomech."},{"issue":"4","key":"10.1016\/j.jmbbm.2014.12.020_bib53","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.bone.2011.06.035","article-title":"Compressive behaviour of child and adult cortical bone","volume":"49","author":"\u00d6hman","year":"2011","journal-title":"Bone"},{"key":"10.1016\/j.jmbbm.2014.12.020_bib2","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/s00223-013-9771-1","article-title":"The long bone deformity of osteogenesis imperfecta III: Analysis of structural changes carried out with scanning electron microscopic morphometry","volume":"93","author":"Pazzaglia","year":"2013","journal-title":"Calcif. Tissue Int.."},{"issue":"1","key":"10.1016\/j.jmbbm.2014.12.020_bib47","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.bone.2005.01.023","article-title":"The morphological association between microcracks and osteocyte lacunae in human cortical bone","volume":"37","author":"Qiu","year":"2005","journal-title":"Bone"},{"key":"10.1016\/j.jmbbm.2014.12.020_bib7","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1016\/S0140-6736(04)16051-0","article-title":"Osteogenesis imperfecta","volume":"363","author":"Rauch","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.jmbbm.2014.12.020_bib24","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/S8756-3282(00)00269-6","article-title":"Static and dynamic bone histomorphometry in children with osteogenesis imperfecta","volume":"26","author":"Rauch","year":"2000","journal-title":"Bone"},{"key":"10.1016\/j.jmbbm.2014.12.020_bib23","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.bone.2005.06.007","article-title":"High and low density in the same bone: a study on children and adolescents with mild osteogenesis imperfecta","volume":"37","author":"Rauch","year":"2005","journal-title":"Bone"},{"key":"10.1016\/j.jmbbm.2014.12.020_bib9","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s002239900387","article-title":"Differing lumbar vertebral mineralization rates in ambulatory pediatric patients with osteogenesis imperfecta","volume":"62","author":"Reinus","year":"1998","journal-title":"Calcif. Tissue Int."},{"issue":"4","key":"10.1016\/j.jmbbm.2014.12.020_bib40","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S8756-3282(98)00112-4","article-title":"Validation of quantitative backscattered electron imaging for the measurement of mineral density distribution in human bone biopsies","volume":"23","author":"Roschger","year":"1998","journal-title":"Bone"},{"key":"10.1016\/j.jmbbm.2014.12.020_bib44","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S8756-3282(01)00485-9","article-title":"Alendronate increases degree and uniformity of mineralization in cancellous bone and decreases the porosity in cortical bone in osteoporotic women","volume":"29","author":"Roschger","year":"2001","journal-title":"Bone"},{"key":"10.1016\/j.jmbbm.2014.12.020_bib42","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.bone.2007.10.021","article-title":"Bone mineralization density distribution in health and disease","volume":"42","author":"Roschger","year":"2008","journal-title":"Bone"},{"key":"10.1016\/j.jmbbm.2014.12.020_bib26","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s00223-008-9113-x","article-title":"Evidence that abnormal high bone mineralization in growing children with osteogenesis imperfecta is not associated with specific collagen mutations","volume":"82","author":"Roschger","year":"2008","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.jmbbm.2014.12.020_bib28","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/PL00005829","article-title":"Abnormal mineral composition of osteogenesis imperfecta bone as determined by electron probe X-ray microanalysis on conventional and cryosections","volume":"65","author":"Sarathchandra","year":"1999","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.jmbbm.2014.12.020_bib29","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1007\/s002239900719","article-title":"Morphometric analysis of type I collagen fibrils in the osteoid of osteogenesis imperfecta","volume":"65","author":"Sarathchandra","year":"1999","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.jmbbm.2014.12.020_bib30","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1002\/1096-9896(2000)9999:9999<::AID-PATH704>3.0.CO;2-U","article-title":"A light and electron microscopic study of osteogenesis imperfecta bone samples, with reference to collagen chemistry and clinical phenotype","volume":"192","author":"Sarathchandra","year":"2000","journal-title":"J. Pathol."},{"key":"10.1016\/j.jmbbm.2014.12.020_bib15","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s00223-001-1055-5","article-title":"The effect of intravenous pamidronate on bone mineral density, bone histomorphometry, and parameters of bone turnover in adults with Type IA osteogenesis imperfect","volume":"72","author":"Shapiro","year":"2003","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.jmbbm.2014.12.020_bib1","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1136\/jmg.16.2.101","article-title":"Genetic heterogeneity in osteogenesis imperfecta","volume":"16","author":"Sillence","year":"1979","journal-title":"J. Med. Genet."},{"issue":"3","key":"10.1016\/j.jmbbm.2014.12.020_bib17","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1182\/blood-2010-05-287565","article-title":"Transplantation of human fetal blood stem cells in the osteogenesis imperfecta mouse leads to improvement in multiscale tissue properties","volume":"117","author":"Vanleene","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.jmbbm.2014.12.020_bib16","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1016\/j.bone.2012.03.007","article-title":"Ultra-structural defects cause low bone matrix stiffness despite high mineralization in osteogenesis imperfecta mice","volume":"50","author":"Vanleene","year":"2012","journal-title":"Bone"},{"issue":"4","key":"10.1016\/j.jmbbm.2014.12.020_bib48","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S8756-3282(00)00236-2","article-title":"Decline in osteocyte lacunar density in human cortical bone is associated with accumulation of microcracks with age","volume":"26","author":"Vashishth","year":"2000","journal-title":"Bone"},{"key":"10.1016\/j.jmbbm.2014.12.020_bib31","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1007\/BF02556213","article-title":"Changes in apatite crystal size in bones of patients with osteogenesis imperfecta","volume":"49","author":"Vetter","year":"1991","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.jmbbm.2014.12.020_bib13","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.jbspin.2004.09.005","article-title":"Effect of alendronate therapy in children with osteogenesis imperfecta","volume":"72","author":"Vysko\u010dil","year":"2005","journal-title":"Joint Bone Spine"},{"key":"10.1016\/j.jmbbm.2014.12.020_bib12","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1210\/jc.2010-0636","article-title":"Alendronate for the treatment of pediatric osteogenesis imperfecta: a randomized placebo-controlled study","volume":"96","author":"Ward","year":"2010","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.jmbbm.2014.12.020_bib14","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1136\/adc.76.2.169","article-title":"Hypercalcaemia in osteogenesis imperfecta treated with pamidronate","volume":"76","author":"Williams","year":"1997","journal-title":"Arch. Dis. Child."},{"key":"10.1016\/j.jmbbm.2014.12.020_bib19","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1007\/s10439-013-0793-7","article-title":"Gender-dependence of bone structure and properties in adult osteogenesis imperfecta murine model","volume":"41","author":"Yao","year":"2013","journal-title":"Ann. Biomed. Eng."}],"container-title":["Journal of the Mechanical Behavior of Biomedical Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1751616115000375?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1751616115000375?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T22:07:27Z","timestamp":1761689247000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1751616115000375"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6]]},"references-count":56,"alternative-id":["S1751616115000375"],"URL":"https:\/\/doi.org\/10.1016\/j.jmbbm.2014.12.020","relation":{},"ISSN":["1751-6161"],"issn-type":[{"value":"1751-6161","type":"print"}],"subject":[],"published":{"date-parts":[[2015,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Microstructure and compressive mechanical properties of cortical bone in children with osteogenesis imperfecta treated with bisphosphonates compared with healthy children","name":"articletitle","label":"Article Title"},{"value":"Journal of the Mechanical Behavior of Biomedical Materials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jmbbm.2014.12.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}