{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T23:51:29Z","timestamp":1790725889389,"version":"4.1.0"},"reference-count":83,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"INTENSE Project","award":["prot. FILAS-RU-2014-1193"],"award-info":[{"award-number":["prot. FILAS-RU-2014-1193"]}]},{"name":"Italian National Group for Mathematical Physics"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Mechanical Behavior of Biomedical Materials"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1016\/j.jmbbm.2019.01.014","type":"journal-article","created":{"date-parts":[[2019,1,30]],"date-time":"2019-01-30T12:44:42Z","timestamp":1548852282000},"page":"9-22","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"special_numbering":"C","title":["Mechanical behavior of metastatic femurs through patient-specific computational models accounting for bone-metastasis interaction"],"prefix":"10.1016","volume":"93","author":[{"given":"Cristina","family":"Falcinelli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Di Martino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessio","family":"Gizzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Vairo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Denaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.jmbbm.2019.01.014_bib1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0021-9290(03)00257-4","article-title":"Comparison of the elastic and yield properties of human femoral trabecular and cortical bone tissue","volume":"37","author":"Bayraktar","year":"2004","journal-title":"J. Biomech."},{"key":"10.1016\/j.jmbbm.2019.01.014_bib2","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1590\/S1982-21702014000400053","article-title":"Orthogonal distance from an ellipsoid","volume":"20","author":"Bektas","year":"2014","journal-title":"Bol. Cienc. Geod."},{"key":"10.1016\/j.jmbbm.2019.01.014_bib3","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1590\/S1982-21702015000200019","article-title":"Least squares fitting of ellipsoid using orthogonal distances","volume":"21","author":"Bektas","year":"2015","journal-title":"Bol. Cienc. Geod."},{"key":"10.1016\/j.jmbbm.2019.01.014_bib4","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.bonr.2016.02.003","article-title":"The insufficiencies of risk analysis of impending pathological fractures in patients with femoral metastases: a literature review","volume":"5","author":"Benca","year":"2016","journal-title":"Bone Rep."},{"issue":"11","key":"10.1016\/j.jmbbm.2019.01.014_bib5","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.1002\/jor.23550","article-title":"Effect of simulated metastatic lesions on the biomechanical behavior of the proximal femur","volume":"35","author":"Benca","year":"2017","journal-title":"J. Orthop. Res."},{"issue":"8","key":"10.1016\/j.jmbbm.2019.01.014_bib6","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1016\/j.jbiomech.2006.08.003","article-title":"Prediction of strength and strain of the proximal femur by a CT based finite element method","volume":"40","author":"Bessho","year":"2007","journal-title":"J. Biomech."},{"issue":"2","key":"10.1016\/j.jmbbm.2019.01.014_bib7","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1063\/1.1712886","article-title":"General theory of three-dimensional consolidation","volume":"12","author":"Biot","year":"1941","journal-title":"J. Appl. Phys."},{"key":"10.1016\/j.jmbbm.2019.01.014_bib8","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.jmbbm.2016.12.017","article-title":"The impact of metastasis on the mineral phase of vertebral bone tissue","volume":"69","author":"Burke","year":"2017","journal-title":"J. Mech. Behav. Biomed. Mater."},{"issue":"10","key":"10.1016\/j.jmbbm.2019.01.014_bib9","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1586\/14737140.2014.947691","article-title":"Management of long bone metastases: recommendations from the italian orthopaedic society bone metastasis study group","volume":"14","author":"Capanna","year":"2014","journal-title":"Expert Rev. Anticancer Ther."},{"issue":"7","key":"10.1016\/j.jmbbm.2019.01.014_bib10","doi-asserted-by":"crossref","first-page":"954","DOI":"10.2106\/00004623-197759070-00021","article-title":"The compressive behavior of bone as two phase porous structure","volume":"59","author":"Carter","year":"1977","journal-title":"J. Bone Jt. Surg. Am."},{"issue":"309","key":"10.1016\/j.jmbbm.2019.01.014_bib11","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.morpho.2011.02.004","article-title":"Bone metastasis: histological changes and pathophysiological mechanisms in osteolytic or osteosclerotic localizations. a review","volume":"95","author":"Chappard","year":"2011","journal-title":"Morphologie"},{"issue":"6","key":"10.1016\/j.jmbbm.2019.01.014_bib12","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.jbspin.2017.05.006","article-title":"Pathophysiology of bone metastases from solid malignancies","volume":"84","author":"Cl\u00e9zardin","year":"2017","journal-title":"Jt. Bone Spine"},{"issue":"3","key":"10.1016\/j.jmbbm.2019.01.014_bib13","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0021-9290(98)00161-4","article-title":"Bone poroelasticity","volume":"32","author":"Cowin","year":"1999","journal-title":"J. Biomech."},{"key":"10.1016\/j.jmbbm.2019.01.014_bib14","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/0021-9290(94)00106-E","article-title":"Influence of thigh muscles on the axial strains in a proximal femur during early stance in gait","volume":"28","author":"Cristofolini","year":"1995","journal-title":"J. Biomech."},{"key":"10.1016\/j.jmbbm.2019.01.014_bib15","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1007\/s11012-016-0472-5","article-title":"Growth and remodeling of load-bearing biological soft tissues","volume":"52","author":"Cyron","year":"2017","journal-title":"Meccanica"},{"key":"10.1016\/j.jmbbm.2019.01.014_bib16","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1007\/s10237-016-0770-9","article-title":"A homogenized constrained mixture (and mechanical analog) model for growth and remodeling of soft tissue","volume":"15","author":"Cyron","year":"2016","journal-title":"Biomech. Mod. Mechanobiol."},{"key":"10.1016\/j.jmbbm.2019.01.014_bib17","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1007\/s11999-015-4453-0","article-title":"CT-based structural rigidity analysis is more accurate than mirels scoring for fracture prediction in metastatic femoral lesions","volume":"474","author":"Damron","year":"2016","journal-title":"Clin. Orthop. Relat. Res."},{"key":"10.1016\/j.jmbbm.2019.01.014_bib18","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1302\/0301-620X.94B8.28449","article-title":"The assessment of the risk of fracture in femora with metastatic lesions: comparing case-specific finite element analyses with predictions by clinical experts","volume":"94","author":"Derikx","year":"2012","journal-title":"J. Bone Jt. Surg. Br."},{"issue":"5","key":"10.1016\/j.jmbbm.2019.01.014_bib19","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.jbiomech.2014.12.017","article-title":"Towards clinical application of biomechanical tools for the prediction of fracture risk in metastatic bone disease","volume":"48","author":"Derikx","year":"2015","journal-title":"J. Biomech."},{"issue":"S3","key":"10.1016\/j.jmbbm.2019.01.014_bib20","doi-asserted-by":"crossref","first-page":"S48","DOI":"10.1016\/S0020-1383(17)30658-7","article-title":"Is endoprosthesis safer than internal fixation for metastatic disease of the proximal femur? A systematic review","volume":"48","author":"Di Martino","year":"2017","journal-title":"Injury"},{"issue":"2","key":"10.1016\/j.jmbbm.2019.01.014_bib21","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1080\/10255840701535965","article-title":"An anatomical subject-specific FE-model for hip fracture load prediction","volume":"11","author":"Duchemin","year":"2008","journal-title":"Comput. Methods Biomech. Biomed. Eng."},{"key":"10.1016\/j.jmbbm.2019.01.014_bib22","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.bone.2014.06.038","article-title":"Multiple loading conditions analysis can improve the association between finite element bone strength estimates and proximal femur fractures: a preliminary study in elderly women","volume":"67","author":"Falcinelli","year":"2014","journal-title":"Bone"},{"key":"10.1016\/j.jmbbm.2019.01.014_bib23","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.jmbbm.2016.07.004","article-title":"Can CT image deblurring improve finite element predictions at the proximal femur?","volume":"63","author":"Falcinelli","year":"2016","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"10.1016\/j.jmbbm.2019.01.014_bib24","doi-asserted-by":"crossref","first-page":"111010","DOI":"10.1115\/1.4041541","article-title":"Diffusion-tensor imaging versus digitization in reconstructing the masseter architecture","volume":"140","author":"Falcinelli","year":"2018","journal-title":"J. Biomech. Eng."},{"issue":"3","key":"10.1016\/j.jmbbm.2019.01.014_bib25","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1002\/jbmr.5650110311","article-title":"The effect of impact direction on the structural capacity of the proximal femur during falls","volume":"11","author":"Ford","year":"1996","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.jmbbm.2019.01.014_bib26","first-page":"166","article-title":"A contribution to the mechanics and thermodynamics of surface growth. application to bone external remodeling","volume":"50","author":"Ganghoffer","year":"2012","journal-title":"World J. Nano Sci. Eng."},{"issue":"8","key":"10.1016\/j.jmbbm.2019.01.014_bib27","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1002\/jor.22887","article-title":"Simulating activities of daily living with finite element analysis improves fracture prediction for patients with metastatic femoral lesions","volume":"33","author":"Goodheart","year":"2015","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.jmbbm.2019.01.014_bib28","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1097\/00004424-199111000-00003","article-title":"Local demineralization as a model for bone strength reductions in lytic transcortical metastatic lesions","volume":"26","author":"Hipp","year":"1991","journal-title":"Invest. Radiol."},{"issue":"10","key":"10.1016\/j.jmbbm.2019.01.014_bib29","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1002\/jbmr.5650071008","article-title":"Mechanical properties of trabecular bone within and adjacent to osseous metastases","volume":"7","author":"Hipp","year":"1992","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.jmbbm.2019.01.014_bib30","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.4028\/www.scientific.net\/KEM.345-346.1157","article-title":"Development of pore pressure measurement system in lacunocanalicular network of trabeculae using mems based micro-pressure transducer","volume":"345\u2013346","author":"Hong","year":"2007","journal-title":"Key Eng. Mater."},{"key":"10.1016\/j.jmbbm.2019.01.014_bib31","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1146\/annurev-bioeng-071813-105259","article-title":"The role of mechanical forces in tumor growth and therapy","volume":"16","author":"Jain","year":"2014","journal-title":"Annu. Rev. Biomed. Eng."},{"issue":"10","key":"10.1016\/j.jmbbm.2019.01.014_bib32","doi-asserted-by":"crossref","first-page":"2825","DOI":"10.1007\/s11999-010-1326-4","article-title":"In brief: classifications in brief: Mirel's classification: metastatic disease in long bones and impending pathologic fracture","volume":"468","author":"Jawad","year":"2010","journal-title":"Clin. Orthop. Relat. Res."},{"key":"10.1016\/j.jmbbm.2019.01.014_bib33","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/S1350-4533(03)00030-4","article-title":"Relationships between material properties and ct scan data of cortical bone with and without metastatic lesions","volume":"25","author":"Kaneko","year":"2003","journal-title":"Med. Eng. Phys."},{"key":"10.1016\/j.jmbbm.2019.01.014_bib34","first-page":"3140","article-title":"Mri analysis of bone metastasis: shape-related exclusion criteria","volume":"19","author":"Kedzierski","year":"2011","journal-title":"Proc. Int. Soc. Mag. Reson. Med."},{"key":"10.1016\/j.jmbbm.2019.01.014_bib35","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0021-9290(97)00123-1","article-title":"Prediction of femoral fracture load using automated finite element modeling","volume":"31","author":"Keyak","year":"1998","journal-title":"J. Biomech."},{"key":"10.1016\/j.jmbbm.2019.01.014_bib36","first-page":"654","article-title":"Prediction of fracture location in the proximal femur using finite element models","volume":"23","author":"Keyak","year":"2001","journal-title":"Med. Eng. Phys."},{"key":"10.1016\/j.jmbbm.2019.01.014_bib37","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1097\/01.blo.0000164400.37905.22","article-title":"Predicting proximal femoral strength using structural engineering models","volume":"437","author":"Keyak","year":"2005","journal-title":"Clin. Orthop. Relat. Res."},{"key":"10.1016\/j.jmbbm.2019.01.014_bib38","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1097\/BLO.0b013e3180514caa","article-title":"The effect of simulated metastatic lytic lesions on proximal femoral strength","volume":"459","author":"Keyak","year":"2007","journal-title":"Clin. Orthop. Relat. Res."},{"key":"10.1016\/j.jmbbm.2019.01.014_bib39","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1016\/j.bone.2011.03.682","article-title":"Male-female differences in the association between incident hip fracture and proximal femoral strength: a finite element analysis study","volume":"48","author":"Keyak","year":"2011","journal-title":"Bone"},{"key":"10.1016\/j.jmbbm.2019.01.014_bib40","doi-asserted-by":"crossref","unstructured":"Kim, H., Lee, T., Lee, Y., Kim, J., Jung, S., Yang, D., Lim, T., 2016. Permeability prediction of human proximal femoral trabeculae in the direction of superior-to-fovea utilizing directly measured microscopic poroelastic properties. In: Kyriacou, E., Christofides, S., Pattichis, C. (eds.), XIV Mediterranean Conference on Medical and Biological Engineering and Computing 2016. IFMBE Proceedings 57, 685\u2013687. \u3008http:\/\/dx.doi.org\/10.1007\/978-3-319-32703-7_132\u3009.","DOI":"10.1007\/978-3-319-32703-7_132"},{"issue":"3","key":"10.1016\/j.jmbbm.2019.01.014_bib41","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1002\/jbmr.2069","article-title":"Assessment of incident spine and hip fractures in women and men using finite element analysis of CT scans","volume":"29","author":"Kopperdahl","year":"2014","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.jmbbm.2019.01.014_bib42","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1021\/acsbiomaterials.7b00041","article-title":"In vitro modeling of mechanics in cancer metastasis","volume":"4","author":"Malandrino","year":"2018","journal-title":"ACS Biomater. Sci. Eng."},{"key":"10.1016\/j.jmbbm.2019.01.014_bib43","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.jmps.2014.08.009","article-title":"Influence of inter-molecular interactions on the elasto-damage mechanics of collagen fibrils: a bottom-up approach towards macroscopic tissue modeling","volume":"73","author":"Marino","year":"2014","journal-title":"J. Mech. Phys. Solids"},{"key":"10.1016\/j.jmbbm.2019.01.014_bib44","doi-asserted-by":"crossref","first-page":"20170615","DOI":"10.1098\/rsif.2017.0615","article-title":"A chemo-mechano-biological formulation for the effects of biochemical alterations on arterial mechanics: the role of molecular transport and multiscale tissue remodelling","volume":"14","author":"Marino","year":"2017","journal-title":"J. R. Soc. Interface"},{"issue":"17","key":"10.1016\/j.jmbbm.2019.01.014_bib45","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1007\/s10237-018-1009-8","article-title":"Direct and inverse identification of constitutive parameters from the structure of soft tissues. Part 1: micro- and nanostructure of collagen fibers","volume":"4","author":"Marino","year":"2018","journal-title":"Biomech. Model. Mechanobiol."},{"issue":"15","key":"10.1016\/j.jmbbm.2019.01.014_bib46","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s10237-015-0707-8","article-title":"Molecular and intermolecular effects in collagen fibril mechanics: a multiscale analytical model compared with atomistic and experimental studies","volume":"1","author":"Marino","year":"2016","journal-title":"Biomech. Model. Mechanobiol."},{"issue":"12","key":"10.1016\/j.jmbbm.2019.01.014_bib47","doi-asserted-by":"crossref","first-page":"3035","DOI":"10.1016\/j.jbiomech.2015.07.028","article-title":"Pressure and shear stress in trabecular bone marrow during whole bone loading","volume":"48","author":"Metzger","year":"2015","journal-title":"J. Biomech."},{"key":"10.1016\/j.jmbbm.2019.01.014_bib48","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1097\/00003086-198912000-00027","article-title":"Metastatic disease in long bones. a proposed scoring system for diagnosing impending pathologic fractures","volume":"249","author":"Mirels","year":"1989","journal-title":"Clin. Orthop. Relat. Res."},{"key":"10.1016\/j.jmbbm.2019.01.014_bib49","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/nmat832","article-title":"Mechanistic fracture criteria for the failure of human cortical bone","volume":"2","author":"Nalla","year":"2003","journal-title":"Nat. Mater."},{"key":"10.1016\/j.jmbbm.2019.01.014_bib50","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1007\/s00223-008-9174-x","article-title":"Bone volume fraction explains the variation in strength and stiffness of cancellous bone affected by metastatic cancer and osteoporosis","volume":"83","author":"Nazarian","year":"2008","journal-title":"Calcif. Tissue Int."},{"issue":"7","key":"10.1016\/j.jmbbm.2019.01.014_bib51","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/j.jbiomech.2013.02.025","article-title":"Proximal femur bone strength estimated by a computationally fast finite element analysis in a sideways fall configuration","volume":"46","author":"Nishiyama","year":"2013","journal-title":"J. Biomech."},{"issue":"1","key":"10.1016\/j.jmbbm.2019.01.014_bib52","doi-asserted-by":"crossref","first-page":"010802","DOI":"10.1115\/1.4029176","article-title":"Biomechanics and mechanobiology of trabecular bone: a review","volume":"137","author":"Oftadeh","year":"2015","journal-title":"J. Biomech. Eng."},{"issue":"3","key":"10.1016\/j.jmbbm.2019.01.014_bib53","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1359\/jbmr.081201","article-title":"Finite element analysis of the proximal femur and hip fracture risk in older men","volume":"24","author":"Orwoll","year":"2009","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.jmbbm.2019.01.014_bib54","doi-asserted-by":"crossref","first-page":"111005","DOI":"10.1115\/1.4040587","article-title":"The size of simulated lytic metastases affects the strain distribution on the anterior surface of the vertebra","volume":"140","author":"Palanca","year":"2018","journal-title":"J. Biomech. Eng."},{"issue":"48","key":"10.1016\/j.jmbbm.2019.01.014_bib55","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.bone.2010.12.022","article-title":"3D hierarchical geometric modeling and multiscale FE analysis as a base for individualized medical diagnosis of bone structure","volume":"4","author":"Podshivalov","year":"2011","journal-title":"Bone"},{"key":"10.1016\/j.jmbbm.2019.01.014_bib56","doi-asserted-by":"crossref","first-page":"2815","DOI":"10.1007\/s00198-016-3597-4","article-title":"Patient-specific finite element estimated femur strength as a predictor of the risk of hip fracture: the effect of methodological determinants","volume":"27","author":"Qasim","year":"2016","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.jmbbm.2019.01.014_bib57","first-page":"219","article-title":"Nanoscale stiffness distribution in bone metastasis","volume":"5","author":"Richert","year":"2015","journal-title":"Int. J. Eng. Sci."},{"key":"10.1016\/j.jmbbm.2019.01.014_bib58","doi-asserted-by":"crossref","first-page":"538","DOI":"10.32098\/mltj.04.2017.08","article-title":"Full-field in vitro investigation of hard and soft tissue strain in the spine by means of digital image correlation","volume":"7","author":"Ruspi","year":"2018","journal-title":"Muscles Liga. Tendons J."},{"key":"10.1016\/j.jmbbm.2019.01.014_bib59","doi-asserted-by":"crossref","first-page":"2982","DOI":"10.1016\/j.jbiomech.2007.02.010","article-title":"Subject-specific finite element models can accurately predict strain levels in long bones","volume":"40","author":"Schileo","year":"2007","journal-title":"J. Biomech."},{"issue":"11","key":"10.1016\/j.jmbbm.2019.01.014_bib60","doi-asserted-by":"crossref","first-page":"2491","DOI":"10.1016\/j.jbiomech.2008.05.017","article-title":"An accurate estimation of bone density improves the accuracy of subject-specific finite element models","volume":"41","author":"Schileo","year":"2008","journal-title":"J. Biomech."},{"issue":"14","key":"10.1016\/j.jmbbm.2019.01.014_bib61","doi-asserted-by":"crossref","first-page":"3531","DOI":"10.1016\/j.jbiomech.2014.08.024","article-title":"To what extent can linear finite element models of human femora predict failure under stance and fall loading configurations?","volume":"47","author":"Schileo","year":"2014","journal-title":"J. Biomech."},{"key":"10.1016\/j.jmbbm.2019.01.014_bib62","doi-asserted-by":"crossref","first-page":"015005","DOI":"10.1088\/1367-2630\/15\/1\/015005","article-title":"A multiphase model for three-dimensional tumor growth","volume":"15","author":"Sciume'","year":"2013","journal-title":"New J. Phys."},{"key":"10.1016\/j.jmbbm.2019.01.014_bib63","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s11831-013-9090-8","article-title":"On computational modeling in tumor growth","volume":"20","author":"Sciume'","year":"2013","journal-title":"Arch. Comput. Methods Eng."},{"issue":"11","key":"10.1016\/j.jmbbm.2019.01.014_bib64","doi-asserted-by":"crossref","first-page":"065004","DOI":"10.1088\/1478-3975\/11\/6\/065004","article-title":"A tumor growth model with deformable ecm","volume":"26","author":"Sciume'","year":"2014","journal-title":"Phys. Biol."},{"issue":"6","key":"10.1016\/j.jmbbm.2019.01.014_bib65","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/S0021-9290(02)00021-0","article-title":"Estimation of the poroelastic parameters of cortical bone","volume":"35","author":"Smith","year":"2002","journal-title":"J. Biomech."},{"issue":"11","key":"10.1016\/j.jmbbm.2019.01.014_bib66","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1158\/0008-5472.CAN-14-2493","article-title":"Tumor-induced pressure in the bone microenvironment causes osteocytes to promote the growth of prostate cancer bone metastases","volume":"75","author":"Sottnik","year":"2015","journal-title":"Cance Res."},{"key":"10.1016\/j.jmbbm.2019.01.014_bib67","doi-asserted-by":"crossref","first-page":"2318","DOI":"10.1016\/j.jbiomech.2006.10.038","article-title":"Physiologically based boundary conditions in finite element modelling","volume":"40","author":"Speirs","year":"2007","journal-title":"J. Biomech."},{"issue":"4 Suppl.","key":"10.1016\/j.jmbbm.2019.01.014_bib68","first-page":"S73","article-title":"Pathologic and impending fractures: biological and clinical aspects","volume":"29","author":"Spinelli","year":"2015","journal-title":"J. Biol. Regul. Homeost. Agents"},{"issue":"3","key":"10.1016\/j.jmbbm.2019.01.014_bib69","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1080\/17453670610046424","article-title":"Prediction of torsional failure in 22 cadaver femora with and without simulated subtrochanteric metastatic defects: a CT scan-based finite element analysis","volume":"77","author":"Spruijt","year":"2006","journal-title":"Acta Orthop."},{"key":"10.1016\/j.jmbbm.2019.01.014_bib70","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.bone.2018.02.011","article-title":"Pathological fracture risk assessment in patients with femoral metastases using CT-based finite element methods. a retrospective clinical study","volume":"110","author":"Sternheim","year":"2018","journal-title":"Bone"},{"issue":"1","key":"10.1016\/j.jmbbm.2019.01.014_bib71","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S1350-4533(03)00138-3","article-title":"An improved method for the automatic mapping of computed tomography numbers onto finite element models","volume":"26","author":"Taddei","year":"2004","journal-title":"Med. Eng. Phys."},{"issue":"27","key":"10.1016\/j.jmbbm.2019.01.014_bib72","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1007\/s00198-015-3404-7","article-title":"Left-right differences in the proximal femur's strength of post-menopausal women: a multicentric finite element study","volume":"4","author":"Taddei","year":"2016","journal-title":"Osteoporos. Int."},{"issue":"4","key":"10.1016\/j.jmbbm.2019.01.014_bib73","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.bone.2009.06.009","article-title":"Pathological fracture prediction in patients with metastatic lesions can be improved with quantitative computed tomography based computer models","volume":"45","author":"Tanck","year":"2009","journal-title":"Bone"},{"key":"10.1016\/j.jmbbm.2019.01.014_bib74","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nmat843","article-title":"Fracture mechanics: how does bone break?","volume":"2","author":"Taylor","year":"2003","journal-title":"Nat. Mater."},{"key":"10.1016\/j.jmbbm.2019.01.014_bib75","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1016\/j.jbiomech.2011.03.024","article-title":"Patient-specific finite element analysis of the human femur. A double-blinded biomechanical validation","volume":"44","author":"Trabelsi","year":"2011","journal-title":"J. Biomech."},{"issue":"5","key":"10.1016\/j.jmbbm.2019.01.014_bib76","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.jbiomech.2003.09.027","article-title":"Effects of tumor location, shape and surface serration on burst fracture risk in the metastatic spine","volume":"37","author":"Tschirhart","year":"2004","journal-title":"J. Biomech."},{"issue":"9","key":"10.1016\/j.jmbbm.2019.01.014_bib77","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1114\/1.1313773","article-title":"Biphasic material properties of lytic bone metastases","volume":"28","author":"Whyne","year":"2000","journal-title":"Ann. Biomed. Eng."},{"issue":"10","key":"10.1016\/j.jmbbm.2019.01.014_bib78","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1016\/S0021-9290(01)00086-0","article-title":"Parametric finite element analysis of vertebral bodies affected by tumors","volume":"34","author":"Whyne","year":"2001","journal-title":"J. Biomech."},{"issue":"10","key":"10.1016\/j.jmbbm.2019.01.014_bib79","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1016\/S0021-9290(00)00069-5","article-title":"Critical evaluation of known bone material properties to realize anisotropic FE-simulation of the proximal femur","volume":"33","author":"Wirtz","year":"2000","journal-title":"J. Biomech."},{"key":"10.1016\/j.jmbbm.2019.01.014_bib80","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.jtbi.2017.08.021","article-title":"A nonlinear poroelastic theory of solid tumors with glycosaminoglycan swelling","volume":"433","author":"Xue","year":"2017","journal-title":"J. Theor. Biol."},{"issue":"368","key":"10.1016\/j.jmbbm.2019.01.014_bib81","first-page":"2707","article-title":"Predicting the yield of the proximal femur using high-order finite-element analysis with inhomogeneous orthotropic material properties","volume":"1920","author":"Yosibash","year":"2010","journal-title":"Philos. Trans. A Math. Phys. Eng. Sci."},{"key":"10.1016\/j.jmbbm.2019.01.014_bib82","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.bone.2014.09.022","article-title":"Predicting the stiffness and strength of human femurs with real metastatic tumors","volume":"69","author":"Yosibash","year":"2014","journal-title":"Bone"},{"key":"10.1016\/j.jmbbm.2019.01.014_bib83","series-title":"The Finite Element Method","author":"Zienkiewicz","year":"1998"}],"container-title":["Journal of the Mechanical Behavior of Biomedical Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1751616118311378?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1751616118311378?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T22:26:18Z","timestamp":1761690378000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1751616118311378"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":83,"alternative-id":["S1751616118311378"],"URL":"https:\/\/doi.org\/10.1016\/j.jmbbm.2019.01.014","relation":{},"ISSN":["1751-6161"],"issn-type":[{"value":"1751-6161","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mechanical behavior of metastatic femurs through patient-specific computational models accounting for bone-metastasis interaction","name":"articletitle","label":"Article Title"},{"value":"Journal of the Mechanical Behavior of Biomedical Materials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jmbbm.2019.01.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}