{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T12:33:00Z","timestamp":1781267580562,"version":"3.54.1"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["11572235"],"award-info":[{"award-number":["11572235"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["11772245"],"award-info":[{"award-number":["11772245"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["11472205"],"award-info":[{"award-number":["11472205"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81100787"],"award-info":[{"award-number":["81100787"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Mechanical Behavior of Biomedical Materials"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1016\/j.jmbbm.2019.02.004","type":"journal-article","created":{"date-parts":[[2019,2,4]],"date-time":"2019-02-04T12:23:37Z","timestamp":1549283017000},"page":"194-203","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Fracture toughening of peritubular microstructure in biological porous dentine"],"prefix":"10.1016","volume":"93","author":[{"given":"Rong","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangyan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jmbbm.2019.02.004_bib1","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.jmbbm.2016.03.008","article-title":"Role of microstructure on fracture of dentin","volume":"59","author":"An","year":"2016","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"10.1016\/j.jmbbm.2019.02.004_bib2","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.jmbbm.2018.02.029","article-title":"An analysis of crack growth in dentin at the microstructural scale","volume":"81","author":"An","year":"2018","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"10.1016\/j.jmbbm.2019.02.004_bib3","doi-asserted-by":"crossref","first-page":"4051","DOI":"10.1016\/j.biomaterials.2004.10.029","article-title":"Effects of aging on the mechanical behavior of human dentin","volume":"26","author":"Arola","year":"2005","journal-title":"Biomaterials"},{"key":"10.1016\/j.jmbbm.2019.02.004_bib4","doi-asserted-by":"crossref","first-page":"405","DOI":"10.14219\/jada.archive.1964.0108","article-title":"Cracked tooth syndrome","volume":"68","author":"Cameron","year":"1964","journal-title":"J. Am. Dent. Assoc."},{"key":"10.1016\/j.jmbbm.2019.02.004_bib5","series-title":"Advances in Conservation Laws and Energy Release Rates","author":"Chen","year":"2002"},{"key":"10.1016\/j.jmbbm.2019.02.004_bib6","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/0021-8928(67)90034-2","article-title":"Crack propagation in continuous media","volume":"31","author":"Cherepanov","year":"1967","journal-title":"J. Appl. Math. Mech."},{"key":"10.1016\/j.jmbbm.2019.02.004_bib7","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1590\/S1516-14392007000200010","article-title":"Evaluation of microstructural parameters of human dentin by digital image analysis","volume":"10","author":"Coutinho","year":"2007","journal-title":"Mater. Res."},{"key":"10.1016\/j.jmbbm.2019.02.004_bib8","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0003-9969(76)80003-9","article-title":"Scanning electron microscopic investigation of human dentinal tubules","volume":"21","author":"Garberoglio","year":"1976","journal-title":"Arch. Oral. Biol."},{"key":"10.1016\/j.jmbbm.2019.02.004_bib9","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/S0300-5712(96)00065-6","article-title":"The dentin substrate: structure and properties related to bonding","volume":"25","author":"Grayson","year":"1997","journal-title":"J. Dent."},{"key":"10.1016\/j.jmbbm.2019.02.004_bib10","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1016\/j.biomaterials.2012.10.032","article-title":"The importance of microstructural variations on the fracture toughness of human dentin","volume":"34","author":"Ivancik","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.jmbbm.2019.02.004_bib11","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1177\/0022034511408429","article-title":"The reduction in fatigue crack growth resistance of dentin with depth","volume":"90","author":"Ivancik","year":"2011","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.jmbbm.2019.02.004_bib12","doi-asserted-by":"crossref","first-page":"e73","DOI":"10.1016\/j.dental.2009.06.006","article-title":"Effect of dentinal tubules and resin-based endodontic sealers on fracture properties of root dentin","volume":"25","author":"Jainaen","year":"2009","journal-title":"Dent. Mater."},{"key":"10.1016\/j.jmbbm.2019.02.004_bib13","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1007\/s10853-006-2871-9","article-title":"Porosity dependence of mechanical properties of solid materials","volume":"41","author":"Ji","year":"2006","journal-title":"J. Mater. Sci."},{"key":"10.1016\/j.jmbbm.2019.02.004_bib14","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0021-9290(02)00327-5","article-title":"Fracture-toughening mechanisms responsible for differences in work to fracture of hydrated and dehydrated dentine","volume":"36","author":"Kahler","year":"2003","journal-title":"J. Biomech."},{"key":"10.1016\/j.jmbbm.2019.02.004_bib15","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0021-9290(02)00327-5","article-title":"Fracture-toughening mechanisms responsible for differences in work to fracture of hydrated and dehydrated dentine","volume":"36","author":"Kahler","year":"2003","journal-title":"J. Biomech."},{"key":"10.1016\/j.jmbbm.2019.02.004_bib16","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1177\/154411130301400103","article-title":"The mechanical properties of human dentin: a critical review and re-evaluation of the dental literature","volume":"14","author":"Kinney","year":"2003","journal-title":"Crit. Rev. Oral. Biol. Med."},{"key":"10.1016\/j.jmbbm.2019.02.004_bib17","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/S0003-9969(99)00080-1","article-title":"A micromechanics model of the elastic properties of human dentine","volume":"44","author":"Kinney","year":"1999","journal-title":"Arch. Oral. Biol."},{"key":"10.1016\/j.jmbbm.2019.02.004_bib18","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1016\/j.biomaterials.2007.12.008","article-title":"The effect of aging on crack-growth resistance and toughening mechanisms in human dentin","volume":"29","author":"Koester","year":"2008","journal-title":"Biomaterials"},{"key":"10.1016\/j.jmbbm.2019.02.004_bib19","doi-asserted-by":"crossref","first-page":"5209","DOI":"10.1016\/S0142-9612(03)00458-7","article-title":"Crack blunting, crack bridging and resistance-curve fracture mechanics in dentin: effect of hydration","volume":"24","author":"Kruzic","year":"2003","journal-title":"Biomaterials"},{"key":"10.1016\/j.jmbbm.2019.02.004_bib20","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.tafmec.2015.06.005","article-title":"Crack-tip shielding by the dilatant transformation of particles\/fibers embedded in composite materials","volume":"80","author":"Li","year":"2015","journal-title":"Theor. Appl. Fract. Mech."},{"key":"10.1016\/j.jmbbm.2019.02.004_bib21","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0272-8842(98)00037-6","article-title":"Porosity-dependence of elastic moduli and hardness of 3Y-TZP ceramics","volume":"25","author":"Luo","year":"1999","journal-title":"Ceram. Int."},{"key":"10.1016\/j.jmbbm.2019.02.004_bib22","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1002\/jbm.b.30012","article-title":"Micromechanical analysis of dentin\/adhesive interface by the finite element method","volume":"70","author":"Misra","year":"2004","journal-title":"J. Biomed. Mater. Res. B Appl. Biomater."},{"key":"10.1016\/j.jmbbm.2019.02.004_bib23","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1016\/j.archoralbio.2015.10.002","article-title":"Effect of aging on the microstructure, hardness and chemical composition of dentin","volume":"60","author":"Montoya","year":"2015","journal-title":"Arch. Oral. Biol."},{"key":"10.1016\/j.jmbbm.2019.02.004_bib24","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.archoralbio.2016.03.003","article-title":"Importance of tubule density to the fracture toughness of dentin","volume":"67","author":"Montoya","year":"2016","journal-title":"Arch. Oral. Biol."},{"key":"10.1016\/j.jmbbm.2019.02.004_bib25","doi-asserted-by":"crossref","first-page":"3955","DOI":"10.1016\/S0142-9612(03)00278-3","article-title":"Effect of orientation on the in vitro fracture toughness of dentin: the role of toughening mechanisms","volume":"24","author":"Nalla","year":"2003","journal-title":"Biomaterials"},{"key":"10.1016\/j.jmbbm.2019.02.004_bib26","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1115\/1.3601206","article-title":"A path independent integral and the approximate analysis of strain concentration by notch and cracks","volume":"35","author":"Rice","year":"1968","journal-title":"Int. J. Appl. Mech."},{"key":"10.1016\/j.jmbbm.2019.02.004_bib27","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.archoralbio.2005.11.006","article-title":"Age-related changes in hardness and modulus of elasticity of dentine","volume":"51","author":"Senawongse","year":"2006","journal-title":"Arch. Oral. Biol."},{"key":"10.1016\/j.jmbbm.2019.02.004_bib28","doi-asserted-by":"crossref","first-page":"e0183982","DOI":"10.1371\/journal.pone.0183982","article-title":"The peritubular reinforcement effect of porous dentine microstructure","volume":"12","author":"Wang","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.jmbbm.2019.02.004_bib29","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1006\/jsbi.1999.4096","article-title":"Peritubular dentin formation: crystal organization and the macromolecular constituents in human teeth","volume":"126","author":"Weiner","year":"1999","journal-title":"J. Struct. Biol."},{"key":"10.1016\/j.jmbbm.2019.02.004_bib30","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1177\/002203459607502S06","article-title":"Selected restoration and tooth conditions: United States","volume":"75","author":"White","year":"1996","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.jmbbm.2019.02.004_bib31","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1115\/1.4011454","article-title":"On the stress distribution at the base of a stationary crack","volume":"24","author":"Williams","year":"1957","journal-title":"J. Appl. Mech."},{"key":"10.1016\/j.jmbbm.2019.02.004_bib32","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.archoralbio.2011.09.008","article-title":"Chemical composition and structure of peritubular and intertubular human dentine revisited","volume":"57","author":"Xu","year":"2012","journal-title":"Arch. Oral. Biol."}],"container-title":["Journal of the Mechanical Behavior of Biomedical Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S175161611831662X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S175161611831662X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T22:25:36Z","timestamp":1761690336000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S175161611831662X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":32,"alternative-id":["S175161611831662X"],"URL":"https:\/\/doi.org\/10.1016\/j.jmbbm.2019.02.004","relation":{},"ISSN":["1751-6161"],"issn-type":[{"value":"1751-6161","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fracture toughening of peritubular microstructure in biological porous dentine","name":"articletitle","label":"Article Title"},{"value":"Journal of the Mechanical Behavior of Biomedical Materials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jmbbm.2019.02.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}