{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:54:56Z","timestamp":1790628896861,"version":"4.1.0"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T00:00:00Z","timestamp":1596153600000},"content-version":"am","delay-in-days":273,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100011773","name":"Conseil r\u00e9gional de Bourgogne-Franche-Comt\u00e9","doi-asserted-by":"publisher","award":["36381"],"award-info":[{"award-number":["36381"]}],"id":[{"id":"10.13039\/501100011773","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Mechanical Behavior of Biomedical Materials"],"published-print":{"date-parts":[[2019,11]]},"DOI":"10.1016\/j.jmbbm.2019.07.025","type":"journal-article","created":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T20:42:13Z","timestamp":1564087333000},"page":"206-215","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Multimodal investigation of a keloid scar by combining mechanical tests in vivo with diverse imaging techniques"],"prefix":"10.1016","volume":"99","author":[{"given":"J\u00e9r\u00f4me","family":"Chambert","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Lihoreau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvain","family":"Joly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brice","family":"Chatelain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Sandoz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Humbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle","family":"Jacquet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwena\u00ebl","family":"Rolin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jmbbm.2019.07.025_bib1","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1097\/SAP.0b013e3181238dd7","article-title":"The relationship between keloid growth pattern and stretching tension: visual analysis using the finite element method","volume":"60","author":"Akaishi","year":"2008","journal-title":"Ann. Plast. Surg."},{"key":"10.1016\/j.jmbbm.2019.07.025_bib2","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.mehy.2008.01.032","article-title":"Keloid and hypertrophic scar: neurogenic inflammation hypotheses","volume":"71","author":"Akaishi","year":"2008","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.jmbbm.2019.07.025_bib3","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1097\/SAP.0b013e31819967ed","article-title":"Visual and pathologic analyses of keloid growth patterns","volume":"64","author":"Akaishi","year":"2010","journal-title":"Ann. Plast. Surg."},{"key":"10.1016\/j.jmbbm.2019.07.025_bib4","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1097\/01.prs.0000195073.73580.46","article-title":"Keloid pathogenesis and treatment","volume":"117","author":"Al-Attar","year":"2006","journal-title":"Plast. Reconstr. Surg."},{"key":"10.1016\/j.jmbbm.2019.07.025_bib5","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1097\/01.prs.0000187147.73963.a5","article-title":"A randomized, controlled trial to determine the efficacy of paper tape in preventing hypertrophic scar formation in surgical incisions that traverse Langer's skin tension lines","volume":"116","author":"Atkinson","year":"2005","journal-title":"Plast. Reconstr. Surg."},{"key":"10.1016\/j.jmbbm.2019.07.025_bib6","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1136\/bmj.326.7380.88","article-title":"Skin scarring","volume":"326","author":"Bayat","year":"2003","journal-title":"BMJ Br. Med. J. (Clin. Res. Ed.)"},{"key":"10.1016\/j.jmbbm.2019.07.025_bib7","first-page":"91","article-title":"Hardware and measuring principle: the Cutometer\u00ae","volume":"vol V","author":"Berndt","year":"2002"},{"key":"10.1016\/j.jmbbm.2019.07.025_bib8","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.jmbbm.2013.05.024","article-title":"Assessment of the in-plane biomechanical properties of human skin using a finite element model updating approach combined with an optical full-field measurement on a new tensile device","volume":"27","author":"Boyer","year":"2013","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"10.1016\/j.jmbbm.2019.07.025_bib9","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.jamcollsurg.2007.12.001","article-title":"Current progress in keloid research and treatment","volume":"206","author":"Butler","year":"2008","journal-title":"J. Am. Coll. Surg."},{"key":"10.1016\/j.jmbbm.2019.07.025_bib10","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1016\/j.jbiomech.2004.07.026","article-title":"Mechanics of scars","volume":"38","author":"Cerda","year":"2005","journal-title":"J. Biomech."},{"issue":"Suppl. 1","key":"10.1016\/j.jmbbm.2019.07.025_bib11","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1080\/10255842.2012.713659","article-title":"Numerical analysis of keloid scar in the presternal area","volume":"15","author":"Chambert","year":"2012","journal-title":"Comput. Methods Biomech. Biomed. Eng."},{"key":"10.1016\/j.jmbbm.2019.07.025_bib12","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1055\/s-0029-1224797","article-title":"Keloids: pathogenesis, clinical features, and management","volume":"23","author":"Chike-Obi","year":"2009","journal-title":"Semin. Plast. Surg."},{"key":"10.1016\/j.jmbbm.2019.07.025_bib13","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/0305-4179(96)00038-1","article-title":"Mechanical properties of normal skin and hypertrophic scars","volume":"22","author":"Clark","year":"1996","journal-title":"Burns"},{"key":"10.1016\/j.jmbbm.2019.07.025_bib14","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s00238-010-0455-z","article-title":"Abnormal scar modulation with the use of micropore tape","volume":"34","author":"Daya","year":"2011","journal-title":"Eur. J. Plast. Surg."},{"key":"10.1016\/j.jmbbm.2019.07.025_bib15","first-page":"63","article-title":"Hardware and basic principles of the dermal torque meter","volume":"vol V","author":"de Rigal","year":"2002"},{"key":"10.1016\/j.jmbbm.2019.07.025_bib16","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1080\/000155599750010058","article-title":"Non-invasive monitoring of the mechanical properties of keloids during cryosurgery","volume":"79","author":"Dobrev","year":"1999","journal-title":"Acta Derm. Venereol."},{"key":"10.1016\/j.jmbbm.2019.07.025_bib17","series-title":"Non Invasive Diagnostic Techniques in Clinical Dermatology","first-page":"315","article-title":"Cutometer\u00ae","author":"Dobrev","year":"2014"},{"key":"10.1016\/j.jmbbm.2019.07.025_bib18","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.burns.2003.09.003","article-title":"Skin elasticity meter or subjective evaluation in scars: a reliability assessment","volume":"30","author":"Draaijers","year":"2004","journal-title":"Burns"},{"key":"10.1016\/j.jmbbm.2019.07.025_bib19","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/1523-1747.ep12274528","article-title":"Mechanical analysis of hypertrophic scar tissue: structural basis for apparent increased rigidity","volume":"84","author":"Dunn","year":"1985","journal-title":"J. Investig. Dermatol."},{"key":"10.1016\/j.jmbbm.2019.07.025_bib20","series-title":"Digital Image Correlation and Tracking with Matlab. Tech. rep., Matlab Central File Exchange","author":"Eberl","year":"2010"},{"key":"10.1016\/j.jmbbm.2019.07.025_bib21","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.medengphy.2010.12.017","article-title":"Measurement of the force\u2013displacement response of in vivo human skin under a rich set of deformations","volume":"33","author":"Flynn","year":"2011","journal-title":"Med. Eng. Phys."},{"issue":"Suppl. 1","key":"10.1016\/j.jmbbm.2019.07.025_bib22","doi-asserted-by":"crossref","first-page":"S12","DOI":"10.1016\/S0305-4179(97)90095-4","article-title":"The cutometer and ultrasonography in the assessment of postburn hypertrophic scara preliminary study","volume":"23","author":"Fong","year":"1997","journal-title":"Burns"},{"key":"10.1016\/j.jmbbm.2019.07.025_bib23","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1111\/j.1742-481X.2012.00988.x","article-title":"Can single use negative pressure wound therapy be an alternative method to manage keloid scarring? A preliminary report of a clinical and ultrasound\/colour-power-Doppler study","volume":"10","author":"Fraccalvieri","year":"2013","journal-title":"Int. Wound J."},{"key":"10.1016\/j.jmbbm.2019.07.025_bib24","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/0021-9290(69)90032-3","article-title":"Directional variation in extensibility of human skin in vivo","volume":"2","author":"Gibson","year":"1969","journal-title":"J. Biomech."},{"key":"10.1016\/j.jmbbm.2019.07.025_bib25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1468-2494.2008.00406.x","article-title":"In vivo reflectance-mode confocal microscopy in clinical dermatology and cosmetology","volume":"30","author":"Gonzalez","year":"2008","journal-title":"Int. J. Cosmet. Sci."},{"key":"10.1016\/j.jmbbm.2019.07.025_bib26","series-title":"Reflectance Confocal Microscopy for Skin Diseases","author":"Hofmann-Wellenhof","year":"2012"},{"key":"10.1016\/j.jmbbm.2019.07.025_bib27","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1111\/j.1742-481X.2012.01118.x","article-title":"Are keloid and hypertrophic scar different forms of the same disorder? A fibroproliferative skin disorder hypothesis based on keloid findings","volume":"11","author":"Huang","year":"2014","journal-title":"Int. Wound J."},{"issue":"4","key":"10.1016\/j.jmbbm.2019.07.025_bib28","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1111\/srt.12361","article-title":"Intra- and inter-individual variability in the mechanical properties of the human skin from in vivo measurements on 20 volunteers","volume":"23","author":"Jacquet","year":"2017","journal-title":"Skin Res. Technol."},{"issue":"4","key":"10.1016\/j.jmbbm.2019.07.025_bib29","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1111\/srt.12367","article-title":"Ultra-light extensometer for the assessment of the mechanical properties of the human skin in vivo","volume":"23","author":"Jacquet","year":"2017","journal-title":"Skin Res. Technol."},{"key":"10.1016\/j.jmbbm.2019.07.025_bib30","series-title":"Dermatologic Ultrasound with Clinical and Histologic Correlations","author":"Jemec","year":"2013"},{"key":"10.1016\/j.jmbbm.2019.07.025_bib31","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/BF01105081","article-title":"Mechanical properties of keloids in vivo during treatment with intralesional triamcinolone acetonide","volume":"287","author":"Krusche","year":"1995","journal-title":"Arch. Dermatol. Res."},{"key":"10.1016\/j.jmbbm.2019.07.025_bib32","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1097\/00006534-200103000-00022","article-title":"Investigation of the influence of keloid-derived keratinocytes on fibroblast growth and proliferation in vitro","volume":"107","author":"Lim","year":"2001","journal-title":"Plast. Reconstr. Surg."},{"key":"10.1016\/j.jmbbm.2019.07.025_bib33","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1111\/bjd.14844","article-title":"Increased epidermal thickness and abnormal epidermal differentiation in keloid scars","volume":"176","author":"Limandjaja","year":"2017","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.jmbbm.2019.07.025_bib34","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1111\/j.0022-202X.2004.22327.x","article-title":"Genome scans provide evidence for keloid susceptibility loci on chromosomes 2q23 and 7p11","volume":"122","author":"Marneros","year":"2004","journal-title":"J. Investig. Dermatol."},{"key":"10.1016\/j.jmbbm.2019.07.025_bib35","first-page":"83","article-title":"Ultrastructural differentiation of abnormal scars","volume":"18","author":"Meenakshi","year":"2005","journal-title":"Ann. Burns Fire Disasters"},{"key":"10.1016\/j.jmbbm.2019.07.025_bib36","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.mehy.2013.04.016","article-title":"Transformation of keloids is determined by stress occurrence patterns on peri-keloid regions in response to body movement","volume":"81","author":"Nagasao","year":"2013","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.jmbbm.2019.07.025_bib37","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.mehy.2008.05.020","article-title":"Keloid and hypertrophic scarring may result from a mechanoreceptor or mechanosensitive nociceptor disorder","volume":"71","author":"Ogawa","year":"2008","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.jmbbm.2019.07.025_bib38","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1111\/jcmm.12060","article-title":"Mechanobiological dysregulation of the epidermis and dermis in skin disorders and in degeneration","volume":"17","author":"Ogawa","year":"2013","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.jmbbm.2019.07.025_bib39","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/j.1524-475X.2012.00766.x","article-title":"The relationship between skin stretching\/contraction and pathologic scarring: the important role of mechanical forces in keloid generation","volume":"20","author":"Ogawa","year":"2012","journal-title":"Wound Repair Regen."},{"key":"10.1016\/j.jmbbm.2019.07.025_bib40","series-title":"Bioengineering Research of Chronic Wounds","first-page":"31","article-title":"Mechanobiology of cutaneous wound healing and scarring","author":"Ogawa","year":"2009"},{"key":"10.1016\/j.jmbbm.2019.07.025_bib41","series-title":"Handbook of Non-invasive Methods and the Skin","first-page":"579","article-title":"Suction chamber method for measurement of skin mechanics: the Cutometer\u00ae","author":"O'Goshi","year":"2006"},{"key":"10.1016\/j.jmbbm.2019.07.025_bib42","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1007\/BF02684226","article-title":"Ex vivo biomechanical behavior of abdominal aortic aneurysm: assessment using a new mathematical model","volume":"24","author":"Raghavan","year":"1996","journal-title":"Ann. Biomed. Eng."},{"key":"10.1016\/j.jmbbm.2019.07.025_bib43","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1097\/00006534-197403000-00004","article-title":"Study of 1,000 patients with keloids in South India","volume":"53","author":"Ramakrishnan","year":"1974","journal-title":"Plast. Reconstr. Surg."},{"key":"10.1016\/j.jmbbm.2019.07.025_bib44","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1684\/ejd.2016.2873","article-title":"Objective and subjective treatment evaluation of scars using optical coherence tomography, sonography, photography, and standardised questionnaires","volume":"26","author":"Reinholz","year":"2016","journal-title":"Eur. J. Dermatol."},{"key":"10.1016\/j.jmbbm.2019.07.025_bib45","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1097\/00006534-198911000-00021","article-title":"Keloids and hypertrophic scars: a comprehensive review","volume":"84","author":"Rockwell","year":"1989","journal-title":"Plast. Reconstr. Surg."},{"key":"10.1016\/j.jmbbm.2019.07.025_bib46","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1097\/DSS.0000000000001434","article-title":"Novel stereoscopic optical system for objectively measuring above-surface scar volume\u2014first-time quantification of responses to various treatment modalities","volume":"44","author":"Salameh","year":"2018","journal-title":"Dermatol. Surg."},{"key":"10.1016\/j.jmbbm.2019.07.025_bib47","doi-asserted-by":"crossref","DOI":"10.1117\/1.JBO.18.6.061224","article-title":"Optical coherence tomography in dermatology","volume":"18","author":"Sattler","year":"2013","journal-title":"J. Biomed. Opt."},{"key":"10.1016\/j.jmbbm.2019.07.025_bib48","first-page":"499","article-title":"Optical coherence tomography: its role in daily dermatological practice","volume":"11","author":"Schmitz","year":"2013","journal-title":"JDDG J. der Deutschen Dermatol. Gesellschaft"},{"key":"10.1016\/j.jmbbm.2019.07.025_bib49","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s00403-016-1703-2","article-title":"3D modeling of keloid scars in vitro by cell and tissue engineering","volume":"309","author":"Suttho","year":"2017","journal-title":"Arch. Dermatol. Res."},{"key":"10.1016\/j.jmbbm.2019.07.025_bib50","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/bjd.12588","article-title":"Strategic management of keloid disease in ethnic skin: a structured approach supported by the emerging literature","volume":"169","author":"Ud-Din","year":"2013","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.jmbbm.2019.07.025_bib51","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1002\/jcp.20486","article-title":"Increased transcriptional response to mechanical strain in keloid fibroblasts due to increased focal adhesion complex formation","volume":"206","author":"Wang","year":"2006","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.jmbbm.2019.07.025_bib52","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.1038\/jid.2011.212","article-title":"Pushing back: wound mechanotransduction in repair and regeneration","volume":"131","author":"Wong","year":"2011","journal-title":"J. Investig. Dermatol."},{"key":"10.1016\/j.jmbbm.2019.07.025_bib53","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1089\/wound.2012.0396","article-title":"A mechanomodulatory device to minimize incisional scar formation","volume":"2","author":"Wong","year":"2013","journal-title":"Adv. Wound Care"},{"key":"10.1016\/j.jmbbm.2019.07.025_bib54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10409-007-0128-8","article-title":"Biothermomechanical behavior of skin tissue","volume":"24","author":"Xu","year":"2008","journal-title":"Acta Mech. Sin."}],"container-title":["Journal of the Mechanical Behavior of Biomedical Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1751616118316102?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1751616118316102?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T22:29:25Z","timestamp":1761690565000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1751616118316102"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11]]},"references-count":54,"alternative-id":["S1751616118316102"],"URL":"https:\/\/doi.org\/10.1016\/j.jmbbm.2019.07.025","relation":{},"ISSN":["1751-6161"],"issn-type":[{"value":"1751-6161","type":"print"}],"subject":[],"published":{"date-parts":[[2019,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multimodal investigation of a keloid scar by combining mechanical tests in vivo with diverse imaging techniques","name":"articletitle","label":"Article Title"},{"value":"Journal of the Mechanical Behavior of Biomedical Materials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jmbbm.2019.07.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}