{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T04:20:46Z","timestamp":1782793246938,"version":"3.54.5"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004410","name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ftirma Kurumu","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Mechanical Behavior of Biomedical Materials"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.jmbbm.2019.103538","type":"journal-article","created":{"date-parts":[[2019,11,15]],"date-time":"2019-11-15T02:27:53Z","timestamp":1573784873000},"page":"103538","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Impact of PDMS surface treatment in cell-mechanics applications"],"prefix":"10.1016","volume":"103","author":[{"given":"Sedat","family":"Dogru","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duygu","family":"Aydemir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naveed","family":"Salman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuray N.","family":"Ulusu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. Erdem","family":"Alaca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.jmbbm.2019.103538_bib1","doi-asserted-by":"crossref","first-page":"3541","DOI":"10.1002\/art.20601","article-title":"Role of NF\u2010\u03baB transcription factors in antiinflammatory and proinflammatory actions of mechanical signals","volume":"50","author":"Agarwal","year":"2004","journal-title":"Arthritis Rheum."},{"issue":"4","key":"10.1016\/j.jmbbm.2019.103538_bib2","doi-asserted-by":"crossref","DOI":"10.1088\/1361-6439\/aa6058","article-title":"High-resolution spatiotemporal strain mapping reveals non-uniform deformation in micropatterned elastomers","volume":"27","author":"Aksoy","year":"2017","journal-title":"J. Micromech. Microeng."},{"issue":"119","key":"10.1016\/j.jmbbm.2019.103538_bib3","doi-asserted-by":"crossref","DOI":"10.1126\/stke.2002.119.pe6","article-title":"Mechanotransduction: all signals point to cytoskeleton, matrix, and integrins","volume":"2002","author":"Alenghat","year":"2002","journal-title":"Sci. Signal."},{"issue":"2","key":"10.1016\/j.jmbbm.2019.103538_bib4","doi-asserted-by":"crossref","DOI":"10.1063\/1.4941715","article-title":"Time-resolved local strain tracking microscopy for cell mechanics","volume":"87","author":"Aydin","year":"2016","journal-title":"Rev. Sci. Instrum."},{"key":"10.1016\/j.jmbbm.2019.103538_bib5","first-page":"673","volume":"vol. 8","author":"Bartalena","year":"2012"},{"key":"10.1016\/j.jmbbm.2019.103538_bib6","series-title":"European Microscopy Congress 2016: Proceedings","article-title":"Temporally and spatially resolved local strain tracking microscopy","author":"Bayraktar","year":"2016"},{"issue":"3","key":"10.1016\/j.jmbbm.2019.103538_bib7","doi-asserted-by":"crossref","first-page":"C595","DOI":"10.1152\/ajpcell.00270.2001","article-title":"Traction fields, moments, and strain energy that cells exert on their surroundings","volume":"282","author":"Butler","year":"2002","journal-title":"Am. J. Physiol. Cell Physiol."},{"issue":"1","key":"10.1016\/j.jmbbm.2019.103538_bib8","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1007\/s10409-014-0022-0","article-title":"Nanoscale viscoelastic properties and adhesion of polydimethylsiloxane for tissue engineering","volume":"30","author":"Chen","year":"2014","journal-title":"Acta Mech. Sin."},{"issue":"8","key":"10.1016\/j.jmbbm.2019.103538_bib9","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1039\/b803925a","article-title":"Traction force microscopy on-chip: shear deformation of fibroblast cells","volume":"8","author":"Das","year":"2008","journal-title":"Lab Chip"},{"issue":"24","key":"10.1016\/j.jmbbm.2019.103538_bib10","doi-asserted-by":"crossref","first-page":"248103","DOI":"10.1103\/PhysRevLett.105.248103","article-title":"4D traction force microscopy reveals asymmetric cortical forces in migrating Dictyostelium cells","volume":"105","author":"Delano\u00eb-Ayari","year":"2010","journal-title":"Phys. Rev. Lett."},{"key":"10.1016\/j.jmbbm.2019.103538_bib11","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.polymertesting.2018.05.044","article-title":"Poisson's ratio of PDMS thin films","volume":"69","author":"Dogru","year":"2018","journal-title":"Polym. Test."},{"key":"10.1016\/j.jmbbm.2019.103538_bib12","first-page":"2390","volume":"vol. 102","author":"Du Roure","year":"2005"},{"key":"10.1016\/j.jmbbm.2019.103538_bib13","series-title":"Current Topics in Developmental Biology","first-page":"243","article-title":"Mechanotransduction in development","author":"Farge","year":"2011"},{"key":"10.1016\/j.jmbbm.2019.103538_bib14","series-title":"Creep and Relaxation of Nonlinear Viscoelastic Materials","author":"Findley","year":"2013"},{"issue":"1","key":"10.1016\/j.jmbbm.2019.103538_bib15","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1111\/j.1749-6632.2000.tb06318.x","article-title":"Endothelial dysfunction, hemodynamic forces, and atherogenesis a","volume":"902","author":"Gimbrone","year":"2000","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.jmbbm.2019.103538_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.actbio.2015.04.008","article-title":"Mechanobiology of mesenchymal stem cells: perspective into mechanical induction of MSC fate","volume":"20","author":"Hao","year":"2015","journal-title":"Acta Biomater."},{"issue":"4440","key":"10.1016\/j.jmbbm.2019.103538_bib17","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1126\/science.6987736","article-title":"Silicone rubber substrata: a new wrinkle in the study of cell locomotion","volume":"208","author":"Harris","year":"1980","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.jmbbm.2019.103538_bib18","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.tcm.2006.12.002","article-title":"Consequences of disrupting the dystrophin-sarcoglycan complex in cardiac and skeletal myopathy","volume":"17","author":"Heydemann","year":"2007","journal-title":"Trends Cardiovasc. Med."},{"issue":"8","key":"10.1016\/j.jmbbm.2019.103538_bib19","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1080\/07853890310016333","article-title":"Mechanobiology and diseases of mechanotransduction","volume":"35","author":"Ingber","year":"2003","journal-title":"Ann. Med."},{"issue":"7","key":"10.1016\/j.jmbbm.2019.103538_bib20","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1096\/fj.05-5424rev","article-title":"Cellular mechanotransduction: putting all the pieces together again","volume":"20","author":"Ingber","year":"2006","journal-title":"FASEB J."},{"issue":"12","key":"10.1016\/j.jmbbm.2019.103538_bib21","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1038\/nrm3903","article-title":"Appreciating force and shape\u2014the rise of mechanotransduction in cell biology","volume":"15","author":"Iskratsch","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"8","key":"10.1016\/j.jmbbm.2019.103538_bib22","first-page":"695","article-title":"Robust single-particle tracking in live-cell time-lapse sequences","volume":"5","author":"Jaqaman","year":"2008"},{"issue":"3","key":"10.1016\/j.jmbbm.2019.103538_bib23","doi-asserted-by":"crossref","DOI":"10.1088\/0960-1317\/24\/3\/035017","article-title":"Mechanical characterization of bulk Sylgard 184 for microfluidics and microengineering","volume":"24","author":"Johnston","year":"2014","journal-title":"J. Micromech. Microeng."},{"key":"10.1016\/j.jmbbm.2019.103538_bib24","series-title":"Tissue Stiffening Promotes Keratinocyte Proliferation via Activation of Epidermal Growth Factor Signaling","author":"Kenny","year":"2018"},{"issue":"2","key":"10.1016\/j.jmbbm.2019.103538_bib25","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1007\/s10544-008-9256-6","article-title":"Effects of strain rate, mixing ratio, and stress\u2013strain definition on the mechanical behavior of the polydimethylsiloxane (PDMS) material as related to its biological applications","volume":"11","author":"Khanafer","year":"2009","journal-title":"Biomed. Microdevices"},{"key":"10.1016\/j.jmbbm.2019.103538_bib26","first-page":"34632","volume":"vol. 6","author":"Kim","year":"2016"},{"issue":"8","key":"10.1016\/j.jmbbm.2019.103538_bib27","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1016\/S0273-1177(03)90395-4","article-title":"Microgravity and bone cell mechanosensitivity","volume":"32","author":"Klein-Nulend","year":"2003","journal-title":"Adv. Space Res."},{"issue":"13","key":"10.1016\/j.jmbbm.2019.103538_bib28","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1096\/fj.02-1148com","article-title":"Mechanical stretch activates nuclear factor-kappaB, activator protein-1, and mitogen-activated protein kinases in lung parenchyma: implications in asthma","volume":"17","author":"Kumar","year":"2003","journal-title":"FASEB J."},{"issue":"11","key":"10.1016\/j.jmbbm.2019.103538_bib29","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1016\/j.optlaseng.2005.10.004","article-title":"Quality assessment of speckle patterns for digital image correlation","volume":"44","author":"Lecompte","year":"2006","journal-title":"Opt. Lasers Eng."},{"issue":"48","key":"10.1016\/j.jmbbm.2019.103538_bib30","doi-asserted-by":"crossref","first-page":"30455","DOI":"10.1074\/jbc.272.48.30455","article-title":"Fluid shear stress activation of focal adhesion kinase linking to mitogen-activated protein kinases","volume":"272","author":"Li","year":"1997","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.jmbbm.2019.103538_bib31","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1109\/JMEMS.2009.2029166","article-title":"Viscoelastic characterization and modeling of polymer transducers for biological applications","volume":"18","author":"Lin","year":"2009","journal-title":"J. Microelectromech. Syst."},{"issue":"1","key":"10.1016\/j.jmbbm.2019.103538_bib32","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.sna.2009.02.016","article-title":"Influences of heating temperature on mechanical properties of polydimethylsiloxane","volume":"151","author":"Liu","year":"2009","journal-title":"Sens. Actuators A Phys."},{"issue":"3","key":"10.1016\/j.jmbbm.2019.103538_bib33","doi-asserted-by":"crossref","DOI":"10.1088\/0960-1317\/19\/3\/035028","article-title":"Thickness-dependent mechanical properties of polydimethylsiloxane membranes","volume":"19","author":"Liu","year":"2009","journal-title":"J. Micromech. Microeng."},{"issue":"7","key":"10.1016\/j.jmbbm.2019.103538_bib34","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1161\/01.RES.84.7.852","article-title":"Regulation of smooth muscle \u03b1-actin expression in vivo is dependent on CArG elements within the 5\u2032 and first intron promoter regions","volume":"84","author":"Mack","year":"1999","journal-title":"Circ. Res."},{"issue":"9","key":"10.1016\/j.jmbbm.2019.103538_bib35","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1242\/dev.024166","article-title":"Mechanical control of tissue and organ development","volume":"137","author":"Mammoto","year":"2010","journal-title":"Development"},{"key":"10.1016\/j.jmbbm.2019.103538_bib36","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.093005","article-title":"Mechanosensitive mechanisms in transcriptional regulation","author":"Mammoto","year":"2012","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.jmbbm.2019.103538_bib37","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1146\/annurev-cellbio-101512-122340","article-title":"Mechanobiology and developmental control","volume":"29","author":"Mammoto","year":"2013","journal-title":"Annu. Rev. Cell Dev. Biol."},{"issue":"12","key":"10.1016\/j.jmbbm.2019.103538_bib38","doi-asserted-by":"crossref","first-page":"124601","DOI":"10.1088\/0034-4885\/78\/12\/124601","article-title":"A review of progress in single particle tracking: from methods to biophysical insights","volume":"78","author":"Manzo","year":"2015","journal-title":"Rep. Prog. Phys."},{"issue":"4","key":"10.1016\/j.jmbbm.2019.103538_bib39","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s10544-005-6070-2","article-title":"Characterization of polydimethylsiloxane (PDMS) properties for biomedical micro\/nanosystems","volume":"7","author":"Mata","year":"2005","journal-title":"Biomed. Microdevices"},{"key":"10.1016\/j.jmbbm.2019.103538_bib40","first-page":"52","volume":"vol. 13","author":"McCormick","year":"2010"},{"issue":"3","key":"10.1016\/j.jmbbm.2019.103538_bib41","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.ccr.2005.08.010","article-title":"Tensional homeostasis and the malignant phenotype","volume":"8","author":"Paszek","year":"2005","journal-title":"Cancer Cell"},{"issue":"5","key":"10.1016\/j.jmbbm.2019.103538_bib42","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nmeth.3834","article-title":"Measuring cell-generated forces: a guide to the available tools","volume":"13","author":"Polacheck","year":"2016","journal-title":"Nat. Methods"},{"issue":"26","key":"10.1016\/j.jmbbm.2019.103538_bib43","doi-asserted-by":"crossref","first-page":"6037","DOI":"10.1039\/c3sm50901j","article-title":"Precise determination of the Poisson ratio in soft materials with 2D digital image correlation","volume":"9","author":"Pritchard","year":"2013","journal-title":"Soft Matter"},{"issue":"1\u20133","key":"10.1016\/j.jmbbm.2019.103538_bib44","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.bbaexp.2005.11.004","article-title":"Inflammation-responsive transcription factors SAF-1 and c-Jun\/c-Fos promote canine MMP-1 gene expression","volume":"1732","author":"Ray","year":"2005","journal-title":"Biochim. Biophys. Acta Gene Struct. Expr."},{"key":"10.1016\/j.jmbbm.2019.103538_bib45","first-page":"11222","volume":"vol. 9","author":"Rianna","year":"2017"},{"issue":"6","key":"10.1016\/j.jmbbm.2019.103538_bib46","doi-asserted-by":"crossref","DOI":"10.1115\/1.4025355","article-title":"Review on cell mechanics: experimental and modeling approaches","volume":"65","author":"Rodriguez","year":"2013","journal-title":"Appl. Mech. Rev."},{"issue":"11","key":"10.1016\/j.jmbbm.2019.103538_bib47","doi-asserted-by":"crossref","first-page":"3095","DOI":"10.1016\/j.bbamcr.2015.05.028","article-title":"Traction force microscopy on soft elastic substrates: a guide to recent computational advances","volume":"1853","author":"Schwarz","year":"2015","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"issue":"11","key":"10.1016\/j.jmbbm.2019.103538_bib48","doi-asserted-by":"crossref","first-page":"3095","DOI":"10.1016\/j.bbamcr.2015.05.028","article-title":"Traction force microscopy on soft elastic substrates: a guide to recent computational advances","volume":"1853","author":"Schwarz","year":"2015","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"issue":"3","key":"10.1016\/j.jmbbm.2019.103538_bib49","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1016\/S0006-3495(02)73909-X","article-title":"Calculation of forces at focal adhesions from elastic substrate data: the effect of localized force and the need for regularization","volume":"83","author":"Schwarz","year":"2002","journal-title":"Biophys. J."},{"issue":"3","key":"10.1016\/j.jmbbm.2019.103538_bib50","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.polymertesting.2009.12.005","article-title":"Poisson's ratio and the incompressibility relation for various strain measures with the example of a silica-filled SBR rubber in uniaxial tension tests","volume":"29","author":"Starkova","year":"2010","journal-title":"Polym. Test."},{"issue":"23","key":"10.1016\/j.jmbbm.2019.103538_bib51","doi-asserted-by":"crossref","first-page":"4047","DOI":"10.1039\/c4sm00264d","article-title":"Traction force microscopy in physics and biology","volume":"10","author":"Style","year":"2014","journal-title":"Soft Matter"},{"issue":"3","key":"10.1016\/j.jmbbm.2019.103538_bib52","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1136\/bjo.2005.079905","article-title":"Mechanosensitivity and the eye: cells coping with the pressure","volume":"90","author":"Tan","year":"2006","journal-title":"Br. J. Ophthalmol."},{"issue":"1","key":"10.1016\/j.jmbbm.2019.103538_bib53","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1023\/A:1014411503170","article-title":"Poisson's ratio in linear viscoelasticity\u2013a critical review","volume":"6","author":"Tschoegl","year":"2002","journal-title":"Mech. Time-Dependent Mater."},{"issue":"14","key":"10.1016\/j.jmbbm.2019.103538_bib54","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1002\/polb.20454","article-title":"Viscoelastic characterization of polymers using instrumented indentation. I. Quasi\u2010static testing","volume":"43","author":"VanLandingham","year":"2005","journal-title":"J. Polym. Sci. B Polym. Phys."},{"issue":"14","key":"10.1016\/j.jmbbm.2019.103538_bib55","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1002\/polb.20455","article-title":"Viscoelastic characterization of polymers using instrumented indentation. II. Dynamic testing","volume":"43","author":"White","year":"2005","journal-title":"J. Polym. Sci. B Polym. Phys."},{"issue":"1","key":"10.1016\/j.jmbbm.2019.103538_bib56","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/nrm2592","article-title":"Mechanotransduction in development: a growing role for contractility","volume":"10","author":"Wozniak","year":"2009","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.jmbbm.2019.103538_bib57","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.gene.2005.08.006","article-title":"Repetitive mechanical stretching modulates IL-1\u03b2 induced COX-2, MMP-1 expression, and PGE 2 production in human patellar tendon fibroblasts","volume":"363","author":"Yang","year":"2005","journal-title":"Gene"},{"issue":"10","key":"10.1016\/j.jmbbm.2019.103538_bib58","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1242\/jcs.001586","article-title":"Force activates smooth muscle \u03b1-actin promoter activity through the Rho signaling pathway","volume":"120","author":"Zhao","year":"2007","journal-title":"J. Cell Sci."}],"container-title":["Journal of the Mechanical Behavior of Biomedical Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1751616119304965?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1751616119304965?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T22:40:28Z","timestamp":1761691228000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1751616119304965"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":58,"alternative-id":["S1751616119304965"],"URL":"https:\/\/doi.org\/10.1016\/j.jmbbm.2019.103538","relation":{},"ISSN":["1751-6161"],"issn-type":[{"value":"1751-6161","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impact of PDMS surface treatment in cell-mechanics applications","name":"articletitle","label":"Article Title"},{"value":"Journal of the Mechanical Behavior of Biomedical Materials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jmbbm.2019.103538","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"103538"}}