{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T19:26:38Z","timestamp":1774898798100,"version":"3.50.1"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100011264","name":"FP7 People: Marie-Curie Actions","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011264","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Mechanical Behavior of Biomedical Materials"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.jmbbm.2019.103541","type":"journal-article","created":{"date-parts":[[2019,11,15]],"date-time":"2019-11-15T11:47:54Z","timestamp":1573818474000},"page":"103541","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["De novo topology optimization of total ossicular replacement prostheses"],"prefix":"10.1016","volume":"103","author":[{"given":"Mario","family":"Milazzo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pieter G.G.","family":"Muyshondt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josephine","family":"Carstensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joris J.J.","family":"Dirckx","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serena","family":"Danti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus J.","family":"Buehler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jmbbm.2019.103541_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.anl.2009.05.004","article-title":"Kurz titanium prosthesis ossiculoplasty-Follow-up statistical analysis of factors affecting one year hearing results","author":"Alaani","year":"2010","journal-title":"Auris Nasus Larynx"},{"key":"10.1016\/j.jmbbm.2019.103541_bib2","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1097\/MAO.0b013e31823c9352","article-title":"New total ossicular replacement prostheses with a resilient joint: experimental data from human temporal bones","volume":"33","author":"Arechvo","year":"2012","journal-title":"Otol. Neurotol.: Off. Publ. Am. Otol. Soc., Am. Neurotol. Soc. Eur. Acad. Otol. Neurotol."},{"key":"10.1016\/j.jmbbm.2019.103541_bib3","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1055\/s-2007-966514","article-title":"Experimentelle Untersuchungen zu Mittelohrimplantaten mit integriertem mikromechanischem Gelenk","volume":"86","author":"Beleites","year":"2007","journal-title":"Laryngo-Rhino-Otol."},{"key":"10.1016\/j.jmbbm.2019.103541_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/0045-7825(88)90086-2","article-title":"Generating optimal topologies in structural design using a homogenization method","author":"Bends\u00f8e","year":"1988","journal-title":"Comput. Methods Appl. Mech. Eng."},{"key":"10.1016\/j.jmbbm.2019.103541_bib5","series-title":"Topology Optimization Theory, Methods and Applications, Engineering","author":"Bends\u00f8e","year":"2002"},{"key":"10.1016\/j.jmbbm.2019.103541_bib6","doi-asserted-by":"crossref","DOI":"10.1177\/000348941112000102","article-title":"Good manufacturing practices-grade preformed ossicular prostheses from banked bone via computer numerically controlled micromilling","author":"Berrettini","year":"2011","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"10.1016\/j.jmbbm.2019.103541_bib7","doi-asserted-by":"crossref","DOI":"10.1097\/MAO.0b013e318064e8e8","article-title":"Audiometric outcomes of tympanoplasty with hydroxylapatite prosthesis: consultant versus trainees","author":"Charlett","year":"2007","journal-title":"Otol. Neurotol."},{"key":"10.1016\/j.jmbbm.2019.103541_bib8","series-title":"Eurographics Italian Chapter Conference 2008: Salerno, Italy","article-title":"MeshLab: an open-source mesh processing tool","author":"Cignoni","year":"2008"},{"key":"10.1016\/j.jmbbm.2019.103541_bib9","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/BF00120378","article-title":"Investigation into the formation and mechanical properties of a bioactive material based on collagen and calcium phosphate","volume":"4","author":"Clarke","year":"1993","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"10.1016\/j.jmbbm.2019.103541_bib10","doi-asserted-by":"crossref","DOI":"10.1097\/MAO.0b013e31826a527d","article-title":"Histologic characterization of human ear ossicles for the development of tissue-engineered replacements","author":"D'Alessandro","year":"2012","journal-title":"Otol. Neurotol."},{"key":"10.1016\/j.jmbbm.2019.103541_bib11","doi-asserted-by":"crossref","DOI":"10.1002\/jbm.a.32447","article-title":"Development of tissue-engineered substitutes of the ear ossicles: PORP-shaped poly(propylene fumarate)-based scaffolds cultured with human mesenchymal stromal cells","author":"Danti","year":"2010","journal-title":"J. Biomed. Mater. Res. A"},{"key":"10.1016\/j.jmbbm.2019.103541_bib12","doi-asserted-by":"crossref","DOI":"10.1007\/s10544-009-9293-9","article-title":"Novel biological\/biohybrid prostheses for the ossicular chain: fabrication feasibility and preliminary functional characterization","author":"Danti","year":"2009","journal-title":"Biomed. Microdevices"},{"key":"10.1016\/j.jmbbm.2019.103541_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.heares.2016.11.011","article-title":"Effects of model definitions and parameter values in finite element modeling of human middle ear mechanics","author":"De Greef","year":"2017","journal-title":"Hear. Res."},{"key":"10.1016\/j.jmbbm.2019.103541_bib14","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1007\/s11665-014-0958-z","article-title":"Metal additive manufacturing: a review","volume":"23","author":"Frazier","year":"2014","journal-title":"J. Mater. Eng. Perform."},{"key":"10.1016\/j.jmbbm.2019.103541_bib15","series-title":"Results with Titanium Ossicular Reconstruction Prostheses","author":"Gardner","year":"2004"},{"key":"10.1016\/j.jmbbm.2019.103541_bib16","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.heares.2012.10.009","article-title":"Titanium ball joint total ossicular replacement prosthesis \u2013 experimental evaluation and midterm clinical results","volume":"301","author":"Gostian","year":"2013","journal-title":"Hear. Res."},{"key":"10.1016\/j.jmbbm.2019.103541_bib17","doi-asserted-by":"crossref","DOI":"10.1002\/lary.25901","article-title":"First results of a novel adjustable-length ossicular reconstruction prosthesis in temporal bones","author":"Gottlieb","year":"2016","journal-title":"The Laryngoscope"},{"key":"10.1016\/j.jmbbm.2019.103541_bib18","doi-asserted-by":"crossref","DOI":"10.1159\/000069475","article-title":"Three-dimensional stapes footplate motion in human temporal bones","author":"Hato","year":"2003","journal-title":"Audiol. Neuro. Otol."},{"key":"10.1016\/j.jmbbm.2019.103541_bib19","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1016\/j.otc.2006.08.010","article-title":"Ossiculoplasty","volume":"39","author":"Javia","year":"2006","journal-title":"Otolaryngol. Clin. N. Am."},{"key":"10.1016\/j.jmbbm.2019.103541_bib20","doi-asserted-by":"crossref","DOI":"10.1146\/annurev-bioeng-071516-044555","article-title":"Multiscale modeling of muscular-skeletal systems","author":"Jung","year":"2017","journal-title":"Annu. Rev. Biomed. Eng."},{"key":"10.1016\/j.jmbbm.2019.103541_bib21","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1017\/S0022215100120572","article-title":"Long-term results of total ossicular chain reconstruction using autografts","volume":"106","author":"Kapur","year":"1992","journal-title":"J. Laryngol. Otol."},{"key":"10.1016\/j.jmbbm.2019.103541_bib22","series-title":"2015 IEEE International Conference on Robotics and Biomimetics (ROBIO)","first-page":"385","article-title":"A new postoperative adjustable prosthesis for ossicular chain reconstructions","author":"Kuru","year":"2015"},{"key":"10.1016\/j.jmbbm.2019.103541_bib23","article-title":"[How do metallic middle ear implants behave in the MRI?","author":"Kwok","year":"2003","journal-title":"Laryngo-Rhino-Otol."},{"key":"10.1016\/j.jmbbm.2019.103541_bib24","doi-asserted-by":"crossref","DOI":"10.1243\/0954411981534187","article-title":"Collagen-calcium phosphate composites","author":"Lawson","year":"1998","journal-title":"Proc. Inst. Mech. Eng. H J. Eng. Med."},{"key":"10.1016\/j.jmbbm.2019.103541_bib25","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.biomaterials.2016.09.014","article-title":"Regenerated silk materials for functionalized silk orthopedic devices by mimicking natural processing","volume":"110","author":"Li","year":"2016","journal-title":"Biomaterials"},{"key":"10.1016\/j.jmbbm.2019.103541_bib26","doi-asserted-by":"crossref","DOI":"10.1039\/C6LC00519E","article-title":"Printing of stretchable silk membranes for strain measurements","author":"Ling","year":"2016","journal-title":"Lab Chip"},{"key":"10.1016\/j.jmbbm.2019.103541_bib27","doi-asserted-by":"crossref","DOI":"10.1097\/mao.0b013e31815c2575","article-title":"Titanium CliP piston versus platinum-ribbon Teflon piston: piston and fenestra size affect air-bone gap","author":"Mangham","year":"2008","journal-title":"Otol. Neurotol."},{"key":"10.1016\/j.jmbbm.2019.103541_bib28","author":"Mardassi"},{"key":"10.1016\/j.jmbbm.2019.103541_bib29","series-title":"Otolaryngology - Head and Neck Surgery","article-title":"Safety evaluation of titanium middle ear prostheses at 3.0 tesla","author":"Martin","year":"2005"},{"key":"10.1016\/j.jmbbm.2019.103541_bib30","series-title":"The Middle Ear: Science, Otosurgery, and Technology","first-page":"253","article-title":"Surgical reconstruction and passive prostheses","author":"Merchant","year":"2013"},{"key":"10.1016\/j.jmbbm.2019.103541_bib31","series-title":"Additive Manufacturing Approaches for Hydroxyapatite-Reinforced Composites","author":"Milazzo","year":"2019"},{"key":"10.1016\/j.jmbbm.2019.103541_bib32","series-title":"European Society for Precision Engineering and Nanotechnology, Conference Proceedings - 18th International Conference and Exhibition, EUSPEN 2018. Euspen","first-page":"375","article-title":"Micro-machining of bovine bone for otologic applications","author":"Milazzo","year":"2018"},{"key":"10.1016\/j.jmbbm.2019.103541_bib33","article-title":"Ossicular replacement prostheses from banked bone with ergonomic and functional geometry","author":"Milazzo","year":"2016","journal-title":"J. Biomed. Mater. Res. B Appl. Biomater."},{"key":"10.1016\/j.jmbbm.2019.103541_bib34","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms2720","article-title":"Molecular mechanics of mineralized collagen fibrils in bone","author":"Nair","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jmbbm.2019.103541_bib35","series-title":"From Sound to Synapse: Physiology of the Mammalian Ear. Ear and Hearing","author":"Neely","year":"1998"},{"key":"10.1016\/j.jmbbm.2019.103541_bib36","article-title":"Failure rate and revision surgery in ossiculoplasty with Kurz titanium prosthesis","author":"Nguyen","year":"2004","journal-title":"Rev. Laryngol. Otol. Rhinol."},{"key":"10.1016\/j.jmbbm.2019.103541_bib37","doi-asserted-by":"crossref","DOI":"10.1121\/1.418563","article-title":"Sound-pressure measurements in the cochlear vestibule of human-cadaver ears","author":"Puria","year":"1997","journal-title":"J. Acoust. Soc. Am."},{"key":"10.1016\/j.jmbbm.2019.103541_bib38","doi-asserted-by":"crossref","DOI":"10.1159\/000101474","article-title":"Testing a method for quantifying the output of implantable middle ear hearing devices","author":"Rosowski","year":"2007","journal-title":"Audiol. Neurotol."},{"key":"10.1016\/j.jmbbm.2019.103541_bib39","doi-asserted-by":"crossref","DOI":"10.1177\/1179550617749614","article-title":"Total ossicular replacement prosthesis: a new fat interposition technique","author":"Saliba","year":"2018","journal-title":"Clin. Med. Insights Ear, Nose Throat"},{"key":"10.1016\/j.jmbbm.2019.103541_bib40","doi-asserted-by":"crossref","DOI":"10.1007\/s12070-011-0373-9","article-title":"The efficiency of titanium middle ear prosthesis in ossicular chain reconstruction: our experience","author":"Shah","year":"2013","journal-title":"Indian J. Otolaryngol. Head Neck Surg."},{"key":"10.1016\/j.jmbbm.2019.103541_bib41","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1288\/00005537-197602000-00015","article-title":"Plastipore total ossicular replacement prosthesis","volume":"86","author":"Shea","year":"1976","journal-title":"The Laryngoscope"},{"key":"10.1016\/j.jmbbm.2019.103541_bib42","first-page":"343","article-title":"Five-year report on partial ossicular replacement prostheses and total ossicular replacement prostheses","volume":"90","author":"Smyth","year":"1982","journal-title":"Otolaryngology-Head Neck Surg.\u00a0: Off. J. Am. Acad. Otolaryngology-Head and Neck Surgery"},{"key":"10.1016\/j.jmbbm.2019.103541_bib43","article-title":"Replacement of ear ossicles with titanium prostheses","author":"Stupp","year":"1996","journal-title":"Laryngo-Rhino-Otol."},{"key":"10.1016\/j.jmbbm.2019.103541_bib44","doi-asserted-by":"crossref","DOI":"10.1097\/MAO.0b013e3181f6c8b7","article-title":"A self-adjusting ossicular prosthesis containing polyurethane sponge","author":"Yamada","year":"2010","journal-title":"Otol. Neurotol."},{"key":"10.1016\/j.jmbbm.2019.103541_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2003.12.057","article-title":"Preparation of collagen\/calcium phosphate multilayer sheet using enzymatic mineralization","author":"Yamauchi","year":"2004","journal-title":"Biomaterials"},{"key":"10.1016\/j.jmbbm.2019.103541_bib46","doi-asserted-by":"crossref","DOI":"10.1080\/00016480410018250","article-title":"Experimental study of an adjustable-length titanium ossicular prosthesis in a temporal bone model","author":"Zhao","year":"2005","journal-title":"Acta Otolaryngol."},{"key":"10.1016\/j.jmbbm.2019.103541_bib47","doi-asserted-by":"crossref","DOI":"10.3390\/polym11010079","article-title":"Biological and physicochemical assessment of middle ear prosthesis","author":"Ziabka","year":"2019","journal-title":"Polymers"},{"key":"10.1016\/j.jmbbm.2019.103541_bib48","doi-asserted-by":"crossref","DOI":"10.1080\/17434440.2019.1596796","article-title":"Polymeric middle ear prosthesis enriched with silver nanoparticles\u2013first clinical results","author":"Zi\u0105bka","year":"2019","journal-title":"Expert Rev. Med. Devices"}],"container-title":["Journal of the Mechanical Behavior of Biomedical Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1751616119314742?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1751616119314742?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T22:35:53Z","timestamp":1761690953000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1751616119314742"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":48,"alternative-id":["S1751616119314742"],"URL":"https:\/\/doi.org\/10.1016\/j.jmbbm.2019.103541","relation":{},"ISSN":["1751-6161"],"issn-type":[{"value":"1751-6161","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"De novo topology optimization of total ossicular replacement prostheses","name":"articletitle","label":"Article Title"},{"value":"Journal of the Mechanical Behavior of Biomedical Materials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jmbbm.2019.103541","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"103541"}}