{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:47:28Z","timestamp":1761709648210,"version":"build-2065373602"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Mechanical Behavior of Biomedical Materials"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.jmbbm.2020.104246","type":"journal-article","created":{"date-parts":[[2020,12,5]],"date-time":"2020-12-05T19:11:19Z","timestamp":1607195479000},"page":"104246","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Ballistic delivery of compounds to inner layers of the cornea is limited by tough mechanical properties of stromal tissue"],"prefix":"10.1016","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0399-1204","authenticated-orcid":false,"given":"Benjamin","family":"Laccetti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Kornfield","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jmbbm.2020.104246_bib1","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1002\/ar.23890","article-title":"Anatomic studies of the miniature swine cornea","volume":"301","author":"Abhari","year":"2018","journal-title":"Anat. Rec."},{"key":"10.1016\/j.jmbbm.2020.104246_bib2","article-title":"Why Doesn\u2019t the Ocular Drug Work? A look at the various barriers and aids to the efficacy of ocular medications","author":"Ableson","year":"2009","journal-title":"Rev. Opthalmol."},{"key":"10.1016\/j.jmbbm.2020.104246_bib3","first-page":"335","article-title":"The noncorneal route in ocular drug delivery","author":"Ahmed","year":"2003","journal-title":"Ophthalmic Drug Delivery Sys."},{"key":"10.1016\/j.jmbbm.2020.104246_bib4","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.jnnfm.2006.01.004","article-title":"Impact dynamics of a solid sphere falling into a viscoelastic micellar fluid","volume":"135","author":"Akers","year":"2006","journal-title":"J. Nonnewton. Fluid Mech."},{"key":"10.1016\/j.jmbbm.2020.104246_bib5","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1021\/es60074a001","article-title":"Generation of monodisperse aerosol standards","volume":"7","author":"Berglund","year":"1973","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.jmbbm.2020.104246_bib6","first-page":"1","article-title":"A corneal penetrating drug delivery system based on elastin-like polypeptide","volume":"28","author":"Bidwell","year":"2014","journal-title":"Fed. Am. Soc. Exp. Biol."},{"key":"10.1016\/j.jmbbm.2020.104246_bib7","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2019.00066","article-title":"A review of structural and biomechanical changes in the cornea in aging, disease, and photochemical crosslinking","volume":"7","author":"Blackburn","year":"2019","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.jmbbm.2020.104246_bib8","article-title":"Corneal foreign body","volume":"1\u201310","author":"Camodeca","year":"2020","journal-title":"StatPearls"},{"key":"10.1016\/j.jmbbm.2020.104246_bib9","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/4947983","article-title":"Epi-off versus epi-on corneal collagen cross-linking in keratoconus patients: a comparative study through 2-year follow-up","author":"Cifariello","year":"2018","journal-title":"J. Ophthalmol."},{"key":"10.1016\/j.jmbbm.2020.104246_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.35248\/2684-1622.17.2.107","article-title":"Novasorb\u00ae cationic nanoemulsion and latanoprost: the ideal combination for glaucoma management? Journal of eye diseases and disorders","volume":"2","author":"Daull","year":"2017","journal-title":"J Eye Dis Disord"},{"key":"10.1016\/j.jmbbm.2020.104246_bib11","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1155\/2015\/795738","article-title":"The genetic and environmental factors for keratoconus","volume":"2015","author":"Gordon-Shaag","year":"2015","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.jmbbm.2020.104246_bib12","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1097\/ICL.0b013e31802c140c","article-title":"Corneal injury from a metallic foreign body: an occupational hazard","volume":"33","author":"Gumus","year":"2007","journal-title":"Eye Contact Lens"},{"issue":"3","key":"10.1016\/j.jmbbm.2020.104246_bib13","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0014-4835(66)80010-6","article-title":"The thickness-hydration relationship of the cornea","volume":"5","author":"Hedbys","year":"1966","journal-title":"Exp. Eye Res."},{"year":"2011","series-title":"Factors Governing Photodynamic Cross-Linking of Ocular Coat","author":"Huynh","key":"10.1016\/j.jmbbm.2020.104246_bib14"},{"key":"10.1016\/j.jmbbm.2020.104246_bib15","first-page":"687","article-title":"Efficacy of iontophoresis-assisted epithelium-on corneal cross-linking for keratoconus","volume":"11","author":"Jia","year":"2018","journal-title":"Int. J. Ophthalmol."},{"issue":"91\u201398","key":"10.1016\/j.jmbbm.2020.104246_bib16","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.forsciint.2003.11.036","article-title":"Preparing ballistic gelatin - review and proposal for a standard method","volume":"141","author":"Jussila","year":"2004","journal-title":"Forensic Sci. Int."},{"key":"10.1016\/j.jmbbm.2020.104246_bib17","first-page":"1621","article-title":"Transdermal ballistic delivery of micro-particles: investigation into skin penetration","author":"Kendall","year":"2000","journal-title":"BS EMBS Int. Conf."},{"key":"10.1016\/j.jmbbm.2020.104246_bib18","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1016\/j.jbiomech.2004.01.032","article-title":"Intradermal ballistic delivery of microparticles into excised human skin for pharmaceutical applications","volume":"37","author":"Kendall","year":"2004","journal-title":"J. Biomech."},{"key":"10.1016\/j.jmbbm.2020.104246_bib19","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1016\/j.micron.2012.02.014","article-title":"Compliance profile of the human cornea as measured by atomic force microscopy","volume":"43","author":"Last","year":"2012","journal-title":"Micron"},{"key":"10.1016\/j.jmbbm.2020.104246_bib20","first-page":"189","article-title":"Gene transfer into corneal endothelial cells by Helios gene gun. Nihon","volume":"107","author":"Lu","year":"2003","journal-title":"Ganka Gakkai Zasshi"},{"key":"10.1016\/j.jmbbm.2020.104246_bib21","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1007\/s004170000144","article-title":"Ballistic transfer of minimalistic immunologically defined expression constructs for IL4 and CTLA4 into the corneal epithelium in mice after orthotopic corneal allograft transplantation","volume":"238","author":"Merediz","year":"2000","journal-title":"Graefe\u2019s Arch. Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.jmbbm.2020.104246_bib22","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/S0734-743X(02)00150-1","article-title":"A ballistic study of micro-particle penetration of the oral mucosa","volume":"28","author":"Mitchell","year":"2003","journal-title":"Int. J. Impact Eng."},{"key":"10.1016\/j.jmbbm.2020.104246_bib23","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1098\/rstb.2010.0234","article-title":"The injured eye","volume":"366","author":"Scott","year":"2011","journal-title":"Philos. Trans. R. Soc. B Biol. Sci."},{"key":"10.1016\/j.jmbbm.2020.104246_bib24","article-title":"The effects of Davidson's fixative solution in preserving the rabbit eye","volume":"49","author":"Shariati","year":"2008","journal-title":"Investig. Opthalmology Vis. Sci."},{"key":"10.1016\/j.jmbbm.2020.104246_bib25","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.jmbbm.2013.09.024","article-title":"Projectile penetration into ballistic gelatin","volume":"29","author":"Swain","year":"2014","journal-title":"J. Mech. Behav. Biomater."},{"key":"10.1016\/j.jmbbm.2020.104246_bib26","doi-asserted-by":"crossref","first-page":"484","DOI":"10.2144\/97233st06","article-title":"Controlled gene gun delivery and expression of DNA within the cornea","volume":"23","author":"Tanelian","year":"1997","journal-title":"Biotechniques"},{"key":"10.1016\/j.jmbbm.2020.104246_bib27","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.jmbbm.2018.06.016","article-title":"High-velocity micro-particle impact on gelatin and synthetic hydrogel","volume":"86","author":"Veysset","year":"2018","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"10.1016\/j.jmbbm.2020.104246_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijimpeng.2019.103465","article-title":"Laser-driven high-velocity microparticle launcher in atmosphere and under vacuum","volume":"137","author":"Veysset","year":"2020","journal-title":"Int. J. Impact Eng."},{"key":"10.1016\/j.jmbbm.2020.104246_bib29","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1111\/1523-1747.ep12462252","article-title":"Electron probe analysis of human skin: determination of the water concentration profile","volume":"90","author":"Warner","year":"1988","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.jmbbm.2020.104246_bib30","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1007\/s00417-001-0411-5","article-title":"Minimizing side effects of ballistic gene transfer into the murine corneal epithelium","volume":"240","author":"Zhang","year":"2002","journal-title":"Graefe\u2019s Arch. Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.jmbbm.2020.104246_bib31","article-title":"Experimental investigation on ballistic stability of high-speed projectile in sand","volume":"1793","author":"Zhang","year":"2017","journal-title":"AIP Conf. Proc."}],"container-title":["Journal of the Mechanical Behavior of Biomedical Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1751616120307852?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1751616120307852?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T22:34:35Z","timestamp":1761690875000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1751616120307852"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":31,"alternative-id":["S1751616120307852"],"URL":"https:\/\/doi.org\/10.1016\/j.jmbbm.2020.104246","relation":{},"ISSN":["1751-6161"],"issn-type":[{"type":"print","value":"1751-6161"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ballistic delivery of compounds to inner layers of the cornea is limited by tough mechanical properties of stromal tissue","name":"articletitle","label":"Article Title"},{"value":"Journal of the Mechanical Behavior of Biomedical Materials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jmbbm.2020.104246","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104246"}}