{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T16:16:02Z","timestamp":1780071362787,"version":"3.54.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Mechanical Behavior of Biomedical Materials"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.jmbbm.2021.104847","type":"journal-article","created":{"date-parts":[[2021,9,20]],"date-time":"2021-09-20T17:36:32Z","timestamp":1632159392000},"page":"104847","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["In silico analysis of modular bone plates"],"prefix":"10.1016","volume":"124","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8383-6000","authenticated-orcid":false,"given":"Omer","family":"Subasi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atacan","family":"Oral","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sinan","family":"Noyan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4710-3563","authenticated-orcid":false,"given":"Orcun","family":"Tuncozgur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8316-9623","authenticated-orcid":false,"given":"Ismail","family":"Lazoglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jmbbm.2021.104847_bib1","doi-asserted-by":"crossref","first-page":"104062","DOI":"10.1016\/j.compbiomed.2020.104062","article-title":"Biomechanical evaluation of three different configurations of external fixators for treating distal third tibia fracture: finite element analysis in axial, bending and torsion load","volume":"127","author":"Abdul Wahab","year":"2020","journal-title":"Comput. Biol. Med."},{"key":"10.1016\/j.jmbbm.2021.104847_bib3","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1007\/s10237-019-01240-3","article-title":"Stress analysis in a bone fracture fixed with topology-optimised plates","volume":"19","author":"Al-Tamimi","year":"2020","journal-title":"Biomech. Model. Mechanobiol."},{"key":"10.1016\/j.jmbbm.2021.104847_bib4","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1016\/S0020-1383(18)30294-8","article-title":"Evolution of fracture treatment with bone plates","volume":"49","author":"Augat","year":"2018","journal-title":"Injury"},{"key":"10.1016\/j.jmbbm.2021.104847_bib5","article-title":"Biomechanical analysis of a new carbon fiber\/flax\/epoxy bone fracture plate shows less stress shielding compared to a standard clinical metal plate","volume":"136","author":"Bagheri","year":"2014","journal-title":"J Mech Behav Biomed Mater"},{"key":"10.1016\/j.jmbbm.2021.104847_bib6","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1007\/s12018-018-9256-x","article-title":"Bone fracture acute phase response\u2014a unifying theory of fracture repair: clinical and scientific implications","volume":"16","author":"Baker","year":"2018","journal-title":"Clin. Rev. Bone Miner. Metabol."},{"key":"10.1016\/j.jmbbm.2021.104847_bib7","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1533\/9781845694807.2.190","article-title":"Cementless fixation techniques in joint replacement","author":"Cross","year":"2008","journal-title":"Jt Replace Technol"},{"key":"10.1016\/j.jmbbm.2021.104847_bib8","unstructured":"Destainville A, Richart O. \u201c WO2019243703A1- Module for a modular bone plate, modular bone plate of this construction, and system comprising said plate.\u201d Google patents, https:\/\/patents.google.com\/patent\/WO2019243703A1\/en?oq=WO2019243703A1."},{"key":"10.1016\/j.jmbbm.2021.104847_bib9","first-page":"175","article-title":"Wolff's Law and bone's structural adaptations to mechanical usage: an overview for clinicians","volume":"64","author":"Frost","year":"1994","journal-title":"Angle Orthod."},{"key":"10.1016\/j.jmbbm.2021.104847_bib10","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.asej.2018.12.005","article-title":"Numerical study of stress shielding reduction at fractured bone using metallic and composite bone-plate models","volume":"10","author":"Fouda","year":"2019","journal-title":"Ain Shams Eng J"},{"key":"10.1016\/j.jmbbm.2021.104847_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1475-925X-4-46","article-title":"Biomechanics of bone-fracture fixation by stiffness-graded plates in comparison with stainless-steel plates","volume":"4","author":"Ganesh","year":"2005","journal-title":"Biomed. Eng. Online"},{"key":"10.1016\/j.jmbbm.2021.104847_bib12","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1002\/cnm.2633","article-title":"A comparative study of orthotropic and isotropic bone adaptation in the femur","volume":"30","author":"Geraldes","year":"2014","journal-title":"Int. J. Numer. Meth. Biomed. Engng."},{"key":"10.1016\/j.jmbbm.2021.104847_bib13","doi-asserted-by":"crossref","first-page":"S8","DOI":"10.1016\/S0020-1383(18)30295-X","article-title":"Evolution of plate design and material composition","volume":"49","author":"Hak","year":"2018","journal-title":"Injury"},{"key":"10.1016\/j.jmbbm.2021.104847_bib14","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1007\/s00264-016-3347-4","article-title":"History of internal fixation (part 1): early developments with wires and plates before World War II","volume":"41","author":"Hernigou","year":"2017","journal-title":"Int. Orthop."},{"key":"10.1016\/j.jmbbm.2021.104847_bib15","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.engfailanal.2007.04.001","article-title":"Fatigue failure of an orthopedic implant - a locking compression plate","volume":"15","author":"Kanchanomai","year":"2008","journal-title":"Eng. Fail. Anal."},{"key":"10.1016\/j.jmbbm.2021.104847_bib16","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/7059413","article-title":"Can preoperative 3D printing change surgeon's operative plan for distal tibia fracture?","volume":"2019","author":"Kang","year":"2019","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.jmbbm.2021.104847_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13018-015-0233-5","article-title":"Use of a real-size 3D-printed model as a preoperative and intraoperative tool for minimally invasive plating of comminuted midshaft clavicle fractures","volume":"10","author":"Kim","year":"2015","journal-title":"J. Orthop. Surg. Res."},{"key":"10.1016\/j.jmbbm.2021.104847_bib18","doi-asserted-by":"crossref","first-page":"104552","DOI":"10.1016\/j.jmbbm.2021.104552","article-title":"Journal of the Mechanical Behavior of Biomedical Materials Enhanced biomechanical performance of additively manufactured Ti-6Al-4V bone plates","volume":"119","author":"Kumar","year":"2021","journal-title":"J Mech Behav Biomed Mater"},{"key":"10.1016\/j.jmbbm.2021.104847_bib19","first-page":"115","article-title":"A theoretical analysis and finite element simulation of fixator\u2013bone system stiffness on healing progression","volume":"16","author":"Li","year":"2018","journal-title":"J. Appl. Biomater. Funct. Mater."},{"key":"10.1016\/j.jmbbm.2021.104847_bib20","first-page":"1","article-title":"Stiffness of the locking compression plate as an external fixator for treating distal tibial fractures: a biomechanics study","volume":"18","author":"Liu","year":"2017","journal-title":"BMC Muscoskel. Disord."},{"key":"10.1016\/j.jmbbm.2021.104847_bib21","unstructured":"Long JF, Marbaugh KR, Huffman BR. \u201cWO2009042512A1- Modular bone plate system. \u201d Google patents, https:\/\/patents.google.com\/patent\/WO2009042512A1\/en?oq=WO2009042512A1."},{"key":"10.1016\/j.jmbbm.2021.104847_bib22","doi-asserted-by":"crossref","first-page":"2908","DOI":"10.3390\/jcm9092908","article-title":"A review on 3D-printed templates for precontouring fixation plates in orthopedic surgery","volume":"9","author":"Marinescu","year":"2020","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.jmbbm.2021.104847_bib23","unstructured":"Markku B. \u201cUS10898245B2- Modular bone plate and member of such a modular bone plate.\u201d Google patents, https:\/\/patents.google.com\/patent\/US10898245B2\/en?oq=US10898245B2."},{"key":"10.1016\/j.jmbbm.2021.104847_bib24","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.injury.2017.01.040","article-title":"Construct failure after open reduction and plate fixation of displaced midshaft clavicular fractures","volume":"48","author":"Meeuwis","year":"2017","journal-title":"Injury"},{"key":"10.1016\/j.jmbbm.2021.104847_bib25","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/j.clinbiomech.2007.08.004","article-title":"A review of locking compression plate biomechanics and their advantages as internal fixators in fracture healing","volume":"22","author":"Miller","year":"2007","journal-title":"Clin. Biomech."},{"key":"10.1016\/j.jmbbm.2021.104847_bib26","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s13246-015-0407-9","article-title":"The relationship between interfragmentary movement and cell differentiation in early fracture healing under locking plate fixation","volume":"39","author":"Miramini","year":"2016","journal-title":"Australas. Phys. Eng. Sci. Med."},{"key":"10.1016\/j.jmbbm.2021.104847_bib27","unstructured":"Mirghasemi SA, Gabaran NR. \u201cUS20150289910A1- modular Bone Plate.\u201d Google patents, https:\/\/patents.google.com\/patent\/US20150289910?oq=US2015289910A1."},{"key":"10.1016\/j.jmbbm.2021.104847_bib28","first-page":"398","article-title":"An evaluation of poly (L-lactic acid) plate and screw system for fixation of mandible fracture in rabbit model","volume":"8","author":"Park","year":"2011","journal-title":"J Tissue Eng and Regen Med"},{"key":"10.1016\/j.jmbbm.2021.104847_bib29","doi-asserted-by":"crossref","first-page":"884","DOI":"10.3390\/ma10080884","article-title":"Metallic biomaterials: current challenges and opportunities","volume":"10","author":"Prasad","year":"2017","journal-title":"Materials"},{"key":"10.1016\/j.jmbbm.2021.104847_bib30","first-page":"1086","article-title":"Design of fracture fixation plate for necessary and sufficient bone stress shielding","volume":"47","author":"Ramakrishna","year":"2004","journal-title":"JSME Int Journal, Ser C Mech Syst Mach Elem Manuf"},{"key":"10.1016\/j.jmbbm.2021.104847_bib31","first-page":"347","article-title":"Towards patient specific plate implants for the human long bones: a distal humerus example","volume":"16","author":"Rashid","year":"2018","journal-title":"Facta Univ. \u2013 Ser. Mech. Eng."},{"key":"10.1016\/j.jmbbm.2021.104847_bib33","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1016\/j.injury.2019.08.034","article-title":"A novel adjustable locking plate (ALP) for segmental bone fracture treatment","volume":"50","author":"Subasi","year":"2019","journal-title":"Injury"},{"key":"10.1016\/j.jmbbm.2021.104847_bib34","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1007\/s00776-003-0671-5","article-title":"Biomechanical analysis for stress fractures of the anterior middle third of the tibia in athletes: nonlinear analysis using a three-dimensional finite element method","volume":"8","author":"Sonoda","year":"2003","journal-title":"J. Orthop. Sci."},{"key":"10.1016\/j.jmbbm.2021.104847_bib35","first-page":"447","article-title":"Modular adaptive bone plate for humerus bone osteosynthesis","volume":"50","author":"Tarni\u0163\u01ce","year":"2008","journal-title":"Rom. J. Morphol. Embryol."},{"key":"10.1016\/j.jmbbm.2021.104847_bib36","first-page":"315","article-title":"In vitro experiment of the modular orthopedic plate based on nitinol, used for human radius bone fractures","volume":"51","author":"Tarni\u0163\u01ce","year":"2010","journal-title":"Rom. J. Morphol. Embryol."},{"key":"10.1016\/j.jmbbm.2021.104847_bib37","series-title":"Tibia Fractures Overview. StatPearls, Treasure Island (FL)","author":"Thompson","year":"2020"},{"key":"10.1016\/j.jmbbm.2021.104847_bib38","first-page":"1","article-title":"Hybrid fracture fixation systems developed for orthopaedic applications: a general review","volume":"16","author":"Tian","year":"2019","journal-title":"J Orthop Transl"},{"key":"10.1016\/j.jmbbm.2021.104847_bib39","first-page":"RC01","article-title":"Distal femur locking plate: the answer to all distal femoral fractures","volume":"10","author":"Virk","year":"2016","journal-title":"J. Clin. Diagn. Res."},{"key":"10.1016\/j.jmbbm.2021.104847_bib40","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1007\/s42242-020-00066-8","article-title":"A new design of 3D-printed orthopedic bone plates with auxetic structures to mitigate stress shielding and improve intra-operative bending","volume":"3","author":"Vijayavenkataraman","year":"2020","journal-title":"Bio-Design Manuf"},{"key":"10.1016\/j.jmbbm.2021.104847_bib41","article-title":"European surgical orthopaedics and traumatology","author":"Volpin","year":"2014","journal-title":"Eur Surg Orthop Traumatol"},{"key":"10.1016\/j.jmbbm.2021.104847_bib42","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.clinbiomech.2008.12.007","article-title":"Internal loads in the human tibia during gait","volume":"24","author":"Wehner","year":"2009","journal-title":"Clin. Biomech."},{"key":"10.1016\/j.jmbbm.2021.104847_bib43","article-title":"Non-union bone fractures","volume":"7","author":"Wildemann","year":"2021","journal-title":"Nat Rev Dis Prim"},{"key":"10.1016\/j.jmbbm.2021.104847_bib44","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.cxom.2019.05.002","article-title":"Concepts of rigid fixation in facial fractures","volume":"27","author":"Yeoh","year":"2019","journal-title":"Atlas Oral Maxillofac Surg Clin North Am"}],"container-title":["Journal of the Mechanical Behavior of Biomedical Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1751616121004872?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1751616121004872?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T22:42:53Z","timestamp":1761691373000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1751616121004872"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":42,"alternative-id":["S1751616121004872"],"URL":"https:\/\/doi.org\/10.1016\/j.jmbbm.2021.104847","relation":{},"ISSN":["1751-6161"],"issn-type":[{"value":"1751-6161","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In silico analysis of modular bone plates","name":"articletitle","label":"Article Title"},{"value":"Journal of the Mechanical Behavior of Biomedical Materials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jmbbm.2021.104847","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104847"}}