{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T17:28:50Z","timestamp":1781890130339,"version":"3.54.5"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T00:00:00Z","timestamp":1698451200000},"content-version":"am","delay-in-days":665,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Mechanical Behavior of Biomedical Materials"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.jmbbm.2021.104907","type":"journal-article","created":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T14:35:15Z","timestamp":1635172515000},"page":"104907","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Linking collagen fiber architecture to tissue-level biaxial mechanical behaviors of porcine semilunar heart valve cusps"],"prefix":"10.1016","volume":"125","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4518-5531","authenticated-orcid":false,"given":"Luke T.","family":"Hudson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9681-4708","authenticated-orcid":false,"given":"Devin W.","family":"Laurence","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hunter M.","family":"Lau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brennan T.","family":"Mullins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7295-1663","authenticated-orcid":false,"given":"Deenna D.","family":"Doan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8019-3329","authenticated-orcid":false,"given":"Chung-Hao","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jmbbm.2021.104907_b1","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.jmbbm.2019.02.011","article-title":"Insights into the micromechanics of stress-relaxation and creep behaviours in the aortic valve","volume":"93","author":"Anssari-Benam","year":"2019","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"10.1016\/j.jmbbm.2021.104907_b2","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.actbio.2019.02.008","article-title":"Rate-dependency of the mechanical behaviour of semilunar heart valves under biaxial deformation","volume":"88","author":"Anssari-Benam","year":"2019","journal-title":"Acta Biomater."},{"issue":"1","key":"10.1016\/j.jmbbm.2021.104907_b3","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0142-9612(01)00077-1","article-title":"Hydrodynamic function of polyurethane prosthetic heart valves: Influences of Young\u2019s modulus and leaflet thickness","volume":"23","author":"Bernacca","year":"2002","journal-title":"Biomaterials"},{"issue":"7","key":"10.1016\/j.jmbbm.2021.104907_b4","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/S0021-9290(97)00019-5","article-title":"A method to quantify the fiber kinematics of planar tissues under biaxial stretch","volume":"30","author":"Billiar","year":"1997","journal-title":"J. Biomech."},{"issue":"4","key":"10.1016\/j.jmbbm.2021.104907_b5","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1115\/1.1287158","article-title":"Biaxial mechanical properties of the native and glutaraldehyde-treated aortic valve cusp: Part II\u2014-A structural constitutive model","volume":"122","author":"Billiar","year":"2000","journal-title":"J. Biomech. Eng."},{"issue":"1","key":"10.1016\/j.jmbbm.2021.104907_b6","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1115\/1.429624","article-title":"Biaxial mechanical properties of the natural and glutaraldehyde treated aortic valve cusp- Part I: Experimental results","volume":"122","author":"Billiar","year":"2000","journal-title":"J. Biomech. Eng."},{"issue":"9","key":"10.1016\/j.jmbbm.2021.104907_b7","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1016\/j.jbiomech.2009.03.023","article-title":"The effects of preconditioning strain on measured tissue properties","volume":"42","author":"Cheng","year":"2009","journal-title":"J. Biomech."},{"issue":"9","key":"10.1016\/j.jmbbm.2021.104907_b8","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1016\/j.jbiomech.2009.03.023","article-title":"The effects of preconditioning strain on measured tissue properties","volume":"42","author":"Cheng","year":"2009","journal-title":"J. Biomech."},{"key":"10.1016\/j.jmbbm.2021.104907_b9","doi-asserted-by":"crossref","first-page":"S195","DOI":"10.1016\/0003-4975(95)00279-T","article-title":"Mechanical properties of porcine pulmonary valve leaflets: How do they differ from aortic leaflets?","volume":"60","author":"Christie","year":"1995","journal-title":"Ann. Throac. Surg."},{"issue":"2","key":"10.1016\/j.jmbbm.2021.104907_b10","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1115\/1.1865187","article-title":"Improved prediction of the collagen fiber architecture in the aortic heart valve","volume":"127","author":"Driessen","year":"2004","journal-title":"J. Biomech. Eng."},{"issue":"2","key":"10.1016\/j.jmbbm.2021.104907_b11","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s10237-007-0078-x","article-title":"Remodelling of the angular collagen fiber distribution in cardiovascular tissues","volume":"7","author":"Driessen","year":"2008","journal-title":"Biomech. Model. Mechanobiol."},{"issue":"5","key":"10.1016\/j.jmbbm.2021.104907_b12","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1007\/s10439-019-02233-0","article-title":"Non-destructive reflectance mapping of collagen fiber alignment in heart valve leaflets","volume":"47","author":"Goth","year":"2019","journal-title":"Ann. Biomed. Eng."},{"issue":"4","key":"10.1016\/j.jmbbm.2021.104907_b13","doi-asserted-by":"crossref","first-page":"643","DOI":"10.3390\/polym11040643","article-title":"Optimization of electrospun poly(caprolactone) fiber diameter for vascular scaffolds to maximize smooth muscle cell infiltration and phenotype modulation","volume":"11","author":"Han","year":"2019","journal-title":"Polymers"},{"key":"10.1016\/j.jmbbm.2021.104907_b14","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbiomech.2020.110124","article-title":"Manifold learning based data-driven modeling for soft biological tissues","volume":"117","author":"He","year":"2021","journal-title":"J. Biomech."},{"issue":"11","key":"10.1016\/j.jmbbm.2021.104907_b15","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1177\/0954411912455004","article-title":"Application of simple biomechanical and biochemical tests to heart valve leaflets: Implications for heart valve characterization and tissue engineering","volume":"226","author":"Huang","year":"2012","journal-title":"Proc. Inst. Mech. Eng. H J. Eng. Med."},{"issue":"10","key":"10.1016\/j.jmbbm.2021.104907_b16","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1177\/0954411915604336","article-title":"Biaxial stress relaxation of semilunar heart valve leaflets during simulated collagen catabolism: Effects of collagenase concentration and equibiaxial strain state","volume":"229","author":"Huang","year":"2015","journal-title":"Proc. Inst. Mech. Eng. H J. Eng. Med."},{"issue":"2","key":"10.1016\/j.jmbbm.2021.104907_b17","doi-asserted-by":"crossref","first-page":"60","DOI":"10.3390\/bioengineering7020060","article-title":"A pilot study on linking tissue mechanics with load-dependent collagen microstructures in porcine tricuspid valve leaflets","volume":"7","author":"Hudson","year":"2020","journal-title":"Bioengineering"},{"key":"10.1016\/j.jmbbm.2021.104907_b18","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.actbio.2019.11.028","article-title":"Integration of polarized spatial frequency domain imaging (pSFDI) with a biaxial mechanical testing system for quantification of load-dependent collagen architecture in soft collagenous tissues","volume":"102","author":"Jett","year":"2020","journal-title":"Acta Biomater."},{"key":"10.1016\/j.jmbbm.2021.104907_b19","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.jmbbm.2018.07.024","article-title":"An investigation of the anisotropic mechanical properties and anatomical structure of porcine atrioventricular heart valves","volume":"87","author":"Jett","year":"2018","journal-title":"J. Mech. Behav. Biomed. Mater."},{"issue":"4","key":"10.1016\/j.jmbbm.2021.104907_b20","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1016\/j.athoracsur.2008.12.049","article-title":"Functional collagen fiber architecture of the pulmonary heart valve cusp","volume":"87","author":"Joyce","year":"2009","journal-title":"Ann. Thorac. Surg."},{"key":"10.1016\/j.jmbbm.2021.104907_b21","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.aanat.2017.03.004","article-title":"The composition and biomechanical properties of human cryopreserved aortas, pulmonary trunks, and aortic and pulmonary cusps","volume":"212","author":"Kub\u00edkov\u00e1","year":"2017","journal-title":"Ann. Anat."},{"key":"10.1016\/j.jmbbm.2021.104907_b22","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.actbio.2016.08.036","article-title":"Planar biaxial testing of heart valve cusp replacement biomaterials: Experiments, theory and material constants","volume":"45","author":"Labrosse","year":"2016","journal-title":"Acta Biomater."},{"key":"10.1016\/j.jmbbm.2021.104907_b23","first-page":"1","article-title":"A pilot study on biaxial mechanical, collagen microstructural, and morphological characterizations of a resected human intracranial aneurysm tissue","volume":"11","author":"Laurence","year":"2021","journal-title":"Nat. Sci. Rep."},{"issue":"6","key":"10.1016\/j.jmbbm.2021.104907_b24","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1002\/jbm.a.34099","article-title":"Biomechanical characterization of aortic valve tissue in humans and common animal models","volume":"100A","author":"Martin","year":"2012","journal-title":"J. Biomed. Mater. Res. Part A"},{"issue":"8","key":"10.1016\/j.jmbbm.2021.104907_b25","doi-asserted-by":"crossref","DOI":"10.1115\/1.3127261","article-title":"A hyperelastic constitutive law for aortic valve tissue","volume":"131","author":"May-Newman","year":"2009","journal-title":"J. Biomech. Eng."},{"issue":"1484","key":"10.1016\/j.jmbbm.2021.104907_b26","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1098\/rstb.2007.2125","article-title":"Heart valve macro- and microstructure","volume":"362","author":"Misfeld","year":"2007","journal-title":"Philos. Trans. Roy. Soc. Lond. B Biol. Sci."},{"key":"10.1016\/j.jmbbm.2021.104907_b27","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.actbio.2015.10.044","article-title":"Age-dependent changes of stress and strain in the human heart valve and their relation with collagen remodeling","volume":"29","author":"Oomen","year":"2016","journal-title":"Acta Biomater."},{"issue":"1","key":"10.1016\/j.jmbbm.2021.104907_b28","article-title":"Hemodynamics of the aortic valve and root: Implications for surgery","volume":"2","author":"Paulis","year":"2013","journal-title":"Ann. Cardiovasc. Surg."},{"key":"10.1016\/j.jmbbm.2021.104907_b29","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.actbio.2017.03.026","article-title":"Quantification and comparison of the mechanical properties of four human cardiac valves","volume":"54","author":"Pham","year":"2017","journal-title":"Acta Biomater."},{"key":"10.1016\/j.jmbbm.2021.104907_b30","doi-asserted-by":"crossref","first-page":"2058","DOI":"10.1007\/s10439-014-1077-6","article-title":"Pregnancy-induced remodeling of collagen architecture and content in the mitral valve","volume":"42","author":"Pierlot","year":"2014","journal-title":"Ann. Biomed. Eng."},{"issue":"4","key":"10.1016\/j.jmbbm.2021.104907_b31","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.jtcvs.2012.03.060","article-title":"Role of the sinuses of Valsalva on the opening of the aortic valve","volume":"145","author":"Pisani","year":"2013","journal-title":"J. Thorac. Cardiovas. Surg."},{"issue":"1","key":"10.1016\/j.jmbbm.2021.104907_b32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0086087","article-title":"Complex collagen fiber and membrane morphologies of the whole porcine aortic valve","volume":"9","author":"Rock","year":"2014","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.jmbbm.2021.104907_b33","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s10237-020-01379-4","article-title":"Quantification of load-dependent changes in the collagen fiber architecture for the strut chordae tendineae-leaflet insertion of porcine atrioventricular heart valves","volume":"20","author":"Ross","year":"2021","journal-title":"Biomech. Model. Mechanobiol."},{"key":"10.1016\/j.jmbbm.2021.104907_b34","article-title":"Biaxial mechanical characterizations of atrioventricular heart valves","volume":"146","author":"Ross","year":"2019","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.jmbbm.2021.104907_b35","series-title":"The 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Vol. 2","first-page":"3734","article-title":"A structural constitutive model for the native pulmonary valve","author":"Sacks","year":"2004"},{"issue":"1","key":"10.1016\/j.jmbbm.2021.104907_b36","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/(SICI)1097-4636(199807)41:1<131::AID-JBM16>3.0.CO;2-Q","article-title":"The aortic valve microstructure: Effects of transvalvular pressure","volume":"41","author":"Sacks","year":"1998","journal-title":"J. Biomed. Mater. Res."},{"key":"10.1016\/j.jmbbm.2021.104907_b37","doi-asserted-by":"crossref","first-page":"S391","DOI":"10.1016\/0003-4975(95)00263-K","article-title":"Aortic valve cusp microstructure: The role of elastin","volume":"60","author":"Scott","year":"1995","journal-title":"Ann. Thorac. Surg."},{"issue":"14","key":"10.1016\/j.jmbbm.2021.104907_b38","doi-asserted-by":"crossref","first-page":"3169","DOI":"10.1016\/j.jbiomech.2007.04.001","article-title":"Time-dependent biaxial mechanical behavior of the aortic heart valve leaflet","volume":"40","author":"Stella","year":"2007","journal-title":"J. Biomech."},{"issue":"5","key":"10.1016\/j.jmbbm.2021.104907_b39","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1115\/1.2768111","article-title":"On the Biaxial mechanical properties of the layers of the aortic valve leaflet","volume":"129","author":"Stella","year":"2007","journal-title":"J. Biomech. Eng."},{"issue":"3","key":"10.1016\/j.jmbbm.2021.104907_b40","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1089\/ten.tea.2009.0288","article-title":"Age-related changes in material behavior of porcine mitral and aortic valves and correlation to matrix composition","volume":"16","author":"Stephens","year":"2010","journal-title":"Tissue Eng. A"},{"issue":"3","key":"10.1016\/j.jmbbm.2021.104907_b41","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.ejcts.2004.05.043","article-title":"Comparison of biomechanical and structural properties between human aortic and pulmonary valve","volume":"26","author":"Stradins","year":"2004","journal-title":"Eur. J. Cardiothorac. Surg."},{"issue":"4","key":"10.1016\/j.jmbbm.2021.104907_b42","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1115\/1.1933931","article-title":"Effects of boundary conditions on the estimation of the planar biaxial mechanical properties of soft tissues","volume":"127","author":"Sun","year":"2005","journal-title":"J. Biomech. Eng."},{"issue":"5\u20136","key":"10.1016\/j.jmbbm.2021.104907_b43","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1089\/ten.tea.2012.0365","article-title":"Decellularized tissue-engineered heart valve leaflets with recellularization potential","volume":"19","author":"Syedain","year":"2013","journal-title":"Tissue Eng. A"},{"key":"10.1016\/j.jmbbm.2021.104907_b44","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1114\/1.1527047","article-title":"Fiber alignment imaging during mechanical testing of soft tissues","volume":"30","author":"Tower","year":"2002","journal-title":"Ann. Biomed. Eng."},{"issue":"5","key":"10.1016\/j.jmbbm.2021.104907_b45","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1016\/j.actbio.2011.01.022","article-title":"Elastic fibers in the aortic valve spongiosa: A fresh perspective on its structure and role in overall tissue function","volume":"7","author":"Tseng","year":"2011","journal-title":"Acta Biomater."},{"key":"10.1016\/j.jmbbm.2021.104907_b46","first-page":"933","article-title":"Boundary conditions during biaxial testing of planar connective tissues. Part 1: Dynamic behavior","volume":"13","author":"Waldman","year":"2002","journal-title":"J. Mater. Sci.: Mater. Med."},{"issue":"4","key":"10.1016\/j.jmbbm.2021.104907_b47","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1007\/s10558-007-9038-4","article-title":"Transient, three-dimensional, multiscale simulations of the human aortic valve","volume":"7","author":"Weinberg","year":"2007","journal-title":"Cardiovasc. Eng."},{"issue":"4","key":"10.1016\/j.jmbbm.2021.104907_b48","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1364\/BOE.6.001520","article-title":"Polarized light spatial frequency domain imaging for non-destructive quantification of soft tissue fibrous structures","volume":"6","author":"Yang","year":"2015","journal-title":"Biomed. Opt. Exp."},{"issue":"7","key":"10.1016\/j.jmbbm.2021.104907_b49","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1109\/TCYB.2013.2279211","article-title":"Differential evolution with two-level parameter adaptation","volume":"44","author":"Yu","year":"2014","journal-title":"IEEE Trans. Cybern."},{"issue":"4","key":"10.1016\/j.jmbbm.2021.104907_b50","doi-asserted-by":"crossref","DOI":"10.1088\/1748-605X\/aa766d","article-title":"Construction of cell-containing, anisotropic, three-dimensional collagen fibril scaffolds using external vibration and their influence on smooth muscle cell phenotype modulation","volume":"12","author":"Zeng","year":"2017","journal-title":"Biomed. Mater."},{"key":"10.1016\/j.jmbbm.2021.104907_b51","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.actbio.2015.12.001","article-title":"A meso-scale layer-specific structural constitutive model of the mitral heart valve leaflets","volume":"32","author":"Zhang","year":"2016","journal-title":"Acta Biomater."}],"container-title":["Journal of the Mechanical Behavior of Biomedical Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1751616121005373?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1751616121005373?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T22:49:01Z","timestamp":1761691741000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1751616121005373"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":51,"alternative-id":["S1751616121005373"],"URL":"https:\/\/doi.org\/10.1016\/j.jmbbm.2021.104907","relation":{},"ISSN":["1751-6161"],"issn-type":[{"value":"1751-6161","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Linking collagen fiber architecture to tissue-level biaxial mechanical behaviors of porcine semilunar heart valve cusps","name":"articletitle","label":"Article Title"},{"value":"Journal of the Mechanical Behavior of Biomedical Materials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jmbbm.2021.104907","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104907"}}