{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T04:05:49Z","timestamp":1761710749597,"version":"build-2065373602"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100020302","name":"Universidad Nacional de Cuyo Secretaria de Investigacion Internacionales y Posgrado","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020302","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002909","name":"Comisi\u00f3n Nacional de Energ\u00eda At\u00f3mica, Gobierno de Argentina","doi-asserted-by":"publisher","award":["SIIP UNCuyo 06\/045 (2019\u20132021"],"award-info":[{"award-number":["SIIP UNCuyo 06\/045 (2019\u20132021"]}],"id":[{"id":"10.13039\/501100002909","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003074","name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["PICT 2018-03300"],"award-info":[{"award-number":["PICT 2018-03300"]}],"id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Mechanical Behavior of Biomedical Materials"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1016\/j.jmbbm.2021.104946","type":"journal-article","created":{"date-parts":[[2021,11,13]],"date-time":"2021-11-13T17:01:53Z","timestamp":1636822913000},"page":"104946","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["A tool for solving bone growth related problems using finite elements adaptive meshes"],"prefix":"10.1016","volume":"126","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4964-2015","authenticated-orcid":false,"given":"M.G.","family":"Alonso","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4126-3494","authenticated-orcid":false,"given":"A.","family":"Yawny","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Bertolino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jmbbm.2021.104946_b1","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.jbiomech.2020.109905","article-title":"Mechanobiological based long bone growth model for the design of limb deformities correction devices","volume":"109","author":"Alonso","year":"2020","journal-title":"J. Biomech."},{"key":"10.1016\/j.jmbbm.2021.104946_b2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2106\/00004623-196345010-00001","article-title":"Growth and predictions of growth in the lower extremities","volume":"45","author":"Anderson","year":"1963","journal-title":"J. Bone Joint Surg."},{"year":"2016","series-title":"The BEL repository","author":"Anon","key":"10.1016\/j.jmbbm.2021.104946_b3"},{"key":"10.1016\/j.jmbbm.2021.104946_b4","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1002\/jor.1100080507","article-title":"An approach for time-dependent bone modeling and remodeling. application: A preliminary remodeling simulation","volume":"8","author":"Beaupr\u00e9","year":"1990","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.jmbbm.2021.104946_b5","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1002\/jor.1100080506","article-title":"An approach for time-dependent bone modeling and remodeling. theoretical development","volume":"8","author":"Beaupr\u00e9","year":"1990","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.jmbbm.2021.104946_b6","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/BF01811214","article-title":"Biomechanical activity of the growth plate.","volume":"6","author":"Bonnel","year":"1984","journal-title":"Clin. Anat."},{"issue":"6","key":"10.1016\/j.jmbbm.2021.104946_b7","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1097\/01241398-200111000-00023","article-title":"Growth plate forces in the adolescent human knee: A radiographic and mechanical study of epiphyseal staples","volume":"21","author":"Bylski-Austrow","year":"2001","journal-title":"J. Pediatr. Orthop."},{"issue":"3","key":"10.1016\/j.jmbbm.2021.104946_b8","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1080\/10255841003682505","article-title":"Mechanobiological prediction of proximal femoral deformities in children with cerebral palsy","volume":"14","author":"Carriero","year":"2011","journal-title":"Comput. Methods Biomech. Biomed. Eng."},{"key":"10.1016\/j.jmbbm.2021.104946_b9","series-title":"Mechanobiology of skele- tal development, aging and regeneration","isbn-type":"print","article-title":"Skeletal function and form","author":"Carter","year":"2001","ISBN":"https:\/\/id.crossref.org\/isbn\/9780521790000"},{"key":"10.1016\/j.jmbbm.2021.104946_b10","doi-asserted-by":"crossref","first-page":"5S","DOI":"10.1016\/8756-3282(95)00373-8","article-title":"Mechanical factors in bone growth and development","volume":"18","author":"Carter","year":"1996","journal-title":"Bone"},{"key":"10.1016\/j.jmbbm.2021.104946_b11","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1002\/jor.1100060604","article-title":"The role of mechanical loading histories in the development of diarthrodial joints","volume":"6","author":"Carter","year":"1988","journal-title":"J. Orthop. Res."},{"year":"2020","series-title":"Cast3M V20.0.1","author":"CEA","key":"10.1016\/j.jmbbm.2021.104946_b12"},{"key":"10.1016\/j.jmbbm.2021.104946_b13","doi-asserted-by":"crossref","DOI":"10.1080\/10255842.2018.1425997","article-title":"A novel adaptive algorithm for 3D finite element analysis to model extracortical bone growth","author":"Cheong","year":"2018","journal-title":"Comput. Methods Biomech. Biomed. Eng."},{"key":"10.1016\/j.jmbbm.2021.104946_b14","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.cma.2013.12.014","article-title":"Numerical stability and convergence analysis of bone remodeling model","volume":"271","author":"Garijo","year":"2014","journal-title":"Comput. Methods. Appl. Mech. Eng."},{"key":"10.1016\/j.jmbbm.2021.104946_b15","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/j.jbiomech.2014.01.002","article-title":"Mechanobiological simulations of prenatal joint morphogenesis","volume":"47","author":"Giorgi","year":"2014","journal-title":"J. Biomech."},{"key":"10.1016\/j.jmbbm.2021.104946_b16","doi-asserted-by":"crossref","first-page":"3390","DOI":"10.1016\/j.jbiomech.2015.06.002","article-title":"Effects of normal and abnormal loading conditions on morphogenesis of the prenatal hip joint: application to hip dysplasia","volume":"48","author":"Giorgi","year":"2015","journal-title":"J. Biomech."},{"key":"10.1016\/j.jmbbm.2021.104946_b17","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijsolstr.2016.04.036","article-title":"Combined bone internal and external remodeling based on eshelby stress","author":"Goda","year":"2016","journal-title":"Int. J. Solids Struct."},{"key":"10.1016\/j.jmbbm.2021.104946_b18","first-page":"191","article-title":"Connecting mechanics and bone cell activities in the bone remodeling process: an integrated finite element modeling","volume":"5","author":"Hambli","year":"2014","journal-title":"J. Arthroplast."},{"key":"10.1016\/j.jmbbm.2021.104946_b19","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1002\/jemt.1070280606","article-title":"Mechanism of longitudinal bone growth and its regulation by growth plate chondrocites","volume":"28","author":"Hunziker","year":"1994","journal-title":"Microsc. Res. Tech."},{"key":"10.1016\/j.jmbbm.2021.104946_b20","article-title":"Growth plate cartilage shows different strain patterns in response to static versus dynamic mechanical modulation","author":"Kaviani","year":"2015","journal-title":"Biomech. Model Mechanobiol."},{"key":"10.1016\/j.jmbbm.2021.104946_b21","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/s11517-008-0425-9","article-title":"Mechanobiological bone growth: comparative analysis of two biomechanical modelling approaches","volume":"47","author":"Lin","year":"2009","journal-title":"Med. Biol. Eng. Comput."},{"key":"10.1016\/j.jmbbm.2021.104946_b22","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1016\/j.matcom.2009.02.014","article-title":"Remodelling of livin bone induced by dynamic loading and drug delivery - numerical modelling and clinical treatment","volume":"80","author":"Marsik","year":"2010","journal-title":"Math. Comput. Simulation"},{"key":"10.1016\/j.jmbbm.2021.104946_b23","first-page":"179","article-title":"Porosity and specific surface of bone","author":"Martin","year":"1984","journal-title":"Crit. Revi. Biomed. Eng."},{"key":"10.1016\/j.jmbbm.2021.104946_b24","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/6271898","article-title":"A review of pediatric lower extremity data for pedestrian numerical modeling: Injury epidemiology, anatomy, anthropometry, structural, and mechanical properties","volume":"2018","author":"Meng","year":"2018","journal-title":"Appl. Bionics Biomech."},{"year":"1996","series-title":"Epigenetic Influences on Long Bone Growth, Development, and Evolution","author":"Mikic","key":"10.1016\/j.jmbbm.2021.104946_b25"},{"key":"10.1016\/j.jmbbm.2021.104946_b26","first-page":"552","article-title":"Altered hypertrophic chondrocyte kinetics in GDF-5 deficient murine tibial growth plate","volume":"22","author":"Mikic","year":"2004","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.jmbbm.2021.104946_b27","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0883-5403(08)80074-5","article-title":"Computer predictions of bone remodeling around porous-coated implants","volume":"5","author":"Orr","year":"1990","journal-title":"J. Arthroplast."},{"key":"10.1016\/j.jmbbm.2021.104946_b28","series-title":"Physeal Injury Other than Fracture","isbn-type":"print","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-642-22563-5","author":"Peterson","year":"2012","ISBN":"https:\/\/id.crossref.org\/isbn\/9783642225635"},{"key":"10.1016\/j.jmbbm.2021.104946_b29","doi-asserted-by":"crossref","unstructured":"Phillips, A., Villette, C., Modenese, L., 2015. Femoral bone mesoscale structural architecture prediction using musculoskeletal and finite element modelling, Vol.2, pp. 43\u201361.","DOI":"10.1080\/23335432.2015.1017609"},{"key":"10.1016\/j.jmbbm.2021.104946_b30","series-title":"Notions Fondamentales En Orthop\u00e9die, Vol. 28","first-page":"1","article-title":"Cartilage de conjugaison et croissance","author":"Pous","year":"1980"},{"issue":"11\u201312","key":"10.1016\/j.jmbbm.2021.104946_b31","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/0021-9290(87)90020-0","article-title":"The history of some fundamental concepts in bone biomechanics","volume":"20","author":"Roesler","year":"1987","journal-title":"J. Biomech."},{"key":"10.1016\/j.jmbbm.2021.104946_b32","series-title":"Limb Lenghthening and Reconstruction Surgery","isbn-type":"print","first-page":"1","author":"Rozbruch","year":"2007","ISBN":"https:\/\/id.crossref.org\/isbn\/9780849340512"},{"year":"2020","series-title":"Salome-mesh V9.2","author":"Salome","key":"10.1016\/j.jmbbm.2021.104946_b33"},{"issue":"11","key":"10.1016\/j.jmbbm.2021.104946_b34","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1016\/j.jbiomech.2010.04.003","article-title":"Muscle contributions to support and progression during single-limb stance in crouch gait","volume":"43","author":"Steele","year":"2010","journal-title":"J. Biomech."},{"key":"10.1016\/j.jmbbm.2021.104946_b35","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1002\/jor.1100170505","article-title":"Computer model of endochondral growth and ossification in long bones. biological and mechanobiological influences.","volume":"17","author":"Stevens","year":"1999","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.jmbbm.2021.104946_b36","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/0021-9290(90)90051-4","article-title":"Three-dimensional osseo-ligamentous model of the thorax representing initiation of scoliosis by assymetric growth","volume":"23","author":"Stokes","year":"1989","journal-title":"J. Biomech."},{"key":"10.1016\/j.jmbbm.2021.104946_b37","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1007\/s11517-007-0220-z","article-title":"Finite element modeling of the growth plate in a detailed spine model","volume":"45","author":"Sylvestre","year":"2007","journal-title":"Med. Biol. Eng. Comput."},{"issue":"5","key":"10.1016\/j.jmbbm.2021.104946_b38","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1007\/s10439-008-9462-7","article-title":"The effect of mechanical loading on the metabolism of growth plate chondrocytes","volume":"36","author":"Ueki","year":"2008","journal-title":"Ann. Biomed. Eng."},{"year":"2020","series-title":"Cal poly human motion biomechanics lab knee joint finite element model","author":"Wangerin","key":"10.1016\/j.jmbbm.2021.104946_b39"},{"key":"10.1016\/j.jmbbm.2021.104946_b40","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1016\/j.jbiomech.2004.06.029","article-title":"The application of topology optimization on the quantitative description of the external shape of bone structure","volume":"38","author":"Xinghua","year":"2005","journal-title":"J. Biomech."},{"key":"10.1016\/j.jmbbm.2021.104946_b41","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbiomech.2016.03.039","article-title":"Effect of growth plate geometry and growth direction on prediction of proximal femoral morphology.","author":"Yadav","year":"2016","journal-title":"J. Biomech."},{"year":"2000","series-title":"Mechanical Testing of Bone and the Bone Implant Interface","author":"Yuehuei","key":"10.1016\/j.jmbbm.2021.104946_b42"}],"container-title":["Journal of the Mechanical Behavior of Biomedical Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1751616121005774?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1751616121005774?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T22:51:55Z","timestamp":1761691915000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1751616121005774"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":42,"alternative-id":["S1751616121005774"],"URL":"https:\/\/doi.org\/10.1016\/j.jmbbm.2021.104946","relation":{},"ISSN":["1751-6161"],"issn-type":[{"type":"print","value":"1751-6161"}],"subject":[],"published":{"date-parts":[[2022,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A tool for solving bone growth related problems using finite elements adaptive meshes","name":"articletitle","label":"Article Title"},{"value":"Journal of the Mechanical Behavior of Biomedical Materials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jmbbm.2021.104946","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104946"}}