{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T19:29:59Z","timestamp":1784575799921,"version":"3.55.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["NORTE-01-0247-FEDER-034074"],"award-info":[{"award-number":["NORTE-01-0247-FEDER-034074"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["POCI-01-0145-FEDER-00694"],"award-info":[{"award-number":["POCI-01-0145-FEDER-00694"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UID\/EEA\/04436\/2019"],"award-info":[{"award-number":["UID\/EEA\/04436\/2019"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["PTDC\/CTM\/100120\/2008"],"award-info":[{"award-number":["PTDC\/CTM\/100120\/2008"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["SFRH\/BD\/112280\/2015"],"award-info":[{"award-number":["SFRH\/BD\/112280\/2015"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["FCT \/SFRH\/BD\/36220\/2007"],"award-info":[{"award-number":["FCT \/SFRH\/BD\/36220\/2007"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Mechanical Behavior of Biomedical Materials"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1016\/j.jmbbm.2021.105060","type":"journal-article","created":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T21:34:39Z","timestamp":1640295279000},"page":"105060","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Design and surface characterization of micropatterned silica coatings for zirconia dental implants"],"prefix":"10.1016","volume":"126","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6699-1626","authenticated-orcid":false,"given":"Andr\u00e9","family":"Moreira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Madeira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihaela","family":"Buciumeanu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joana","family":"Fialho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filipe","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando J.","family":"Monteiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o","family":"Caram\u00eas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jmbbm.2021.105060_bib1","first-page":"536","article-title":"Oral implant surfaces: part 1 - review focusing on topographic and chemical properties of different surfaces and in vivo responses to them","volume":"17","author":"Albrektsson","year":"2004","journal-title":"Int. J. Prosthod."},{"key":"10.1016\/j.jmbbm.2021.105060_bib2","first-page":"544","article-title":"Oral implant surfaces. Part II: review focusing on clinical knowledge of different surfaces","volume":"17","author":"Albrektsson","year":"2004","journal-title":"Int. J. Prosthodont. (IJP)"},{"key":"10.1016\/j.jmbbm.2021.105060_bib3","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1708-8208.1999.tb00087.x","article-title":"Astra Tech and Br\u00e5nemark System implants: a prospective 5-year comparative study. results after one year","volume":"1","author":"Astrand","year":"1999","journal-title":"Clin. Implant Dent. Relat. Res."},{"key":"10.1016\/j.jmbbm.2021.105060_bib4","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.pmatsci.2012.09.001","article-title":"Engineering biocompatible implant surfaces. Part I: materials and surfaces","volume":"58","author":"Bauer","year":"2013","journal-title":"Prog. Mater. Sci."},{"key":"10.1016\/j.jmbbm.2021.105060_bib5","first-page":"1","article-title":"Osseointegrated implants in the treatment ofs the edentulous jaw. Experience from a 10-year period","volume":"16","author":"Br\u00e5nemark","year":"1977","journal-title":"Scand. J. Plast. Reconstr. Surg. Suppl."},{"key":"10.1016\/j.jmbbm.2021.105060_bib6","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1016\/j.dental.2012.09.002","article-title":"Micropatterned silica thin films with nanohydroxyapatite micro-aggregates for guided tissue regeneration","volume":"28","author":"Carvalho","year":"2012","journal-title":"Dent. Mater."},{"key":"10.1016\/j.jmbbm.2021.105060_bib7","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1902\/jop.2011.100464","article-title":"A 5-year prospective multicenter clinical trial of non-submerged dental implants with a titanium plasma-sprayed surface in 200 patients","volume":"82","author":"Cochran","year":"2011","journal-title":"J. Periodontol."},{"key":"10.1016\/j.jmbbm.2021.105060_bib8","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1002\/jbm.b.31264","article-title":"Basic research methods and current trends of dental implant surfaces","volume":"88","author":"Coelho","year":"2009","journal-title":"J. Biomed. Mater. Res. B Appl. Biomater."},{"key":"10.1016\/j.jmbbm.2021.105060_bib9","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1002\/jbm.a.30789","article-title":"Increased osteoblast and decreased Staphylococcus epidermidis functions on nanophase ZnO and TiO2","volume":"78","author":"Colon","year":"2006","journal-title":"J. Biomed. Mater. Res."},{"key":"10.1016\/j.jmbbm.2021.105060_bib10","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.apsusc.2015.12.022","article-title":"Osseointegration properties of titanium dental implants modified with a nanostructured coating based on ordered porous silica and bioactive glass nanoparticles","volume":"363","author":"Covarrubias","year":"2016","journal-title":"Appl. Surf. Sci."},{"key":"10.1016\/j.jmbbm.2021.105060_bib11","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1016\/S0142-9612(97)00144-0","article-title":"Topographical control of cells","volume":"18","author":"Curtis","year":"1997","journal-title":"Biomaterials"},{"key":"10.1016\/j.jmbbm.2021.105060_bib12","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1007\/s11517-010-0619-9","article-title":"Microfabricated substrates as a tool to study cell mechanotransduction","volume":"48","author":"Digabel","year":"2010","journal-title":"Med. Biol. Eng. Comput."},{"key":"10.1016\/j.jmbbm.2021.105060_bib13","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1111\/clr.12718","article-title":"Metal elements in tissue with dental peri-implantitis: a pilot study","volume":"27","author":"Fretwurst","year":"2016","journal-title":"Clin. Oral Implants Res."},{"key":"10.1016\/j.jmbbm.2021.105060_bib14","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1111\/j.1600-0501.2007.01401.x","article-title":"Biomechanical and histomorphometric comparison between zirconia implants with varying surface textures and a titanium implant in the maxilla of miniature pigs","volume":"18","author":"Gahlert","year":"2007","journal-title":"Clin. Oral Implants Res."},{"key":"10.1016\/j.jmbbm.2021.105060_bib15","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1002\/1521-4095(200106)13:11<822::AID-ADMA822>3.0.CO;2-0","article-title":"Ordered mesoporous silica coatings that induce apatite formation in vitro","volume":"13","author":"Gomez-Vega","year":"2001","journal-title":"Adv Mater"},{"key":"10.1016\/j.jmbbm.2021.105060_bib16","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.jpor.2015.12.004","article-title":"Allergic contact dermatitis caused by titanium screws and dental implants","volume":"60","author":"Hosoki","year":"2016","journal-title":"J Prosthodont Res"},{"key":"10.1016\/j.jmbbm.2021.105060_bib17","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1002\/jbm.a.34673","article-title":"Synthesis of nanostructured porous silica coatings on titanium and their cell adhesive and osteogenic differentiation properties","volume":"102","author":"Inzunza","year":"2014","journal-title":"J. Biomed. Mater. Res."},{"key":"10.1016\/j.jmbbm.2021.105060_bib18","doi-asserted-by":"crossref","first-page":"4286","DOI":"10.1016\/j.biomaterials.2010.01.103","article-title":"The effect of micronscale anisotropic cross patterns on fibroblast migration","volume":"31","author":"Jeon","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.jmbbm.2021.105060_bib19","first-page":"1367","article-title":"The role of well-defined nanotopography of titanium implants on osseointegration: cellular and molecular events in vivo","volume":"11","author":"Karazisis","year":"2016","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.jmbbm.2021.105060_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1088\/1468-6996\/15\/2\/025001","article-title":"Modulation of human dermal microvascular endothelial cell and human gingival fibroblast behavior by micropatterned silica coating surfaces for zirconia dental implant applications","volume":"15","author":"Laranjeira","year":"2014","journal-title":"Sci. Technol. Adv. Mater."},{"key":"10.1016\/j.jmbbm.2021.105060_bib21","doi-asserted-by":"crossref","first-page":"15227","DOI":"10.1016\/j.ceramint.2017.08.058","article-title":"Effect of laser surface texturing on primary stability and surface properties of zirconia implants","volume":"43","author":"Moura","year":"2017","journal-title":"Ceram. Int."},{"key":"10.1016\/j.jmbbm.2021.105060_bib22","first-page":"299","article-title":"Zirconia as a dental implant abutment material: a systematic review","volume":"23","author":"Nakamura","year":"2010","journal-title":"Int. J. Prosthodont. (IJP)"},{"key":"10.1016\/j.jmbbm.2021.105060_bib23","doi-asserted-by":"crossref","first-page":"5230","DOI":"10.1016\/j.biomaterials.2012.03.079","article-title":"Engineering microscale topographies to control the cell-substrate interface","volume":"33","author":"Nikkhah","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.jmbbm.2021.105060_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jnoncrysol.2015.05.024","article-title":"Sol\u2013gel hybrid coatings with strontium-doped 45S5 glass particles for enhancing the performance of stainless steel implants: electrochemical, bioactive and in vivo response","volume":"425","author":"Omar","year":"2015","journal-title":"J. Non-Cryst. Solids"},{"key":"10.1016\/j.jmbbm.2021.105060_bib25","doi-asserted-by":"crossref","first-page":"4857","DOI":"10.1002\/adma.201002255","article-title":"The topographic effect of zinc oxide nanoflowers on osteoblast growth and osseointegration","volume":"22","author":"Park","year":"2010","journal-title":"Adv Mater"},{"key":"10.1016\/j.jmbbm.2021.105060_bib26","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1017\/S1431927610094158","article-title":"Early spreading and propagation of human bone marrow stem cells on isotropic and anisotropic topographies of silica thin films produced via microstamping","volume":"16","author":"Pelaez-Vargas","year":"2010","journal-title":"Microsc. Microanal."},{"key":"10.1016\/j.jmbbm.2021.105060_bib27","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.dental.2011.02.014","article-title":"Isotropic micropatterned silica coatings on zirconia induce guided cell growth for dental implants","volume":"27","author":"Pelaez-Vargas","year":"2011","journal-title":"Dent. Mater."},{"key":"10.1016\/j.jmbbm.2021.105060_bib28","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1002\/jbm.b.32879","article-title":"Effects of density of anisotropic microstamped silica thin films on guided bone tissue regeneration-in vitro study","volume":"101","author":"Pelaez-Vargas","year":"2013","journal-title":"J. Biomed. Mater. Res. B Appl. Biomater."},{"key":"10.1016\/j.jmbbm.2021.105060_bib29","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1002\/adma.200801864","article-title":"Microcontact printing: limitations and achievements","volume":"21","author":"Perl","year":"2009","journal-title":"Adv Mater"},{"key":"10.1016\/j.jmbbm.2021.105060_bib30","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1177\/0022034516664043","article-title":"Clinical outcomes of zirconia dental implants: a systematic review","volume":"96","author":"Pieralli","year":"2017","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.jmbbm.2021.105060_bib31","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/j.1600-0501.2012.02546.x","article-title":"A systematic review of the survival and complication rates of implant-supported fixed dental prostheses (FDPs) after a mean observation period of at least 5 years","volume":"6","author":"Pjetursson","year":"2012","journal-title":"Clin. Oral Implants Res."},{"key":"10.1016\/j.jmbbm.2021.105060_bib32","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/nprot.2009.234","article-title":"Soft lithography for micro and nanoscale patterning","volume":"5","author":"Qin","year":"2010","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.jmbbm.2021.105060_bib33","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1016\/j.actbio.2011.03.016","article-title":"Bioactive glass in tissue engineering","volume":"7","author":"Rahaman","year":"2011","journal-title":"Acta Biomater."},{"key":"10.1016\/j.jmbbm.2021.105060_bib34","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1039\/C8BM00021B","article-title":"A review of nanostructured surfaces and materials for dental implants: surface coating, patterning and functionalization for improved performance","volume":"6","author":"Rasouli","year":"2018","journal-title":"Biomater Sci"},{"key":"10.1016\/j.jmbbm.2021.105060_bib35","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1111\/j.1600-0501.2012.02524.x","article-title":"Long-term evaluation of Astra Tech and Branemark implants in patients treated with full-arch bridges: results after 12-15 years","volume":"24","author":"Ravald","year":"2013","journal-title":"Clin. Oral Implants Res."},{"key":"10.1016\/j.jmbbm.2021.105060_bib36","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1563\/AAID-JOI-D-10-00208","article-title":"An overview of immediate root analogue zirconia implants","volume":"39","author":"Regish","year":"2013","journal-title":"J. Oral Implantol."},{"key":"10.1016\/j.jmbbm.2021.105060_bib37","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1111\/j.1600-0765.1997.tb01399.x","article-title":"Underlying mechanisms at the bone-surface interface during regeneration","volume":"32","author":"Schwartz","year":"1997","journal-title":"J. Periodontal. Res."},{"key":"10.1016\/j.jmbbm.2021.105060_bib38","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.2106\/JBJS.G.00499","article-title":"Effect of micrometer-scale roughness of the surface of Ti6Al4V pedicle screws in vitro and in vivo","volume":"90","author":"Schwartz","year":"2008","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.jmbbm.2021.105060_bib39","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1708-8208.2005.tb00070.x","article-title":"Bone tissue responses to surface-modifed zirconia implants: a histomorphometric and removal torque study in the rabbit","volume":"7","author":"Sennerby","year":"2005","journal-title":"Clin. Implant Dent. Relat. Res."},{"key":"10.1016\/j.jmbbm.2021.105060_bib40","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1002\/adhm.201200353","article-title":"2D and 3D nanopatterning of titanium for enhancing osteoinduction of stem cells at implant surfaces","volume":"2","author":"Sj\u00f6str\u00f6m","year":"2013","journal-title":"Adv Healthc Mater"},{"key":"10.1016\/j.jmbbm.2021.105060_bib41","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1002\/jbm.b.20021","article-title":"Ber- nard JP . Etched implants: a comparative surface analysis of four implant systems","volume":"69","author":"Szmukler-Moncler","year":"2004","journal-title":"J. Biomed. Mater. Res. B Appl. Biomater."},{"key":"10.1016\/j.jmbbm.2021.105060_bib42","first-page":"7","article-title":"Nanosurface - the future of implants","volume":"8","author":"Thakral","year":"2014","journal-title":"J. Clin. Diagn. Res."},{"key":"10.1016\/j.jmbbm.2021.105060_bib43","doi-asserted-by":"crossref","first-page":"39","DOI":"10.11607\/prd.2663","article-title":"Discoloration of the peri-implant mucosa caused by zirconia and titanium implants","volume":"36","author":"Thoma","year":"2016","journal-title":"Int. J. Periodontics Restor. Dent."},{"key":"10.1016\/j.jmbbm.2021.105060_bib44","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1002\/bit.260430811","article-title":"Review: effects of substratum morphology on cell physiology","volume":"43","author":"Tomsia","year":"1994","journal-title":"Biotechnol. Bioeng."},{"key":"10.1016\/j.jmbbm.2021.105060_bib45","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1111\/j.1600-0501.2010.02082.x","article-title":"The effect of zirconia and titanium implant abutments on light reflection of the supporting soft tissues","volume":"22","author":"van Brakel","year":"2011","journal-title":"Clin. Oral Implants Res."},{"key":"10.1016\/j.jmbbm.2021.105060_bib46","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1111\/j.1600-0501.2009.01775.x","article-title":"Effects of titanium surface topography on bone integration: a systematic review","volume":"20","author":"Wennerberg","year":"2009","journal-title":"Clin. Oral Implants Res."}],"container-title":["Journal of the Mechanical Behavior of Biomedical Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1751616121006858?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1751616121006858?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T22:39:56Z","timestamp":1778625596000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1751616121006858"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":46,"alternative-id":["S1751616121006858"],"URL":"https:\/\/doi.org\/10.1016\/j.jmbbm.2021.105060","relation":{},"ISSN":["1751-6161"],"issn-type":[{"value":"1751-6161","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Design and surface characterization of micropatterned silica coatings for zirconia dental implants","name":"articletitle","label":"Article Title"},{"value":"Journal of the Mechanical Behavior of Biomedical Materials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jmbbm.2021.105060","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"105060"}}