{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T07:56:29Z","timestamp":1793174189235,"version":"4.5.0"},"reference-count":82,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001602","name":"Taighde \u00c9ireann \u2013 Research Ireland","doi-asserted-by":"publisher","award":["12\/RC\/2278_2"],"award-info":[{"award-number":["12\/RC\/2278_2"]}],"id":[{"id":"10.13039\/501100001602","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Mechanical Behavior of Biomedical Materials"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.jmbbm.2024.106787","type":"journal-article","created":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T21:53:11Z","timestamp":1730843591000},"page":"106787","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Tailoring the mechanical properties of macro-porous PVA hydrogels for biomedical applications"],"prefix":"10.1016","volume":"161","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3560-3034","authenticated-orcid":false,"given":"Shirsha","family":"Bose","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2210-0876","authenticated-orcid":false,"given":"Majid","family":"Akbarzadeh Khorshidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4141-1685","authenticated-orcid":false,"given":"Caitr\u00edona","family":"Lally","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jmbbm.2024.106787_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.eurpolymj.2021.110974","article-title":"Freeze\/thawed polyvinyl alcohol hydrogels: present, past and future","volume":"164","author":"Adelnia","year":"2022","journal-title":"Eur. Polym. J."},{"issue":"2","key":"10.1016\/j.jmbbm.2024.106787_bib2","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.jare.2013.07.006","article-title":"Hydrogel: preparation, characterization, and applications: a review","volume":"6","author":"Ahmed","year":"2015","journal-title":"J. Adv. Res."},{"issue":"1","key":"10.1016\/j.jmbbm.2024.106787_bib3","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1038\/s41598-018-36789-z","article-title":"3D printing of sacrificial templates into hierarchical porous materials","volume":"9","author":"Alison","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jmbbm.2024.106787_bib4","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.actbio.2016.03.008","article-title":"Fibrin hydrogels functionalized with cartilage extracellular matrix and incorporating freshly isolated stromal cells as an injectable for cartilage regeneration","volume":"36","author":"Almeida","year":"2016","journal-title":"Acta Biomater."},{"issue":"6","key":"10.1016\/j.jmbbm.2024.106787_bib5","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1089\/ten.teb.2014.0086","article-title":"Review of collagen I hydrogels for bioengineered tissue microenvironments: characterization of mechanics, structure, and transport","volume":"20","author":"Antoine","year":"2014","journal-title":"Tissue Eng. Part B Rev."},{"key":"10.1016\/j.jmbbm.2024.106787_bib6","doi-asserted-by":"crossref","unstructured":"B. M. Baker et al., \u201cThe potential to improve cell infiltration in composite fiber-aligned electrospun scaffolds by the selective removal of sacrificial fibers,\u201d Biomaterials, vol. 29, no. 15, pp. 2348\u20132358.","DOI":"10.1016\/j.biomaterials.2008.01.032"},{"key":"10.1016\/j.jmbbm.2024.106787_bib7","first-page":"29","article-title":"Design of a 3D printer head for additive manufacturing of sugar glass for tissue engineering applications","volume":"15","author":"B\u00e9gin-Drolet","year":"2017","journal-title":"Addit. Manuf."},{"key":"10.1016\/j.jmbbm.2024.106787_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmbbm.2020.103983","article-title":"Dry vs. wet: properties and performance of collagen films. Part I. mechanical behaviour and strain-rate effect","volume":"111","author":"Bose","year":"2020","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"10.1016\/j.jmbbm.2024.106787_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.polymdegradstab.2022.109853","article-title":"Stability and mechanical performance of collagen films under different environmental conditions","author":"Bose","year":"2022","journal-title":"Polym. Degrad. Stabil."},{"issue":"8","key":"10.1016\/j.jmbbm.2024.106787_bib10","doi-asserted-by":"crossref","first-page":"2753","DOI":"10.3390\/ma15082753","article-title":"Exploring the mechanical properties and performance of type-I collagen at various length scales: a progress report","volume":"15","author":"Bose","year":"2022","journal-title":"Materials"},{"issue":"3","key":"10.1016\/j.jmbbm.2024.106787_bib11","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1093\/sxmrev\/qead013","article-title":"The role of tissue biomechanics in the implantation and performance of inflatable penile prostheses: current state of the art and future perspective","volume":"11","author":"Bose","year":"2023","journal-title":"Sex. Med. Rev."},{"key":"10.1016\/j.jmbbm.2024.106787_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.actbio.2024.03.013","article-title":"Experimental testing combined with inverse-FE for mechanical characterisation of penile tissues","author":"Bose","year":"2024","journal-title":"Acta Biomater."},{"key":"10.1016\/j.jmbbm.2024.106787_bib13","doi-asserted-by":"crossref","unstructured":"A. C. Branco et al., \u201cPVA-based hydrogels loaded with diclofenac for cartilage replacement,\u201d Gels, vol. 8, no. 3, p. 143.","DOI":"10.3390\/gels8030143"},{"key":"10.1016\/j.jmbbm.2024.106787_bib14","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.jmbbm.2015.02.024","article-title":"Mechanical properties of gray and white matter brain tissue by indentation","volume":"46","author":"Budday","year":"2015","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"10.1016\/j.jmbbm.2024.106787_bib15","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.eurpolymj.2014.11.024","article-title":"Biomedical applications of hydrogels: a review of patents and commercial products","volume":"65","author":"Cal\u00f3","year":"2015","journal-title":"Eur. Polym. J."},{"issue":"5","key":"10.1016\/j.jmbbm.2024.106787_bib16","first-page":"1518","article-title":"Porous poly (vinyl alcohol)-based hydrogel for knee meniscus functional repair","volume":"4","author":"Coluccino","year":"2018","journal-title":"ACS Biomater. Sci. Eng."},{"issue":"21","key":"10.1016\/j.jmbbm.2024.106787_bib17","doi-asserted-by":"crossref","first-page":"2982","DOI":"10.1016\/j.ijsolstr.2010.07.001","article-title":"A micromechanical model for the Young's modulus of adipose tissue","volume":"47","author":"Comley","year":"2010","journal-title":"Int. J. Solid Struct."},{"key":"10.1016\/j.jmbbm.2024.106787_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmbbm.2021.104516","article-title":"Cryopreservation of porcine urethral tissue: storage at\u2212 20 C preserves the mechanical, failure and geometrical properties","volume":"119","author":"Cunnane","year":"2021","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"10.1016\/j.jmbbm.2024.106787_bib19","article-title":"Effect of pore size on the flexural strength of porous silicon carbide ceramics","volume":"17","author":"Das","year":"2024","journal-title":"Open Ceram"},{"issue":"24","key":"10.1016\/j.jmbbm.2024.106787_bib20","doi-asserted-by":"crossref","first-page":"12895","DOI":"10.1039\/C9CP01582E","article-title":"Micromechanical simulation of the pore size effect on the structural stability of brittle porous materials with bicontinuous morphology","volume":"21","author":"Deng","year":"2019","journal-title":"Phys. Chem. Chem. Phys."},{"key":"10.1016\/j.jmbbm.2024.106787_bib21","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.matdes.2016.09.063","article-title":"A composite hydrogel for brain tissue phantoms","volume":"112","author":"Forte","year":"2016","journal-title":"Mater. Des."},{"issue":"6","key":"10.1016\/j.jmbbm.2024.106787_bib22","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.1021\/acs.langmuir.2c02253","article-title":"Porous hydrogels: present challenges and future opportunities","volume":"39","author":"Foudazi","year":"2023","journal-title":"Langmuir"},{"issue":"9","key":"10.1016\/j.jmbbm.2024.106787_bib23","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.2217\/nnm.16.21","article-title":"Influence of porosity and pore shape on structural, mechanical and biological properties of poly \u03b5-caprolactone electro-spun fibrous scaffolds","volume":"11","author":"Fuller","year":"2016","journal-title":"Nanomedicine"},{"key":"10.1016\/j.jmbbm.2024.106787_bib24","series-title":"Mechanical Properties of Living Tissues","author":"Fung","year":"1981"},{"key":"10.1016\/j.jmbbm.2024.106787_bib25","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.polymertesting.2015.03.021","article-title":"Inelastic behaviour of bacterial cellulose hydrogel: in aqua cyclic tests","volume":"44","author":"Gao","year":"2015","journal-title":"Polym. Test."},{"issue":"3","key":"10.1016\/j.jmbbm.2024.106787_bib26","doi-asserted-by":"crossref","DOI":"10.1002\/mame.201700484","article-title":"Fabrication of 3D microfluidic channels and in\u2010channel features using 3D printed, water\u2010soluble sacrificial mold","volume":"303","author":"Goh","year":"2018","journal-title":"Macromol. Mater. Eng."},{"key":"10.1016\/j.jmbbm.2024.106787_bib27","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.jmbbm.2014.01.019","article-title":"Mechanical properties of polyvinylalcohol\/hydroxyapatite cryogel as potential artificial cartilage","volume":"34","author":"Gonzalez","year":"2014","journal-title":"J. Mech. Behav. Biomed. Mater."},{"issue":"9\u201310","key":"10.1016\/j.jmbbm.2024.106787_bib28","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1089\/ten.tea.2015.0576","article-title":"Gene delivery of TGF-\u03b23 and BMP2 in an MSC-laden alginate hydrogel for articular cartilage and endochondral bone tissue engineering","volume":"22","author":"Gonzalez-Fernandez","year":"2016","journal-title":"Tissue Eng. Part A"},{"issue":"5","key":"10.1016\/j.jmbbm.2024.106787_bib29","article-title":"Inverse finite element framework combining ultrasound imaging and inflation testing of PVA artery phantoms","author":"Guendouz","year":"2024","journal-title":"bioRxiv"},{"issue":"1","key":"10.1016\/j.jmbbm.2024.106787_bib30","doi-asserted-by":"crossref","DOI":"10.1088\/1748-6041\/7\/1\/015006","article-title":"A combined effect of freeze--thaw cycles and polymer concentration on the structure and mechanical properties of transparent PVA gels","volume":"7","author":"Gupta","year":"2012","journal-title":"Biomed. Mater."},{"issue":"1","key":"10.1016\/j.jmbbm.2024.106787_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/15476278.2015.1019687","article-title":"Tissue stiffness dictates development, homeostasis, and disease progression","volume":"11","author":"Handorf","year":"2015","journal-title":"Organogenesis"},{"key":"10.1016\/j.jmbbm.2024.106787_bib32","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.biomaterials.2018.04.026","article-title":"Investigating the interplay between substrate stiffness and ligand chemistry in directing mesenchymal stem cell differentiation within 3D macro-porous substrates","volume":"171","author":"Haugh","year":"2018","journal-title":"Biomaterials"},{"issue":"8","key":"10.1016\/j.jmbbm.2024.106787_bib33","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1016\/j.biomaterials.2005.08.035","article-title":"A comparison of micro CT with other techniques used in the characterization of scaffolds","volume":"27","author":"Ho","year":"2006","journal-title":"Biomaterials"},{"issue":"12","key":"10.1016\/j.jmbbm.2024.106787_bib34","doi-asserted-by":"crossref","first-page":"4716","DOI":"10.1016\/j.actbio.2010.06.025","article-title":"Mechanical evaluation of poly (vinyl alcohol)-based fibrous composites as biomaterials for meniscal tissue replacement","volume":"6","author":"Holloway","year":"2010","journal-title":"Acta Biomater."},{"issue":"3","key":"10.1016\/j.jmbbm.2024.106787_bib35","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1039\/C2SM26763B","article-title":"The role of crystallization and phase separation in the formation of physically cross-linked PVA hydrogels","volume":"9","author":"Holloway","year":"2013","journal-title":"Soft Matter"},{"issue":"15","key":"10.1016\/j.jmbbm.2024.106787_bib36","doi-asserted-by":"crossref","first-page":"2510","DOI":"10.3390\/polym13152510","article-title":"3D-printed gelatin methacrylate scaffolds with controlled architecture and stiffness modulate the fibroblast phenotype towards dermal regeneration","volume":"13","author":"Iba\u00f1ez","year":"2021","journal-title":"Polymers"},{"issue":"3","key":"10.1016\/j.jmbbm.2024.106787_bib37","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.jiec.2009.02.001","article-title":"Effects of gamma irradiation on the thermal and mechanical properties of chitosan\/PVA nanofibrous mats","volume":"15","author":"Jeun","year":"2009","journal-title":"J. Ind. Eng. Chem."},{"issue":"7","key":"10.1016\/j.jmbbm.2024.106787_bib38","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1016\/j.jmbbm.2011.04.005","article-title":"PVA hydrogel properties for biomedical application","volume":"4","author":"Jiang","year":"2011","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"10.1016\/j.jmbbm.2024.106787_bib39","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1007\/s10856-013-5121-0","article-title":"Property-based design: optimization and characterization of polyvinyl alcohol (PVA) hydrogel and PVA-matrix composite for artificial cornea","volume":"25","author":"Jiang","year":"2014","journal-title":"J. Mater. Sci. Mater. Med."},{"issue":"1","key":"10.1016\/j.jmbbm.2024.106787_bib40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.arabjc.2014.07.005","article-title":"Crosslinked poly (vinyl alcohol) hydrogels for wound dressing applications: a review of remarkably blended polymers","volume":"8","author":"Kamoun","year":"2015","journal-title":"Arab. J. Chem."},{"issue":"2","key":"10.1016\/j.jmbbm.2024.106787_bib41","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1002\/jbm.a.37455","article-title":"Effect of porosity on mechanical and biological properties of bioprinted scaffolds","volume":"111","author":"Khajehmohammadi","year":"2023","journal-title":"J. Biomed. Mater. Res., Part A"},{"key":"10.1016\/j.jmbbm.2024.106787_bib42","article-title":"Characterisation of human penile tissue properties using experimental testing combined with multi-target inverse Finite Element modelling","author":"Khorshidi","year":"2024","journal-title":"Acta Biomater."},{"key":"10.1016\/j.jmbbm.2024.106787_bib43","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.biomaterials.2014.11.017","article-title":"Creating stiffness gradient polyvinyl alcohol hydrogel using a simple gradual freezing\u2013thawing method to investigate stem cell differentiation behaviors","volume":"40","author":"Kim","year":"2015","journal-title":"Biomaterials"},{"issue":"38","key":"10.1016\/j.jmbbm.2024.106787_bib44","doi-asserted-by":"crossref","first-page":"25096","DOI":"10.1021\/acsami.6b07725","article-title":"A versatile method for fabricating tissue engineering scaffolds with a three-dimensional channel for prevasculature networks","volume":"8","author":"Li","year":"2016","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"10","key":"10.1016\/j.jmbbm.2024.106787_bib45","first-page":"3396","article-title":"3D printed silk-gelatin hydrogel scaffold with different porous structure and cell seeding strategy for cartilage regeneration","volume":"6","author":"Li","year":"2021","journal-title":"Bioact. Mater."},{"issue":"12","key":"10.1016\/j.jmbbm.2024.106787_bib46","doi-asserted-by":"crossref","first-page":"4334","DOI":"10.1016\/j.actbio.2012.07.007","article-title":"Microbubbles as biocompatible porogens for hydrogel scaffolds","volume":"8","author":"Lima","year":"2012","journal-title":"Acta Biomater."},{"issue":"1","key":"10.1016\/j.jmbbm.2024.106787_bib47","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.foodhyd.2012.03.007","article-title":"Influences of degree of hydrolysis and molecular weight of poly (vinyl alcohol)(PVA) on properties of fish myofibrillar protein\/PVA blend films","volume":"29","author":"Limpan","year":"2012","journal-title":"Food Hydrocolloids"},{"issue":"6","key":"10.1016\/j.jmbbm.2024.106787_bib48","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1016\/j.msec.2012.04.030","article-title":"Development and characterization of poly (vinyl alcohol) based hydrogels for potential use as an articular cartilage replacement","volume":"32","author":"Maiolo","year":"2012","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.jmbbm.2024.106787_bib49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejmp.2019.11.012","article-title":"Polyvinyl alcohol cryogel based vessel mimicking material for modelling the progression of atherosclerosis","volume":"69","author":"Malone","year":"2020","journal-title":"Phys. Med."},{"key":"10.1016\/j.jmbbm.2024.106787_bib50","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.actbio.2016.08.055","article-title":"Sample, testing and analysis variables affecting liver mechanical properties: a review","volume":"45","author":"Mattei","year":"2016","journal-title":"Acta Biomater."},{"key":"10.1016\/j.jmbbm.2024.106787_bib51","doi-asserted-by":"crossref","first-page":"9167","DOI":"10.1007\/s11356-019-07296-z","article-title":"Rapid immobilization of viable Bacillus pseudomycoides in polyvinyl alcohol\/glutaraldehyde hydrogel for biological treatment of municipal wastewater","volume":"27","author":"Mehrotra","year":"2020","journal-title":"Environ. Sci. Pollut. Res."},{"issue":"1","key":"10.1016\/j.jmbbm.2024.106787_bib52","doi-asserted-by":"crossref","first-page":"2","DOI":"10.3390\/jfb13010002","article-title":"Properties and applications of PDMS for biomedical engineering: a review","volume":"13","author":"Miranda","year":"2021","journal-title":"J. Funct. Biomater."},{"key":"10.1016\/j.jmbbm.2024.106787_bib53","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.jmbbm.2016.12.014","article-title":"Formation of porous HPCL\/LPCL\/HA scaffolds with supercritical CO2 gas foaming method","volume":"69","author":"Moghadam","year":"2017","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"10.1016\/j.jmbbm.2024.106787_bib54","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.msec.2015.06.002","article-title":"Fabrication of scalable and structured tissue engineering scaffolds using water dissolvable sacrificial 3D printed moulds","volume":"55","author":"Mohanty","year":"2015","journal-title":"Mater. Sci. Eng. C"},{"issue":"3","key":"10.1016\/j.jmbbm.2024.106787_bib55","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1039\/C7MH00084G","article-title":"Porous polymeric materials by 3D printing of photocurable resin","volume":"4","author":"Mu","year":"2017","journal-title":"Mater. Horiz."},{"issue":"1","key":"10.1016\/j.jmbbm.2024.106787_bib56","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1002\/jbm.a.35567","article-title":"Effect of collagen\u2010glycosaminoglycan scaffold pore size on matrix mineralization and cellular behavior in different cell types","volume":"104","author":"Murphy","year":"2016","journal-title":"J. Biomed. Mater. Res., Part A"},{"key":"10.1016\/j.jmbbm.2024.106787_bib57","doi-asserted-by":"crossref","unstructured":"S. Nagarajan et al., \u201cSacrificial mold-assisted 3D printing of stable biocompatible gelatin scaffolds,\u201d Bioprinting, vol. 22, p. 00140.","DOI":"10.1016\/j.bprint.2021.e00140"},{"issue":"9","key":"10.1016\/j.jmbbm.2024.106787_bib58","doi-asserted-by":"crossref","first-page":"3294","DOI":"10.1016\/j.actbio.2012.05.019","article-title":"Functional porous hydrogels to study angiogenesis under the effect of controlled release of vascular endothelial growth factor","volume":"8","author":"Oliviero","year":"2012","journal-title":"Acta Biomater."},{"issue":"1","key":"10.1016\/j.jmbbm.2024.106787_bib59","article-title":"An injectable and 3D printable pro-chondrogenic hyaluronic acid and collagen type II composite hydrogel for the repair of articular cartilage defects","volume":"16","author":"O'Shea","year":"2023","journal-title":"Biofabrication"},{"key":"10.1016\/j.jmbbm.2024.106787_bib60","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.matdes.2016.03.156","article-title":"Preparation of highly porous interconnected poly (lactic acid) scaffolds based on a novel dynamic elongational flow procedure","volume":"101","author":"Peng","year":"2016","journal-title":"Mater. Des."},{"issue":"10","key":"10.1016\/j.jmbbm.2024.106787_bib61","doi-asserted-by":"crossref","first-page":"640","DOI":"10.3390\/gels8100640","article-title":"Effects of non-conventional sterilisation methods on PBO-reinforced PVA hydrogels for cartilage replacement","volume":"8","author":"Pires","year":"2022","journal-title":"Gels"},{"key":"10.1016\/j.jmbbm.2024.106787_bib62","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.actbio.2019.01.023","article-title":"Tensile behavior and structural characterization of pig dermis","volume":"86","author":"Pissarenko","year":"2019","journal-title":"Acta Biomater."},{"key":"10.1016\/j.jmbbm.2024.106787_bib63","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1007\/s10237-016-0763-8","article-title":"Biomechanical properties of breast tissue, a state-of-the-art review","volume":"15","author":"Ramiao","year":"2016","journal-title":"Biomech. Model. Mechanobiol."},{"issue":"13","key":"10.1016\/j.jmbbm.2024.106787_bib64","doi-asserted-by":"crossref","first-page":"4703","DOI":"10.1016\/j.polymer.2006.04.029","article-title":"Preparation of interconnected poly (\u03b5-caprolactone) porous scaffolds by a combination of polymer and salt particulate leaching","volume":"47","author":"Reignier","year":"2006","journal-title":"Polymer"},{"issue":"5","key":"10.1016\/j.jmbbm.2024.106787_bib65","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1021\/ma035663q","article-title":"X-ray diffraction analysis of poly (vinyl alcohol) hydrogels, obtained by freezing and thawing techniques","volume":"37","author":"Ricciardi","year":"2004","journal-title":"Macromolecules"},{"issue":"1","key":"10.1016\/j.jmbbm.2024.106787_bib66","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1002\/app.27116","article-title":"Mechanical properties and porosity of polylactide for biomedical applications","volume":"107","author":"Sawalha","year":"2008","journal-title":"J. Appl. Polym. Sci."},{"issue":"18","key":"10.1016\/j.jmbbm.2024.106787_bib67","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202100644","article-title":"3D printing of microgel scaffolds with tunable void fraction to promote cell infiltration","volume":"10","author":"Seymour","year":"2021","journal-title":"Adv. Healthcare Mater."},{"issue":"1","key":"10.1016\/j.jmbbm.2024.106787_bib68","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1002\/app.31136","article-title":"In vitro degradation of starch\/PVA films and biocompatibility evaluation","volume":"115","author":"Shi","year":"2010","journal-title":"J. Appl. Polym. Sci."},{"key":"10.1016\/j.jmbbm.2024.106787_bib69","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.jmbbm.2017.05.039","article-title":"Measured pulmonary arterial tissue stiffness is highly sensitive to AFM indenter dimensions","volume":"74","author":"Sicard","year":"2017","journal-title":"J. Mech. Behav. Biomed. Mater."},{"issue":"6","key":"10.1016\/j.jmbbm.2024.106787_bib70","doi-asserted-by":"crossref","DOI":"10.1088\/1748-605X\/ac2b7a","article-title":"Mechanical properties of whole-body soft human tissues: a review","volume":"16","author":"Singh","year":"2021","journal-title":"Biomed. Mater."},{"issue":"18","key":"10.1016\/j.jmbbm.2024.106787_bib71","doi-asserted-by":"crossref","first-page":"3932","DOI":"10.1016\/0032-3861(92)90385-A","article-title":"Poly (vinyl alcohol) hydrogels prepared by freezing-thawing cyclic processing","volume":"33","author":"Stauffer","year":"1992","journal-title":"Polymer"},{"issue":"7","key":"10.1016\/j.jmbbm.2024.106787_bib72","doi-asserted-by":"crossref","first-page":"8402","DOI":"10.1016\/j.ceramint.2015.03.037","article-title":"Preparation of finely macroporous SiOC foams with high mechanical properties and with hierarchical porosity via pyrolysis of a siloxane\/epoxide composite","volume":"41","author":"Strachota","year":"2015","journal-title":"Ceram. Int."},{"key":"10.1016\/j.jmbbm.2024.106787_bib73","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.msec.2018.07.016","article-title":"Interpenetrating polymer network hydrogels composed of chitosan and photocrosslinkable gelatin with enhanced mechanical properties for tissue engineering","volume":"92","author":"Suo","year":"2018","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.jmbbm.2024.106787_bib74","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.msec.2017.03.249","article-title":"The effect of pore size and porosity on mechanical properties and biological response of porous titanium scaffolds","volume":"77","author":"Torres-Sanchez","year":"2017","journal-title":"Mater. Sci. Eng. C"},{"issue":"1","key":"10.1016\/j.jmbbm.2024.106787_bib75","first-page":"39","article-title":"Hydrogel as a bioactive material to regulate stem cell fate","volume":"1","author":"Tsou","year":"2016","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.jmbbm.2024.106787_bib76","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.actbio.2017.07.028","article-title":"Manufacturing of hydrogel biomaterials with controlled mechanical properties for tissue engineering applications","volume":"62","author":"Vedadghavami","year":"2017","journal-title":"Acta Biomater."},{"key":"10.1016\/j.jmbbm.2024.106787_bib77","doi-asserted-by":"crossref","DOI":"10.1088\/2053-1591\/acb98e","article-title":"Freeze\u2013thaw hydrogel fabrication method: basic principles, synthesis parameters, properties, and biomedical applications","author":"Waresindo","year":"2023","journal-title":"Mater. Res. Express"},{"issue":"4","key":"10.1016\/j.jmbbm.2024.106787_bib78","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1021\/acsapm.9b00118","article-title":"Reprocessable 3D-printed conductive elastomeric composite foams for strain and gas sensing","volume":"1","author":"Wei","year":"2019","journal-title":"ACS Appl. Polym. Mater."},{"issue":"18","key":"10.1016\/j.jmbbm.2024.106787_bib79","doi-asserted-by":"crossref","first-page":"4149","DOI":"10.1016\/j.biomaterials.2003.10.056","article-title":"Design of porous scaffolds for cartilage tissue engineering using a three-dimensional fiber-deposition technique","volume":"25","author":"Woodfield","year":"2004","journal-title":"Biomaterials"},{"key":"10.1016\/j.jmbbm.2024.106787_bib80","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmbbm.2022.105496","article-title":"Study on swelling, compression property and degradation stability of PVA composite hydrogels for artificial nucleus pulposus","volume":"136","author":"Xiang","year":"2022","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"10.1016\/j.jmbbm.2024.106787_bib81","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s12649-017-0051-6","article-title":"Biodegradable sheets of starch\/polyvinyl alcohol (PVA): effects of PVA molecular weight and hydrolysis degree","volume":"10","author":"Zanela","year":"2019","journal-title":"Waste and Biomass Valorization"},{"key":"10.1016\/j.jmbbm.2024.106787_bib82","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1007\/s10965-009-9362-z","article-title":"Crosslinking reaction of poly (vinyl alcohol) with glyoxal","volume":"17","author":"Zhang","year":"2010","journal-title":"J. Polym. Res."}],"container-title":["Journal of the Mechanical Behavior of Biomedical Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1751616124004193?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1751616124004193?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T23:25:05Z","timestamp":1762557905000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1751616124004193"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":82,"alternative-id":["S1751616124004193"],"URL":"https:\/\/doi.org\/10.1016\/j.jmbbm.2024.106787","relation":{},"ISSN":["1751-6161"],"issn-type":[{"value":"1751-6161","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tailoring the mechanical properties of macro-porous PVA hydrogels for biomedical applications","name":"articletitle","label":"Article Title"},{"value":"Journal of the Mechanical Behavior of Biomedical Materials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jmbbm.2024.106787","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"106787"}}