{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T05:47:47Z","timestamp":1784008067129,"version":"3.55.0"},"reference-count":216,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T00:00:00Z","timestamp":1751241600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Molecular and Cellular Cardiology Plus"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.jmccpl.2025.100474","type":"journal-article","created":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T22:47:53Z","timestamp":1751582873000},"page":"100474","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Cardiology's best friend: Using naturally occurring disease in dogs to understand heart disease in humans"],"prefix":"10.1016","volume":"13","author":[{"given":"W. Glen","family":"Pyle","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jmccpl.2025.100474_bb0005","series-title":"Handbook of cardiac anatomy, physiology, and devices","first-page":"87","article-title":"Comparative cardiac anatomy","author":"Hill","year":"2009"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.vascn.2023.107278","article-title":"Assessment of sarcomere shortening and calcium transient in primary human and dog ventricular myocytes","volume":"123","author":"Gao","year":"2023","journal-title":"J Pharmacol Toxicol Methods"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0015","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.3390\/ph17081091","article-title":"A comparative study of the rapid (IKr) and slow (IKs) delayed rectifier potassium currents in undiseased human, dog, rabbit, and guinea pig cardiac ventricular preparations","volume":"17","author":"\u00c1goston","year":"2024","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0020","doi-asserted-by":"crossref","first-page":"748","DOI":"10.3390\/ph14080748","article-title":"Canine myocytes represent a good model for human ventricular cells regarding their electrophysiological properties","volume":"14","author":"N\u00e1n\u00e1si","year":"2021","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0025","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.jvc.2017.10.004","article-title":"Comparative anatomy and angiography of the cardiac coronary venous system in four species: human, ovine, porcine, and canine","volume":"20","author":"Genain","year":"2018","journal-title":"J Vet Cardiol"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0030","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.pharmthera.2006.08.006","article-title":"Animal models of ventricular arrhythmias","volume":"113","author":"Hamlin","year":"2007","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0035","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2019.00117","article-title":"Large animal models of heart failure with reduced ejection fraction (HFrEF)","volume":"6","author":"Spannbauer","year":"2019","journal-title":"Front Cardiovasc Med"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0040","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1007\/s00335-022-09965-w","article-title":"Dog models of human atherosclerotic cardiovascular diseases","volume":"34","author":"Zhao","year":"2023","journal-title":"Mamm Genome"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0045","doi-asserted-by":"crossref","first-page":"371","DOI":"10.3390\/biom15030371","article-title":"Stem cell therapies in canine cardiology: comparative efficacy, emerging trends, and clinical integration","volume":"15","author":"Farag","year":"2025","journal-title":"Biomolecules"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0050","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1161\/CIRCRESAHA.122.320496","article-title":"CRISPR modeling and correction of cardiovascular disease","volume":"130","author":"Liu","year":"2022","journal-title":"Circ Res"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0055","first-page":"1225","article-title":"Idiopathic cardiomyopathy in the dog","volume":"156","author":"Ettinger","year":"1970","journal-title":"J Am Vet Med Assoc"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0060","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1111\/j.1749-6632.1965.tb49422.x","article-title":"Cardiovascular lesions in dogs","volume":"127","author":"Luginb\u00fchl","year":"1965","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0065","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.jvc.2017.08.006","article-title":"European Society of Veterinary Cardiology screening guidelines for dilated cardiomyopathy in Doberman pinschers","volume":"19","author":"Wess","year":"2017","journal-title":"J Vet Cardiol"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0070","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/0735-1097(90)90480-D","article-title":"Naturally occurring cardiomyopathy in the Doberman pinscher: a possible large animal model of human cardiomyopathy?","volume":"16","author":"Smucker","year":"1990","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0075","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/s41569-024-01074-2","article-title":"Pathophysiology of dilated cardiomyopathy: from mechanisms to precision medicine","volume":"22","author":"Gigli","year":"2025","journal-title":"Nat Rev Cardiol"},{"issue":"2023","key":"10.1016\/j.jmccpl.2025.100474_bb0080","doi-asserted-by":"crossref","first-page":"3503","DOI":"10.1093\/eurheartj\/ehad194","article-title":"ESC guidelines for the management of cardiomyopathies","volume":"44","author":"Arbelo","year":"2023","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0085","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1001\/jama.2021.24674","article-title":"Prevalence and cumulative risk of familial idiopathic dilated cardiomyopathy","volume":"327","author":"Huggins","year":"2022","journal-title":"JAMA"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0090","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1038\/s41569-019-0284-0","article-title":"Genetics of dilated cardiomyopathy: practical implications for heart failure management","volume":"17","author":"Rosenbaum","year":"2020","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.shj.2023.100200","article-title":"The genetic evaluation of dilated cardiomyopathy","volume":"7","author":"Bui","year":"2023","journal-title":"Structural Heart"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0100","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1111\/j.1939-1676.2007.tb03058.x","article-title":"A prospective genetic evaluation of familial dilated cardiomyopathy in the Doberman pinscher","volume":"21","author":"Meurs","year":"2007","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0105","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1097\/HCO.0000000000000512","article-title":"Genetic cardiomyopathies","volume":"33","author":"Wilcox","year":"2018","journal-title":"Curr Opin Cardiol"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0110","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s13073-023-01221-3","article-title":"Identification of novel genetic risk factors of dilated cardiomyopathy: from canine to human","volume":"15","author":"Niskanen","year":"2023","journal-title":"Genome Med"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0115","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1016\/j.cvsm.2023.05.016","article-title":"The role of personalized medicine in companion animal cardiology","volume":"53","author":"Rivas","year":"2023","journal-title":"Veterinary Clinics of North America: Small Animal Practice"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0120","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/j.cvsm.2004.05.009","article-title":"Dilated cardiomyopathy: an update","volume":"34","author":"O\u2019Grady","year":"2004","journal-title":"Vet Clin North Am Small Anim Pract"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0125","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1053\/tvjl.2001.0571","article-title":"Canine idiopathic dilated cardiomyopathy. Part I: aetiology, clinical characteristics, epidemiology and pathology","volume":"162","author":"Tidholm","year":"2001","journal-title":"Veterinary Journal"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0130","doi-asserted-by":"crossref","unstructured":"A.C. Vollmar, The prevalence of cardiomyopathy in the Irish wolfhound: a clinical study of 500 dogs., J Am Anim Hosp Assoc 36 (n.d.) 125\u201332. doi:https:\/\/doi.org\/10.5326\/15473317-36-2-125.","DOI":"10.5326\/15473317-36-2-125"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0135","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.842","article-title":"A predictive model for canine dilated cardiomyopathy-a meta-analysis of Doberman pinscher data","volume":"3","author":"Simpson","year":"2015","journal-title":"PeerJ"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0140","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.jvc.2021.05.003","article-title":"A review of the underlying genetics and emerging therapies for canine cardiomyopathies","volume":"40","author":"Shen","year":"2022","journal-title":"J Vet Cardiol"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0145","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1111\/j.1939-1676.1997.tb00474.x","article-title":"Signalment, survival, and prognostic factors in Doberman pinschers with end-stage cardiomyopathy","volume":"11","author":"Calvert","year":"1997","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0150","first-page":"205","article-title":"A retrospective study of heart disease in doberman pinscher dogs","volume":"24","author":"Hazlett","year":"1983","journal-title":"Can Vet J"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0155","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1111\/j.1939-1676.2010.0479.x","article-title":"Prevalence of dilated cardiomyopathy in Doberman pinschers in various age groups","volume":"24","author":"Wess","year":"2010","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0160","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1354\/vp.42-1-1","article-title":"Histologic characterization of canine dilated cardiomyopathy","volume":"42","author":"Tidholm","year":"2005","journal-title":"Vet Pathol"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0165","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1111\/j.1939-1676.2012.01026.x","article-title":"Efficacy of pimobendan in the prevention of congestive heart failure or sudden death in Doberman pinschers with preclinical dilated cardiomyopathy (the PROTECT study)","volume":"26","author":"Summerfield","year":"2012","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0170","doi-asserted-by":"crossref","first-page":"293","DOI":"10.2460\/javma.1986.189.03.293","article-title":"Use of M-mode echocardiography in the diagnosis of congestive cardiomyopathy in Doberman pinschers","volume":"189","author":"Calvert","year":"1986","journal-title":"J Am Vet Med Assoc"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0175","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1111\/j.1939-1676.2012.1000.x","article-title":"Prospective evaluation of NT-proBNP assay to detect occult dilated cardiomyopathy and predict survival in Doberman pinschers","volume":"26","author":"Singletary","year":"2012","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0180","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1111\/jvim.13941","article-title":"Predictors of sudden cardiac death in Doberman pinschers with dilated cardiomyopathy","volume":"30","author":"Kl\u00fcser","year":"2016","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0185","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1093\/eurheartj\/ehz553","article-title":"What causes sudden death in patients with chronic heart failure and a reduced ejection fraction?","volume":"41","author":"Packer","year":"2020","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0190","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jvc.2021.09.004","article-title":"Screening for dilated cardiomyopathy in dogs","volume":"40","author":"Wess","year":"2022","journal-title":"J Vet Cardiol"},{"issue":"2022","key":"10.1016\/j.jmccpl.2025.100474_bb0195","doi-asserted-by":"crossref","first-page":"e263","DOI":"10.1016\/j.jacc.2021.12.012","article-title":"AHA\/ACC\/HFSA guideline for the management of heart failure","volume":"79","author":"Heidenreich","year":"2022","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0200","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1161\/01.CIR.65.2.384","article-title":"Right ventricular dysplasia: a report of 24 adult cases","volume":"65","author":"Marcus","year":"1982","journal-title":"Circulation"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0205","series-title":"Current veterinary therapy VIII: Small animal practice","first-page":"329","article-title":"Boxer cardiomyopathy","author":"Harpster","year":"1983"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0210","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1093\/eurheartj\/ehu493","article-title":"The research venture in arrhythmogenic right ventricular cardiomyopathy: a paradigm of translational medicine","volume":"36","author":"Thiene","year":"2015","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0215","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1016\/j.jacc.2013.01.073","article-title":"Genetics of arrhythmogenic right ventricular cardiomyopathy: a practical guide for physicians","volume":"61","author":"Marcus","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0220","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1161\/01.CIR.0000118494.07530.65","article-title":"Arrhythmogenic right ventricular cardiomyopathy causing sudden cardiac death in boxer dogs","volume":"109","author":"Basso","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0225","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.121.021987","article-title":"Evolving diagnostic criteria for arrhythmogenic cardiomyopathy","volume":"10","author":"Corrado","year":"2021","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0230","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.jvc.2021.07.001","article-title":"Arrhythmogenic right ventricular cardiomyopathy in dogs","volume":"40","author":"Cunningham","year":"2022","journal-title":"J Vet Cardiol"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0235","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.jacep.2021.12.002","article-title":"Arrhythmogenic right ventricular cardiomyopathy","volume":"8","author":"Krahn","year":"2022","journal-title":"JACC Clin Electrophysiol"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0240","doi-asserted-by":"crossref","first-page":"95","DOI":"10.5326\/JAAHA-MS-6550","article-title":"Clinical features of English bulldogs with presumed arrhythmogenic right ventricular cardiomyopathy: 31 cases (2001\u22122013)","volume":"54","author":"Cunningham","year":"2018","journal-title":"J Am Anim Hosp Assoc"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0245","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1056\/NEJMra1509267","article-title":"Arrhythmogenic right ventricular cardiomyopathy","volume":"376","author":"Corrado","year":"2017","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0250","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/j.1939-1676.2008.0266.x","article-title":"Magnetic resonance imaging of right ventricular morphology and function in boxer dogs with arrhythmogenic right ventricular cardiomyopathy","volume":"23","author":"Baumwart","year":"2009","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0255","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1111\/jvim.12385","article-title":"Natural history of arrhythmogenic right ventricular cardiomyopathy in the boxer dog: a prospective study","volume":"28","author":"Meurs","year":"2014","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0260","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S1760-2734(06)70043-1","article-title":"Arrhythmogenic right ventricular cardiomyopathy (ARVC) in a boxer","volume":"5","author":"Boujon","year":"2003","journal-title":"J Vet Cardiol"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0265","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.repc.2020.10.011","article-title":"Current status of the treatment of degenerative mitral valve regurgitation","volume":"40","author":"Coutinho","year":"2021","journal-title":"Rev Port Cardiol"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0270","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1111\/jvim.15488","article-title":"ACVIM consensus guidelines for the diagnosis and treatment of myxomatous mitral valve disease in dogs","volume":"33","author":"Keene","year":"2019","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0275","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1136\/heartjnl-2017-312420","article-title":"Genetics of syndromic and non-syndromic mitral valve prolapse","volume":"104","author":"Le Tourneau","year":"2018","journal-title":"Heart"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0280","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/S0140-6736(06)69208-8","article-title":"Burden of valvular heart diseases: a population-based study","volume":"368","author":"Nkomo","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0285","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.jvc.2012.01.006","article-title":"Myxomatous mitral valve disease in dogs: does size matter?","volume":"14","author":"Parker","year":"2012","journal-title":"J Vet Cardiol"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0290","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.2460\/javma.20.05.0291","article-title":"Myxomatous mitral valve disease in miniature schnauzers and Yorkshire terriers: 134 cases (2007\u20132016)","volume":"259","author":"DeProspero","year":"2021","journal-title":"J Am Vet Med Assoc"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0295","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S1760-2734(06)70055-8","article-title":"Comparison of primary mitral valve disease in German Shepherd dogs and in small breeds","volume":"6","author":"Borgarelli","year":"2004","journal-title":"J Vet Cardiol"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0300","doi-asserted-by":"crossref","DOI":"10.1016\/j.carpath.2019.107196","article-title":"Comparative pathology of human and canine myxomatous mitral valve degeneration: 5HT and TGF-\u03b2 mechanisms","volume":"46","author":"Oyama","year":"2020","journal-title":"Cardiovasc Pathol"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0305","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2022.872288","article-title":"The role of transforming growth factor-\u03b2 signaling in myxomatous mitral valve degeneration","volume":"9","author":"Tang","year":"2022","journal-title":"Front Cardiovasc Med"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0310","first-page":"34","article-title":"Comparative transcriptomic profiling and gene expression for myxomatous mitral valve disease in the dog and human","volume":"4","author":"Markby","year":"2017","journal-title":"Vet Sci"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0315","doi-asserted-by":"crossref","first-page":"e579","DOI":"10.1161\/CIR.0000000000000455","article-title":"Current diagnostic and treatment strategies for specific dilated cardiomyopathies: a scientific statement from the American Heart Association","volume":"134","author":"Bozkurt","year":"2016","journal-title":"Circulation"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0320","article-title":"Corrigendum to: review of canine dilated cardiomyopathy in the wake of diet-associated concerns","volume":"98","author":"McCauley","year":"2020","journal-title":"J Anim Sci"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0325","doi-asserted-by":"crossref","first-page":"e505","DOI":"10.7861\/clinmed.2021-0121","article-title":"Acute myocarditis: aetiology, diagnosis and management","volume":"21","author":"Lampejo","year":"2021","journal-title":"Clin Med"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0330","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1177\/0300985819839241","article-title":"The causes of canine myocarditis and myocardial fibrosis are elusive by targeted molecular testing: retrospective analysis and literature review","volume":"56","author":"Molesan","year":"2019","journal-title":"Vet Pathol"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0335","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.120.007405","article-title":"Management of acute myocarditis and chronic inflammatory cardiomyopathy","volume":"13","author":"Ammirati","year":"2020","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0340","doi-asserted-by":"crossref","DOI":"10.3389\/fviro.2024.1304779","article-title":"Analysis of Parvovirus B19 persistence and reactivation in human heart layers","volume":"4","author":"Badrinath","year":"2024","journal-title":"Frontiers in Virology"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0345","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/s41569-020-00435-x","article-title":"Myocarditis and inflammatory cardiomyopathy: current evidence and future directions","volume":"18","author":"Tsch\u00f6pe","year":"2021","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0350","doi-asserted-by":"crossref","DOI":"10.1080\/21505594.2023.2180951","article-title":"Immune mechanisms of group B coxsackievirus induced viral myocarditis","volume":"14","author":"Zhang","year":"2023","journal-title":"Virulence"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0355","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.jvc.2024.02.008","article-title":"Gene-expression profiling of endomyocardial biopsies from dogs with dilated cardiomyopathy phenotype","volume":"52","author":"Di Loria","year":"2024","journal-title":"J Vet Cardiol"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0360","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1161\/CIRCRESAHA.118.313578","article-title":"Management of myocarditis-related cardiomyopathy in adults","volume":"124","author":"Tsch\u00f6pe","year":"2019","journal-title":"Circ Res"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0365","doi-asserted-by":"crossref","first-page":"B90","DOI":"10.1093\/eurheartj\/suz033","article-title":"Myocarditis evolving in cardiomyopathy: when genetics and offending causes work together","volume":"21","author":"Cannata\u2019","year":"2019","journal-title":"European Heart Journal Supplements"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0370","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2460\/javma.24.08.0551","article-title":"Trust in veterinarians and association with vaccine information sources and vaccination status among dog and cat owners","volume":"263","author":"Haeder","year":"2025","journal-title":"J Am Vet Med Assoc"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0375","doi-asserted-by":"crossref","first-page":"177","DOI":"10.4103\/jpgm.JPGM_154_17","article-title":"Hypothyroidism-induced reversible dilated cardiomyopathy","volume":"64","author":"Rastogi","year":"2018","journal-title":"J Postgrad Med"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0380","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1016\/j.jacc.2018.02.045","article-title":"Thyroid hormones and cardiovascular function and diseases","volume":"71","author":"Razvi","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0385","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1136\/vr.145.17.481","article-title":"Epidemiological, clinical, haematological and biochemical characteristics of canine hypothyroidism","volume":"145","author":"Dixon","year":"1999","journal-title":"Vet Rec"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0390","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.cvsm.2007.03.003","article-title":"Clinical signs and concurrent diseases of hypothyroidism in dogs and cats","volume":"37","author":"Scott-Moncrieff","year":"2007","journal-title":"Veterinary Clinics of North America: Small Animal Practice"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0395","doi-asserted-by":"crossref","first-page":"761","DOI":"10.2460\/javma.1994.204.05.761","article-title":"Hypothyroidism in dogs: 66 cases (1987\u20131992)","volume":"204","author":"Panciera","year":"1994","journal-title":"J Am Vet Med Assoc"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0400","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.cvsm.2004.12.006","article-title":"Thyroid disorders in the geriatric patient","volume":"35","author":"Meeking","year":"2005","journal-title":"Vet Clin North Am Small Anim Pract"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0405","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/jvim.12476","article-title":"The role of hypothyroidism in the etiology and progression of dilated cardiomyopathy in Doberman pinschers","volume":"29","author":"Beier","year":"2015","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0410","doi-asserted-by":"crossref","DOI":"10.1016\/j.cpcardiol.2025.103076","article-title":"Precision medicine applications in dilated cardiomyopathy: advancing personalized care","volume":"50","author":"Khattab","year":"2025","journal-title":"Curr Probl Cardiol"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0415","doi-asserted-by":"crossref","first-page":"932","DOI":"10.2460\/ajvr.72.7.932","article-title":"Evaluation of 10 genes encoding cardiac proteins in Doberman pinschers with dilated cardiomyopathy","volume":"72","author":"Lynne O\u2019Sullivan","year":"2011","journal-title":"Am J Vet Res"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0420","doi-asserted-by":"crossref","first-page":"H585","DOI":"10.1152\/ajpheart.00369.2023","article-title":"Predominant myosin superrelaxed state in canine myocardium with naturally occurring dilated cardiomyopathy","volume":"325","author":"Ochala","year":"2023","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0425","doi-asserted-by":"crossref","first-page":"H80","DOI":"10.1152\/ajpheart.00530.2015","article-title":"2-Deoxyadenosine triphosphate restores the contractile function of cardiac myofibril from adult dogs with naturally occurring dilated cardiomyopathy","volume":"310","author":"Cheng","year":"2016","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0430","doi-asserted-by":"crossref","first-page":"5390","DOI":"10.1038\/s41467-018-07812-8","article-title":"PI3K\u03b1-regulated gelsolin activity is a critical determinant of cardiac cytoskeletal remodeling and heart disease","volume":"9","author":"Patel","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0435","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1007\/s00439-012-1158-2","article-title":"A splice site mutation in a gene encoding for PDK4, a mitochondrial protein, is associated with the development of dilated cardiomyopathy in the Doberman pinscher","volume":"131","author":"Meurs","year":"2012","journal-title":"Hum Genet"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0440","doi-asserted-by":"crossref","first-page":"3930","DOI":"10.1038\/s41598-020-60879-6","article-title":"Functional consequences of PDK4 deficiency in Doberman pinscher fibroblasts","volume":"10","author":"Bolfer","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0445","first-page":"182","article-title":"PDK4 deficiency induces intrinsic apoptosis in response to starvation in fibroblasts from Doberman pinschers with dilated cardiomyopathy., biores open","volume":"6","author":"Taggart","year":"2017","journal-title":"Access"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0450","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1111\/j.1365-2052.2012.02396.x","article-title":"A 16-bp deletion in the canine PDK4 gene is not associated with dilated cardiomyopathy in a European cohort of Doberman pinschers","volume":"44","author":"Owczarek-Lipska","year":"2013","journal-title":"Anim Genet"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0455","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1161\/CIRCRESAHA.121.318241","article-title":"Cardiac energy metabolism in heart failure","volume":"128","author":"Lopaschuk","year":"2021","journal-title":"Circ Res"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0460","doi-asserted-by":"crossref","first-page":"H1103","DOI":"10.1152\/ajpheart.00636.2012","article-title":"ANG II causes insulin resistance and induces cardiac metabolic switch and inefficiency: a critical role of PDK4","volume":"304","author":"Mori","year":"2013","journal-title":"American Journal of Physiology-Heart and Circulatory Physiology"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0465","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3390\/cells13010087","article-title":"A potent PDK4 inhibitor for treatment of heart failure with reduced ejection fraction","volume":"13","author":"Aizawa","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0470","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/S0002-8703(97)80007-5","article-title":"Dichloroacetate as metabolic therapy for myocardial ischemia and failure","volume":"134","author":"Bersin","year":"1997","journal-title":"Am Heart J"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0475","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1007\/s00439-019-01973-2","article-title":"A missense variant in the titin gene in Doberman pinscher dogs with familial dilated cardiomyopathy and sudden cardiac death","volume":"138","author":"Meurs","year":"2019","journal-title":"Hum Genet"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0480","first-page":"1","article-title":"Computational exploration of TITIN variations: insights from whole exome sequencing and molecular dynamics simulation study","author":"Mukhopadhyay","year":"2025","journal-title":"J Biomol Struct Dyn"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0485","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1007\/s12551-021-00836-3","article-title":"The titin N2B and N2A regions: biomechanical and metabolic signaling hubs in cross-striated muscles","volume":"13","author":"van der Pijl","year":"2021","journal-title":"Biophys Rev"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0490","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1186\/s11658-024-00647-w","article-title":"Research progress of ankyrin repeat domain 1 protein: an updated review","volume":"29","author":"Xu","year":"2024","journal-title":"Cell Mol Biol Lett"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0495","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.bbrc.2007.03.128","article-title":"Structural analysis of four and half LIM protein-2 in dilated cardiomyopathy","volume":"357","author":"Arimura","year":"2007","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0500","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2024.1385821","article-title":"Titin: roles in cardiac function and diseases","volume":"15","author":"Stroik","year":"2024","journal-title":"Front Physiol"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0505","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s11886-025-02239-2","article-title":"Polygenic risk scores in dilated cardiomyopathy: towards the future","volume":"27","author":"Kramarenko","year":"2025","journal-title":"Curr Cardiol Rep"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0510","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/s41588-025-02094-5","article-title":"Evaluation of polygenic scores for hypertrophic cardiomyopathy in the general population and across clinical settings","volume":"57","author":"Zheng","year":"2025","journal-title":"Nat Genet"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0515","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.gene.2019.02.022","article-title":"The R9H phospholamban mutation is associated with highly penetrant dilated cardiomyopathy and sudden death in a spontaneous canine model","volume":"697","author":"Yost","year":"2019","journal-title":"Gene"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0520","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1139\/bcb-2014-0080","article-title":"Deception in simplicity: hereditary phospholamban mutations in dilated cardiomyopathy","volume":"93","author":"Young","year":"2015","journal-title":"Biochem Cell Biol"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0525","doi-asserted-by":"crossref","first-page":"38","DOI":"10.5326\/JAAHA-MS-6506","article-title":"Dilated cardiomyopathy in standard schnauzers: retrospective study of 15 cases","volume":"53","author":"Harmon","year":"2017","journal-title":"J Am Anim Hosp Assoc"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0530","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1161\/CIRCULATIONAHA.117.031947","article-title":"RBM20 mutations induce an arrhythmogenic dilated cardiomyopathy related to disturbed calcium handling","volume":"138","author":"van den Hoogenhof","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0535","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCGEN.123.004355","article-title":"Mechanisms of RBM20 cardiomyopathy: insights from model systems","volume":"17","author":"Gregorich","year":"2024","journal-title":"Circ Genom Precis Med"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0540","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.jvc.2021.05.002","article-title":"Prevalence, geographic distribution, and impact on lifespan of a dilated cardiomyopathy-associated RNA-binding motif protein 20 variant in genotyped dogs","volume":"40","author":"Leach","year":"2022","journal-title":"J Vet Cardiol"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0545","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/s11886-023-01876-9","article-title":"Mechanisms of sarcomere protein mutation-induced cardiomyopathies","volume":"25","author":"Barefield","year":"2023","journal-title":"Curr Cardiol Rep"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0550","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.77415","article-title":"Dilated cardiomyopathy mutation E525K in human beta-cardiac myosin stabilizes the interacting-heads motif and super-relaxed state of myosin","volume":"11","author":"Rasicci","year":"2022","journal-title":"Elife"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0555","doi-asserted-by":"crossref","DOI":"10.3390\/biom14050524","article-title":"Unraveling the etiology of dilated cardiomyopathy through differential miRNA-mRNA interactome","volume":"14","author":"Bonet","year":"2024","journal-title":"Biomolecules"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0560","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.trsl.2016.02.006","article-title":"Differential impact of mechanical unloading on structural and nonstructural components of the extracellular matrix in advanced human heart failure","volume":"172","author":"Sakamuri","year":"2016","journal-title":"Transl Res"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0565","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.118.010427","article-title":"Disparate remodeling of the extracellular matrix and proteoglycans in failing pediatric versus adult hearts","volume":"7","author":"Jana","year":"2018","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0570","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1161\/CIRCULATIONAHA.123.067107","article-title":"Cardiovascular magnetic resonance radiomics to identify components of the extracellular matrix in dilated cardiomyopathy","volume":"150","author":"Nakamori","year":"2024","journal-title":"Circulation"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0575","doi-asserted-by":"crossref","first-page":"216","DOI":"10.2460\/ajvr.74.2.216","article-title":"Expression of matrix metalloproteinases, their inhibitors, and lysyl oxidase in myocardial samples from dogs with end-stage systemic and cardiac diseases","volume":"74","author":"Fonfara","year":"2013","journal-title":"Am J Vet Res"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0580","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1053\/rvsc.2000.0423","article-title":"Alterations in the organisation, ultrastructure and biochemistry of the myocardial collagen matrix in Doberman pinschers with dilated cardiomyopathy","volume":"69","author":"Gilbert","year":"2000","journal-title":"Res Vet Sci"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0585","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/S0008-6363(97)00011-4","article-title":"Increased expression of promatrix metalloproteinase-9 and neutrophil elastase in canine dilated cardiomyopathy","volume":"34","author":"Gilbert","year":"1997","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0590","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1177\/0300985820906895","article-title":"Canine dilated cardiomyopathy: diffuse remodeling, focal lesions, and the involvement of macrophages and new vessel formation","volume":"57","author":"Gasparini","year":"2020","journal-title":"Vet Pathol"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0595","doi-asserted-by":"crossref","first-page":"3053","DOI":"10.1093\/eurheartj\/ehac235","article-title":"Importance of genotype for risk stratification in arrhythmogenic right ventricular cardiomyopathy using the 2019 ARVC risk calculator","volume":"43","author":"Protonotarios","year":"2022","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0600","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1007\/s11886-022-01777-3","article-title":"Genotype-phenotype correlates in arrhythmogenic cardiomyopathies","volume":"24","author":"Murray","year":"2022","journal-title":"Curr Cardiol Rep"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0605","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1136\/vr.102821","article-title":"A pedigree-based genetic appraisal of Boxer ARVC and the role of the Striatin mutation","volume":"176","author":"Cattanach","year":"2015","journal-title":"Vet Rec"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0610","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2023.1077788","article-title":"Genetics and pathophysiology of mitral valve prolapse","volume":"10","author":"Delwarde","year":"2023","journal-title":"Front Cardiovasc Med"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0615","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.phrs.2018.09.009","article-title":"Serotonin contribution to cardiac valve degeneration: new insights for novel therapies?","volume":"140","author":"Ayme-Dietrich","year":"2019","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0620","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1007\/s00439-021-02297-w","article-title":"Use of whole genome analysis to identify shared genomic variants across breeds in canine mitral valve disease","volume":"140","author":"Williams","year":"2021","journal-title":"Hum Genet"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0625","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1111\/jvim.12163","article-title":"Association of dilated cardiomyopathy with the striatin mutation genotype in boxer dogs","volume":"27","author":"Meurs","year":"2013","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0630","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s00439-010-0855-y","article-title":"Genome-wide association identifies a deletion in the 3\u2032 untranslated region of striatin in a canine model of arrhythmogenic right ventricular cardiomyopathy","volume":"128","author":"Meurs","year":"2010","journal-title":"Hum Genet"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0635","doi-asserted-by":"crossref","first-page":"iii125","DOI":"10.1093\/europace\/euy238","article-title":"Bioinformatic analysis of a plakophilin-2-dependent transcription network: implications for the mechanisms of arrhythmogenic right ventricular cardiomyopathy in humans and in boxer dogs","volume":"20","author":"Montnach","year":"2018","journal-title":"Europace"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0640","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/exd.14193","article-title":"Cellular and molecular mechanisms in fibrosis","volume":"30","author":"Dees","year":"2021","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0645","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.yjmcc.2017.12.014","article-title":"Serotonin receptor 2B signaling with interstitial cell activation and leaflet remodeling in degenerative mitral regurgitation","volume":"115","author":"Driesbaugh","year":"2018","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0650","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.pharmthera.2011.03.008","article-title":"Serotonin receptors and heart valve disease\u2014it was meant 2B","volume":"132","author":"Hutcheson","year":"2011","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0655","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.adc9606","article-title":"Decreased serotonin transporter activity in the mitral valve contributes to progression of degenerative mitral regurgitation","volume":"15","author":"Castillero","year":"2023","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0660","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1111\/j.1939-1676.2009.0378.x","article-title":"Serum serotonin concentrations in dogs with degenerative mitral valve disease","volume":"23","author":"Arndt","year":"2009","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0665","doi-asserted-by":"crossref","first-page":"129","DOI":"10.4142\/jvs.2018.19.1.129","article-title":"Polymorphism in the serotonin transporter protein gene in Maltese dogs with degenerative mitral valve disease","volume":"19","author":"Lee","year":"2018","journal-title":"J Vet Sci"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0670","doi-asserted-by":"crossref","first-page":"2596","DOI":"10.1111\/jvim.16277","article-title":"Polymorphisms in the serotonin transporter gene and circulating concentrations of neurotransmitters in Cavalier King Charles spaniels with myxomatous mitral valve disease","volume":"35","author":"Reimann","year":"2021","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0675","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1111\/jvim.12137","article-title":"Serum serotonin concentration is associated with severity of myxomatous mitral valve disease in dogs","volume":"27","author":"Ljungvall","year":"2013","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0680","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.jvc.2010.06.002","article-title":"Serotonin transmembrane transporter is down-regulated in late-stage canine degenerative mitral valve disease","volume":"12","author":"Scruggs","year":"2010","journal-title":"J Vet Cardiol"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0685","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.jvc.2011.12.002","article-title":"Static and cyclic tensile strain induce myxomatous effector proteins and serotonin in canine mitral valves","volume":"14","author":"Lacerda","year":"2012","journal-title":"J Vet Cardiol"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0690","doi-asserted-by":"crossref","first-page":"H223","DOI":"10.1152\/ajpheart.00401.2023","article-title":"Fibroblasts under pressure: cardiac fibroblast responses to hypertension and antihypertensive therapies","volume":"326","author":"Chalise","year":"2024","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0695","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s00335-023-10024-1","article-title":"Mitral valve transcriptome analysis in thirty-four age-matched Cavalier King Charles spaniels with or without congestive heart failure caused by myxomatous mitral valve disease","volume":"35","author":"Reimann","year":"2024","journal-title":"Mamm Genome"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0700","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/s41569-018-0108-7","article-title":"Dietary metabolism, the gut microbiome, and heart failure","volume":"16","author":"Tang","year":"2019","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0705","doi-asserted-by":"crossref","DOI":"10.1128\/msystems.00111-21","article-title":"Gut dysbiosis and its associations with gut microbiota-derived metabolites in dogs with myxomatous mitral valve disease","volume":"6","author":"Li","year":"2021","journal-title":"MSystems"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0710","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1002\/ehf2.12155","article-title":"Heart failure is associated with depletion of core intestinal microbiota","volume":"4","author":"Luedde","year":"2017","journal-title":"ESC Heart Fail"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0715","doi-asserted-by":"crossref","DOI":"10.1007\/s15010-025-02568-y","article-title":"Bridging oral and systemic health: exploring pathogenesis, biomarkers, and diagnostic innovations in periodontal disease","author":"Foroughi","year":"2025","journal-title":"Infection"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0720","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1093\/ehjqcco\/qcae109","article-title":"Diagnosis and management of dilated cardiomyopathy: a systematic review of clinical practice guidelines and recommendations","volume":"11","author":"Sorella","year":"2025","journal-title":"Eur Heart J Qual Care Clin Outcomes"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0725","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1002\/inpr.486","article-title":"Canine dilated cardiomyopathy. Part 1: screening, diagnosis and management of preclinical DCM","volume":"46","author":"Davis","year":"2024","journal-title":"In Pract"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0730","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/j.jacc.2017.04.025","volume":"70","author":"Yancy","year":"2017","journal-title":"J Am Coll Cardiol"},{"issue":"2021","key":"10.1016\/j.jmccpl.2025.100474_bb0735","first-page":"e72","article-title":"ACC\/AHA guideline for the management of patients with Valvular Heart Disease: a report of the American College of Cardiology\/American Heart Association joint committee on clinical practice guidelines","volume":"143","author":"Otto","year":"2020","journal-title":"Circulation"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0740","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.autrev.2017.01.012","article-title":"Cardiomyopathy - an approach to the autoimmune background","volume":"16","author":"Becker","year":"2017","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0745","doi-asserted-by":"crossref","first-page":"48","DOI":"10.2741\/4709","article-title":"Functional autoantibody diseases: basics and treatment related to cardiomyopathies","volume":"24","author":"Becker","year":"2019","journal-title":"Front Biosci (Landmark Ed)"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0750","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0214263","article-title":"Doberman pinschers present autoimmunity associated with functional autoantibodies: a model to study the autoimmune background of human dilated cardiomyopathy","volume":"14","author":"Wess","year":"2019","journal-title":"PloS One"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0755","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1161\/CIRCRESAHA.118.312706","article-title":"Established and emerging roles of biomarkers in heart failure","volume":"123","author":"Ibrahim","year":"2018","journal-title":"Circ Res"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0760","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1002\/ehf2.13864","article-title":"Outcome and prognostic value of N-terminal pro-brain natriuretic peptide and high-sensitivity C-reactive protein in mildly dilated cardiomyopathy vs. dilated cardiomyopathy","volume":"9","author":"Feng","year":"2022","journal-title":"ESC Heart Fail"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0765","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.rvsc.2019.12.001","article-title":"Diagnostic methods for the canine idiopathic dilated cardiomyopathy: a narrative evidence-based rapid review","volume":"128","author":"P\u00e9rez","year":"2020","journal-title":"Res Vet Sci"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0770","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1093\/eurjhf\/hfq189","article-title":"Prognostic value of serial B-type natriuretic peptide measurement in asymptomatic organic mitral regurgitation","volume":"13","author":"Klaar","year":"2011","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0775","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S1760-2734(06)70002-9","article-title":"Relationship between different natriuretic peptides and severity of naturally acquired mitral regurgitation in dogs with chronic myxomatous valve disease","volume":"2","author":"H\u00e4ggstr\u00f6m","year":"2000","journal-title":"J Vet Cardiol"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0780","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1111\/j.1939-1676.2003.tb02430.x","article-title":"Brain natriuretic peptide concentration in dogs with heart disease and congestive heart failure","volume":"17","author":"MacDonald","year":"2003","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0785","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1186\/s12917-022-03548-2","article-title":"Diagnostic value of atrial natriuretic peptide (ANP), B-type natriuretic peptide (BNP) and their correlation with lipoproteins in dogs with myxomatous mitral valve disease","volume":"18","author":"Khaki","year":"2022","journal-title":"BMC Vet Res"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0790","doi-asserted-by":"crossref","first-page":"340","DOI":"10.2460\/javma.256.3.340","article-title":"Evaluation of atrial natriuretic peptide and cardiac troponin I concentrations for assessment of disease severity in dogs with naturally occurring mitral valve disease","volume":"256","author":"Hori","year":"2020","journal-title":"J Am Vet Med Assoc"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0795","doi-asserted-by":"crossref","DOI":"10.1177\/1040638717747070","article-title":"Analytical validation of cardiac troponin I assays in horses","volume":"30","author":"Rossi","year":"2018","journal-title":"J Vet Diagn Invest"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0800","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1186\/s12917-021-02878-x","article-title":"Inflammation and its association with oxidative stress in dogs with heart failure","volume":"17","author":"Nemec Svete","year":"2021","journal-title":"BMC Vet Res"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0805","doi-asserted-by":"crossref","first-page":"2888","DOI":"10.3390\/ani12202888","article-title":"C-reactive protein as a diagnostic marker in dogs: a review","volume":"12","author":"Malin","year":"2022","journal-title":"Animals"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0810","doi-asserted-by":"crossref","first-page":"3932","DOI":"10.1093\/eurheartj\/ehy567","article-title":"An autoantibody identifies arrhythmogenic right ventricular cardiomyopathy and participates in its pathogenesis","volume":"39","author":"Chatterjee","year":"2018","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0815","doi-asserted-by":"crossref","first-page":"5044","DOI":"10.1038\/s41598-023-32081-x","article-title":"Evaluation of autoantibodies to desmoglein-2 in dogs with and without cardiac disease","volume":"13","author":"Walker","year":"2023","journal-title":"Sci Rep"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0820","first-page":"619","article-title":"Interatrial block and P-terminal force: a reflection of mitral stenosis severity on electrocardiography","volume":"20","author":"Yuce","year":"2011","journal-title":"J Heart Valve Dis"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0825","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0002-8703(76)80405-X","article-title":"Comparison of left atrial size and pulmonary capillary pressure with P wave of electrocardiogram","volume":"92","author":"Rubler","year":"1976","journal-title":"Am Heart J"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0830","doi-asserted-by":"crossref","DOI":"10.1016\/j.tcam.2021.100531","article-title":"P-wave terminal force in dogs with myxomatous mitral valve disease","volume":"44","author":"Calder\u00f3n-Olaguivel","year":"2021","journal-title":"Top Companion Anim Med"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0835","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.ijcard.2018.01.049","article-title":"Prognostic impact of leaflet-to-annulus index in patients treated with transapical off-pump echo-guided mitral valve repair with NeoChord implantation","volume":"257","author":"Colli","year":"2018","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0840","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.rvsc.2022.08.004","article-title":"The leaflet-annulus index in canine myxomatous mitral valve disease","volume":"152","author":"Isaka","year":"2022","journal-title":"Res Vet Sci"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0845","article-title":"Correlation between the leaflet-annulus index and echocardiographic indices in Maltese dogs with myxomatous mitral valve disease","volume":"10","author":"Lee","year":"2023","journal-title":"Vet Sci"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0850","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.echo.2021.02.013","article-title":"Simple two-dimensional echocardiographic scoring system for the estimation of left ventricular filling pressure","volume":"34","author":"Murayama","year":"2021","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0855","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.jvc.2023.11.011","article-title":"Interventricular inflow time difference assessed by dual pulsed-wave Doppler echocardiography in dogs with myxomatous mitral valve disease","volume":"51","author":"Morita","year":"2024","journal-title":"J Vet Cardiol"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0860","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.120.018923","article-title":"Metabolomics analysis reveals deranged energy metabolism and amino acid metabolic reprogramming in dogs with myxomatous mitral valve disease","volume":"10","author":"Li","year":"2021","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0865","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1007\/s11306-022-01887-7","article-title":"Evidence of altered fatty acid metabolism in dogs with naturally occurring valvular heart disease and congestive heart failure","volume":"18","author":"Wilshaw","year":"2022","journal-title":"Metabolomics"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0870","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2021.643092","article-title":"Microbiota in gut, oral cavity, and mitral valves are associated with rheumatic heart disease","volume":"11","author":"Shi","year":"2021","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0875","doi-asserted-by":"crossref","DOI":"10.1371\/annotation\/c2287fc7-c976-4d78-a28f-1d4e024d568f","article-title":"The canine oral microbiome","volume":"7","author":"Dewhirst","year":"2012","journal-title":"PloS One"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0880","doi-asserted-by":"crossref","DOI":"10.3389\/fvets.2020.00616","article-title":"An assessment of the stability of the canine oral microbiota after probiotic administration in healthy dogs over time","volume":"7","author":"Bell","year":"2020","journal-title":"Front Vet Sci"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0885","doi-asserted-by":"crossref","first-page":"486","DOI":"10.2460\/javma.234.4.486","article-title":"Evaluation of the risk of endocarditis and other cardiovascular events on the basis of the severity of periodontal disease in dogs","volume":"234","author":"Glickman","year":"2009","journal-title":"J Am Vet Med Assoc"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0890","first-page":"1525","article-title":"Questions validity of study on periodontal disease and cardiovascular events in dogs","volume":"234","author":"Peddle","year":"2009","journal-title":"J Am Vet Med Assoc"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0895","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.cvsm.2021.08.004","article-title":"Oral microbiome in dogs and cats: dysbiosis and the utility of antimicrobial therapy in the treatment of periodontal disease","volume":"52","author":"Davis","year":"2022","journal-title":"Veterinary Clinics of North America: Small Animal Practice"},{"issue":"2023","key":"10.1016\/j.jmccpl.2025.100474_bb0900","doi-asserted-by":"crossref","first-page":"3627","DOI":"10.1093\/eurheartj\/ehad195","article-title":"Focused update of the 2021 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure","volume":"44","author":"McDonagh","year":"2023","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0905","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1002\/inpr.494","article-title":"Canine dilated cardiomyopathy. Part 2: manifestations and treatment of clinical DCM","volume":"46","author":"Crosland","year":"2024","journal-title":"In Pract"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0910","article-title":"Arrhythmogenic cardiomyopathy: towards genotype based diagnoses and management","author":"Muller","year":"2024","journal-title":"J Cardiovasc Electrophysiol"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0915","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.jvc.2011.04.006","article-title":"Implantable cardioverter-defibrillator in a German shepherd dog with ventricular arrhythmias","volume":"13","author":"Pariaut","year":"2011","journal-title":"J Vet Cardiol"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0920","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1111\/jcmm.13077","article-title":"Intracoronary allogeneic cardiosphere-derived stem cells are safe for use in dogs with dilated cardiomyopathy","volume":"21","author":"Hensley","year":"2017","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0925","doi-asserted-by":"crossref","first-page":"3451","DOI":"10.1093\/eurheartj\/ehaa541","article-title":"Intracoronary ALLogeneic heart STem cells to Achieve myocardial Regeneration (ALLSTAR): a randomized, placebo-controlled, double-blinded trial","volume":"41","author":"Makkar","year":"2020","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0930","doi-asserted-by":"crossref","first-page":"e293","DOI":"10.4244\/EIJ-D-19-00035","article-title":"Allogeneic cardiosphere-derived cells for the treatment of heart failure with reduced ejection fraction: the Dilated cardiomYopathy iNtervention with Allogeneic MyocardIally-regenerative Cells (DYNAMIC) trial","volume":"16","author":"Chakravarty","year":"2020","journal-title":"EuroIntervention"},{"issue":"Suppl. 2","key":"10.1016\/j.jmccpl.2025.100474_bb0935","first-page":"S1","article-title":"Hemodynamic profile of the cardiotonic agent pimobendan","volume":"14","author":"van Meel","year":"1989","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0940","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1161\/01.RES.63.5.911","article-title":"Sensitization of dog and guinea pig heart myofilaments to Ca2+ activation and the inotropic effect of pimobendan: comparison with milrinone","volume":"63","author":"Fujino","year":"1988","journal-title":"Circ Res"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0945","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1136\/hrt.76.3.223","article-title":"Effect of pimobendan on exercise capacity in patients with heart failure: main results from the Pimobendan in Congestive Heart Failure (PICO) trial","volume":"76","author":"Lubsen","year":"1996","journal-title":"Heart"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0950","first-page":"255","article-title":"A double-blind, randomized, placebo-controlled study of pimobendan in dogs with dilated cardiomyopathy","volume":"16","author":"Fuentes","year":"2002","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0955","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1111\/j.1939-1676.2008.0116.x","article-title":"Effect of pimobendan on case fatality rate in Doberman pinschers with congestive heart failure caused by dilated cardiomyopathy","volume":"22","author":"O\u2019Grady","year":"2008","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0960","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1186\/s12917-021-03014-5","article-title":"The effect of treatment with pimobendan in dogs with preclinical mitral valve disease - a placebo-controlled double-blinded crossover study","volume":"17","author":"Klein","year":"2021","journal-title":"BMC Vet Res"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0965","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1111\/jvim.14586","article-title":"Effect of Pimobendan in dogs with preclinical myxomatous mitral valve disease and cardiomegaly: the EPIC study-a randomized clinical trial","volume":"30","author":"Boswood","year":"2016","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0970","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1111\/j.1939-1676.2008.0150.x","article-title":"Effect of pimobendan or benazepril hydrochloride on survival times in dogs with congestive heart failure caused by naturally occurring myxomatous mitral valve disease: the QUEST study","volume":"22","author":"H\u00e4ggstr\u00f6m","year":"2008","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0975","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1111\/jvim.12181","article-title":"Longitudinal analysis of quality of life, clinical, radiographic, echocardiographic, and laboratory variables in dogs with myxomatous mitral valve disease receiving pimobendan or benazepril: the QUEST study","volume":"27","author":"H\u00e4ggstr\u00f6m","year":"2013","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0980","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.jacbts.2016.07.006","article-title":"Translation of cardiac myosin activation with 2-deoxy-ATP to treat heart failure via an experimental ribonucleotide reductase-based gene therapy","volume":"1","author":"Thomson","year":"2016","journal-title":"JACC Basic Transl Sci"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0985","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1002\/ehf2.12628","article-title":"The aptamer BC 007 for treatment of dilated cardiomyopathy: evaluation in Doberman pinschers of efficacy and outcomes","volume":"7","author":"Werner","year":"2020","journal-title":"ESC Heart Fail"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0990","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/s40261-020-00903-9","article-title":"Randomised study to investigate the safety, tolerability, pharmacokinetics and mode of action of BC 007, neutraliser of pathogenic autoantibodies against G-protein coupled receptors in healthy, young and elderly subjects","volume":"40","author":"Becker","year":"2020","journal-title":"Clin Drug Investig"},{"key":"10.1016\/j.jmccpl.2025.100474_bb0995","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1038\/s44161-023-00370-3","article-title":"Plakophilin2 gene therapy prevents and rescues arrhythmogenic right ventricular cardiomyopathy in a mouse model harboring patient genetics","volume":"2","author":"Bradford","year":"2023","journal-title":"Nature Cardiovascular Research"},{"key":"10.1016\/j.jmccpl.2025.100474_bb1000","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1056\/NEJMoa1814052","article-title":"Transcatheter aortic-valve replacement with a balloon-expandable valve in low-risk patients","volume":"380","author":"Mack","year":"2019","journal-title":"New England Journal of Medicine"},{"key":"10.1016\/j.jmccpl.2025.100474_bb1005","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1016\/j.jacc.2023.09.813","article-title":"4-Year outcomes of patients with aortic stenosis in the evolut low risk trial","volume":"82","author":"Forrest","year":"2023","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jmccpl.2025.100474_bb1010","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.jvc.2012.01.004","article-title":"Mitral valve repair in dogs","volume":"14","author":"Uechi","year":"2012","journal-title":"J Vet Cardiol"},{"key":"10.1016\/j.jmccpl.2025.100474_bb1015","doi-asserted-by":"crossref","first-page":"3068","DOI":"10.3390\/ani14213068","article-title":"Transcatheter edge-to-edge repair of the mitral valve in four dogs: preliminary results regarding efficacy and safety","volume":"14","author":"Petchdee","year":"2024","journal-title":"Animals"},{"key":"10.1016\/j.jmccpl.2025.100474_bb1020","doi-asserted-by":"crossref","DOI":"10.3389\/fvets.2020.597879","article-title":"Preliminary outcome of a novel edge-to-edge closure device to manage mitral regurgitation in dogs","volume":"7","author":"Liu","year":"2020","journal-title":"Front Vet Sci"},{"key":"10.1016\/j.jmccpl.2025.100474_bb1025","article-title":"Metabolic reprogramming, gut dysbiosis, and nutrition intervention in canine heart disease","volume":"9","author":"Li","year":"2022","journal-title":"Front Vet Sci"},{"key":"10.1016\/j.jmccpl.2025.100474_bb1030","doi-asserted-by":"crossref","first-page":"S61","DOI":"10.2460\/javma.22.07.0319","article-title":"Key nutrients important in the management of canine myxomatous mitral valve disease and heart failure","volume":"260","author":"Laflamme","year":"2022","journal-title":"J Am Vet Med Assoc"},{"key":"10.1016\/j.jmccpl.2025.100474_bb1035","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0254887","article-title":"Protective effects of omega-3 fatty acids in dogs with myxomatous mitral valve disease stages B2 and C","volume":"16","author":"Nasciutti","year":"2021","journal-title":"PloS One"},{"key":"10.1016\/j.jmccpl.2025.100474_bb1040","article-title":"Effect of 6-month feeding with a diet enriched in EPA + DHA from fish meat on the blood metabolomic profile of dogs with myxomatous mitral valve disease","volume":"11","author":"Pas\u0142awski","year":"2021","journal-title":"Animals (Basel)"},{"key":"10.1016\/j.jmccpl.2025.100474_bb1045","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1186\/s12917-019-2169-1","article-title":"Dietary intervention reduces left atrial enlargement in dogs with early preclinical myxomatous mitral valve disease: a blinded randomized controlled study in 36 dogs","volume":"15","author":"Li","year":"2019","journal-title":"BMC Vet Res"},{"key":"10.1016\/j.jmccpl.2025.100474_bb1050","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1161\/CIRCULATIONAHA.119.045033","article-title":"Implications of altered ketone metabolism and therapeutic ketosis in heart failure","volume":"141","author":"Selvaraj","year":"2020","journal-title":"Circulation"},{"key":"10.1016\/j.jmccpl.2025.100474_bb1055","article-title":"Serum untargeted metabolomic changes in response to diet intervention in dogs with preclinical myxomatous mitral valve disease","volume":"15","author":"Li","year":"2020","journal-title":"PloS One"},{"issue":"2018","key":"10.1016\/j.jmccpl.2025.100474_bb1060","first-page":"86","article-title":"Gene editing restores dystrophin expression in a canine model of Duchenne muscular dystrophy","volume":"362","author":"Amoasii","year":"1979","journal-title":"Science"},{"key":"10.1016\/j.jmccpl.2025.100474_bb1065","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1161\/01.CIR.0000151812.86142.45","article-title":"Mesenchymal stem cells differentiate into an endothelial phenotype, enhance vascular density, and improve heart function in a canine chronic ischemia model","volume":"111","author":"Silva","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.jmccpl.2025.100474_bb1070","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.yjmcc.2007.09.012","article-title":"Comparison of intracoronary and transendocardial delivery of allogeneic mesenchymal cells in a canine model of acute myocardial infarction","volume":"44","author":"Perin","year":"2008","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.jmccpl.2025.100474_bb1075","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCEP.116.004508","article-title":"Induced pluripotent stem cell\u2013derived cardiomyocytes provide in vivo biological pacemaker function","volume":"10","author":"Chauveau","year":"2017","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.jmccpl.2025.100474_bb1080","doi-asserted-by":"crossref","DOI":"10.3389\/fvets.2024.1404607","article-title":"Safety and efficacy of canine gonadal tissue-derived mesenchymal stem cells for early myxomatous mitral valve disease","volume":"11","author":"Jeung","year":"2024","journal-title":"Front Vet Sci"}],"container-title":["Journal of Molecular and Cellular Cardiology Plus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S277297612500193X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S277297612500193X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T01:58:53Z","timestamp":1768442333000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S277297612500193X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":216,"alternative-id":["S277297612500193X"],"URL":"https:\/\/doi.org\/10.1016\/j.jmccpl.2025.100474","relation":{},"ISSN":["2772-9761"],"issn-type":[{"value":"2772-9761","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cardiology's best friend: Using naturally occurring disease in dogs to understand heart disease in humans","name":"articletitle","label":"Article Title"},{"value":"Journal of Molecular and Cellular Cardiology Plus","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jmccpl.2025.100474","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"100474"}}