{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T06:57:48Z","timestamp":1781333868347,"version":"3.54.1"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T00:00:00Z","timestamp":1773792000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005075","name":"University Medical Centre Groningen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005075","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Molecular and Cellular Cardiology Plus"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.jmccpl.2026.100845","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T07:25:47Z","timestamp":1774250747000},"page":"100845","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Characteristics, clinical outcomes and molecular mechanisms associated with severe diastolic dysfunction in aortic stenosis"],"prefix":"10.1016","volume":"16","author":[{"given":"Kyriakos","family":"Panaou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constantijn S.","family":"Venema","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kees H.","family":"van Bergeijk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Demetra","family":"Hadjicharalambous","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Girerd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Trenkwalder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Joner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pim","family":"van der Harst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasper","family":"Tromp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriaan A.","family":"Voors","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna J.","family":"Wykrzykowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.jmccpl.2026.100845_bb0005","doi-asserted-by":"crossref","first-page":"e347","DOI":"10.1161\/CIR.0000000000001209","article-title":"2024 heart disease and stroke statistics: a report of US and global data from the American Heart Association","volume":"149","author":"Martin","year":"2024","journal-title":"Circulation"},{"issue":"45","key":"10.1016\/j.jmccpl.2026.100845_bb0010","doi-asserted-by":"crossref","first-page":"3351","DOI":"10.1093\/eurheartj\/ehx381","article-title":"Staging classification of aortic stenosis based on the extent of cardiac damage","volume":"38","author":"G\u00e9n\u00e9reux","year":"2017","journal-title":"Eur Heart J"},{"issue":"5","key":"10.1016\/j.jmccpl.2026.100845_bb0015","doi-asserted-by":"crossref","DOI":"10.1111\/echo.15829","article-title":"Prognostic value of left atrial strain in aortic stenosis: a systematic review","volume":"41","author":"Lacy","year":"2024","journal-title":"Echocardiography"},{"issue":"11","key":"10.1016\/j.jmccpl.2026.100845_bb0020","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.117.006615","article-title":"Left atrial volume and mortality in patients with aortic stenosis","volume":"6","author":"Rusinaru","year":"2017","journal-title":"J Am Heart Assoc"},{"issue":"3","key":"10.1016\/j.jmccpl.2026.100845_bb0025","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1002\/ejhf.1643","article-title":"Left atrial function in heart failure with preserved ejection fraction: a systematic review and meta-analysis","volume":"22","author":"Khan","year":"2020","journal-title":"Eur J Heart Fail"},{"issue":"17","key":"10.1016\/j.jmccpl.2026.100845_bb0030","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1136\/heartjnl-2022-320886","article-title":"Prognostic implications of left ventricular diastolic dysfunction in moderate aortic stenosis","volume":"108","author":"Stassen","year":"2022","journal-title":"Heart"},{"issue":"9","key":"10.1016\/j.jmccpl.2026.100845_bb0035","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1016\/j.jcmg.2021.04.009","article-title":"Prognostic implications of associated cardiac abnormalities detected on echocardiography in patients with moderate aortic stenosis","volume":"14","author":"Amanullah","year":"2021","journal-title":"JACC Cardiovasc Imaging"},{"issue":"25","key":"10.1016\/j.jmccpl.2026.100845_bb0040","doi-asserted-by":"crossref","first-page":"2519","DOI":"10.1161\/CIRCULATIONAHA.117.029895","article-title":"Left ventricular hypertrophy revisited","volume":"136","author":"Treibel","year":"2017","journal-title":"Circulation"},{"issue":"12","key":"10.1016\/j.jmccpl.2026.100845_bb0045","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1016\/j.jacc.2016.01.013","article-title":"Coronary microvascular dysfunction as a mechanism of angina in severe AS","volume":"67","author":"Ahn","year":"2016","journal-title":"JACC"},{"issue":"8","key":"10.1016\/j.jmccpl.2026.100845_bb0050","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1093\/eurheartj\/ehx353","article-title":"Reappraising myocardial fibrosis in severe aortic stenosis: an invasive and non-invasive study in 133 patients","volume":"39","author":"Treibel","year":"2018","journal-title":"Eur Heart J"},{"issue":"11","key":"10.1016\/j.jmccpl.2026.100845_bb0055","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1016\/j.jcmg.2016.10.007","article-title":"Myocardial fibrosis and cardiac decompensation in aortic stenosis","volume":"10","author":"Chin","year":"2017","journal-title":"JACC Cardiovasc Imaging"},{"issue":"1","key":"10.1016\/j.jmccpl.2026.100845_bb0060","doi-asserted-by":"crossref","first-page":"6889","DOI":"10.1038\/s41467-025-62201-2","article-title":"Integrated multiomics of pressure overload in the human heart prioritizes targets relevant to heart failure","volume":"16","author":"Lindman","year":"2025","journal-title":"Nat Commun"},{"issue":"3","key":"10.1016\/j.jmccpl.2026.100845_bb0065","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/s00392-020-01754-2","article-title":"Metabolomic profiling of patients with high gradient aortic stenosis undergoing transcatheter aortic valve replacement","volume":"110","author":"Haase","year":"2021","journal-title":"Clin Res Cardiol"},{"issue":"19","key":"10.1016\/j.jmccpl.2026.100845_bb0070","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.124.035486","article-title":"Circulating plasma proteins in aortic stenosis: associations with severity, myocardial response, and clinical outcomes","volume":"13","author":"Tan","year":"2024","journal-title":"J Am Heart Assoc"},{"issue":"1","key":"10.1016\/j.jmccpl.2026.100845_bb0075","doi-asserted-by":"crossref","first-page":"6776","DOI":"10.1038\/s41467-022-34245-1","article-title":"A formal validation of a deep learning-based automated workflow for the interpretation of the echocardiogram","volume":"13","author":"Tromp","year":"2022","journal-title":"Nat Commun"},{"issue":"19","key":"10.1016\/j.jmccpl.2026.100845_bb0080","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.1093\/eurheartj\/ehs255","article-title":"Updated standardized endpoint definitions for transcatheter aortic valve implantation: the Valve Academic Research Consortium-2 consensus document","volume":"33","author":"Kappetein","year":"2012","journal-title":"Eur Heart J"},{"issue":"7","key":"10.1016\/j.jmccpl.2026.100845_bb0085","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.echo.2025.03.011","article-title":"Recommendations for the evaluation of left ventricular diastolic function by echocardiography and for heart failure with preserved ejection fraction diagnosis: an update from the American Society of Echocardiography","volume":"38","author":"Nagueh","year":"2025","journal-title":"J Am Soc Echocardiogr"},{"issue":"3","key":"10.1016\/j.jmccpl.2026.100845_bb0090","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1001\/jamacardio.2017.4873","article-title":"Association of acylcarnitines with left ventricular remodeling in patients with severe aortic stenosis undergoing transcatheter aortic valve replacement","volume":"3","author":"Elmariah","year":"2018","journal-title":"JAMA Cardiol"},{"issue":"1","key":"10.1016\/j.jmccpl.2026.100845_bb0095","doi-asserted-by":"crossref","DOI":"10.3390\/biom13010095","article-title":"Metabolomic profiling in patients with different hemodynamic subtypes of severe aortic valve stenosis","volume":"13","author":"Bengel","year":"2023","journal-title":"Biomolecules"},{"issue":"3","key":"10.1016\/j.jmccpl.2026.100845_bb0100","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1124\/pharmrev.121.000408","article-title":"Acylcarnitines: nomenclature, biomarkers, therapeutic potential, drug targets, and clinical trials","volume":"74","author":"Dambrova","year":"2022","journal-title":"Pharmacol Rev"},{"issue":"10","key":"10.1016\/j.jmccpl.2026.100845_bb0105","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/nrendo.2015.129","article-title":"Acylcarnitines\u2014old actors auditioning for new roles in metabolic physiology","volume":"11","author":"McCoin","year":"2015","journal-title":"Nat Rev Endocrinol"},{"issue":"10","key":"10.1016\/j.jmccpl.2026.100845_bb0110","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1161\/CIRCRESAHA.121.318241","article-title":"Cardiac energy metabolism in heart failure","volume":"128","author":"Lopaschuk","year":"2021","journal-title":"Circ Res"},{"issue":"11","key":"10.1016\/j.jmccpl.2026.100845_bb0115","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1056\/NEJMra063052","article-title":"The failing heart \u2014 an engine out of fuel","volume":"356","author":"Neubauer","year":"2007","journal-title":"N Engl J Med"},{"issue":"6","key":"10.1016\/j.jmccpl.2026.100845_bb0120","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1161\/CIRCHEARTFAILURE.114.001469","article-title":"Energy metabolic reprogramming in the hypertrophied and early stage failing heart","volume":"7","author":"Lai","year":"2014","journal-title":"Circ Heart Fail"},{"issue":"3","key":"10.1016\/j.jmccpl.2026.100845_bb0125","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.jacc.2015.10.079","article-title":"Prognostic implications of long-chain acylcarnitines in heart failure and reversibility with mechanical circulatory support","volume":"67","author":"Ahmad","year":"2016","journal-title":"J Am Coll Cardiol"},{"issue":"10","key":"10.1016\/j.jmccpl.2026.100845_bb0130","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCIMAGING.122.014863","article-title":"Role of cardiac energetics in aortic stenosis disease progression: identifying the high-risk metabolic phenotype","volume":"16","author":"Monga","year":"2023","journal-title":"Circ Cardiovasc Imaging"},{"issue":"12","key":"10.1016\/j.jmccpl.2026.100845_bb0135","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.1016\/j.jcmg.2022.04.025","article-title":"Insights into the metabolic aspects of aortic stenosis with the use of magnetic resonance imaging","volume":"15","author":"Monga","year":"2022","journal-title":"JACC Cardiovasc Imaging"},{"issue":"Supplement_2","key":"10.1016\/j.jmccpl.2026.100845_bb0140","article-title":"Complement component-7 is a long-term predictor of all-cause mortality in chest-pain patients with suspected acute coronary syndrome","volume":"41","author":"Aarsetoey","year":"2020","journal-title":"Eur Heart J"},{"issue":"1","key":"10.1016\/j.jmccpl.2026.100845_bb0145","doi-asserted-by":"crossref","first-page":"42532","DOI":"10.1038\/srep42532","article-title":"The alternative complement pathway is dysregulated in patients with chronic heart failure","volume":"7","author":"Shahini","year":"2017","journal-title":"Sci Rep"},{"issue":"5","key":"10.1016\/j.jmccpl.2026.100845_bb0150","doi-asserted-by":"crossref","first-page":"2240","DOI":"10.1002\/ehf2.12699","article-title":"Extracellular vesicle Cystatin C and CD14 are associated with both renal dysfunction and heart failure","volume":"7","author":"Verbree-Willemsen","year":"2020","journal-title":"ESC Heart Fail"},{"key":"10.1016\/j.jmccpl.2026.100845_bb0155","first-page":"e919422-1","article-title":"Association between cystatin C and cardiac function and long-term prognosis in patients with chronic heart failure","volume":"26","author":"Wu","year":"2020","journal-title":"Med Sci Monit"},{"issue":"4","key":"10.1016\/j.jmccpl.2026.100845_bb0160","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1093\/cvr\/cvq138","article-title":"Cystatin C increases in cardiac injury: a role in extracellular matrix protein modulation","volume":"87","author":"Xie","year":"2010","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jmccpl.2026.100845_bb0165","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.atherosclerosis.2021.01.018","article-title":"Association of beta-2-microglobulin and cardiovascular events and mortality: a systematic review and meta-analysis","volume":"320","author":"Shi","year":"2021","journal-title":"Atherosclerosis"},{"issue":"1","key":"10.1016\/j.jmccpl.2026.100845_bb0170","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.121.009446","article-title":"The association of protein biomarkers with incident heart failure with preserved and reduced ejection fraction","volume":"16","author":"Takvorian","year":"2023","journal-title":"Circ Heart Fail"},{"issue":"23","key":"10.1016\/j.jmccpl.2026.100845_bb0175","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.119.013716","article-title":"Identification of adipsin as a novel prognostic biomarker in patients with coronary artery disease","volume":"8","author":"Ohtsuki","year":"2019","journal-title":"J Am Heart Assoc"},{"issue":"9","key":"10.1016\/j.jmccpl.2026.100845_bb0180","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1161\/CIRCULATIONAHA.121.054885","article-title":"PKM1 exerts critical roles in cardiac remodeling under pressure overload in the heart","volume":"144","author":"Li","year":"2021","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.jmccpl.2026.100845_bb0185","doi-asserted-by":"crossref","first-page":"222","DOI":"10.3390\/cells9010222","article-title":"Crosstalk between mitochondria and cytoskeleton in cardiac cells","volume":"9","author":"Kuznetsov","year":"2020","journal-title":"Cells"},{"issue":"3","key":"10.1016\/j.jmccpl.2026.100845_bb0190","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1083\/jcb.201502062","article-title":"Cytoskeletal dynamics: a view from the membrane","volume":"209","author":"Bezanilla","year":"2015","journal-title":"J Cell Biol"},{"issue":"1","key":"10.1016\/j.jmccpl.2026.100845_bb0195","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/s41421-020-00233-2","article-title":"Plasma membrane integrity in health and disease: significance and therapeutic potential","volume":"7","author":"Dias","year":"2021","journal-title":"Cell Discov"},{"key":"10.1016\/j.jmccpl.2026.100845_bb0200","doi-asserted-by":"crossref","first-page":"5477","DOI":"10.2147\/JIR.S515757","article-title":"Sphingolipid metabolism and signalling pathways in heart failure: from molecular mechanism to therapeutic potential","volume":"18","author":"Zhao","year":"2025","journal-title":"J Inflamm Res"},{"issue":"3\u20134","key":"10.1016\/j.jmccpl.2026.100845_bb0205","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s10974-019-09539-5","article-title":"Cardiomyocyte damage control in heart failure and the role of the sarcolemma","volume":"40","author":"Kitmitto","year":"2019","journal-title":"J Muscle Res Cell Motil"},{"issue":"10","key":"10.1016\/j.jmccpl.2026.100845_bb0210","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/j.jacc.2018.06.050","article-title":"Identifying pathophysiological mechanisms in heart failure with reduced versus preserved ejection fraction","volume":"72","author":"Tromp","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jmccpl.2026.100845_bb0215","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2025.1676988","article-title":"Mitochondrial dysfunction as a therapeutic nexus in HFpEF: therapeutic target and pharmacological advances","volume":"16","author":"Yue","year":"2025","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.jmccpl.2026.100845_bb0220","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2021.742178","article-title":"Inflammation in metabolic cardiomyopathy","volume":"8","author":"Wenzl","year":"2021","journal-title":"Front Cardiovasc Med"},{"issue":"6","key":"10.1016\/j.jmccpl.2026.100845_bb0225","doi-asserted-by":"crossref","first-page":"2960","DOI":"10.3390\/ijms23062960","article-title":"Heart failure and drug therapies: a metabolic review","volume":"23","author":"Yu","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"20","key":"10.1016\/j.jmccpl.2026.100845_bb0230","doi-asserted-by":"crossref","DOI":"10.3390\/cells13201685","article-title":"The extracellular matrix and cardiac pressure overload: focus on novel treatment targets","volume":"13","author":"Snelders","year":"2024","journal-title":"Cells"},{"key":"10.1016\/j.jmccpl.2026.100845_bb0235","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1186\/s12933-024-02504-8","article-title":"SGLT2-inhibitors in diabetic patients with severe aortic stenosis and cardiac damage undergoing transcatheter aortic valve implantation (TAVI)","volume":"23","author":"Paolisso","year":"2024","journal-title":"Cardiovasc Diabetol"},{"key":"10.1016\/j.jmccpl.2026.100845_bb0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcin.2024.11.036","article-title":"Effect of sodium-glucose cotransporter-2 inhibitors on the progression of aortic stenosis","author":"Shah","year":"2025","journal-title":"JACC Cardiovasc Interv"},{"issue":"10","key":"10.1016\/j.jmccpl.2026.100845_bb0245","doi-asserted-by":"crossref","first-page":"4494","DOI":"10.3390\/ijms26104494","article-title":"Sodium-glucose cotransporter 2 inhibitors in aortic stenosis: toward a comprehensive cardiometabolic approach","volume":"26","author":"Karakasis","year":"2025","journal-title":"Int J Mol Sci"},{"issue":"14","key":"10.1016\/j.jmccpl.2026.100845_bb0250","doi-asserted-by":"crossref","first-page":"6777","DOI":"10.3390\/ijms26146777","article-title":"Molecular insights into the potential cardiometabolic effects of GLP-1 receptor analogs and DPP-4 inhibitors","volume":"26","author":"Kr\u00f3l","year":"2025","journal-title":"Int J Mol Sci"},{"issue":"5","key":"10.1016\/j.jmccpl.2026.100845_bb0255","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpha.2023.12.007","article-title":"GLP-1 receptor agonists and myocardial metabolism in atrial fibrillation","volume":"14","author":"Zhong","year":"2024","journal-title":"J Pharm Anal"}],"container-title":["Journal of Molecular and Cellular Cardiology Plus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772976126000127?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772976126000127?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T06:52:41Z","timestamp":1781333561000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2772976126000127"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":51,"alternative-id":["S2772976126000127"],"URL":"https:\/\/doi.org\/10.1016\/j.jmccpl.2026.100845","relation":{},"ISSN":["2772-9761"],"issn-type":[{"value":"2772-9761","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Characteristics, clinical outcomes and molecular mechanisms associated with severe diastolic dysfunction in aortic stenosis","name":"articletitle","label":"Article Title"},{"value":"Journal of Molecular and Cellular Cardiology Plus","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jmccpl.2026.100845","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"100845"}}