{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T13:18:45Z","timestamp":1783171125116,"version":"3.54.6"},"reference-count":70,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["530849567"],"award-info":[{"award-number":["530849567"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["554784412"],"award-info":[{"award-number":["554784412"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008769","name":"Julius-Maximilians-Universit\u00e4t W\u00fcrzburg","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008769","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002491","name":"Bristol-Myers Squibb","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002491","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Molecular and Cellular Cardiology Plus"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.jmccpl.2026.100849","type":"journal-article","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T07:11:14Z","timestamp":1776841874000},"page":"100849","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Why the septum thickens in hypertrophic cardiomyopathy"],"prefix":"10.1016","volume":"16","author":[{"given":"Jan M.","family":"Federspiel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan-Christian","family":"Reil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasco","family":"Sequeira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jmccpl.2026.100849_bb0005","doi-asserted-by":"crossref","first-page":"3503","DOI":"10.1093\/eurheartj\/ehad194","article-title":"2023 ESC Guidelines for the management of cardiomyopathies: developed by the task force on the management of cardiomyopathies of the European Society of Cardiology (ESC)","volume":"44","author":"Arbelo","year":"2023","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jmccpl.2026.100849_bb0010","doi-asserted-by":"crossref","first-page":"e1239","DOI":"10.1161\/CIR.0000000000001250","article-title":"2024 AHA\/ACC\/AMSSM\/HRS\/PACES\/SCMR Guideline for the Management of Hypertrophic Cardiomyopathy: a report of the American Heart Association\/American College of Cardiology Joint Committee on Clinical Practice Guidelines","volume":"149","author":"Ommen","year":"2024","journal-title":"Circulation"},{"key":"10.1016\/j.jmccpl.2026.100849_bb0015","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.1016\/j.jacc.2019.08.1057","article-title":"Distinct subgroups in hypertrophic cardiomyopathy in the NHLBI HCM Registry","volume":"74","author":"Neubauer","year":"2019","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jmccpl.2026.100849_bb0020","article-title":"Mechano-energetic uncoupling in hypertrophic cardiomyopathy: pathophysiological mechanisms and therapeutic opportunities","volume":"4","author":"Sequeira","year":"2023","journal-title":"J Mol Cell Cardiol Plus"},{"key":"10.1016\/j.jmccpl.2026.100849_bb0025","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1016\/S0140-6736(16)31321-6","article-title":"Hypertrophic obstructive cardiomyopathy","volume":"389","author":"Veselka","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.jmccpl.2026.100849_bb0030","doi-asserted-by":"crossref","first-page":"2309","DOI":"10.21037\/jtd-22-182","article-title":"Systolic anterior motion of the mitral valve in hypertrophic cardiomyopathy: a narrative review","volume":"14","author":"Guigui","year":"2022","journal-title":"J Thorac Dis"},{"key":"10.1016\/j.jmccpl.2026.100849_bb0035","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.echo.2024.05.002","article-title":"Mitral geometry on the mechanism of left ventricular outflow tract obstruction in hypertrophic cardiomyopathy","volume":"37","author":"Lin","year":"2024","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.jmccpl.2026.100849_bb0040","article-title":"Histopathology of the mitral valve residual leaflet in obstructive hypertrophic cardiomyopathy","volume":"2","author":"Troy","year":"2023","journal-title":"JACC: Adv"},{"key":"10.1016\/j.jmccpl.2026.100849_bb0045","article-title":"Investigating the Anrep effect in hypertrophic obstructive cardiomyopathy with invasive pressure-volume analysis","volume":"4","author":"Reil","year":"2025","journal-title":"JACC: Adv"},{"key":"10.1016\/j.jmccpl.2026.100849_bb0050","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1161\/CIRCRESAHA.123.323173","article-title":"Exploring the connection between relaxed myosin states and the Anrep effect","volume":"134","author":"Sequeira","year":"2024","journal-title":"Circ Res"},{"key":"10.1016\/j.jmccpl.2026.100849_bb0055","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.125.013392","article-title":"Mavacamten versus alcohol septal ablation in obstructive hypertrophic cardiomyopathy: an echocardiography-derived pressure-volume analysis","author":"Reil","year":"2026","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.jmccpl.2026.100849_bb0060","doi-asserted-by":"crossref","first-page":"3129","DOI":"10.1113\/JP279607","article-title":"CaMKII activity contributes to homeometric autoregulation of the heart: a novel mechanism for the Anrep effect","volume":"598","author":"Reil","year":"2020","journal-title":"J Physiol"},{"key":"10.1016\/j.jmccpl.2026.100849_bb0065","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCIMAGING.116.005604","article-title":"Disease stage-dependent changes in cardiac contractile performance and oxygen utilization underlie reduced myocardial efficiency in human inherited hypertrophic cardiomyopathy","volume":"10","author":"G\u00fc\u00e7l\u00fc","year":"2017","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.jmccpl.2026.100849_bb0070","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1016\/S0735-1097(02)03009-7","article-title":"Hypertrophic cardiomyopathy due to sarcomeric gene mutations is characterized by impaired energy metabolism irrespective of the degree of hypertrophy","volume":"41","author":"Crilley","year":"2003","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jmccpl.2026.100849_bb0075","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1093\/eurheartj\/ehv120","article-title":"Exacerbation of cardiac energetic impairment during exercise in hypertrophic cardiomyopathy: a potential mechanism for diastolic dysfunction","volume":"36","author":"Dass","year":"2015","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jmccpl.2026.100849_bb0080","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCULATIONAHA.125.074120","article-title":"Hypercontractility and oxidative stress drive creatine kinase dysfunction in hypertrophic cardiomyopathy","author":"Xu","year":"2025","journal-title":"Circulation"},{"key":"10.1016\/j.jmccpl.2026.100849_bb0085","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.123.011435","article-title":"Retrofitting the heart: explaining the enigmatic septal thickening in hypertrophic cardiomyopathy","author":"Federspiel","year":"2024","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.jmccpl.2026.100849_bb0090","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s40677-019-0123-y","article-title":"Review on seismic isolation and response control methods of buildings in Japan","volume":"6","author":"Nakamura","year":"2019","journal-title":"Geoenviron Disasters"},{"key":"10.1016\/j.jmccpl.2026.100849_bb0095","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.jacc.2016.11.051","article-title":"Assessment of myocardial microstructural dynamics by in vivo diffusion tensor cardiac magnetic resonance","volume":"69","author":"Nielles-Vallespin","year":"2017","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jmccpl.2026.100849_bb0100","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1161\/CIRCULATIONAHA.123.063835","article-title":"Microstructural and microvascular phenotype of sarcomere mutation carriers and overt hypertrophic cardiomyopathy","volume":"148","author":"Joy","year":"2023","journal-title":"Circulation"},{"key":"10.1016\/j.jmccpl.2026.100849_bb0105","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1056\/NEJM197412192912501","article-title":"Ventricular systolic septal thickening and excursion in idiopathic hypertrophic subaortic stenosis","volume":"291","author":"Rossen","year":"1974","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jmccpl.2026.100849_bb0110","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1136\/hrt.39.6.627","article-title":"Ultrasound study of dynamic behaviour of left ventricle in genetic asymmetric septal hypertrophy","volume":"39","author":"ten Cate","year":"1977","journal-title":"Br Heart J"},{"key":"10.1016\/j.jmccpl.2026.100849_bb0115","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1016\/j.jcmg.2017.06.014","article-title":"Abnormal motion patterns of the interventricular septum","volume":"10","author":"Dwivedi","year":"2017","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.jmccpl.2026.100849_bb0120","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/j.jacc.2005.10.061","article-title":"Global and regional myocardial function quantification by two-dimensional strain: application in hypertrophic cardiomyopathy","volume":"47","author":"Serri","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jmccpl.2026.100849_bb0125","doi-asserted-by":"crossref","DOI":"10.1007\/s10237-025-02003-z","article-title":"A computational model-based study on the mechano-energetic characteristics of the left ventricle with obstructive hypertrophic cardiomyopathy before and after septal myectomy","author":"Liu","year":"2025","journal-title":"Biomech Model Mechanobiol"},{"key":"10.1016\/j.jmccpl.2026.100849_bb0130","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/nrcardio.2009.9","article-title":"Developmental origins of hypertrophic cardiomyopathy phenotypes: a unifying hypothesis","volume":"6","author":"Olivotto","year":"2009","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.jmccpl.2026.100849_bb0135","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/s42003-022-03153-x","article-title":"A pictorial account of the human embryonic heart between 3.5 and 8 weeks of development","volume":"5","author":"Hikspoors","year":"2022","journal-title":"Commun Biol"},{"key":"10.1016\/j.jmccpl.2026.100849_bb0140","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1056\/NEJM197701202960303","article-title":"Isometric cardiac contraction. A possible cause of the disorganized myocardial pattern of idiopathic hypertrophic subaortic stenosis","volume":"296","author":"Bulkley","year":"1977","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jmccpl.2026.100849_bb0145","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1161\/01.CIR.58.3.392","article-title":"Catenoid shape of the interventricular septum: possible cause of idiopathic hypertrophic subaortic stenosis","volume":"58","author":"Hutchins","year":"1978","journal-title":"Circulation"},{"key":"10.1016\/j.jmccpl.2026.100849_bb0150","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1093\/ajcp\/83.1.53","article-title":"Catenoidal shape of the interventricular septum acquired secondary to myocardial infarction","volume":"83","author":"Hutchins","year":"1985","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.jmccpl.2026.100849_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2025.113901","article-title":"Phenotype specific nuclear lamina remodeling in hiPSC derived cardiomyocytes bearing TNNT2 sarcomeric variants","volume":"28","author":"Coscarella","year":"2025","journal-title":"iScience"},{"key":"10.1016\/j.jmccpl.2026.100849_bb0160","doi-asserted-by":"crossref","first-page":"13341","DOI":"10.3390\/ijms241713341","article-title":"Nucleus mechanosensing in cardiomyocytes","volume":"24","author":"Coscarella","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"50","key":"10.1016\/j.jmccpl.2026.100849_bb0165","doi-asserted-by":"crossref","first-page":"E7003","DOI":"10.1073\/pnas.1513843112","article-title":"ADP-stimulated contraction: a predictor of thin-filament activation in cardiac disease","volume":"112","author":"Sequeira","year":"2015","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.jmccpl.2026.100849_bb0170","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1161\/CIRCRESAHA.111.300436","article-title":"Perturbed length-dependent activation in human hypertrophic cardiomyopathy with missense sarcomeric gene mutations","volume":"112","author":"Sequeira","year":"2013","journal-title":"Circ Res"},{"key":"10.1016\/j.jmccpl.2026.100849_bb0175","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jcmg.2008.02.008","article-title":"Hypertrophic cardiomyopathy: identification of morphological subtypes by echocardiography and cardiac magnetic resonance imaging","volume":"1","author":"Syed","year":"2008","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.jmccpl.2026.100849_bb0180","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1161\/01.CIR.79.3.580","article-title":"Hypertrophic cardiomyopathy in the elderly. Distinctions from the young based on cardiac shape","volume":"79","author":"Lever","year":"1989","journal-title":"Circulation"},{"key":"10.1016\/j.jmccpl.2026.100849_bb0185","doi-asserted-by":"crossref","first-page":"459","DOI":"10.4065\/81.4.459","article-title":"Echocardiography-guided genetic testing in hypertrophic cardiomyopathy: septal morphological features predict the presence of myofilament mutations","volume":"81","author":"Binder","year":"2006","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.jmccpl.2026.100849_bb0190","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.cmet.2015.07.008","article-title":"Reversal of mitochondrial transhydrogenase causes oxidative stress in heart failure","volume":"22","author":"Nickel Alexander","year":"2015","journal-title":"Cell Metab"},{"key":"10.1016\/j.jmccpl.2026.100849_bb0195","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/j.cell.2016.04.002","article-title":"A tension-based model distinguishes hypertrophic versus dilated cardiomyopathy","volume":"165","author":"Davis","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.jmccpl.2026.100849_bb0200","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1038\/nrcardio.2016.98","article-title":"Myocardial energy depletion and dynamic systolic dysfunction in hypertrophic cardiomyopathy","volume":"13","author":"Ormerod","year":"2016","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.jmccpl.2026.100849_bb0205","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.bbamem.2013.07.011","article-title":"The physiological role of cardiac cytoskeleton and its alterations in heart failure","volume":"1838","author":"Sequeira","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jmccpl.2026.100849_bb0210","doi-asserted-by":"crossref","first-page":"7765","DOI":"10.1073\/pnas.141199598","article-title":"Mechanical behavior in living cells consistent with the tensegrity model","volume":"98","author":"Wang","year":"2001","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.jmccpl.2026.100849_bb0215","doi-asserted-by":"crossref","DOI":"10.1088\/0034-4885\/77\/4\/046603","article-title":"Tensegrity, cellular biophysics, and the mechanics of living systems","volume":"77","author":"Ingber","year":"2014","journal-title":"Rep Prog Phys"},{"key":"10.1016\/j.jmccpl.2026.100849_bb0220","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1007\/s12551-020-00737-x","article-title":"The intercalated disc: a mechanosensing signalling node in cardiomyopathy","volume":"12","author":"Pruna","year":"2020","journal-title":"Biophys Rev"},{"key":"10.1016\/j.jmccpl.2026.100849_bb0225","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1093\/ejechocard\/jer290","article-title":"Relationship of mechanical dyssynchrony to QT interval prolongation in hypertrophic cardiomyopathy","volume":"13","author":"Badran","year":"2012","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"10.1016\/j.jmccpl.2026.100849_bb0230","doi-asserted-by":"crossref","first-page":"4182","DOI":"10.1038\/s41598-018-22213-z","article-title":"Mechanical dyssynchrony and diastolic dysfunction are common in LVH: a pilot correlation study using Doppler echocardiography and CZT gated-SPECT MPI","volume":"8","author":"Tsai","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.jmccpl.2026.100849_bb0235","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.120.007022","article-title":"Proteomic and functional studies reveal detyrosinated tubulin as treatment target in sarcomere mutation-induced hypertrophic cardiomyopathy","volume":"14","author":"Schuldt","year":"2021","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.jmccpl.2026.100849_bb0240","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s00424-011-0963-0","article-title":"Mechanical modulation of cardiac microtubules","volume":"462","author":"White","year":"2011","journal-title":"Pflugers Arch"},{"key":"10.1016\/j.jmccpl.2026.100849_bb0245","first-page":"H1003","article-title":"Cytoskeletal networks and the regulation of cardiac contractility: microtubules, hypertrophy, and cardiac dysfunction","volume":"291","author":"Cooper","year":"2006","journal-title":"Am J Physiol"},{"key":"10.1016\/j.jmccpl.2026.100849_bb0250","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.ijcard.2021.09.009","article-title":"Stress activated signalling impaired protein quality control pathways in human hypertrophic cardiomyopathy","volume":"344","author":"Hassoun","year":"2021","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jmccpl.2026.100849_bb0255","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1161\/01.RES.60.3.327","article-title":"Microtubules and desmin filaments during onset of heart hypertrophy in rat: a double immunoelectron microscope study","volume":"60","author":"Watkins","year":"1987","journal-title":"Circ Res"},{"key":"10.1016\/j.jmccpl.2026.100849_bb0260","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1161\/CIRCULATIONAHA.113.003437","article-title":"Myocardial titin and collagen in cardiac diastolic dysfunction: partners in crime","volume":"128","author":"Hamdani","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.jmccpl.2026.100849_bb0265","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1056\/NEJMoa1002659","article-title":"Myocardial fibrosis as an early manifestation of hypertrophic cardiomyopathy","volume":"363","author":"Ho","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jmccpl.2026.100849_bb0270","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.1016\/j.jacc.2014.04.090","article-title":"Vector flow mapping in obstructive hypertrophic cardiomyopathy to assess the relationship of early systolic left ventricular flow and the mitral valve","volume":"64","author":"Ro","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jmccpl.2026.100849_bb0275","doi-asserted-by":"crossref","DOI":"10.1007\/s00392-026-02855-0","article-title":"Mavacamten optimizes myocardial work in patients with obstructive hypertrophic cardiomyopathy: a non-invasive pressure\u2013strain analysis","author":"Scholtz","year":"2026","journal-title":"Clin Res Cardiol"},{"key":"10.1016\/j.jmccpl.2026.100849_bb0280","first-page":"47","article-title":"Hypertrophic obstructive cardiomyopathy","volume":"116","author":"Batzner","year":"2019","journal-title":"Dtsch Arztebl Int"},{"key":"10.1016\/j.jmccpl.2026.100849_bb0285","first-page":"12","article-title":"Alcohol septal ablation or mavacamten for obstructive hypertrophic cardiomyopathy","author":"Scholtz","year":"2023","journal-title":"J Clin Med"},{"key":"10.1016\/j.jmccpl.2026.100849_bb0290","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1093\/ehjci\/jead236","article-title":"Non-invasive estimation of left ventricular systolic peak pressure: a prerequisite to calculate myocardial work in hypertrophic obstructive cardiomyopathy","volume":"25","author":"Batzner","year":"2024","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"10.1016\/j.jmccpl.2026.100849_bb0295","doi-asserted-by":"crossref","first-page":"E8143","DOI":"10.1073\/pnas.1809540115","article-title":"Deciphering the super relaxed state of human \u03b2-cardiac myosin and the mode of action of mavacamten from myosin molecules to muscle fibers","volume":"115","author":"Anderson","year":"2018","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.jmccpl.2026.100849_bb0300","article-title":"Myosin in autoinhibited off state(s), stabilized by mavacamten, can be recruited in response to inotropic interventions","volume":"121","author":"Ma","year":"2024","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.jmccpl.2026.100849_bb0305","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1161\/CIRCULATIONAHA.120.052359","article-title":"Mavacamten favorably impacts cardiac structure in obstructive hypertrophic cardiomyopathy","volume":"143","author":"Saberi","year":"2021","journal-title":"Circulation"},{"key":"10.1016\/j.jmccpl.2026.100849_bb0310","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/S0735-1097(23)00770-2","article-title":"96-week cardiac magnetic resonance (cmr) results of treatment with mavacamten from the explorer cohort of the mava-long-term extension (lte) study in patients (pts) with obstructive hypertrophic cardiomyopathy (hcm)","volume":"81","author":"Saberi","year":"2023","journal-title":"JACC"},{"key":"10.1016\/j.jmccpl.2026.100849_bb0315","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.1016\/j.jacc.2021.09.1381","article-title":"Effect of mavacamten on echocardiographic features in symptomatic patients with obstructive hypertrophic cardiomyopathy","volume":"78","author":"Hegde","year":"2021","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jmccpl.2026.100849_bb0320","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.jacc.2022.04.048","article-title":"Myosin inhibition in patients with obstructive hypertrophic cardiomyopathy referred for septal reduction therapy","volume":"80","author":"Desai","year":"2022","journal-title":"JACC"},{"key":"10.1016\/j.jmccpl.2026.100849_bb0325","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1056\/NEJMoa2505927","article-title":"Mavacamten in symptomatic nonobstructive hypertrophic cardiomyopathy","volume":"393","author":"Desai Milind","year":"2025","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jmccpl.2026.100849_bb0330","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1126\/science.aad3456","article-title":"A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice","volume":"351","author":"Green","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.jmccpl.2026.100849_bb0335","doi-asserted-by":"crossref","DOI":"10.1002\/ejhf.3746","article-title":"Computational modelling of myocardial metabolism in patients with advanced heart failure","author":"Beyhoff","year":"2025","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jmccpl.2026.100849_bb0340","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.119.015294","article-title":"Apical hypertrophic cardiomyopathy: the variant less known","volume":"9","author":"Hughes","year":"2020","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.jmccpl.2026.100849_bb0345","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.echo.2011.03.002","article-title":"Apical hypertrophic cardiomyopathy: prevalence and correlates of apical outpouching","volume":"24","author":"Binder","year":"2011","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.jmccpl.2026.100849_bb0350","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.jtcvs.2007.10.088","article-title":"Structure and function relationships of the helical ventricular myocardial band","volume":"136","author":"Buckberg","year":"2008","journal-title":"J Thorac Cardiovasc Surg"}],"container-title":["Journal of Molecular and Cellular Cardiology Plus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772976126000164?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772976126000164?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T12:44:30Z","timestamp":1783169070000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2772976126000164"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":70,"alternative-id":["S2772976126000164"],"URL":"https:\/\/doi.org\/10.1016\/j.jmccpl.2026.100849","relation":{},"ISSN":["2772-9761"],"issn-type":[{"value":"2772-9761","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Why the septum thickens in hypertrophic cardiomyopathy","name":"articletitle","label":"Article Title"},{"value":"Journal of Molecular and Cellular Cardiology Plus","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jmccpl.2026.100849","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"100849"}}