{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T09:40:45Z","timestamp":1792662045289,"version":"4.5.0"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Forschung, Technologie und Raumfahrt","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["INST 35\/1699-1"],"award-info":[{"award-number":["INST 35\/1699-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["Collaborative Research Center CRC1550 \\u201CMolecular Circuits of Heart Disease\\u201D"],"award-info":[{"award-number":["Collaborative Research Center CRC1550 \\u201CMolecular Circuits of Heart Disease\\u201D"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010447","name":"German Center for Cardiovascular Disease","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010447","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003542","name":"State of Baden-Wurttemberg Ministry for Science Research and Art","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003542","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Molecular and Cellular Cardiology Plus"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.jmccpl.2026.100863","type":"journal-article","created":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T15:09:34Z","timestamp":1786806574000},"page":"100863","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Systemic administration of the PRMT5 inhibitor GSK3326595 does not induce overt cardiotoxicity in the murine heart"],"prefix":"10.1016","volume":"18","author":[{"given":"Victoria","family":"Mauz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Steinacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Burhenne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Steimel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Mertens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina U.","family":"Muckenthaler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Dewenter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Backs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jmccpl.2026.100863_bb0005","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1038\/s41580-019-0155-x","article-title":"The regulation, functions and clinical relevance of arginine methylation","volume":"20","author":"Guccione","year":"2019","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.jmccpl.2026.100863_bb0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.molcel.2008.12.013","article-title":"Protein arginine methylation in mammals: who, what, and why","volume":"33","author":"Bedford","year":"2009","journal-title":"Mol Cell"},{"key":"10.1016\/j.jmccpl.2026.100863_bb0015","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/ncb2158","article-title":"Crosstalk between Arg 1175 methylation and Tyr 1173 phosphorylation negatively modulates EGFR-mediated ERK activation","volume":"13","author":"Hsu","year":"2011","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.jmccpl.2026.100863_bb0020","doi-asserted-by":"crossref","first-page":"8419","DOI":"10.1038\/ncomms9419","article-title":"Interplay between arginine methylation and ubiquitylation regulates KLF4-mediated genome stability and carcinogenesis","volume":"6","author":"Hu","year":"2015","journal-title":"Nat Commun"},{"key":"10.1016\/j.jmccpl.2026.100863_bb0025","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1369\/0022155413475452","article-title":"Overexpression of PRMT5 promotes tumor cell growth and is associated with poor disease prognosis in epithelial ovarian cancer","volume":"61","author":"Bao","year":"2013","journal-title":"J Histochem Cytochem"},{"key":"10.1016\/j.jmccpl.2026.100863_bb0030","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1007\/s00018-015-1847-9","article-title":"The PRMT5 arginine methyltransferase: many roles in development, cancer and beyond","volume":"72","author":"Stopa","year":"2015","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.jmccpl.2026.100863_bb0035","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1038\/nchembio.1810","article-title":"A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models","volume":"11","author":"Chan-Penebre","year":"2015","journal-title":"Nat Chem Biol"},{"key":"10.1016\/j.jmccpl.2026.100863_bb0040","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2023114558","article-title":"MST2 methylation by PRMT5 inhibits Hippo signaling and promotes pancreatic cancer progression","volume":"42","author":"Sun","year":"2023","journal-title":"EMBO J"},{"key":"10.1016\/j.jmccpl.2026.100863_bb0045","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1002\/hep.31864","article-title":"Myelocytomatosis-protein arginine N-methyltransferase 5 axis defines the tumorigenesis and immune response in hepatocellular carcinoma","volume":"74","author":"Luo","year":"2021","journal-title":"Hepatology"},{"key":"10.1016\/j.jmccpl.2026.100863_bb0050","doi-asserted-by":"crossref","first-page":"8407","DOI":"10.1021\/acs.jmedchem.3c00250","article-title":"Targeting arginine methyltransferase PRMT5 for cancer therapy: updated progress and novel strategies","volume":"66","author":"Zheng","year":"2023","journal-title":"J Med Chem"},{"key":"10.1016\/j.jmccpl.2026.100863_bb0055","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1016\/j.bmcl.2019.03.042","article-title":"Nucleoside protein arginine methyltransferase 5 (PRMT5) inhibitors","volume":"29","author":"Lin","year":"2019","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.jmccpl.2026.100863_bb0060","doi-asserted-by":"crossref","DOI":"10.1177\/20406207241275376","article-title":"Phase I\/II study of the clinical activity and safety of GSK3326595 in patients with myeloid neoplasms","volume":"15","author":"Watts","year":"2024","journal-title":"Ther Adv Hematol"},{"key":"10.1016\/j.jmccpl.2026.100863_bb0065","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1161\/CIRCRESAHA.121.319456","article-title":"PRMT5 prevents dilated cardiomyopathy via suppression of protein O-GlcNAcylation","volume":"129","author":"Li","year":"2021","journal-title":"Circ Res"},{"key":"10.1016\/j.jmccpl.2026.100863_bb0070","doi-asserted-by":"crossref","first-page":"9711","DOI":"10.1038\/s41598-018-28002-y","article-title":"Activation of the p53-MDM4 regulatory axis defines the anti-tumour response to PRMT5 inhibition through its role in regulating cellular splicing","volume":"8","author":"Gerhart","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.jmccpl.2026.100863_bb0075","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/nsmb.2209","article-title":"Symmetric dimethylation of H3R2 is a newly identified histone mark that supports euchromatin maintenance","volume":"19","author":"Migliori","year":"2012","journal-title":"Nat Struct Mol Biol"},{"key":"10.1016\/j.jmccpl.2026.100863_bb0080","doi-asserted-by":"crossref","first-page":"3558","DOI":"10.1038\/sj.emboj.7601794","article-title":"Low levels of miR-92b\/96 induce PRMT5 translation and H3R8\/H4R3 methylation in mantle cell lymphoma","volume":"26","author":"Pal","year":"2007","journal-title":"EMBO J"},{"key":"10.1016\/j.jmccpl.2026.100863_bb0085","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1093\/nar\/gkt884","article-title":"PRMT5-mediated histone H4 arginine-3 symmetrical dimethylation marks chromatin at G + C-rich regions of the mouse genome","volume":"42","author":"Girardot","year":"2014","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jmccpl.2026.100863_bb0090","doi-asserted-by":"crossref","first-page":"58","DOI":"10.36401\/JIPO-22-1","article-title":"Protein arginine methyltransferase 5 (PRMT5) inhibitors in oncology clinical trials: a review","volume":"5","author":"Feustel","year":"2022","journal-title":"J Immunother Precis Oncol"},{"key":"10.1016\/j.jmccpl.2026.100863_bb0095","doi-asserted-by":"crossref","DOI":"10.1093\/ehjopen\/oead073","article-title":"Association between heart failure and the incidence of cancer: a systematic review and meta-analysis","volume":"3","author":"Jaiswal","year":"2023","journal-title":"Eur Heart J Open"},{"key":"10.1016\/j.jmccpl.2026.100863_bb0100","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1093\/cvr\/cvy141","article-title":"A novel method for high precision aortic constriction that allows for generation of specific cardiac phenotypes in mice","volume":"114","author":"Melleby","year":"2018","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jmccpl.2026.100863_bb0105","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1161\/CIRCULATIONAHA.124.065473","article-title":"Cardio-oncology: a new clinical frontier and novel platform for cardiovascular investigation","volume":"150","author":"Moslehi","year":"2024","journal-title":"Circulation"},{"key":"10.1016\/j.jmccpl.2026.100863_bb0110","doi-asserted-by":"crossref","first-page":"2414","DOI":"10.1002\/cam4.2114","article-title":"Protein arginine methyltransferase 5: a novel therapeutic target for triple-negative breast cancers","volume":"8","author":"Vinet","year":"2019","journal-title":"Cancer Med"},{"key":"10.1016\/j.jmccpl.2026.100863_bb0115","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.tibs.2011.09.001","article-title":"Versatility of PRMT5-induced methylation in growth control and development","volume":"36","author":"Karkhanis","year":"2011","journal-title":"Trends Biochem Sci"},{"key":"10.1016\/j.jmccpl.2026.100863_bb0120","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat Methods"}],"container-title":["Journal of Molecular and Cellular Cardiology Plus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772976126000309?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772976126000309?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T09:03:38Z","timestamp":1792659818000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2772976126000309"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":24,"alternative-id":["S2772976126000309"],"URL":"https:\/\/doi.org\/10.1016\/j.jmccpl.2026.100863","relation":{},"ISSN":["2772-9761"],"issn-type":[{"value":"2772-9761","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Systemic administration of the PRMT5 inhibitor GSK3326595 does not induce overt cardiotoxicity in the murine heart","name":"articletitle","label":"Article Title"},{"value":"Journal of Molecular and Cellular Cardiology Plus","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jmccpl.2026.100863","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"100863"}}