{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T14:23:39Z","timestamp":1768314219669,"version":"3.49.0"},"reference-count":67,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Molecular Graphics and Modelling"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.jmgm.2025.108950","type":"journal-article","created":{"date-parts":[[2025,1,11]],"date-time":"2025-01-11T16:17:09Z","timestamp":1736612229000},"page":"108950","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Glipizide inhibits the glycation of alpha-crystallin: A combined in vitro and in silico approach in retinopathy management"],"prefix":"10.1016","volume":"136","author":[{"given":"Ting","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3616-945X","authenticated-orcid":false,"given":"Mingli","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jmgm.2025.108950_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.diabres.2019.107843","article-title":"Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: results from the international diabetes federation diabetes atlas","volume":"157","author":"Saeedi","year":"2019","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.jmgm.2025.108950_bib2","doi-asserted-by":"crossref","first-page":"S133","DOI":"10.1016\/j.dsx.2016.12.022","article-title":"Diabetes microvascular complications\u2014a clinical update","volume":"11","author":"Khalil","year":"2017","journal-title":"Diabetes Metabol. Syndr.: Clin. Res. Rev."},{"key":"10.1016\/j.jmgm.2025.108950_bib3","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/S0140-6736(09)62124-3","article-title":"Diabetic retinopathy","volume":"376","author":"Cheung","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.jmgm.2025.108950_bib4","doi-asserted-by":"crossref","first-page":"s84","DOI":"10.2337\/diacare.27.2007.S84","article-title":"Retinopathy in diabetes","volume":"27","author":"Fong","year":"2004","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jmgm.2025.108950_bib5","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.survophthal.2012.01.004","article-title":"Prevalence of diabetic retinopathy in various ethnic groups: a worldwide perspective","volume":"57","author":"Sivaprasad","year":"2012","journal-title":"Surv. Ophthalmol."},{"key":"10.1016\/j.jmgm.2025.108950_bib6","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.2337\/dc15-2171","article-title":"Global estimates on the number of people blind or visually impaired by diabetic retinopathy: a meta-analysis from 1990 to 2010","volume":"39","author":"Leasher","year":"2016","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jmgm.2025.108950_bib7","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1016\/j.ophtha.2021.04.027","article-title":"Global prevalence of diabetic retinopathy and projection of burden through 2045","volume":"128","author":"Teo","year":"2021","journal-title":"Ophthalmology"},{"key":"10.1016\/j.jmgm.2025.108950_bib8","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/S0140-6736(09)60937-5","article-title":"Diabetes in Asia","volume":"375","author":"Ramachandran","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.jmgm.2025.108950_bib9","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2024.1501690","article-title":"Global burden of type 2 diabetes mellitus from 1990 to 2021, with projections of prevalence to 2044: a systematic analysis across SDI levels for the global burden of disease study 2021","volume":"15","author":"He","year":"2024","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.jmgm.2025.108950_bib10","doi-asserted-by":"crossref","first-page":"e1352","DOI":"10.1016\/S2214-109X(18)30387-5","article-title":"The increasing burden of diabetes and variations among the states of India: the Global Burden of Disease Study 1990\u20132016","volume":"6","author":"Tandon","year":"2018","journal-title":"Lancet Glob Health"},{"key":"10.1016\/j.jmgm.2025.108950_bib11","doi-asserted-by":"crossref","first-page":"9881","DOI":"10.3390\/ijms24129881","article-title":"A role for advanced glycation end products in molecular ageing","volume":"24","author":"Zgutka","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jmgm.2025.108950_bib12","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1007\/s11892-011-0198-7","article-title":"AGEs, RAGE, and diabetic retinopathy","volume":"11","author":"Zong","year":"2011","journal-title":"Curr Diab Rep"},{"key":"10.1016\/j.jmgm.2025.108950_bib13","series-title":"The Eye and Foot in Diabetes","article-title":"Advanced glycation end products: formation, role in diabetic complications, and potential in clinical applications","author":"Khan","year":"2020"},{"key":"10.1016\/j.jmgm.2025.108950_bib14","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2022.1037186","article-title":"Advanced glycation end products in diabetic retinopathy and phytochemical therapy","volume":"9","author":"Kang","year":"2022","journal-title":"Front. Nutr."},{"key":"10.1016\/j.jmgm.2025.108950_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101799","article-title":"Oxidative stress and diabetic retinopathy: molecular mechanisms, pathogenetic role and therapeutic implications","volume":"37","author":"Kang","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.jmgm.2025.108950_bib16","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1136\/bjo.85.6.746","article-title":"Advanced glycation: an important pathological event in diabetic and age related ocular disease","volume":"85","author":"Stitt","year":"2001","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.jmgm.2025.108950_bib17","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1161\/hc3801.097806","article-title":"Improved arterial compliance by a novel advanced glycation end-product crosslink breaker","volume":"104","author":"Kass","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.jmgm.2025.108950_bib18","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/j.1749-6632.1998.tb09626.x","article-title":"Multifunctional lens crystallins and corneal enzymes: more than meets the eye","volume":"842","author":"Piatigorsky","year":"1998","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.jmgm.2025.108950_bib19","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.molmed.2012.03.005","article-title":"Protein misfolding and aggregation in cataract disease and prospects for prevention","volume":"18","author":"Moreau","year":"2012","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.jmgm.2025.108950_bib20","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1002\/pro.2229","article-title":"Evolution of crystallins for a role in the vertebrate eye lens","volume":"22","author":"Slingsby","year":"2013","journal-title":"Protein Sci."},{"key":"10.1016\/j.jmgm.2025.108950_bib21","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.preteyeres.2006.10.003","article-title":"Crystallins in the eye: function and pathology","volume":"26","author":"Andley","year":"2007","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.jmgm.2025.108950_bib22","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.pbiomolbio.2003.11.012","article-title":"Ageing and vision: structure, stability and function of lens crystallins","volume":"86","author":"Bloemendal","year":"2004","journal-title":"Prog. Biophys. Mol. Biol."},{"key":"10.1016\/j.jmgm.2025.108950_bib23","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1196\/annals.1338.066","article-title":"The maillard reaction in eye diseases","volume":"1043","author":"Stitt","year":"2005","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.jmgm.2025.108950_bib24","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/pai.12142","article-title":"High-mobility group box-1 (HMGB-1) and serum soluble receptor for advanced glycation end products (sRAGE) in children affected by vernal keratoconjunctivitis","volume":"25","author":"Zicari","year":"2014","journal-title":"Pediatr. Allergy Immunol."},{"key":"10.1016\/j.jmgm.2025.108950_bib25","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.bbagen.2015.08.016","article-title":"The etiology of human age-related cataract. Proteins don't last forever","volume":"1860","author":"Truscott","year":"2016","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"key":"10.1016\/j.jmgm.2025.108950_bib26","doi-asserted-by":"crossref","first-page":"3142","DOI":"10.3390\/molecules26113142","article-title":"The physico-chemical properties of glipizide: new findings","volume":"26","author":"Bruni","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.jmgm.2025.108950_bib27","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/379545a0","article-title":"Promiscuous coupling between the sulphonylurea receptor and inwardly rectifying potassium channels","volume":"379","author":"\u00c4mm\u00e4l\u00e4","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.jmgm.2025.108950_bib28","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/s12149-011-0569-9","article-title":"Sulfonylurea receptor as a target for molecular imaging of pancreas beta cells with 99mTc-DTPA-glipizide","volume":"26","author":"Oh","year":"2012","journal-title":"Ann. Nucl. Med."},{"key":"10.1016\/j.jmgm.2025.108950_bib29","doi-asserted-by":"crossref","first-page":"S368","DOI":"10.2337\/diabetes.51.2007.S368","article-title":"Sulfonylurea stimulation of insulin secretion","volume":"51","author":"Proks","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.jmgm.2025.108950_bib30","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.jpba.2017.03.005","article-title":"Simultaneous determination of glipizide and its four hydroxylated metabolites in human urine using LC\u2013MS\/MS and its application in urinary phenotype study","volume":"139","author":"Tan","year":"2017","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jmgm.2025.108950_bib31","doi-asserted-by":"crossref","first-page":"329","DOI":"10.2165\/00003495-197918050-00001","article-title":"Glipizide: a review of its pharmacological properties and therapeutic use","volume":"18","author":"Brogden","year":"1979","journal-title":"Drugs"},{"key":"10.1016\/j.jmgm.2025.108950_bib32","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/BF01218440","article-title":"Pharmacodynamic aspects of two sulphonylurea derivatives glipizide and glibenclamide","volume":"9","author":"Artini","year":"1973","journal-title":"Diabetologia"},{"key":"10.1016\/j.jmgm.2025.108950_bib33","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1007\/s10895-023-03147-w","article-title":"Butein inhibits the glycation of \u03b1-crystallin: an approach in prevention of retinopathy","volume":"33","author":"Liu","year":"2023","journal-title":"J. Fluoresc."},{"key":"10.1016\/j.jmgm.2025.108950_bib34","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.ijbiomac.2022.03.202","article-title":"Ameliorative effect of pioglitazone on glucose induced glycation of \u03b1-crystallin: management of complications associated with diabetic retinopathy","volume":"209","author":"Ren","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jmgm.2025.108950_bib35","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.ijbiomac.2020.12.096","article-title":"Glyburide inhibits non-enzymatic glycation of HSA: an approach for the management of AGEs associated diabetic complications","volume":"169","author":"Qais","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jmgm.2025.108950_bib36","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/0003-2697(69)90032-3","article-title":"Determination of available lysine in proteins","volume":"27","author":"Kakade","year":"1969","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.jmgm.2025.108950_bib37","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/S0076-6879(94)33040-9","article-title":"Carbonyl assays for determination of oxidatively modified proteins","volume":"233","author":"Levine","year":"1994","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.jmgm.2025.108950_bib38","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1016\/j.bbapap.2010.04.001","article-title":"Molecular mechanism of Thioflavin-T binding to amyloid fibrils","volume":"1804","author":"Biancalana","year":"2010","journal-title":"Biochim. Biophys. Acta Protein Proteonomics"},{"key":"10.1016\/j.jmgm.2025.108950_bib39","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading","volume":"31","author":"Trott","year":"2009","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.jmgm.2025.108950_bib40","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1002\/(SICI)1096-987X(19981115)19:14<1639::AID-JCC10>3.0.CO;2-B","article-title":"Automated docking using a Lamarckian genetic algorithm and an empirical binding free energy function","volume":"19","author":"Morris","year":"1998","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.jmgm.2025.108950_bib41","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1002\/jcc.20291","article-title":"GROMACS: fast, flexible, and free","volume":"26","author":"Van Der Spoel","year":"2005","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.jmgm.2025.108950_bib42","doi-asserted-by":"crossref","first-page":"3696","DOI":"10.1021\/acs.jctc.5b00255","article-title":"ff14SB: improving the accuracy of protein side chain and backbone parameters from ff99SB","volume":"11","author":"Maier","year":"2015","journal-title":"J. Chem. Theor. Comput."},{"key":"10.1016\/j.jmgm.2025.108950_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmgm.2021.107870","article-title":"Structure-based mimicking of hydroxylated biphenyl congeners (OHPCBs) for human transthyretin, an important enzyme of thyroid hormone system","volume":"105","author":"Kumari","year":"2021","journal-title":"J. Mol. Graph. Model."},{"key":"10.1016\/j.jmgm.2025.108950_bib44","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.2741\/4859","article-title":"In-silico i approach to identify novel potent inhibitors against GraR of i S aureus","volume":"25","author":"Dhankhar","year":"2020","journal-title":"Front. Biosci."},{"key":"10.1016\/j.jmgm.2025.108950_bib45","doi-asserted-by":"crossref","DOI":"10.1063\/1.2408420","article-title":"Canonical sampling through velocity rescaling","volume":"126","author":"Bussi","year":"2007","journal-title":"J. Chem. Phys."},{"key":"10.1016\/j.jmgm.2025.108950_bib46","doi-asserted-by":"crossref","first-page":"7182","DOI":"10.1063\/1.328693","article-title":"Polymorphic transitions in single crystals: a new molecular dynamics method","volume":"52","author":"Parrinello","year":"1981","journal-title":"J. Appl. Phys."},{"key":"10.1016\/j.jmgm.2025.108950_bib47","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1021\/ci500020m","article-title":"g_mmpbsa \u2014a GROMACS tool for high-throughput MM-PBSA calculations","volume":"54","author":"Kumari","year":"2014","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.jmgm.2025.108950_bib48","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S2213-8587(13)70199-2","article-title":"Fructosamine and glycated albumin for risk stratification and prediction of incident diabetes and microvascular complications: a prospective cohort analysis of the Atherosclerosis Risk in Communities (ARIC) study","volume":"2","author":"Selvin","year":"2014","journal-title":"Lancet Diabetes Endocrinol."},{"key":"10.1016\/j.jmgm.2025.108950_bib49","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1196\/annals.1433.052","article-title":"The role of the Amadori product in the complications of diabetes","volume":"1126","author":"Monnier","year":"2008","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.jmgm.2025.108950_bib50","doi-asserted-by":"crossref","first-page":"39","DOI":"10.4103\/2230-8210.146863","article-title":"Amadori albumin in diabetic nephropathy","volume":"19","author":"Neelofar","year":"2015","journal-title":"Indian J Endocrinol Metab"},{"key":"10.1016\/j.jmgm.2025.108950_bib51","doi-asserted-by":"crossref","first-page":"63605","DOI":"10.1039\/C5RA07232H","article-title":"Impact of in vitro non-enzymatic glycation on biophysical and biochemical regimes of human serum albumin: relevance in diabetes associated complications","volume":"5","author":"Neelofar","year":"2015","journal-title":"RSC Adv."},{"key":"10.1016\/j.jmgm.2025.108950_bib52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijbiomac.2016.02.041","article-title":"Vanillin restrains non-enzymatic glycation and aggregation of albumin by chemical chaperone like function","volume":"87","author":"Awasthi","year":"2016","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jmgm.2025.108950_bib53","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.ab.2005.10.009","article-title":"Infrared spectroscopy used to evaluate glycosylation of proteins","volume":"348","author":"Khajehpour","year":"2006","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.jmgm.2025.108950_bib54","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/S0891-5849(02)00780-3","article-title":"Oxidatively modified proteins in aging and disease","volume":"32","author":"Beal","year":"2002","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.jmgm.2025.108950_bib55","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1002\/bio.2748","article-title":"Comparison of interactions between human serum albumin and silver nanoparticles of different sizes using spectroscopic methods","volume":"30","author":"Zhang","year":"2014","journal-title":"Luminescence"},{"key":"10.1016\/j.jmgm.2025.108950_bib56","doi-asserted-by":"crossref","first-page":"41810","DOI":"10.1074\/jbc.M303925200","article-title":"Glycation induces formation of amyloid cross-\u03b2 structure in albumin","volume":"278","author":"Bouma","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jmgm.2025.108950_bib57","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.ijbiomac.2018.02.137","article-title":"Methylglyoxal induced glycation and aggregation of human serum albumin: biochemical and biophysical approach","volume":"113","author":"Ahmed","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jmgm.2025.108950_bib58","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1016\/j.bbapap.2010.04.001","article-title":"Molecular mechanism of Thioflavin-T binding to amyloid fibrils","volume":"1804","author":"Biancalana","year":"2010","journal-title":"Biochim. Biophys. Acta Protein Proteonomics"},{"key":"10.1016\/j.jmgm.2025.108950_bib59","doi-asserted-by":"crossref","first-page":"12823","DOI":"10.1039\/C9NJ01490J","article-title":"Mechanism of non-enzymatic antiglycation action by coumarin: a biophysical study","volume":"43","author":"Qais","year":"2019","journal-title":"New J. Chem."},{"key":"10.1016\/j.jmgm.2025.108950_bib60","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.jphotochem.2004.05.017","article-title":"The study on the interaction between human serum albumin and a new reagent with antitumour activity by spectrophotometric methods","volume":"167","author":"Gao","year":"2004","journal-title":"J. Photochem. Photobiol. Chem."},{"key":"10.1016\/j.jmgm.2025.108950_bib61","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.ijbiomac.2020.04.226","article-title":"Mechanistic inhibition of non-enzymatic glycation and aldose reductase activity by naringenin: binding, enzyme kinetics and molecular docking analysis","volume":"159","author":"Khan","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jmgm.2025.108950_bib62","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1080\/07391102.2017.1298470","article-title":"Multi-spectroscopic and molecular modelling approach to investigate the interaction of riboflavin with human serum albumin","volume":"36","author":"Alam","year":"2018","journal-title":"J. Biomol. Struct. Dyn."},{"key":"10.1016\/j.jmgm.2025.108950_bib63","doi-asserted-by":"crossref","first-page":"3096","DOI":"10.1021\/bi00514a017","article-title":"Thermodynamics of protein association reactions: forces contributing to stability","volume":"20","author":"Ross","year":"1981","journal-title":"Biochemistry"},{"key":"10.1016\/j.jmgm.2025.108950_bib64","first-page":"1","article-title":"Computational studies on phylogeny and drug designing using molecular simulations for COVID-19","author":"Nabi","year":"2021","journal-title":"J. Biomol. Struct. Dyn."},{"key":"10.1016\/j.jmgm.2025.108950_bib65","first-page":"1","article-title":"Combined molecular docking and dynamics simulations studies of natural compounds as potent inhibitors against SARS-CoV-2 main protease","author":"Ouassaf","year":"2021","journal-title":"J. Biomol. Struct. Dyn."},{"key":"10.1016\/j.jmgm.2025.108950_bib66","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1080\/08927014.2021.1955250","article-title":"Plumbagin inhibits quorum sensing-regulated virulence and biofilms of Gram-negative bacteria: in vitro and in silico investigations","volume":"37","author":"Qais","year":"2021","journal-title":"Biofouling"},{"key":"10.1016\/j.jmgm.2025.108950_bib67","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2021.152947","article-title":"A comparative study based on activity, conformation and computational analysis on the inhibition of human salivary aldehyde dehydrogenase by phthalate plasticizers: implications in assessing the safety of packaged food items","volume":"462","author":"Ahmad","year":"2021","journal-title":"Toxicology"}],"container-title":["Journal of Molecular Graphics and Modelling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1093326325000105?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1093326325000105?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T13:50:19Z","timestamp":1740232219000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1093326325000105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":67,"alternative-id":["S1093326325000105"],"URL":"https:\/\/doi.org\/10.1016\/j.jmgm.2025.108950","relation":{},"ISSN":["1093-3263"],"issn-type":[{"value":"1093-3263","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Glipizide inhibits the glycation of alpha-crystallin: A combined in vitro and in silico approach in retinopathy management","name":"articletitle","label":"Article Title"},{"value":"Journal of Molecular Graphics and Modelling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jmgm.2025.108950","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"108950"}}