{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T01:24:34Z","timestamp":1783560274983,"version":"3.55.0"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Molecular Graphics and Modelling"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.jmgm.2025.109123","type":"journal-article","created":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T15:31:42Z","timestamp":1752593502000},"page":"109123","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Unraveling the potential targeting activity of propolis against transcriptional regulator prfA from Listeria monocytogenes to combat listeriosis"],"prefix":"10.1016","volume":"140","author":[{"given":"Ramya","family":"Ravindhiran","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7498-6082","authenticated-orcid":false,"given":"Kavitha","family":"Dhandapani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.jmgm.2025.109123_bib1","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1186\/s12889-022-14226-1","article-title":"Descriptive study of foodborne disease using disease monitoring data in Zhejiang Province, China, 2016\u20132020","volume":"22","author":"Qi","year":"2022","journal-title":"BMC Public Health"},{"issue":"4","key":"10.1016\/j.jmgm.2025.109123_bib2","doi-asserted-by":"crossref","first-page":"725","DOI":"10.3390\/vaccines11040725","article-title":"An overview of the public health challenges in diagnosing and controlling human foodborne pathogens","volume":"11","author":"Elbehiry","year":"2023","journal-title":"Vaccines"},{"issue":"4","key":"10.1016\/j.jmgm.2025.109123_bib3","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1007\/s00248-023-02269-9","article-title":"Listeria monocytogenes an emerging pathogen: a comprehensive overview on listeriosis, virulence determinants, detection, and anti-listerial interventions","volume":"86","author":"Ravindhiran","year":"2023","journal-title":"Microb. Ecol."},{"key":"10.1016\/j.jmgm.2025.109123_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.imu.2023.101252","article-title":"Molecular docking and dynamic simulation studies of terpenoid compounds against phosphatidylinositol-specific phospholipase C from Listeria monocytogenes","volume":"39","author":"Deepasree","year":"2023","journal-title":"Inform. Med. Unlocked"},{"key":"10.1016\/j.jmgm.2025.109123_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijfoodmicro.2021.109247","article-title":"Characterisation of Listeria monocytogenes food-associated isolates to assess environmental fitness and virulence potential","volume":"350","author":"Gray","year":"2021","journal-title":"Int. J. Food Microbiol."},{"key":"10.1016\/j.jmgm.2025.109123_bib6","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2021.796040","article-title":"Virulence and antibiotic resistance genes in Listeria monocytogenes strains isolated from ready-to-eat foods in Chile","volume":"12","author":"Parra-Flores","year":"2022","journal-title":"Front. Microbiol."},{"issue":"2","key":"10.1016\/j.jmgm.2025.109123_bib7","doi-asserted-by":"crossref","first-page":"376","DOI":"10.3390\/microorganisms9020376","article-title":"Hypo-and hyper-virulent Listeria monocytogenes clones persisting in two different food processing plants of central Italy","volume":"9","author":"Guidi","year":"2021","journal-title":"Microorganisms"},{"issue":"8","key":"10.1016\/j.jmgm.2025.109123_bib8","doi-asserted-by":"crossref","DOI":"10.1128\/aem.00357-22","article-title":"Prevalence and clonal diversity of over 1,200 Listeria monocytogenes isolates collected from public access waters near produce production areas on the central California coast during 2011 to 2016","volume":"88","author":"Gorski","year":"2022","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.jmgm.2025.109123_bib9","doi-asserted-by":"crossref","DOI":"10.1186\/s12866-014-0241-3","article-title":"Virulence and genotypic characterization of Listeria monocytogenes isolated from vegetable and soil samples","volume":"14","author":"Soni","year":"2014","journal-title":"BMC Microbiol."},{"issue":"9","key":"10.1016\/j.jmgm.2025.109123_bib10","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/nrmicro2171","article-title":"Listeria monocytogenes\u2014from saprophyte to intracellular pathogen","volume":"7","author":"Freitag","year":"2009","journal-title":"Nat. Rev. Microbiol."},{"issue":"12","key":"10.1016\/j.jmgm.2025.109123_bib11","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241210141","article-title":"Evaluation of the virulence potential of Listeria monocytogenes through the characterization of the truncated forms of internalin A","volume":"24","author":"Magagna","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.jmgm.2025.109123_bib12","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.1080\/21505594.2021.1975526","article-title":"Pathogenicity and virulence of Listeria monocytogenes: a trip from environmental to medical microbiology","volume":"12","author":"Quereda","year":"2021","journal-title":"Virulence"},{"key":"10.1016\/j.jmgm.2025.109123_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmgm.2020.107728","article-title":"In silico identification of novel PrfA inhibitors to fight listeriosis: a virtual screening and molecular dynamics studies","volume":"101","author":"Nizami","year":"2020","journal-title":"J. Mol. Graph. Model."},{"issue":"12","key":"10.1016\/j.jmgm.2025.109123_bib14","doi-asserted-by":"crossref","first-page":"19610","DOI":"10.3390\/molecules191219610","article-title":"Recent advances in the chemical composition of propolis","volume":"19","author":"Huang","year":"2014","journal-title":"Molecules"},{"issue":"1","key":"10.1016\/j.jmgm.2025.109123_bib15","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/s13020-022-00651-2","article-title":"Propolis: an update on its chemistry and pharmacological applications","volume":"17","author":"Hossain","year":"2022","journal-title":"Chin. Med."},{"issue":"6","key":"10.1016\/j.jmgm.2025.109123_bib16","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.3390\/microorganisms11061429","article-title":"Antimicrobial activity of Spanish propolis against Listeria monocytogenes and other listeria strains","volume":"11","author":"Rendueles","year":"2023","journal-title":"Microorganisms"},{"issue":"1","key":"10.1016\/j.jmgm.2025.109123_bib17","article-title":"Antimicrobial activity of ethanolic extract of propolis in \u201cAlheira\u201d","volume":"2","author":"Casquete","year":"2016","journal-title":"a fermented meat sausage. Cogent Food & Agriculture"},{"key":"10.1016\/j.jmgm.2025.109123_bib18","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.fm.2018.01.021","article-title":"Inhibitory activity of propolis against Listeria monocytogenes in milk stored under refrigeration","volume":"73","author":"Thamnopoulos","year":"2018","journal-title":"Food Microbiol."},{"issue":"1","key":"10.1016\/j.jmgm.2025.109123_bib19","article-title":"Modelling of Listeria monocytogenes growth and survival in presence of royal jelly, a promising anti-biofilm agent","volume":"59","author":"Altuntas","year":"2020","journal-title":"J. Food Nutr. Res."},{"issue":"4","key":"10.1016\/j.jmgm.2025.109123_bib20","doi-asserted-by":"crossref","DOI":"10.4081\/ijfs.2019.8036","article-title":"Effect of an Italian propolis on the growth of Listeria monocytogenes, Staphylococcus aureus and Bacillus cereus in milk and whey cheese","volume":"8","author":"Pedonese","year":"2019","journal-title":"Italian journal of food safety"},{"issue":"2","key":"10.1016\/j.jmgm.2025.109123_bib21","first-page":"297","article-title":"Impact of propolis nanoemulsion on Listeria monocytogenes contaminating chilled stored breaded chicken panne","volume":"12","author":"Saad","year":"2024","journal-title":"Adv. Anim. Vet. Sci."},{"issue":"20","key":"10.1016\/j.jmgm.2025.109123_bib22","first-page":"5058","article-title":"In vitro antibacterial and antifungal activity of Iraqi propolis","volume":"5","author":"Hendi","year":"2011","journal-title":"J. Med. Plants Res."},{"issue":"1","key":"10.1016\/j.jmgm.2025.109123_bib23","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1002\/fsn3.1997","article-title":"Chinese Propolis: ultrasound\u2010assisted enhanced ethanolic extraction, volatile components analysis, antioxidant and antibacterial activity comparison","volume":"9","author":"Ding","year":"2021","journal-title":"Food Sci. Nutr."},{"issue":"7","key":"10.1016\/j.jmgm.2025.109123_bib24","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.apjtb.2017.06.009","article-title":"Red propolis: chemical composition and pharmacological activity","volume":"7","author":"Rufatto","year":"2017","journal-title":"Asian Pac. J. Trop. Biomed."},{"key":"10.1016\/j.jmgm.2025.109123_bib25","first-page":"978","volume":"107","author":"Monzote","year":"2012"},{"issue":"1","key":"10.1016\/j.jmgm.2025.109123_bib26","article-title":"Comparative chemistry of propolis from eight Brazilian localities","volume":"2013","author":"Righi","year":"2013","journal-title":"Evid. base Compl. Alternative Med."},{"issue":"7","key":"10.1016\/j.jmgm.2025.109123_bib27","doi-asserted-by":"crossref","DOI":"10.1002\/cbdv.201900094","article-title":"Insight on propolis from mediterranean countries: chemical composition, biological activities and application fields","volume":"16","author":"El\u2010Guendouz","year":"2019","journal-title":"Chem. Biodivers."},{"issue":"1","key":"10.1016\/j.jmgm.2025.109123_bib28","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1051\/apido:19920109","article-title":"Propolis produced in Bulgaria and Mongolia: phenolic compounds and plant origin","volume":"23","author":"Bankova","year":"1992","journal-title":"Apidologie"},{"issue":"7","key":"10.1016\/j.jmgm.2025.109123_bib29","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.3390\/life13071611","article-title":"Antiviral potential of specially selected Bulgarian propolis extracts: in vitro activity against structurally different viruses","volume":"13","author":"Vilhelmova-Ilieva","year":"2023","journal-title":"Life"},{"issue":"2","key":"10.1016\/j.jmgm.2025.109123_bib30","doi-asserted-by":"crossref","first-page":"109","DOI":"10.17221\/119\/2017-CJFS","article-title":"Chemical composition of propolis from the Baha region in Saudi Arabia","volume":"36","author":"Bakdash","year":"2018","journal-title":"Czech Journal of Food Sciences Research"},{"issue":"6","key":"10.1016\/j.jmgm.2025.109123_bib31","article-title":"Chemical characterization of 64 propolis samples from Hakkari, Turkey","volume":"12","author":"Bayram","year":"2018","journal-title":"Record Nat. Prod."},{"issue":"2","key":"10.1016\/j.jmgm.2025.109123_bib32","article-title":"Chemical characterization of Arabic gum-chitosan-propolis beads and determination of \u03b1-amylase inhibition effect","volume":"22","author":"Keskin","year":"2020","journal-title":"Prog. Nutr."},{"issue":"2","key":"10.1016\/j.jmgm.2025.109123_bib33","doi-asserted-by":"crossref","first-page":"34","DOI":"10.5564\/mjas.v27i02.1283","article-title":"Mongolian crude propolis content analysis and antioxidant activity","volume":"27","author":"Ichinkhorloo","year":"2019","journal-title":"Mongolian Journal of Agricultural Sciences"},{"key":"10.1016\/j.jmgm.2025.109123_bib34","article-title":"GCMS profiling of volatile constituents in Indian propolis","author":"Mishra","year":"2020","journal-title":"EasyChair"},{"key":"10.1016\/j.jmgm.2025.109123_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcab.2024.103269","article-title":"Propolis from the North-East region of India exhibits potent antioxidant and anticancer activity against breast cancer cells","author":"Rahman","year":"2024","journal-title":"Biocatal. Agric. Biotechnol."},{"issue":"2","key":"10.1016\/j.jmgm.2025.109123_bib36","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.eimc.2019.03.010","article-title":"Effect of subinhibitory concentrations of ampicillin on Listeria monocytogenes","volume":"38","author":"Rodr\u00edguez-Villodres","year":"2020","journal-title":"Enferm. Infecc. Microbiol. Cl\u00edn."},{"issue":"3","key":"10.1016\/j.jmgm.2025.109123_bib37","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1111\/mmi.14454","article-title":"Ecogenetics of antibiotic resistance in Listeria monocytogenes","volume":"113","author":"Baquero","year":"2020","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.jmgm.2025.109123_bib38","doi-asserted-by":"crossref","DOI":"10.3389\/fchem.2021.708364","article-title":"In silico pharmacokinetics, ADMET study and conceptual DFT analysis of two plant cyclopeptides isolated from rosaceae as a computational Peptidology approach","volume":"9","author":"Flores-Holgu\u00edn","year":"2021","journal-title":"Front. Chem."},{"issue":"3","key":"10.1016\/j.jmgm.2025.109123_bib39","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.00449-23","article-title":"A highly substituted ring-fused 2-pyridone compound targeting PrfA and the Efflux regulator BrtA in Listeria monocytogenes","volume":"14","author":"T\u00fckenmez","year":"2023","journal-title":"mBio"},{"issue":"3","key":"10.1016\/j.jmgm.2025.109123_bib40","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.chembiol.2016.02.013","article-title":"Attenuating Listeria monocytogenes virulence by targeting the regulatory protein PrfA","volume":"23","author":"Good","year":"2016","journal-title":"Cell Chem. Biol."},{"issue":"11","key":"10.1016\/j.jmgm.2025.109123_bib41","doi-asserted-by":"crossref","first-page":"3887","DOI":"10.1128\/JB.01978-05","article-title":"Overexpression of PrfA leads to growth inhibition of Listeria monocytogenes in glucose-containing culture media by interfering with glucose uptake","volume":"188","author":"Marr","year":"2006","journal-title":"J. Bacteriol."},{"issue":"1","key":"10.1016\/j.jmgm.2025.109123_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.jksus.2021.101707","article-title":"Molecular docking and dynamics studies on propolis sulabiroin-A as a potential inhibitor of SARS-CoV-2","volume":"34","author":"Fatriansyah","year":"2022","journal-title":"J. King Saud Univ. Sci."},{"issue":"6","key":"10.1016\/j.jmgm.2025.109123_bib43","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.1128\/IAI.05073-11","article-title":"LipA, a tyrosine and lipid phosphatase involved in the virulence of Listeria monocytogenes","volume":"79","author":"Kastner","year":"2011","journal-title":"Infect. Immun."},{"issue":"3","key":"10.1016\/j.jmgm.2025.109123_bib44","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.3390\/ijms23031771","article-title":"Molecular docking and molecular dynamics simulations discover curcumin analogue as a plausible dual inhibitor for SARS-CoV-2","volume":"23","author":"Rampogu","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jmgm.2025.109123_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.mex.2023.102537","article-title":"Exploring the effectiveness of flavone derivatives for treating liver diseases: utilizing DFT, molecular docking, and molecular dynamics techniques","volume":"12","author":"Quayum","year":"2024","journal-title":"MethodsX"},{"issue":"1","key":"10.1016\/j.jmgm.2025.109123_bib53","doi-asserted-by":"crossref","first-page":"3696","DOI":"10.1038\/s41598-024-54281-9","article-title":"Protracted molecular dynamics and secondary structure introspection to identify dual-target inhibitors of Nipah virus exerting approved small molecules repurposing","volume":"14","author":"Yang","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jmgm.2025.109123_bib46","doi-asserted-by":"crossref","first-page":"3371","DOI":"10.1007\/s12010-021-03608-7","article-title":"Macrolactin a as a novel inhibitory agent for SARS-CoV-2 M pro: bioinformatics approach","volume":"193","author":"Bharadwaj","year":"2021","journal-title":"Appl. Biochem. Biotechnol."},{"key":"10.1016\/j.jmgm.2025.109123_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.microb.2024.100200","article-title":"Targeting PrfA from Listeria monocytogenes: a computational drug repurposing approach","volume":"5","author":"Arias-Moreno","year":"2024","journal-title":"Microbe"},{"issue":"5","key":"10.1016\/j.jmgm.2025.109123_bib48","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.3390\/foods10051106","article-title":"Antimicrobial activity of Myrtus communis L. and Rosmarinus officinalis L. essential oils against Listeria monocytogenes in cheese","volume":"10","author":"Saraiva","year":"2021","journal-title":"Foods"},{"issue":"1","key":"10.1016\/j.jmgm.2025.109123_bib49","doi-asserted-by":"crossref","first-page":"2288","DOI":"10.1038\/s41598-024-52394-9","article-title":"Elimination of detached Listeria monocytogenes from the biofilm on stainless steel surfaces during milk and cheese processing using natural plant extracts","volume":"14","author":"El-Sawy","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jmgm.2025.109123_bib50","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1590\/S1517-83822013000400022","article-title":"Essential oils of thyme and Rosemary in the control of Listeria monocytogenes in raw beef","volume":"44","author":"Oliveira","year":"2013","journal-title":"Braz. J. Microbiol."},{"issue":"1","key":"10.1016\/j.jmgm.2025.109123_bib51","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1006\/fmic.1994.1008","article-title":"Sensitivity of Listeria monocytogenes to rosemary (Rosmarinus officinalis L.)","volume":"11","author":"Pandit","year":"1994","journal-title":"Food Microbiol."}],"container-title":["Journal of Molecular Graphics and Modelling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1093326325001834?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1093326325001834?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T03:31:40Z","timestamp":1764732700000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1093326325001834"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":52,"alternative-id":["S1093326325001834"],"URL":"https:\/\/doi.org\/10.1016\/j.jmgm.2025.109123","relation":{},"ISSN":["1093-3263"],"issn-type":[{"value":"1093-3263","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Unraveling the potential targeting activity of propolis against transcriptional regulator prfA from Listeria monocytogenes to combat listeriosis","name":"articletitle","label":"Article Title"},{"value":"Journal of Molecular Graphics and Modelling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jmgm.2025.109123","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"109123"}}