{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T21:54:05Z","timestamp":1774648445276,"version":"3.50.1"},"reference-count":39,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jmig.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Minimally Invasive Gynecology"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.jmig.2019.09.773","type":"journal-article","created":{"date-parts":[[2019,9,16]],"date-time":"2019-09-16T01:41:41Z","timestamp":1568598101000},"page":"1264-1272.e2","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Intrauterine Instillation of Tranexamic Acid in Hysteroscopic Myomectomy: A Double-Blind, Placebo-Controlled, Parallel-Group Randomized Clinical Trial"],"prefix":"10.1016","volume":"27","author":[{"given":"Radwa","family":"Rasheedy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Makled","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amgad","family":"Abou-Gamrah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hajer","family":"Giuma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jmig.2019.09.773_bib0001","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1111\/1471-0528.14640","article-title":"Epidemiology of uterine fibroids: A systematic review","volume":"124","author":"Stewart","year":"2017","journal-title":"BJOG"},{"key":"10.1016\/j.jmig.2019.09.773_bib0002","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1093\/humupd\/dmm041","article-title":"Hysteroscopic myomectomy: A comprehensive review of surgical techniques","volume":"14","author":"Di Spiezio Sardo","year":"2008","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.jmig.2019.09.773_bib0003","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/8429047","article-title":"Risk factors for the completion of the cold loop hysteroscopic myomectomy in a one-step procedure: A post hoc analysis","volume":"2018","author":"Mazzon","year":"2018","journal-title":"BioMed Res Int"},{"key":"10.1016\/j.jmig.2019.09.773_bib0004","first-page":"1369","article-title":"The effect of intrauterine instillation of E-Aminocaproeic Acid during hysteroscopic operations in the management of intractable uterine hemorrhage: A Randomized Clinical Trial","volume":"10","author":"Sayyah-melli","year":"2013","journal-title":"Life Sci J"},{"key":"10.1016\/j.jmig.2019.09.773_bib0005","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.jmig.2012.12.002","article-title":"AAGL practice report: practice guidelines for the management of hysteroscopic distending media: (Replaces Hysteroscopic Fluid Monitoring Guidelines. J Am Assoc Gynecol Laparosc. 2000;7:167-168.)","volume":"20","author":"Advancing Minimally Invasive Gynecology Worldwide","year":"2013","journal-title":"J Minim Invasive Gynecol."},{"key":"10.1016\/j.jmig.2019.09.773_bib0006","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s10397-016-0983-z","article-title":"BSGE\/ESGE guideline on management of fluid distension media in operative hysteroscopy","volume":"13","author":"Umranikar","year":"2016","journal-title":"Gynecol Surg"},{"key":"10.1016\/j.jmig.2019.09.773_bib0007","doi-asserted-by":"crossref","first-page":"585","DOI":"10.2165\/11209070-000000000-00000","article-title":"Tranexamic acid: A review of its use in the treatment of hyperfibrinolysis","volume":"72","author":"McCormack","year":"2012","journal-title":"Drugs"},{"key":"10.1016\/j.jmig.2019.09.773_bib0008","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/acem.13345","article-title":"Topical tranexamic acid compared with anterior nasal packing for treatment of epistaxis in patients taking antiplatelet drugs: Randomized controlled trial","volume":"25","author":"Zahed","year":"2018","journal-title":"Acad Emerg Med"},{"key":"10.1016\/j.jmig.2019.09.773_bib0009","first-page":"239","article-title":"Tranexamic acid for the prevention and management of orthopedic surgical hemorrhage: Current evidence","volume":"6","author":"Kim","year":"2015","journal-title":"J Blood Med"},{"key":"10.1016\/j.jmig.2019.09.773_bib0010","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0030-4220(93)90401-O","article-title":"Tranexamic acid as a mouthwash in anticoagulant-treated patients undergoing oral surgery. An alternative method to discontinuing anticoagulant therapy","volume":"75","author":"Borea","year":"1993","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"10.1016\/j.jmig.2019.09.773_bib0011","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD010562","article-title":"Topical application of tranexamic acid for the reduction of bleeding","volume":"7","author":"Ker","year":"2013","journal-title":"Cochrane Database Syst Rev."},{"key":"10.1016\/j.jmig.2019.09.773_bib0012","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/anae.12910","article-title":"The current place of tranexamic acid in the management of bleeding","volume":"70","author":"Hunt","year":"2015","journal-title":"Anaesthesia"},{"key":"10.1016\/j.jmig.2019.09.773_bib0013","doi-asserted-by":"crossref","first-page":"e883","DOI":"10.3928\/01477447-20160526-02","article-title":"Meta-analysis of intravenous tranexamic acid in primary total hip arthroplasty","volume":"39","author":"Moskal","year":"2016","journal-title":"Orthopedics"},{"key":"10.1016\/j.jmig.2019.09.773_bib0014","doi-asserted-by":"crossref","first-page":"48","DOI":"10.4103\/0259-1162.128908","article-title":"Topical versus intravenous tranexamic acid as a blood conservation intervention for reduction of post-operative bleeding in hemiarthroplasty","volume":"8","author":"Emara","year":"2014","journal-title":"Anesth Essays Res"},{"key":"10.1016\/j.jmig.2019.09.773_bib0015","doi-asserted-by":"crossref","first-page":"3585","DOI":"10.1007\/s00167-016-4235-6","article-title":"Intravenous versus topical tranexamic acid administration in primary total knee arthroplasty: A meta-analysis","volume":"25","author":"Shin","year":"2017","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"key":"10.1016\/j.jmig.2019.09.773_bib0016","doi-asserted-by":"crossref","first-page":"2738","DOI":"10.1016\/j.arth.2017.03.059","article-title":"Comparison of 3 routes of administration of tranexamic acid on primary unilateral total knee arthroplasty: A prospective, randomized, controlled study","volume":"32","author":"Yuan","year":"2017","journal-title":"J Arthroplast"},{"key":"10.1016\/j.jmig.2019.09.773_bib0017","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/j.arth.2017.09.062","article-title":"Oral vs intravenous vs topical tranexamic acid in primary hip arthroplasty: A prospective, randomized, double-blind, controlled study","volume":"33","author":"Luo","year":"2018","journal-title":"J Arthroplast"},{"key":"10.1016\/j.jmig.2019.09.773_bib0018","series-title":"StatPearls","article-title":"Tranexamic acid. [Updated 2018 Dec 6]","author":"Chauncey","year":"2019"},{"key":"10.1016\/j.jmig.2019.09.773_bib0019","series-title":"Tranexamic acid 100mg\/ml Solution for Injection - Summary of Product Characteristics (SmPC) - (eMC)","year":"2019"},{"key":"10.1016\/j.jmig.2019.09.773_bib0020","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.jot.2017.12.006","article-title":"Comparison of topical and intravenous administration of tranexamic acid for blood loss control during total joint replacement: Review of literature","volume":"13","author":"Georgiev","year":"2018","journal-title":"J Orthop Translat"},{"key":"10.1016\/j.jmig.2019.09.773_bib0021","first-page":"6792","article-title":"Topical versus intravenous administration of tranexamic acid in primary total hip arthroplasty: A systematic review and meta-analysis of randomized controlled trials","volume":"8","author":"Hanna","year":"2016","journal-title":"Orthop Rev (Pavia)"},{"key":"10.1016\/j.jmig.2019.09.773_bib0022","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1186\/s12891-016-1293-3","article-title":"A comparative, retrospective study of peri-articular and intra-articular injection of tranexamic acid for the management of postoperative blood loss after total knee arthroplasty","volume":"17","author":"Mao","year":"2016","journal-title":"BMC Musculoskelet Disord"},{"key":"10.1016\/j.jmig.2019.09.773_bib0023","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0030-4220(93)90401-O","article-title":"Tranexamic acid as a mouthwash in anticoagulant-treated patients undergoing oral surgery. An alternative method to discontinuing anticoagulant therapy","volume":"75","author":"Borea","year":"1993","journal-title":"Oral Surg Oral Med Oral Pathol"},{"issue":"2 Suppl.","key":"10.1016\/j.jmig.2019.09.773_bib0024","first-page":"178","article-title":"Comparison between topical and oral tranexamic acid in management of traumatic hyphema","volume":"39","author":"Jahadi Hosseini","year":"2014","journal-title":"Iran J Med Sci"},{"key":"10.1016\/j.jmig.2019.09.773_bib0025","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.ijgo.2010.11.011","article-title":"FIGO Working Group on Menstrual Disorders. FIGO classification system (PALM-COEIN) for causes of abnormal uterine bleeding in nongravid women of reproductive age","volume":"113","author":"Munro","year":"2011","journal-title":"Int J Gynaecol Obstet"},{"key":"10.1016\/j.jmig.2019.09.773_bib0026","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1097\/AOG.0000000000000515","article-title":"Transcervical intralesional vasopressin injection compared with placebo in hysteroscopic myomectomy: A randomized controlled trial","volume":"124","author":"Wong","year":"2014","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.jmig.2019.09.773_bib0027","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.jmig.2011.09.005","article-title":"Advancing Minimally Invasive Gynecology Worldwide. AAGL practice report. practice guidelines for the diagnosis and management of submucous leiomyomas","volume":"19","year":"2012","journal-title":"J Minim Invasive Gynecol"},{"key":"10.1016\/j.jmig.2019.09.773_bib0028","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1016\/j.fertnstert.2008.03.029","article-title":"Submucosal uterine leiomyomas have a global effect on molecular determinants of endometrial receptivity","volume":"93","author":"Rackow","year":"2010","journal-title":"Fertil Steril"},{"key":"10.1016\/j.jmig.2019.09.773_bib0029","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/j.fertnstert.2018.03.003","article-title":"Fibroids: When should they be removed to improve in vitro fertilization success?","volume":"109","author":"Taylor","year":"2018","journal-title":"Fertil Steril"},{"key":"10.1016\/j.jmig.2019.09.773_bib0030","doi-asserted-by":"crossref","first-page":"68","DOI":"10.15296\/ijwhr.2016.16","article-title":"Comparison of the intraoperative outcomes of intrauterine instillation of epsilon-aminocaproic acid and intravenous oxytocin in hysteroscopy surgeries","volume":"4","author":"Sayyahmelli","year":"2016","journal-title":"Int J Womens Health Reprod Sci"},{"key":"10.1016\/j.jmig.2019.09.773_bib0031","first-page":"614","article-title":"Direct injection of vasopressin during hysteroscopic myomectomy: A case report","volume":"59","author":"Holloran-Schwartz","year":"2014","journal-title":"J Reprod Med"},{"key":"10.1016\/j.jmig.2019.09.773_bib0032","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/0029-7844(96)00282-7","article-title":"The effect of dilute vasopressin solution on blood loss during operative hysteroscopy: A randomized controlled trial","volume":"88","author":"Phillips","year":"1996","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.jmig.2019.09.773_bib0033","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.ejogrb.2015.10.021","article-title":"Comparative study of vaginal danazol vs diphereline (a synthetic GnRH agonist) in the control of bleeding during hysteroscopic myomectomy in women with abnormal uterine bleeding: a randomized controlled clinical trial","volume":"196","author":"Sayyah-Melli","year":"2016","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.jmig.2019.09.773_bib0034","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1053\/j.jvca.2013.04.003","article-title":"Comparison of epsilon aminocaproic acid and tranexamic acid in thoracic aortic surgery: Clinical efficacy and safety","volume":"27","author":"Makhija","year":"2013","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"10.1016\/j.jmig.2019.09.773_bib0035","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1136\/jcp.s3-14.1.41","article-title":"Clinical pharmacology of aminocaproic and tranexamic acids","volume":"14","author":"Nilsson","year":"1980","journal-title":"J Clin Pathol"},{"key":"10.1016\/j.jmig.2019.09.773_bib0036","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1111\/j.1447-0756.2005.00274.x","article-title":"Safe techniques in surgery for hysteroscopic myomectomy","volume":"31","author":"Murakami","year":"2005","journal-title":"J Obstet Gynaecol Res"},{"key":"10.1016\/j.jmig.2019.09.773_bib0037","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/S0015-0282(16)54349-0","article-title":"Resectoscopic myomectomy","volume":"55","author":"Corson","year":"1991","journal-title":"Fertil Steril"},{"key":"10.1016\/j.jmig.2019.09.773_bib0038","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1159\/000074451","article-title":"Modified hysteroscopic myomectomy of large submucous fibroids","volume":"56","author":"Darwish","year":"2003","journal-title":"Gynecol Obstet Investig"},{"key":"10.1016\/j.jmig.2019.09.773_bib0039","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/S1074-3804(05)60401-X","article-title":"Risk of uterine perforation during hysteroscopic surgery","volume":"9","author":"Agostini","year":"2002","journal-title":"J Am Assoc Gynecol Laparosc"}],"container-title":["Journal of Minimally Invasive Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1553465019311847?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1553465019311847?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T09:37:30Z","timestamp":1761557850000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1553465019311847"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":39,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["S1553465019311847"],"URL":"https:\/\/doi.org\/10.1016\/j.jmig.2019.09.773","relation":{},"ISSN":["1553-4650"],"issn-type":[{"value":"1553-4650","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intrauterine Instillation of Tranexamic Acid in Hysteroscopic Myomectomy: A Double-Blind, Placebo-Controlled, Parallel-Group Randomized Clinical Trial","name":"articletitle","label":"Article Title"},{"value":"Journal of Minimally Invasive Gynecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jmig.2019.09.773","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 AAGL. All rights reserved.","name":"copyright","label":"Copyright"}]}}