{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T07:07:59Z","timestamp":1788505679112,"version":"build-2803163510"},"reference-count":29,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jmig.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Minimally Invasive Gynecology"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.jmig.2021.04.011","type":"journal-article","created":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T10:24:02Z","timestamp":1619000642000},"page":"1876-1881","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"title":["Is Chronic Endometritis Associated with Tubal Infertility? A Prospective Cohort Study"],"prefix":"10.1016","volume":"28","author":[{"given":"Iris","family":"Holzer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2761-5262","authenticated-orcid":false,"given":"Johannes","family":"Ott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Kurz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerda","family":"Hofstetter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlene","family":"Hager","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenz","family":"Kuessel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P.","family":"Parry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jmig.2021.04.011_bib0001","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.fertnstert.2008.12.131","article-title":"Chronic endometritis is a frequent finding in women with recurrent implantation failure after in vitro fertilization","volume":"93","author":"Johnston-MacAnanny","year":"2010","journal-title":"Fertil Steril"},{"key":"10.1016\/j.jmig.2021.04.011_bib0002","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.jmig.2019.02.016","article-title":"Evaluating chronic endometritis in women with recurrent implantation failure and recurrent pregnancy loss by hysteroscopy and immunohistochemistry","volume":"27","author":"Zargar","year":"2020","journal-title":"J Minim Invasive Gynecol"},{"key":"10.1016\/j.jmig.2021.04.011_bib0003","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1093\/humrep\/deh779","article-title":"Endometrial micropolyps at fluid hysteroscopy suggest the existence of chronic endometritis","volume":"20","author":"Cicinelli","year":"2005","journal-title":"Hum Reprod"},{"key":"10.1016\/j.jmig.2021.04.011_bib0004","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.fertnstert.2019.06.021","article-title":"Current controversies in tubal disease, endometriosis, and pelvic adhesion","volume":"112","author":"Goldberg","year":"2019","journal-title":"Fertil Steril"},{"key":"10.1016\/j.jmig.2021.04.011_bib0005","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s12905-016-0341-3","article-title":"Analysis of the diagnostic value of CD138 for chronic endometritis, the risk factors for the pathogenesis of chronic endometritis and the effect of chronic endometritis on pregnancy: a cohort study","volume":"16","author":"Chen","year":"2016","journal-title":"BMC Womens Health"},{"key":"10.1016\/j.jmig.2021.04.011_bib0006","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1038\/modpathol.3880405","article-title":"Plasma cells in chronic endometritis are easily identified when stained with syndecan-1","volume":"14","author":"Bayer-Garner","year":"2001","journal-title":"Mod Pathol"},{"key":"10.1016\/j.jmig.2021.04.011_bib0007","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1093\/humrep\/deu292","article-title":"Prevalence of chronic endometritis in repeated unexplained implantation failure and the IVF success rate after antibiotic therapy","volume":"30","author":"Cicinelli","year":"2015","journal-title":"Hum Reprod"},{"key":"10.1016\/j.jmig.2021.04.011_bib0008","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1007\/s00404-013-3131-2","article-title":"The hysteroscopy and histological diagnosis and treatment value of chronic endometritis in recurrent implantation failure patients","volume":"289","author":"Yang","year":"2014","journal-title":"Arch Gynecol Obstet"},{"key":"10.1016\/j.jmig.2021.04.011_bib0009","doi-asserted-by":"crossref","first-page":"e12782","DOI":"10.1111\/aji.12782","article-title":"Chronic endometritis in patients with unexplained infertility: prevalence and effects of antibiotic treatment on spontaneous conception","volume":"79","author":"Cicinelli","year":"2018","journal-title":"Am J Reprod Immunol"},{"key":"10.1016\/j.jmig.2021.04.011_bib0010","doi-asserted-by":"crossref","first-page":"e88354","DOI":"10.1371\/journal.pone.0088354","article-title":"The association between endometriosis and chronic endometritis","volume":"9","author":"Takebayashi","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jmig.2021.04.011_bib0011","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.bpobgyn.2019.01.011","article-title":"Hydrosalpinx - salpingostomy, salpingectomy or tubal occlusion","volume":"59","author":"Ng","year":"2019","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"10.1016\/j.jmig.2021.04.011_bib0012","first-page":"77","article-title":"Tubo-peritoneal factor of infertility: diagnosis and treatment [in Italian]","volume":"161","author":"Muzii","year":"2010","journal-title":"Clin Ter"},{"key":"10.1016\/j.jmig.2021.04.011_bib0013","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/S0015-0282(99)00014-X","article-title":"Pathophysiology and management of proximal tubal blockage","volume":"71","author":"Honor\u00e9","year":"1999","journal-title":"Fertil Steril"},{"key":"10.1016\/j.jmig.2021.04.011_bib0014","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1016\/j.jmig.2020.01.014","article-title":"Hysteroscopic assessment of tubal patency: a randomized comparison between the flow and Parryscope techniques","volume":"27","author":"Hager","year":"2020","journal-title":"J Minim Invasive Gynecol"},{"key":"10.1016\/j.jmig.2021.04.011_bib0015","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.jmig.2019.03.006","article-title":"Assessment of tubal patency: a prospective comparison of diagnostic hysteroscopy and laparoscopic Chromopertubation","volume":"27","author":"Ott","year":"2020","journal-title":"J Minim Invasive Gynecol"},{"key":"10.1016\/j.jmig.2021.04.011_bib0016","doi-asserted-by":"crossref","DOI":"10.3390\/jcm8081210","article-title":"The prevalence of incidental endometriosis in women undergoing laparoscopic ovarian drilling for clomiphene-resistant polycystic ovary syndrome: a retrospective cohort study and meta-analysis","volume":"8","author":"Hager","year":"2019","journal-title":"J Clin Med"},{"key":"10.1016\/j.jmig.2021.04.011_bib0017","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1093\/humrep\/dew293","article-title":"World Endometriosis Society consensus on the classification of endometriosis","volume":"32","author":"Johnson","year":"2017","journal-title":"Hum Reprod"},{"key":"10.1016\/j.jmig.2021.04.011_bib0018","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.fertnstert.2018.10.013","article-title":"Pathogenesis of endometriosis: the genetic\/epigenetic theory","volume":"111","author":"Koninckx","year":"2019","journal-title":"Fertil Steril"},{"key":"10.1016\/j.jmig.2021.04.011_bib0019","first-page":"209","article-title":"Infection as a potential cofactor in the genetic-epigenetic pathophysiology of endometriosis: a systematic review","volume":"11","author":"Koninckx","year":"2019","journal-title":"Facts Views Vis Obgyn"},{"key":"10.1016\/j.jmig.2021.04.011_bib0020","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a010272","article-title":"Epigenetics and bacterial infections","volume":"2","author":"Bierne","year":"2012","journal-title":"Cold Spring Harb Perspect Med"},{"key":"10.1016\/j.jmig.2021.04.011_bib0021","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1007\/s00109-012-0891-2","article-title":"Infection, mutation, and cancer evolution","volume":"90","author":"Ewald","year":"2012","journal-title":"J Mol Med (Berl)"},{"key":"10.1016\/j.jmig.2021.04.011_bib0022","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.ejogrb.2016.01.040","article-title":"Molecular detection of intrauterine microbial colonization in women with endometriosis","volume":"199","author":"Khan","year":"2016","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.jmig.2021.04.011_bib0023","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/S0140-6736(21)00389-5","article-title":"Endometriosis is a chronic systemic disease: clinical challenges and novel innovations","volume":"397","author":"Taylor","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.jmig.2021.04.011_bib0024","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1007\/s00404-020-05679-z","article-title":"Are uterine natural killer and plasma cells in infertility patients associated with endometriosis, repeated implantation failure, or recurrent pregnancy loss?","volume":"302","author":"Freitag","year":"2020","journal-title":"Arch Gynecol Obstet"},{"key":"10.1016\/j.jmig.2021.04.011_bib0025","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/j.fertnstert.2015.01.007","article-title":"Altered uterine contractility in women with chronic endometritis","volume":"103","author":"Pinto","year":"2015","journal-title":"Fertil Steril"},{"key":"10.1016\/j.jmig.2021.04.011_bib0026","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.fertnstert.2008.02.093","article-title":"Pathogenic mechanisms in endometriosis-associated infertility","volume":"90","author":"Gupta","year":"2008","journal-title":"Fertil Steril"},{"key":"10.1016\/j.jmig.2021.04.011_bib0027","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1055\/a-0826-1326","article-title":"The role of diagnostic hysteroscopy in the evaluation of Fallopian tube patency: a short review","volume":"79","author":"Hager","year":"2019","journal-title":"Geburtshilfe Frauenheilkd"},{"key":"10.1016\/j.jmig.2021.04.011_bib0028","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.jmig.2020.11.013","article-title":"Hysteroscopy for assessing Fallopian tubal obstruction: a systematic review and diagnostic test accuracy meta-analysis","volume":"28","author":"Vitale","year":"2021","journal-title":"J Minim Invasive Gynecol"},{"key":"10.1016\/j.jmig.2021.04.011_bib0029","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.jmig.2012.02.002","article-title":"Direct aspiration endometrial biopsy via flexible hysteroscopy","volume":"19","author":"Breitkopf","year":"2012","journal-title":"J Minim Invasive Gynecol"}],"container-title":["Journal of Minimally Invasive Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1553465021001886?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1553465021001886?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T09:41:09Z","timestamp":1761558069000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1553465021001886"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":29,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["S1553465021001886"],"URL":"https:\/\/doi.org\/10.1016\/j.jmig.2021.04.011","relation":{},"ISSN":["1553-4650"],"issn-type":[{"value":"1553-4650","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Is Chronic Endometritis Associated with Tubal Infertility? A Prospective Cohort Study","name":"articletitle","label":"Article Title"},{"value":"Journal of Minimally Invasive Gynecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jmig.2021.04.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 AAGL. All rights reserved.","name":"copyright","label":"Copyright"}]}}