{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T03:04:39Z","timestamp":1791255879211,"version":"4.1.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,2,12]],"date-time":"2016-02-12T00:00:00Z","timestamp":1455235200000},"content-version":"vor","delay-in-days":1778,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011913","name":"Kaohsiung Veterans General Hospital","doi-asserted-by":"crossref","award":["VGHKS 96-07"],"award-info":[{"award-number":["VGHKS 96-07"]}],"id":[{"id":"10.13039\/501100011913","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Microbiology, Immunology and Infection"],"published-print":{"date-parts":[[2011,4]]},"DOI":"10.1016\/j.jmii.2010.04.001","type":"journal-article","created":{"date-parts":[[2011,1,19]],"date-time":"2011-01-19T07:22:06Z","timestamp":1295421726000},"page":"88-94","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"title":["Differential diagnosis of tuberculous and malignant pleurisy using pleural fluid adenosine deaminase and interferon gamma in Taiwan"],"prefix":"10.1016","volume":"44","author":[{"given":"Yung-Ching","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Shin-Jung Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao-Shen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Zin","family":"Tu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bao-Chen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsi-Shu","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jmii.2010.04.001_bib1","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1378\/chest.63.1.88","article-title":"Tuberculous pleurisy","volume":"63","author":"Berger","year":"1973","journal-title":"Chest"},{"key":"10.1016\/j.jmii.2010.04.001_bib2","first-page":"82","article-title":"Tuberculous empyema","volume":"14","author":"Sahn","year":"1999","journal-title":"Semin Resp Infect"},{"key":"10.1016\/j.jmii.2010.04.001_bib3","first-page":"466","article-title":"Isolation of tubercle bacilli from needle biopsy specimens of parietal pleura","volume":"97","author":"Scharer","year":"1968","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.jmii.2010.04.001_bib4","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1378\/chest.109.2.414","article-title":"Combined use of pleural adenosine deaminase with lymphocyte\/neutrophil ratio: increased specificity for the diagnosis of tuberculous pleuritis","volume":"109","author":"Burgess","year":"1996","journal-title":"Chest"},{"key":"10.1016\/j.jmii.2010.04.001_bib5","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1001\/archinte.1973.03650120060011","article-title":"Cells in pleural fluid: their value in differential diagnosis","volume":"132","author":"Light","year":"1973","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.jmii.2010.04.001_bib6","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1097\/00063198-200007000-00002","article-title":"The use of adenosine deaminase and adenosine deaminase isoenzymes in the diagnosis of tuberculous pleuritis","volume":"6","author":"Perez-Rodriguez","year":"2000","journal-title":"Curr Opin Pulm Med"},{"key":"10.1016\/j.jmii.2010.04.001_bib7","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.cccn.2003.11.016","article-title":"Diagnostic value of pleural fluid adenosine deaminase activity in tuberculous pleurisy","volume":"341","author":"Chen","year":"2004","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.jmii.2010.04.001_bib8","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1258\/000456303766477011","article-title":"Diagnostic value of adenosine deaminase in tuberculous pleural effusion: a metaanalysis","volume":"40","author":"Goto","year":"2003","journal-title":"Ann Clin Biochem"},{"key":"10.1016\/j.jmii.2010.04.001_bib9","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1378\/chest.127.3.1078","article-title":"Diagnosing tubercular pleural effusions","volume":"127","author":"Gupta","year":"2005","journal-title":"Chest"},{"key":"10.1016\/j.jmii.2010.04.001_bib10","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1378\/chest.125.3.987","article-title":"Comparison of six biological markers for the diagnosis of tuberculous pleuritis","volume":"125","author":"Hiraki","year":"2004","journal-title":"Chest"},{"key":"10.1016\/j.jmii.2010.04.001_bib11","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1378\/chest.118.5.1355","article-title":"Evaluation of polymerase chain reaction, adenosine deaminase, and interferon-\u03b3 in pleural fluid for the differential diagnosis of pleural tuberculosis","volume":"118","author":"Villegas","year":"2000","journal-title":"Chest"},{"key":"10.1016\/j.jmii.2010.04.001_bib12","first-page":"777","article-title":"Adenosine deaminase and interferon gamma measurements for the diagnosis of tuberculous pleurisy: a meta-analysis","volume":"7","author":"Greco","year":"2003","journal-title":"Int J Tuberc Lung Dis"},{"key":"10.1016\/j.jmii.2010.04.001_bib13","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1002\/(SICI)1097-0258(19970515)16:9<981::AID-SIM510>3.0.CO;2-N","article-title":"Variation of sensitivity, specificity, likelihood ratios and predictive values with disease prevalence","volume":"16","author":"Brenner","year":"1997","journal-title":"Stat Med"},{"key":"10.1016\/j.jmii.2010.04.001_bib14","doi-asserted-by":"crossref","first-page":"972","DOI":"10.7326\/0003-4819-66-5-972","article-title":"Diagnostic significance of lymphocytes in pleural effusions","volume":"66","author":"Yam","year":"1967","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.jmii.2010.04.001_bib15","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1001\/jama.1971.03190160027005","article-title":"A prospective study of closed pleural biopsies","volume":"218","author":"Scerbo","year":"1971","journal-title":"JAMA"},{"key":"10.1016\/j.jmii.2010.04.001_bib16","series-title":"Methods of enzymatic analysis","first-page":"315","article-title":"Adenosine deaminase: colorimetric method","author":"Giusti","year":"1984"},{"key":"10.1016\/j.jmii.2010.04.001_bib17","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1378\/chest.100.5.1264","article-title":"The relationship between pleural fluid findings and development of pleural thickening in patients with pleural tuberculosis","volume":"100","author":"Barbas","year":"1991","journal-title":"Chest"},{"key":"10.1016\/j.jmii.2010.04.001_bib18","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1183\/09031936.03.00017103a","article-title":"Diagnostic tools in tuberculous pleurisy: a direct comparative study","volume":"22","author":"Diacon","year":"2003","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jmii.2010.04.001_bib19","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1378\/chest.124.3.909","article-title":"Combined use of the polymerase chain reaction and detection of adenosine deaminase activity on pleural fluid improves the rate of diagnosis of pleural tuberculosis","volume":"124","author":"Lima","year":"2003","journal-title":"Chest"},{"key":"10.1016\/j.jmii.2010.04.001_bib20","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1183\/09031936.96.09040747","article-title":"Adenosine deaminase (ADA) isoenzyme analysis in pleural effusions: diagnostic role, and relevance to the origin of increased ADA in tuberculous pleurisy","volume":"9","author":"Vald\u00e9s","year":"1996","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jmii.2010.04.001_bib21","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1378\/chest.97.6.1381","article-title":"Lymphocyte proliferation and gamma-interferon production after \u201cin vivo\u201d stimulation with PPD. Differences between tuberculosis and non-tuberculosis pleurisy in patients with positive tuberculin skin tests","volume":"97","author":"Ribera","year":"1990","journal-title":"Chest"},{"key":"10.1016\/j.jmii.2010.04.001_bib22","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1378\/chest.93.2.308","article-title":"High level of interferon gamma in tuberculous pleural effusion","volume":"93","author":"Ribera","year":"1988","journal-title":"Chest"},{"key":"10.1016\/j.jmii.2010.04.001_bib23","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0954-6111(94)90027-2","article-title":"A comparison study of IFN-\u03b3, ADA and CA 125 as the diagnostic parameters in tuberculous pleuritis","volume":"88","author":"Aoki","year":"1994","journal-title":"Respir Med"},{"key":"10.1016\/j.jmii.2010.04.001_bib24","first-page":"565","article-title":"Clinical significance of cytokine measurement in pleural effusion","volume":"10","author":"Naito","year":"1997","journal-title":"Kekkaku"},{"key":"10.1016\/j.jmii.2010.04.001_bib25","first-page":"453","article-title":"Diagnostic methods of primary tuberculous pleural effusion in a region with high prevalence of tuberculosis: a study in Mexican population","volume":"49","author":"Salazar-Lezama","year":"1997","journal-title":"Rev Invest Clin"},{"key":"10.1016\/j.jmii.2010.04.001_bib26","first-page":"139","article-title":"Value of determining the activity of adenosine deaminase (ADA) in the differential diagnosis of pleural effusions","volume":"42","author":"Chalhoub","year":"1996","journal-title":"Rev Assoc Med Bras"},{"key":"10.1016\/j.jmii.2010.04.001_bib27","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1001\/archinte.158.18.2017","article-title":"Tuberculous pleurisy: study of 254 patients","volume":"158","author":"Vald\u00e9s","year":"1998","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.jmii.2010.04.001_bib28","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1378\/chest.06-2063","article-title":"Diagnosis and treatment of tuberculous pleural effusion in 2006","volume":"131","author":"Gopi","year":"2007","journal-title":"Chest"},{"key":"10.1016\/j.jmii.2010.04.001_bib29","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1136\/thx.50.6.600","article-title":"Value of adenosine deaminase in the diagnosis of tuberculous pleural effusions in young patients in a region of high prevalence of tuberculosis","volume":"50","author":"Vald\u00e9s","year":"1995","journal-title":"Thorax"},{"key":"10.1016\/j.jmii.2010.04.001_bib30","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1093\/clinchem\/42.2.218","article-title":"Rapid automated determination of adenosine deaminase and lysozyme for differentiating tuberculous and nontuberculous pleural effusions","volume":"42","author":"Villena","year":"1996","journal-title":"Clin. Chem"},{"key":"10.1016\/j.jmii.2010.04.001_bib31","series-title":"Pleural diseases","author":"Light","year":"1995"},{"key":"10.1016\/j.jmii.2010.04.001_bib32","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1136\/thx.50.6.672","article-title":"Use of adenosine deaminase as a diagnostic tool for tuberculous pleurisy","volume":"50","author":"Burgess","year":"1995","journal-title":"Thorax"},{"key":"10.1016\/j.jmii.2010.04.001_bib33","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1378\/chest.99.2.355","article-title":"Adenosine deaminase in the diagnosis of tuberculous pleural effusions: a report of 218 patients and review of the literature","volume":"99","author":"Ba\u00f1ales","year":"1991","journal-title":"Chest"},{"key":"10.1016\/j.jmii.2010.04.001_bib34","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1378\/chest.106.1.33","article-title":"Significance of adenosine deaminase activity and its isoenzymes in tuberculous effusions","volume":"106","author":"Ungerer","year":"1994","journal-title":"Chest"},{"key":"10.1016\/j.jmii.2010.04.001_bib35","first-page":"234","article-title":"Clinical investigation on diagnostic value of interferon-gamma, interleukin-12 and adenosine deaminase isoenzyme for tuberculous pleurisy","volume":"118","author":"Gao","year":"2005","journal-title":"Chin Med J (Engl)"},{"key":"10.1016\/j.jmii.2010.04.001_bib36","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1136\/thx.54.10.921","article-title":"Interferon gamma for diagnosing tuberculous pleural effusions","volume":"54","author":"Wongtim","year":"1999","journal-title":"Thorax"},{"key":"10.1016\/j.jmii.2010.04.001_bib37","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1016\/j.rmed.2003.07.003","article-title":"Assay of pleural fluid interleukin-6, tumour necrosis factor-alpha and interferon-gamma in the diagnosis and outcome correlation of tuberculous effusion","volume":"97","author":"Wong","year":"2003","journal-title":"Respir Med"},{"key":"10.1016\/j.jmii.2010.04.001_bib38","first-page":"193","article-title":"Relative abundance and patterns of correlation among six cytokines in pleural fluid measured by cytometric bead array","volume":"12","author":"Aoe","year":"2003","journal-title":"Int J Mol Med"},{"key":"10.1016\/j.jmii.2010.04.001_bib39","first-page":"363","article-title":"Diagnostic utility of adenosine deaminase (ADA) activity in pleural fluid and serum of tuberculous and non-tuberculous respiratory disease patients","volume":"38","author":"Lamsal","year":"2007","journal-title":"Southeast Asian J Trop Med Public Health"},{"key":"10.1016\/j.jmii.2010.04.001_bib40","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1590\/S1807-59322007000500009","article-title":"Clinical and laboratory parameters in the differential diagnosis of pleural effusion secondary to tuberculosis or cancer","volume":"62","author":"Antonangelo","year":"2007","journal-title":"Clinics"},{"key":"10.1016\/j.jmii.2010.04.001_bib41","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s00408-008-9085-7","article-title":"Differential diagnosis of tuberculous and malignant pleural effusions: what is the role of adenosine deaminase?","volume":"186","author":"Zari\u0107","year":"2008","journal-title":"Lung"}],"container-title":["Journal of Microbiology, Immunology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1684118211000181?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1684118211000181?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T13:15:24Z","timestamp":1761657324000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1684118211000181"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,4]]}},"alternative-id":["S1684118211000181"],"URL":"https:\/\/doi.org\/10.1016\/j.jmii.2010.04.001","relation":{},"ISSN":["1684-1182"],"issn-type":[{"value":"1684-1182","type":"print"}],"subject":[],"published":{"date-parts":[[2011,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Differential diagnosis of tuberculous and malignant pleurisy using pleural fluid adenosine deaminase and interferon gamma in Taiwan","name":"articletitle","label":"Article Title"},{"value":"Journal of Microbiology, Immunology and Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jmii.2010.04.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Published by Elsevier Taiwan LLC.","name":"copyright","label":"Copyright"}]}}