{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T12:37:55Z","timestamp":1789648675765,"version":"4.0.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,1,27]],"date-time":"2016-01-27T00:00:00Z","timestamp":1453852800000},"content-version":"vor","delay-in-days":1152,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Microbiology, Immunology and Infection"],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1016\/j.jmii.2012.05.004","type":"journal-article","created":{"date-parts":[[2012,6,30]],"date-time":"2012-06-30T13:45:55Z","timestamp":1341063955000},"page":"435-441","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"title":["Molecular epidemiology and clinical characteristics of hetero-resistant vancomycin intermediate Staphylococcus aureus bacteremia in a Taiwan Medical Center"],"prefix":"10.1016","volume":"45","author":[{"given":"Shang-Yi","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tun-Chieh","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng-Jui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yen-Hsu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yee-In","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Kristopher Siu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po-Liang","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jmii.2012.05.004_bib1","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1007\/s10096-009-0741-5","article-title":"Clinical features and treatment outcomes of vancomycin-intermediate Staphylococcus aureus (VISA) and heteroresistant vancomycin-intermediate Staphylococcus aureus (hVISA) in a tertiary care institution in Singapore","volume":"28","author":"Fong","year":"2009","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"10.1016\/j.jmii.2012.05.004_bib2","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1086\/383036","article-title":"Frequency of reduced vancomycin susceptibility and heterogeneous subpopulation in persistent or recurrent methicillin-resistant Staphylococcus aureus bacteremia","volume":"38","author":"Khosrovaneh","year":"2004","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jmii.2012.05.004_bib3","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1086\/381093","article-title":"Clinical features associated with bacteraemia due to heterogeneous vancomycin-intermediate Staphylococcus aureus","volume":"38","author":"Charles","year":"2004","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jmii.2012.05.004_bib4","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1128\/JCM.01262-06","article-title":"Prevalence and characteristics of heteroresistant vancomycin-intermediate Staphylococcus aureus bacteraemia in a tertiary care center","volume":"45","author":"Maor","year":"2007","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.jmii.2012.05.004_bib5","doi-asserted-by":"crossref","first-page":"2950","DOI":"10.1128\/JCM.00582-08","article-title":"Characterization of vancomycin-heteroresistant Staphylococcus aureus from the metropolitan area of Detroit, Michigan, over a 22-year period (1986 to 2007)","volume":"46","author":"Rybak","year":"2008","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.jmii.2012.05.004_bib6","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.1086\/491710","article-title":"Microbiological features of vancomycin in the 21st century: minimum inhibitory concentration creep, bactericidal\/static activity, and applied breakpoints to predict clinical outcomes or detect resistant strains","volume":"42","author":"Jones","year":"2006","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jmii.2012.05.004_bib7","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1128\/JCM.02135-08","article-title":"Vancomycin MIC plus heteroresistance and outcome of methicillin-resistant Staphylococcus aureus bacteraemia: Trends over 11 Years","volume":"47","author":"Musta","year":"2009","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.jmii.2012.05.004_bib8","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1093\/jac\/dkq128","article-title":"Antimicrobial susceptibility profiles of Staphylococcus aureus isolated in 2007 from French patients with bloodstream infections: goodbye hVISA, welcome Geraldine?","volume":"65","author":"Gallon","year":"2010","journal-title":"J\u00a0Antimicrob Chemother"},{"key":"10.1016\/j.jmii.2012.05.004_bib9","doi-asserted-by":"crossref","first-page":"4926","DOI":"10.1128\/AAC.48.12.4926-4928.2004","article-title":"Emergence in Asian countries of Staphylococcus aureus with reduced susceptibility to vancomycin","volume":"48","author":"Song","year":"2004","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jmii.2012.05.004_bib10","doi-asserted-by":"crossref","first-page":"3642","DOI":"10.1128\/AAC.00206-09","article-title":"Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China","volume":"53","author":"Sun","year":"2009","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jmii.2012.05.004_bib11","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.3201\/eid1009.040239","article-title":"Vancomycin heteroresistance in methicillin-resistant Staphylococcus aureus","volume":"10","author":"Wang","year":"2004","journal-title":"Taiwan. Emerg Infect Dis"},{"key":"10.1016\/j.jmii.2012.05.004_bib12","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/s10096-009-0868-4","article-title":"Prevalence and accessory gene regulator (agr) analysis of vancomycin-intermediate Staphylococcus aureus among methicillin-resistant isolates in Taiwan-SMART program, 2003","volume":"29","author":"Ho","year":"2010","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"10.1016\/j.jmii.2012.05.004_bib13","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1056\/NEJMoa043252","article-title":"Methicillin-resistant Staphylococcus aureus disease in three communities","volume":"352","author":"Fridkin","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jmii.2012.05.004_bib14","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/0021-9681(87)90171-8","article-title":"A new method of classifying prognostic comorbidity in longitudinal studies: development and validation","volume":"40","author":"Charlson","year":"1987","journal-title":"J Chronic Dis"},{"key":"10.1016\/j.jmii.2012.05.004_bib15","series-title":"ATC index with DDDS","author":"World Health Organization","year":"2003"},{"key":"10.1016\/j.jmii.2012.05.004_bib16","series-title":"Performance standards for antimicrobial susceptibility testing; seventeenth informational supplement","author":"Clinical and Laboratory Standards Institute","year":"2007"},{"key":"10.1016\/j.jmii.2012.05.004_bib17","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1128\/JCM.01508-06","article-title":"A multicenter study evaluating the current strategies for isolating Staphylococcus aureus strains with reduced susceptibility to glycopeptides","volume":"45","author":"Wootton","year":"2007","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.jmii.2012.05.004_bib18","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1093\/jac\/47.4.399","article-title":"A modified population analysis profile (PAP) method to detect hetero-resistance to vancomycin in Staphylococcus aureus in a UK hospital","volume":"47","author":"Wootton","year":"2001","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.jmii.2012.05.004_bib19","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1128\/AAC.00165-06","article-title":"Combination of multiplex PCRs for staphylococcal cassette chromosome mec type assignment: Rapid identification system for mec, ccr, and major differences in junkyard regions","volume":"51","author":"Kondo","year":"2007","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jmii.2012.05.004_bib20","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1128\/JCM.38.3.1008-1015.2000","article-title":"Multilocus sequence typing for characterization of methicillin-resistant and methicillin-susceptible clones of Staphylococcus aureus","volume":"38","author":"Enright","year":"2000","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.jmii.2012.05.004_bib21","doi-asserted-by":"crossref","first-page":"5442","DOI":"10.1128\/JCM.41.12.5442-5448.2003","article-title":"Typing of methicillin-resistant Staphylococcus aureus in a university hospital setting by using novel software for spa repeat determination and database management","volume":"41","author":"Harmsen","year":"2003","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.jmii.2012.05.004_bib22","doi-asserted-by":"crossref","first-page":"5113","DOI":"10.1128\/JCM.41.11.5113-5120.2003","article-title":"Pulsed-field gel electrophoresis typing of oxacillin-resistant Staphylococcus aureus isolates from the United States: establishing a national database","volume":"41","author":"McDougal","year":"2003","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.jmii.2012.05.004_bib23","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.3201\/eid1111.050367","article-title":"Methicillin-resistant Staphylococcus aureus in Taiwan","volume":"11","author":"Chen","year":"2005","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.jmii.2012.05.004_bib24","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1086\/498898","article-title":"Control and outcome of a large outbreak of colonization and infection with glycopeptide-intermediate Staphylococcus aureus in an intensive care unit","volume":"42","author":"de Lassence","year":"2006","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jmii.2012.05.004_bib25","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.ijantimicag.2004.11.001","article-title":"Heterogeneous vancomycin-resistant Staphylococcus aureus (hetero-VISA) in Singapore","volume":"25","author":"Sng","year":"2005","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.jmii.2012.05.004_bib26","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1128\/AAC.01133-10","article-title":"The significance of heterogeneous vancomycin intermediate Staphylococcus aureus (hVISA) isolates: a systematic review and meta-analysis","volume":"55","author":"Van Hal","year":"2011","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jmii.2012.05.004_bib27","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.diagmicrobio.2008.11.014","article-title":"Epidemiology and susceptibilities of methicillin-resistant Staphylococcus aureus in Taiwan: emphasis on chlorhexidine susceptibility","volume":"63","author":"Sheng","year":"2009","journal-title":"Diagn Microbiol Infect Dis"},{"key":"10.1016\/j.jmii.2012.05.004_bib28","doi-asserted-by":"crossref","first-page":"4445","DOI":"10.1128\/JCM.39.12.4445-4451.2001","article-title":"Nationwide survey shows that methicillin-resistant Staphylococcus aureus strains heterogeneously and intermediately resistant to vancomycin are not disseminated throughout Japanese hospitals","volume":"39","author":"Ike","year":"2001","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.jmii.2012.05.004_bib29","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1086\/520429","article-title":"Bacteraemia caused by Staphylococci with inducible vancomycin heteroresistance","volume":"29","author":"Wong","year":"1999","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jmii.2012.05.004_bib30","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/S0255-0857(21)03073-5","article-title":"Emergence of low level vancomycin resistance in MRSA","volume":"21","author":"Assadullah","year":"2003","journal-title":"Indian J Med Microbiol"},{"key":"10.1016\/j.jmii.2012.05.004_bib31","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.1128\/JCM.41.6.2279-2281.2003","article-title":"Nationwide surveillance for Staphylococcus aureus with reduced susceptibility to vancomycin in Korea","volume":"41","author":"Kim","year":"2003","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.jmii.2012.05.004_bib32","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.ijantimicag.2005.04.007","article-title":"Nosocomial infections due to methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci at a university hospital in Taiwan from 1991 to 2003: resistance trends, antibiotic usage and in\u00a0vitro activities of newer antimicrobial agents","volume":"26","author":"Hsueh","year":"2005","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.jmii.2012.05.004_bib33","doi-asserted-by":"crossref","first-page":"2311","DOI":"10.1128\/JCM.01749-08","article-title":"The first vancomycin-intermediate Staphylococcus aureus strains isolated from patients in Thailand","volume":"47","author":"Lulitanond","year":"2009","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.jmii.2012.05.004_bib34","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1099\/jmm.0.47829-0","article-title":"Emergence of vancomycin-intermediate Staphylococcus species in southern India","volume":"57","author":"Menezes","year":"2008","journal-title":"J Med Microbiol"},{"key":"10.1016\/j.jmii.2012.05.004_bib35","doi-asserted-by":"crossref","first-page":"494","DOI":"10.3201\/eid1303.060247","article-title":"Staphylococcal Cassette Chromosome mec in MRSA, Taiwan","volume":"13","author":"Wang","year":"2007","journal-title":"Emerg Infect Dis"}],"container-title":["Journal of Microbiology, Immunology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1684118212000771?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1684118212000771?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T13:17:14Z","timestamp":1761657434000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1684118212000771"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12]]},"references-count":35,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["S1684118212000771"],"URL":"https:\/\/doi.org\/10.1016\/j.jmii.2012.05.004","relation":{},"ISSN":["1684-1182"],"issn-type":[{"value":"1684-1182","type":"print"}],"subject":[],"published":{"date-parts":[[2012,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Molecular epidemiology and clinical characteristics of hetero-resistant vancomycin intermediate Staphylococcus aureus bacteremia in a Taiwan Medical Center","name":"articletitle","label":"Article Title"},{"value":"Journal of Microbiology, Immunology and Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jmii.2012.05.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Published by Elsevier Taiwan LLC.","name":"copyright","label":"Copyright"}]}}