{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:53:16Z","timestamp":1790297596230,"version":"4.1.0"},"reference-count":27,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,1,2]],"date-time":"2016-01-02T00:00:00Z","timestamp":1451692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001868","name":"National Science Council","doi-asserted-by":"publisher","award":["NSC 99-2321-B-002-025"],"award-info":[{"award-number":["NSC 99-2321-B-002-025"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001868","name":"National Science Council","doi-asserted-by":"publisher","award":["NSC 100-2321-B-002-012"],"award-info":[{"award-number":["NSC 100-2321-B-002-012"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001868","name":"National Science Council","doi-asserted-by":"publisher","award":["NSC 101-2321-B-002-004"],"award-info":[{"award-number":["NSC 101-2321-B-002-004"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Microbiology, Immunology and Infection"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1016\/j.jmii.2014.11.013","type":"journal-article","created":{"date-parts":[[2014,11,22]],"date-time":"2014-11-22T11:07:12Z","timestamp":1416654432000},"page":"10-16","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Predicting severe enterovirus 71 infection: Age, comorbidity, and parental behavior matter"],"prefix":"10.1016","volume":"50","author":[{"given":"Wen-Chan","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Liang","family":"Shih","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun-Cheng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting-Yu","family":"Yen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Te","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Chuan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung-Chen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Chia","family":"Hsieh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzou-Yin","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luan-Yin","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Min","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jmii.2014.11.013_bib1","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/S1473-3099(10)70194-8","article-title":"Virology, epidemiology, pathogenesis, and control of enterovirus 71","volume":"10","author":"Solomon","year":"2010","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.jmii.2014.11.013_bib2","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1056\/NEJM199909233411301","article-title":"An epidemic of enterovirus 71 infection in Taiwan. Taiwan Enterovirus Epidemic Working Group","volume":"341","author":"Ho","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jmii.2014.11.013_bib3","doi-asserted-by":"crossref","first-page":"S52","DOI":"10.1086\/338819","article-title":"The 1998 enterovirus 71 outbreak in Taiwan: pathogenesis and management","volume":"34","author":"Lin","year":"2002","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jmii.2014.11.013_bib4","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0929-6646(09)60236-9","article-title":"Hand, foot and mouth disease complicated with central nervous system involvement in Taiwan in 1980\u20131981","volume":"106","author":"Chang","year":"2007","journal-title":"J Formos Med Assoc"},{"key":"10.1016\/j.jmii.2014.11.013_bib5","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.jmii.2011.01.029","article-title":"Epidemiologic and clinical features of non-polio enteroviral infections in northern Taiwan in 2008","volume":"44","author":"Hsu","year":"2011","journal-title":"J Microbiol Immunol Infect"},{"key":"10.1016\/j.jmii.2014.11.013_bib6","doi-asserted-by":"crossref","first-page":"e244","DOI":"10.1542\/peds.2006-3331","article-title":"Epidemiologic features of hand\u2013foot\u2013mouth disease and herpangina caused by enterovirus 71 in Taiwan, 1998\u20132005","volume":"120","author":"Chen","year":"2007","journal-title":"Pediatrics"},{"key":"10.1016\/j.jmii.2014.11.013_bib7","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1016\/S0140-6736(99)04434-7","article-title":"Clinical features and risk factors of pulmonary oedema after enterovirus-71-related hand, foot, and mouth disease","volume":"354","author":"Chang","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.jmii.2014.11.013_bib8","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1097\/00006454-200404000-00010","article-title":"Outcome of enterovirus 71 infections with or without stage-based management: 1998 to 2002","volume":"23","author":"Chang","year":"2004","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.jmii.2014.11.013_bib9","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1097\/01.inf.0000157219.19674.98","article-title":"Predictors of unfavorable outcomes in enterovirus 71-related cardiopulmonary failure in children","volume":"24","author":"Hsia","year":"2005","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.jmii.2014.11.013_bib10","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1097\/CCM.0b013e3182771364","article-title":"Hexamethonium reverses the lethal cardiopulmonary damages in a rat model of brainstem lesions mimicking fatal enterovirus 71 encephalitis","volume":"41","author":"Lu","year":"2013","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jmii.2014.11.013_bib11","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1001\/jama.291.2.222","article-title":"Transmission and clinical features of enterovirus 71 infections in household contacts in Taiwan","volume":"291","author":"Chang","year":"2004","journal-title":"JAMA"},{"key":"10.1016\/j.jmii.2014.11.013_bib12","doi-asserted-by":"crossref","first-page":"e88","DOI":"10.1542\/peds.109.6.e88","article-title":"Risk factors of enterovirus 71 infection and associated hand, foot, and mouth disease\/herpangina in children during an epidemic in Taiwan","volume":"109","author":"Chang","year":"2002","journal-title":"Pediatrics"},{"key":"10.1016\/j.jmii.2014.11.013_bib13","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1007\/s00431-013-1939-1","article-title":"Breastfeeding, previous Epstein\u2013Barr virus infection, Enterovirus 71 infection, and rural residence are associated with the severity of hand, foot, and mouth disease","volume":"172","author":"Li","year":"2013","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.jmii.2014.11.013_bib14","doi-asserted-by":"crossref","first-page":"e898","DOI":"10.1542\/peds.2010-1497","article-title":"Risk factors for hand, foot, and mouth disease and herpangina and the preventive effect of hand-washing","volume":"127","author":"Ruan","year":"2011","journal-title":"Pediatrics"},{"key":"10.1016\/j.jmii.2014.11.013_bib15","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.jmii.2011.09.025","article-title":"Seroprevalence of enterovirus 71 and no evidence of crossprotection of enterovirus 71 antibody against the other enteroviruses in kindergarten children in Taipei city","volume":"45","author":"Huang","year":"2012","journal-title":"J Microbiol Immunol Infect"},{"key":"10.1016\/j.jmii.2014.11.013_bib16","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1186\/1743-422X-10-209","article-title":"Atypical hand\u2013foot\u2013mouth disease in children: a hospital-based prospective cohort study","volume":"10","author":"Huang","year":"2013","journal-title":"Virol J"},{"key":"10.1016\/j.jmii.2014.11.013_bib17","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1017\/S0950268809991555","article-title":"Human enterovirus 71 and hand, foot and mouth disease","volume":"138","author":"Wong","year":"2010","journal-title":"Epidemiol Infect"},{"key":"10.1016\/j.jmii.2014.11.013_bib18","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1111\/j.1469-0691.2008.02074.x","article-title":"Healthcare-associated infections: think globally, act locally","volume":"14","author":"Marcel","year":"2008","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.jmii.2014.11.013_bib19","doi-asserted-by":"crossref","first-page":"e101","DOI":"10.1016\/j.ajic.2013.01.031","article-title":"Improving hand hygiene compliance in health care workers: strategies and impact on patient outcomes","volume":"41","author":"Song","year":"2013","journal-title":"Am J Infect Control"},{"key":"10.1016\/j.jmii.2014.11.013_bib20","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1128\/CMR.17.4.863-893.2004","article-title":"Epidemiologic background of hand hygiene and evaluation of the most important agents for scrubs and rubs","volume":"17","author":"Kampf","year":"2004","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.jmii.2014.11.013_bib21","doi-asserted-by":"crossref","first-page":"3113","DOI":"10.1128\/aem.55.12.3113-3118.1989","article-title":"In\u00a0vivo protocol for testing efficacy of hand-washing agents against viruses and bacteria: experiments with rotavirus and Escherichia coli","volume":"55","author":"Ansari","year":"1989","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.jmii.2014.11.013_bib22","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1136\/bmj.39393.510347.BE","article-title":"Physical interventions to interrupt or reduce the spread of respiratory viruses: systematic review","volume":"336","author":"Jefferson","year":"2008","journal-title":"BMJ"},{"key":"10.1016\/j.jmii.2014.11.013_bib23","doi-asserted-by":"crossref","first-page":"24","DOI":"10.3201\/eid1501.080299","article-title":"Enhanced hygiene measures and norovirus transmission during an outbreak","volume":"15","author":"Heijne","year":"2009","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.jmii.2014.11.013_bib24","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/BF02124807","article-title":"An experimental study on the epidemiology of enteroviruses: water and soap washing of poliovirus 1-contaminated hands, its effectiveness and kinetics","volume":"174","author":"Sch\u00fcrmann","year":"1985","journal-title":"Med Microbiol Immunol"},{"key":"10.1016\/j.jmii.2014.11.013_bib25","doi-asserted-by":"crossref","first-page":"3226","DOI":"10.1128\/JCM.00034-09","article-title":"Association between contaminated faucets and colonization or infection by nonfermenting gram-negative bacteria in intensive care units in Taiwan","volume":"47","author":"Wang","year":"2009","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.jmii.2014.11.013_bib26","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1002\/jmv.22027","article-title":"Rhinovirus contamination of surfaces in homes of adults with natural colds: transfer of virus to fingertips during normal daily activities","volume":"83","author":"Winther","year":"2011","journal-title":"J Med Virol"},{"key":"10.1016\/j.jmii.2014.11.013_bib27","series-title":"Annual Report of Taiwan Centers for Disease Control","author":"Centers for Disease Control, Ministry of Health and Welfare, R.O.C. (Taiwan)","year":"2013"}],"container-title":["Journal of Microbiology, Immunology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1684118214002436?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1684118214002436?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T13:20:06Z","timestamp":1761657606000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1684118214002436"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["S1684118214002436"],"URL":"https:\/\/doi.org\/10.1016\/j.jmii.2014.11.013","relation":{},"ISSN":["1684-1182"],"issn-type":[{"value":"1684-1182","type":"print"}],"subject":[],"published":{"date-parts":[[2017,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Predicting severe enterovirus 71 infection: Age, comorbidity, and parental behavior matter","name":"articletitle","label":"Article Title"},{"value":"Journal of Microbiology, Immunology and Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jmii.2014.11.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2015, Taiwan Society of Microbiology. Published by Elsevier Taiwan LLC","name":"copyright","label":"Copyright"}]}}