{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T23:51:10Z","timestamp":1793317870264,"version":"4.5.0"},"reference-count":10,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,1,2]],"date-time":"2016-01-02T00:00:00Z","timestamp":1451692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Microbiology, Immunology and Infection"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1016\/j.jmii.2014.11.015","type":"journal-article","created":{"date-parts":[[2014,12,11]],"date-time":"2014-12-11T06:51:44Z","timestamp":1418280704000},"page":"813-816","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Cytokine profiles in Mycoplasma pneumoniae infection-associated hemophagocytic lymphohistiocytosis"],"prefix":"10.1016","volume":"49","author":[{"given":"Motoko","family":"Yasutomi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shintaro","family":"Okazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikue","family":"Hata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiko","family":"Tanizawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soichi","family":"Tamamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikiko","family":"Kawakita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusei","family":"Ohshima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jmii.2014.11.015_bib1","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1111\/bjh.12293","article-title":"Advances in understanding the pathogenesis of HLH","volume":"161","author":"Usmani","year":"2013","journal-title":"Br J Haematol"},{"key":"10.1016\/j.jmii.2014.11.015_bib2","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1086\/652752","article-title":"Clinical significance of cloned expansion and CD5 down-regulation in Epstein\u2013Barr virus (EBV)-infected CD8+ T lymphocytes in EBV-associated hemophagocytic lymphohistiocytosis","volume":"201","author":"Toga","year":"2010","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jmii.2014.11.015_bib3","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1016\/j.humimm.2013.09.001","article-title":"Down-regulation of CD5 expression on activated CD8+ T cells in familial hemophagocytic lymphohistiocytosis with perforin gene mutations","volume":"74","author":"Wada","year":"2013","journal-title":"Hum Immunol"},{"key":"10.1016\/j.jmii.2014.11.015_bib4","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1046\/j.1442-200x.2004.01878.x","article-title":"Hemophagocytic lymphohistiocytosis secondary to Mycoplasma pneumoniae infection","volume":"46","author":"Ishida","year":"2004","journal-title":"Pediatr Int"},{"key":"10.1016\/j.jmii.2014.11.015_bib5","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1111\/j.1442-200X.2008.02701.x","article-title":"Clinical assessment of Mycoplasma pneumoniae-associated hemophagocytic lymphohistiocytosis","volume":"50","author":"Yoshiyama","year":"2008","journal-title":"Pediatr Int"},{"key":"10.1016\/j.jmii.2014.11.015_bib6","doi-asserted-by":"crossref","first-page":"2918","DOI":"10.1182\/blood.V78.11.2918.2918","article-title":"Hypercytokinemia in familial hemophagocytic lymphohistiocytosis","volume":"78","author":"Henter","year":"1991","journal-title":"Blood"},{"key":"10.1016\/j.jmii.2014.11.015_bib7","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1172\/JCI43157","article-title":"Repeated TLR9 stimulation results in macrophage activation syndrome-like disease in mice","volume":"121","author":"Behrens","year":"2011","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jmii.2014.11.015_bib8","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1182\/blood-2003-10-3413","article-title":"An animal model of hemophagocytic lymphohistiocytosis (HLH): CD8+ T cells and interferon gamma are essential for the disorder","volume":"104","author":"Jordan","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.jmii.2014.11.015_bib9","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.cyto.2013.09.007","article-title":"Sustained elevation of serum interleukin-18 and its association with hemophagocytic lymphohistiocytosis in XIAP deficiency","volume":"65","author":"Wada","year":"2014","journal-title":"Cytokine"},{"key":"10.1016\/j.jmii.2014.11.015_bib10","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1378\/chest.121.5.1493","article-title":"Role of interleukin-18 and T-helper type 1 cytokines in the development of Mycoplasma pneumoniae pneumonia in adults","volume":"121","author":"Tanaka","year":"2002","journal-title":"Chest"}],"container-title":["Journal of Microbiology, Immunology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1684118214002461?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1684118214002461?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T13:21:15Z","timestamp":1761657675000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1684118214002461"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":10,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["S1684118214002461"],"URL":"https:\/\/doi.org\/10.1016\/j.jmii.2014.11.015","relation":{},"ISSN":["1684-1182"],"issn-type":[{"value":"1684-1182","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cytokine profiles in Mycoplasma pneumoniae infection-associated hemophagocytic lymphohistiocytosis","name":"articletitle","label":"Article Title"},{"value":"Journal of Microbiology, Immunology and Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jmii.2014.11.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015, Taiwan Society of Microbiology. Published by Elsevier Taiwan LLC","name":"copyright","label":"Copyright"}]}}