{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T03:39:30Z","timestamp":1762659570041,"version":"build-2065373602"},"reference-count":44,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,6,6]],"date-time":"2017-06-06T00:00:00Z","timestamp":1496707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["5\/8-7(86)2010-ECD-II"],"award-info":[{"award-number":["5\/8-7(86)2010-ECD-II"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Microbiology, Immunology and Infection"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1016\/j.jmii.2017.03.001","type":"journal-article","created":{"date-parts":[[2017,6,8]],"date-time":"2017-06-08T19:15:21Z","timestamp":1496949321000},"page":"435-445","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Cisplatin along with herbal drug treatment reduces the percentage of regulatory T cells and decreased the severity of experimental visceral leishmaniasis"],"prefix":"10.1016","volume":"51","author":[{"given":"Heena","family":"Sachdeva","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sukhbir","family":"Kaur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.jmii.2017.03.001_bib1","article-title":"The IL-33\/ST2 axis is associated with human visceral leishmaniasis and suppresses Th1 responses in the livers of BALB\/c mice infected with","volume":"4","author":"Rostan","year":"2013","journal-title":"Leishmania Donovani. mBio"},{"issue":"2","key":"10.1016\/j.jmii.2017.03.001_bib2","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/j.1574-695X.2007.00311.x","article-title":"Immune response to Leishmania, paradox rather than paradigm","volume":"51","author":"Tripathi","year":"2007","journal-title":"FEMS Immunol Med Microbiol"},{"issue":"1","key":"10.1016\/j.jmii.2017.03.001_bib3","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1365-3156.2007.01974.x","article-title":"Implementation research to support the initiative on the elimination of kala azar from Bangladesh, India and Nepal\u2014the challenges for diagnosis and treatment","volume":"13","author":"Sundar","year":"2008","journal-title":"Trop Med Int Health"},{"issue":"2","key":"10.1016\/j.jmii.2017.03.001_bib4","first-page":"105","article-title":"Can visceral leishmaniasis be eliminated from Asia?","volume":"45","author":"Joshi","year":"2008","journal-title":"J Vector Borne Dis"},{"issue":"3","key":"10.1016\/j.jmii.2017.03.001_bib5","first-page":"345","article-title":"Visceral leishmaniasis\u2013current therapeutic modalities","volume":"123","author":"Sundar","year":"2006","journal-title":"Indian J Med Res"},{"issue":"3","key":"10.1016\/j.jmii.2017.03.001_bib6","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1517\/14728210903153862","article-title":"Developments in the treatment of visceral leishmaniasis","volume":"14","author":"den Boer","year":"2009","journal-title":"Expert Opin Emerg Drugs"},{"issue":"4","key":"10.1016\/j.jmii.2017.03.001_bib7","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1128\/AAC.00524-10","article-title":"Combination therapy with paromomycin-associated stearylamine-bearing liposomes cures experimental visceral leishmaniasis through Th1-biased immunomodulation","volume":"55","author":"Banerjee","year":"2011","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jmii.2017.03.001_bib8","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1111\/j.0105-2896.2004.00188.x","article-title":"The immunopathology of experimental visceral leishmaniasis","volume":"201","author":"Kaye","year":"2004","journal-title":"Immunol Rev"},{"key":"10.1016\/j.jmii.2017.03.001_bib9","doi-asserted-by":"crossref","first-page":"765","DOI":"10.2217\/imt.09.40","article-title":"Immunotherapy as a strategy for treatment of leishmaniasis: a review of the literature","volume":"1","author":"Okwor","year":"2009","journal-title":"Immunotherapy"},{"key":"10.1016\/j.jmii.2017.03.001_bib10","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1093\/jac\/dkq164","article-title":"CpGoligodeoxynucleotide augments the antileishmanial activity of miltefosine against experimental Visceral Leishmaniasis","volume":"65","author":"Sane","year":"2010","journal-title":"J Antimicrob Chemother"},{"issue":"4","key":"10.1016\/j.jmii.2017.03.001_bib11","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1080\/02656730701378684","article-title":"Hyperthermia, cisplatin and radiation trimodality treatment: a promising cancer treatment? A review from preclinical studies to clinical application","volume":"23","author":"Bergs","year":"2007","journal-title":"Int J Hyperth"},{"issue":"14","key":"10.1016\/j.jmii.2017.03.001_bib12","doi-asserted-by":"crossref","first-page":"4451","DOI":"10.1158\/0008-5472.CAN-13-0198","article-title":"Visualizing inhibition of Nucleosome mobility and transcription by cisplatin-DNA interstrand crosslinks in live mammalian cells","volume":"73","author":"Zhu","year":"2013","journal-title":"Cancer Res"},{"issue":"7","key":"10.1016\/j.jmii.2017.03.001_bib13","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1016\/j.fct.2009.03.043","article-title":"Cisplatin induced damage in kidney genomic DNA and nephrotoxicity in male rats: the protective effect of grape seed proanthocyanidin extract","volume":"47","author":"Saad","year":"2009","journal-title":"Food Chem Toxicol"},{"issue":"3","key":"10.1016\/j.jmii.2017.03.001_bib14","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1089\/jmf.2008.0033","article-title":"Garlic powder ameliorates cisplatin-induced nephrotoxicity and oxidative stress","volume":"11","author":"Razo-Rodr\u00edguez","year":"2008","journal-title":"J Med Food"},{"issue":"5","key":"10.1016\/j.jmii.2017.03.001_bib15","first-page":"129","article-title":"Ocimum gratissimum aqueous extract enhances recovery in cisplatin induced nephrotoxicity in albino wistar rats","volume":"1","author":"Arhoghro","year":"2012","journal-title":"Indian J Drugs Dis"},{"issue":"5","key":"10.1016\/j.jmii.2017.03.001_bib16","doi-asserted-by":"crossref","first-page":"528","DOI":"10.9734\/EJMP\/2014\/7314","article-title":"Launaea taraxacifolia ameliorates cisplatin- induced hepato-renal injury","volume":"4","author":"Adejuwon","year":"2014","journal-title":"Eur J Med Plants"},{"issue":"2","key":"10.1016\/j.jmii.2017.03.001_bib17","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.actatropica.2007.05.017","article-title":"Characterization of anti-Leishmania effect induced by cisplatin: an anticancer drug","volume":"103","author":"Tavares","year":"2007","journal-title":"Acta Trop"},{"issue":"1","key":"10.1016\/j.jmii.2017.03.001_bib18","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.parint.2009.10.006","article-title":"Antileishmanial effect of cisplatin against murine viseceral leishmaniasis","volume":"59","author":"Kaur","year":"2010","journal-title":"Parasitol Int"},{"issue":"6","key":"10.1016\/j.jmii.2017.03.001_bib19","doi-asserted-by":"crossref","first-page":"2269","DOI":"10.1007\/s00436-013-3387-2","article-title":"Studies on the protective and immunomodulatory efficacy of Withania somnifera along with cisplatin against experimental visceral leishmaniasis","volume":"112","author":"Sachdeva","year":"2013","journal-title":"Parasitol Res"},{"issue":"1","key":"10.1016\/j.jmii.2017.03.001_bib19a","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.parint.2013.09.016","article-title":"Asparagus racemosus ameliorates cisplatin induced toxicities and augments its antileishmanial activity by immunomodulation in\u00a0vivo","volume":"63","author":"Sachdeva","year":"2014","journal-title":"Parasitol Int"},{"key":"10.1016\/j.jmii.2017.03.001_bib19b","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.exppara.2013.12.006","article-title":"Tinospora cordifolia as a protective and immunomodulatory agent in combination with cisplatin against murine visceral leishmaniasis","volume":"137","author":"Sachdeva","year":"2014","journal-title":"Exp Parasitol"},{"issue":"1","key":"10.1016\/j.jmii.2017.03.001_bib21","first-page":"27","article-title":"Visceral leishmaniasis: experimental models for drug discovery","volume":"133","author":"Gupta","year":"2011","journal-title":"Indian J Med Res"},{"key":"10.1016\/j.jmii.2017.03.001_bib22","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1128\/IAI.71.1.401-410.2003","article-title":"Intradermal infection model for pathogenesis and vaccine studies of murine visceral leishmaniasis","volume":"71","author":"Ahmed","year":"2003","journal-title":"Infect Immun"},{"issue":"1","key":"10.1016\/j.jmii.2017.03.001_bib23","first-page":"119","article-title":"Regulation of Leishmania populations within host.I. the variable course of Leishmania donovani infections in mice","volume":"30","author":"Bradley","year":"1977","journal-title":"Clin Exp Immunol"},{"issue":"1","key":"10.1016\/j.jmii.2017.03.001_bib24","doi-asserted-by":"crossref","first-page":"96","DOI":"10.4103\/0250-474X.40341","article-title":"HPLC estimation of berberine in Tinospora cordifolia and","volume":"70","author":"Srinevasan","year":"2008","journal-title":"Tinospora Sin Indian J Pharm Sci"},{"issue":"5","key":"10.1016\/j.jmii.2017.03.001_bib25","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1007\/s00436-009-1554-2","article-title":"Evaluation of antileishmanial activity of selected Indian plants to have antimicrobial properties","volume":"105","author":"Sharma","year":"2009","journal-title":"Parasitol Res"},{"issue":"9","key":"10.1016\/j.jmii.2017.03.001_bib26","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1099\/jmm.0.47114-0","article-title":"An anti-leishmanial, water-soluble, natural steroidal saponin, induces programmed cell death in Leishmania donovani","volume":"56","author":"Dutta","year":"2007","journal-title":"J Med Microbiol"},{"key":"10.1016\/j.jmii.2017.03.001_bib27","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1097\/00002030-199910010-00015","article-title":"HIV viral load and response to antileishmanial chemotherapy in co-infected patients","volume":"13","author":"Berhe","year":"1999","journal-title":"AIDS"},{"issue":"4","key":"10.1016\/j.jmii.2017.03.001_bib28","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1128\/AAC.00524-10","article-title":"Combination therapy with paromomycin-associated stearylamine-bearing liposomes cures experimental visceral leishmaniasis through Th1-Biased immunomodulation","volume":"55","author":"Banerjee","year":"2011","journal-title":"Antmicrob agents Chemother"},{"key":"10.1016\/j.jmii.2017.03.001_bib29","first-page":"6353","article-title":"Natural regulatory T cells in infectious disease","author":"Belkaid","year":"2005","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jmii.2017.03.001_bib30","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1084\/jem.20061141","article-title":"Splenic accumulation of IL-10 mRNA in Tcells distinct from CD4+CD25+ (Foxp3) regulatory T cells in human visceral leishmaniasis","volume":"204","author":"Nylen","year":"2007","journal-title":"J Exp Med"},{"key":"10.1016\/j.jmii.2017.03.001_bib31","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0031551","article-title":"Regulatory T cells suppress T cell activation at the pathologic site of human visceral leishmaniasis","volume":"7","author":"Rai","year":"2012","journal-title":"PLoSONE"},{"issue":"6","key":"10.1016\/j.jmii.2017.03.001_bib32","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1046\/j.1440-1711.1998.00769.x","article-title":"Antigen presentation by cisplatin activated macrophages: role of soluble factor(s) and second messengers","volume":"76","author":"Singh","year":"1998","journal-title":"Immunol Cell Biol"},{"issue":"1","key":"10.1016\/j.jmii.2017.03.001_bib33","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1097\/00001813-199801000-00012","article-title":"Immune system activation by cisplatin and its analog poly-plat: an in\u00a0vitro and in\u00a0vivo study","volume":"9","author":"Muenchen","year":"1998","journal-title":"Anticancer Drugs"},{"issue":"25","key":"10.1016\/j.jmii.2017.03.001_bib34","doi-asserted-by":"crossref","first-page":"3002","DOI":"10.3748\/wjg.v17.i25.3002","article-title":"Cisplatin pretreatment enhances anti-tumor activity of cytokine-induced killer cells","volume":"17","author":"Huang","year":"2011","journal-title":"World J Gastroenterol"},{"issue":"6","key":"10.1016\/j.jmii.2017.03.001_bib35","doi-asserted-by":"crossref","first-page":"2563","DOI":"10.1182\/blood-2007-06-092817","article-title":"In\u00a0vivo trafficking and survival of cytokine-induced killer cells resulting in minimal GVHD with retention of antitumor activity","volume":"112","author":"Nishimura","year":"2008","journal-title":"Blood"},{"issue":"5838","key":"10.1016\/j.jmii.2017.03.001_bib36","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1126\/science.1142331","article-title":"Emerging challenges in regulatory T cell function and biology","volume":"317","author":"Sakaguchi","year":"2007","journal-title":"Science"},{"issue":"13","key":"10.1016\/j.jmii.2017.03.001_bib37","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1016\/j.intimp.2004.07.024","article-title":"Immune stimulating properties of a novel polysaccharide from the medicinal plant","volume":"4","author":"Nair","year":"2004","journal-title":"Tinospora Cordifolia Int Immunopharmacol"},{"issue":"16","key":"10.1016\/j.jmii.2017.03.001_bib38","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1016\/j.lfs.2007.01.029","article-title":"A standardized root extract of Withania somnifera and its major constituent withanolide-A elicit humoral and cell-mediated immune responses by up regulation of Th1-dominant polarization in BALB\/c mice","volume":"80","author":"Malik","year":"2007","journal-title":"Life Sci"},{"key":"10.1016\/j.jmii.2017.03.001_bib39","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1007\/s00044-012-0048-4","article-title":"Immunomodulatory active steroidal saponins from Asparagus racemosus","volume":"22","author":"Sharma","year":"2013","journal-title":"Med Chem Res"},{"issue":"1","key":"10.1016\/j.jmii.2017.03.001_bib40","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/s12935-014-0092-x","article-title":"Aged garlic extract protects against oxidative stress and renal changes in cisplatin-treated adult male rats","volume":"14","author":"Nasr","year":"2014","journal-title":"Cancer Cell Int"},{"issue":"4","key":"10.1016\/j.jmii.2017.03.001_bib41","first-page":"872","article-title":"Effect of Withania somnifera root powder on the levels of circulatory lipid peroxidation and liver marker enzymes in chronic hyperammonimeia","volume":"5","author":"Harikrishanan","year":"2008","journal-title":"E J Chem"},{"issue":"11","key":"10.1016\/j.jmii.2017.03.001_bib42","first-page":"795","article-title":"Antioxidant and hepatoprotective action of Asparagus racemosus Willd. root extracts","volume":"0","author":"Acharya","year":"2012","journal-title":"Indian J Exp Biol"},{"issue":"12","key":"10.1016\/j.jmii.2017.03.001_bib43","first-page":"544","article-title":"Effects of Tinospora cordifolia against carbon tetrachloride induced liver damage","volume":"21","author":"Rege","year":"1984","journal-title":"Indian Drugs"}],"container-title":["Journal of Microbiology, Immunology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S168411821730052X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S168411821730052X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T13:22:56Z","timestamp":1761657776000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S168411821730052X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":44,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["S168411821730052X"],"URL":"https:\/\/doi.org\/10.1016\/j.jmii.2017.03.001","relation":{},"ISSN":["1684-1182"],"issn-type":[{"type":"print","value":"1684-1182"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cisplatin along with herbal drug treatment reduces the percentage of regulatory T cells and decreased the severity of experimental visceral leishmaniasis","name":"articletitle","label":"Article Title"},{"value":"Journal of Microbiology, Immunology and Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jmii.2017.03.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Taiwan Society of Microbiology. Published by Elsevier Taiwan LLC.","name":"copyright","label":"Copyright"}]}}