{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T19:00:45Z","timestamp":1790362845966,"version":"4.1.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,9,29]],"date-time":"2017-09-29T00:00:00Z","timestamp":1506643200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Microbiology, Immunology and Infection"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1016\/j.jmii.2017.08.026","type":"journal-article","created":{"date-parts":[[2017,10,12]],"date-time":"2017-10-12T03:00:51Z","timestamp":1507777251000},"page":"207-213","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"title":["The impact of inoculum size on the activity of cefoperazone-sulbactam against multidrug resistant organisms"],"prefix":"10.1016","volume":"51","author":[{"given":"Ping-Chin","family":"Chang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi-Chung","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying Chen","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Cheng","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Ling","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin-Ching","family":"Chuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hung-Jen","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jmii.2017.08.026_bib1","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/S0140-6736(06)68853-3","article-title":"Emergence and resurgence of meticillin-resistant Staphylococcus aureus as a public-health threat","volume":"368","author":"Grundmann","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.jmii.2017.08.026_bib2","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S1473-3099(08)70041-0","article-title":"Extended-spectrum beta-lactamase-producing Enterobacteriaceae: an emerging public-health concern","volume":"8","author":"Pitout","year":"2008","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.jmii.2017.08.026_bib3","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.jmii.2015.10.001","article-title":"Antimicrobial susceptibility of clinical Enterobacteriaceae isolates at the emergency department in a regional hospital: a threat of extended spectrum beta-lactamase-producers among nursing home residents","volume":"49","author":"Liu","year":"2016","journal-title":"J Microbiol Immunol Infect"},{"key":"10.1016\/j.jmii.2017.08.026_bib4","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.jmii.2016.12.001","article-title":"Presence of multidrug-resistant organisms in the residents and environments of long-term care facilities in Taiwan","volume":"50","author":"Lee","year":"2017","journal-title":"J Microbiol Immunol Infect"},{"key":"10.1016\/j.jmii.2017.08.026_bib5","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.jmii.2015.05.009","article-title":"Molecular characterization of extended-spectrum \u03b2-lactamase-producing Escherichia coli and Klebsiella spp. isolates in Mongolia","volume":"49","author":"Kao","year":"2016","journal-title":"J Microbiol Immunol Infect"},{"issue":"6","key":"10.1016\/j.jmii.2017.08.026_bib6","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/j.jmii.2014.12.008","article-title":"Rates of susceptibility of carbapenems, ceftobiprole, and colistin against clinically important bacteria collected from intensive care units in 2007: results from the Surveillance of Multicenter Antimicrobial Resistance in Taiwan (SMART)","volume":"49","author":"Jean","year":"2016","journal-title":"J Microbiol Immunol Infect"},{"key":"10.1016\/j.jmii.2017.08.026_bib7","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.jmii.2014.04.009","article-title":"Antimicrobial consumption and resistance in five Gram-negative bacterial species in a hospital from 2003 to 2011","volume":"48","author":"Lee","year":"2015","journal-title":"J Microbiol Immunol Infect"},{"key":"10.1016\/j.jmii.2017.08.026_bib8","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.jmii.2014.05.010","article-title":"Clinical features of patients with carbapenem nonsusceptible Klebsiella pneumoniae and Escherichia coli in intensive care units: a nationwide multicenter study in Taiwan","volume":"48","author":"Chang","year":"2015","journal-title":"J Microbiol Immunol Infect"},{"key":"10.1016\/j.jmii.2017.08.026_bib9","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1517\/14740338.2012.643866","article-title":"Adverse reactions to beta-lactam antimicrobials","volume":"11","author":"Lagace-Wiens","year":"2012","journal-title":"Expert Opin Drug Saf"},{"key":"10.1016\/j.jmii.2017.08.026_bib10","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.mib.2005.08.014","article-title":"The threat of antibiotic resistance in Gram-negative pathogenic bacteria: beta-lactams in peril!","volume":"8","author":"Thomson","year":"2005","journal-title":"Curr Opin Microbiol"},{"key":"10.1016\/j.jmii.2017.08.026_bib11","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1128\/CMR.00037-09","article-title":"Three decades of beta-lactamase inhibitors","volume":"23","author":"Drawz","year":"2010","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.jmii.2017.08.026_bib12","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1086\/420816","article-title":"Antibiotic therapy for Klebsiella pneumoniae bacteremia: implications of production of extended-spectrum beta-lactamases","volume":"39","author":"Paterson","year":"2004","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jmii.2017.08.026_bib13","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1186\/1471-2334-12-245","article-title":"Impact of empirical treatment in extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella spp. bacteremia. A multicentric cohort study","volume":"12","author":"Peralta","year":"2012","journal-title":"BMC Infect Dis"},{"key":"10.1016\/j.jmii.2017.08.026_bib14","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1128\/AAC.50.2.498-504.2006","article-title":"Bloodstream infections caused by extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae: risk factors, molecular epidemiology, and clinical outcome","volume":"50","author":"Tumbarello","year":"2006","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jmii.2017.08.026_bib15","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1128\/AAC.02190-12","article-title":"Inoculum effect on the efficacies of amoxicillin-clavulanate, piperacillin-tazobactam, and imipenem against extended-spectrum beta-lactamase (ESBL)-producing and non-ESBL-producing Escherichia coli in an experimental murine sepsis model","volume":"57","author":"Docobo-Perez","year":"2013","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jmii.2017.08.026_bib16","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1128\/AAC.35.9.1868","article-title":"Comparison of the inoculum effect of cefoxitin and other cephalosporins and of beta-lactamase inhibitors and their penicillin-derived components on the Bacteroides fragilis group","volume":"35","author":"Goldstein","year":"1991","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jmii.2017.08.026_bib17","doi-asserted-by":"crossref","first-page":"O831","DOI":"10.1111\/1469-0691.12677","article-title":"In\u00a0vitro and in\u00a0vivo activities of piperacillin-tazobactam and meropenem at different inoculum sizes of ESBL-producing Klebsiella pneumoniae","volume":"20","author":"Harada","year":"2014","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.jmii.2017.08.026_bib18","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1111\/j.1469-0691.2009.02893.x","article-title":"Comparative assessment of inoculum effects on the antimicrobial activity of amoxycillin-clavulanate and piperacillin-tazobactam with extended-spectrum beta-lactamase-producing and extended-spectrum beta-lactamase-non-producing Escherichia coli isolates","volume":"16","author":"Lopez-Cerero","year":"2010","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.jmii.2017.08.026_bib19","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.diagmicrobio.2009.01.018","article-title":"Killing of Escherichia coli by beta-lactams at different inocula","volume":"64","author":"Tam","year":"2009","journal-title":"Diagn Microbiol Infect Dis"},{"key":"10.1016\/j.jmii.2017.08.026_bib20","series-title":"Performance standards for antimicrobial susceptibility testing, 9th informational supplement. M100\u2013S24","author":"National Committee for Clinical Laboratory Standards","year":"2014"},{"key":"10.1016\/j.jmii.2017.08.026_bib21","doi-asserted-by":"crossref","first-page":"31964","DOI":"10.1038\/srep31964","article-title":"The role of doxycycline in the therapy of multidrug-resistant E. coli \u2013 an in\u00a0vitro study","volume":"6","author":"Lai","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.jmii.2017.08.026_bib22","series-title":"Methods for dilution antimicrobial susceptibility testing of bacteria that grow aerobically","author":"Clinical and Laboratory Standards Institute","year":"2012"},{"key":"10.1016\/j.jmii.2017.08.026_bib23","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1128\/jcm.33.9.2233-2239.1995","article-title":"Interpreting chromosomal DNA restriction patterns produced by pulsed-field gel electrophoresis: criteria for bacterial strain typing","volume":"33","author":"Tenover","year":"1995","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.jmii.2017.08.026_bib24","doi-asserted-by":"crossref","first-page":"5721","DOI":"10.1128\/AAC.01121-13","article-title":"Regional resistance surveillance program results for 12 Asia-Pacific nations (2011)","volume":"57","author":"Mendes","year":"2013","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jmii.2017.08.026_bib25","first-page":"224","article-title":"Comparative evaluation of the in-vitro activity of six beta-lactam\/beta-lactamase inhibitor combinations against gram negative bacilli","volume":"7","author":"Sood","year":"2013","journal-title":"J Clin Diagn Res"},{"key":"10.1016\/j.jmii.2017.08.026_bib26","first-page":"49","article-title":"In\u00a0vitro activities of piperacillin or cefoperazone alone and in combination with beta-lactamase inhibitors against gram-negative bacilli","volume":"32","author":"Kuo","year":"2009","journal-title":"New Microbiol"},{"key":"10.1016\/j.jmii.2017.08.026_bib27","doi-asserted-by":"crossref","first-page":"229","DOI":"10.4103\/1011-4564.196365","article-title":"Antimicrobial activities of cefoperazone-sulbactam in comparison to cefoperazone against clinical organisms from medical centers in Taiwan","volume":"36","author":"Chiang","year":"2016","journal-title":"J Med Sci"},{"key":"10.1016\/j.jmii.2017.08.026_bib28","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.ijantimicag.2003.10.008","article-title":"In\u00a0vitro activities of beta-lactam antibiotics alone and in combination with sulbactam against Gram-negative bacteria","volume":"23","author":"Wang","year":"2004","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.jmii.2017.08.026_bib29","first-page":"45","article-title":"The inoculum effect of antibiotics against CTX-M-extended-spectrum beta-lactamase-producing Escherichia coli","volume":"13","author":"Wu","year":"2014","journal-title":"Ann Clin Microbiol Antimicrob"}],"container-title":["Journal of Microbiology, Immunology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1684118217302268?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1684118217302268?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T13:22:15Z","timestamp":1761657735000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1684118217302268"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["S1684118217302268"],"URL":"https:\/\/doi.org\/10.1016\/j.jmii.2017.08.026","relation":{},"ISSN":["1684-1182"],"issn-type":[{"value":"1684-1182","type":"print"}],"subject":[],"published":{"date-parts":[[2018,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The impact of inoculum size on the activity of cefoperazone-sulbactam against multidrug resistant organisms","name":"articletitle","label":"Article Title"},{"value":"Journal of Microbiology, Immunology and Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jmii.2017.08.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Taiwan Society of Microbiology. Published by Elsevier Taiwan LLC.","name":"copyright","label":"Copyright"}]}}