{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T06:29:40Z","timestamp":1790144980249,"version":"4.0.1"},"reference-count":44,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,1,24]],"date-time":"2018-01-24T00:00:00Z","timestamp":1516752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Microbiology, Immunology and Infection"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1016\/j.jmii.2017.12.005","type":"journal-article","created":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T10:53:51Z","timestamp":1517482431000},"page":"69-78","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":77,"title":["Diabetic patients suffering dengue are at risk for development of dengue shock syndrome\/severe dengue: Emphasizing the impacts of co-existing comorbidity(ies) and glycemic control on dengue severity"],"prefix":"10.1016","volume":"53","author":[{"given":"Ing-Kit","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Jung","family":"Hsieh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien-Te","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jien-Wei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jmii.2017.12.005_bib1","series-title":"Dengue: guidelines for diagnosis, treatment, prevention and control","author":"World Health Organization","year":"2009"},{"key":"10.1016\/j.jmii.2017.12.005_bib2","first-page":"299","article-title":"Epidemiology of dengue: past, present and future prospects","volume":"5","author":"Murray","year":"2013","journal-title":"Clin Epidemiol"},{"key":"10.1016\/j.jmii.2017.12.005_bib3","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1056\/NEJMra041927","article-title":"Dengue in travelers","volume":"353","author":"Wilder-Smith","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jmii.2017.12.005_bib4","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.1708-8305.2009.00374.x","article-title":"Travel-associated dengue infections in the United States, 1996 to 2005","volume":"17","author":"Mohammed","year":"2010","journal-title":"J Trav Med"},{"key":"10.1016\/j.jmii.2017.12.005_bib5","first-page":"715","article-title":"Travel-associated dengue surveillance\u2014United States, 2006-2008","volume":"59","author":"Centers for Disease Control and Prevention (CDC)","year":"2010","journal-title":"Morb Mortal Wkly Rep"},{"key":"10.1016\/j.jmii.2017.12.005_bib6","series-title":"Dengue hemorrhagic fever: diagnosis, treatment, prevention and control","author":"World Health Organization","year":"1997"},{"key":"10.1016\/j.jmii.2017.12.005_bib7","doi-asserted-by":"crossref","first-page":"e1532","DOI":"10.1371\/journal.pntd.0001532","article-title":"Fatal dengue hemorrhagic fever in adults: emphasizing the evolutionary pre-fatal clinical and laboratory manifestations","volume":"6","author":"Lee","year":"2012","journal-title":"PLoS Neglected Trop Dis"},{"key":"10.1016\/j.jmii.2017.12.005_bib8","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.jmii.2012.07.005","article-title":"Comparisons of dengue illness classified based on the 1997 and 2009 World Health Organization dengue classification schemes","volume":"46","author":"Tsai","year":"2013","journal-title":"J Microbiol Immunol Infect"},{"key":"10.1016\/j.jmii.2017.12.005_bib9","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S1473-3099(01)00171-2","article-title":"Dengue: an update","volume":"2","author":"Guzman","year":"2001","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.jmii.2017.12.005_bib10","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1093\/oxfordjournals.aje.a113932","article-title":"Risk factors in dengue shock syndrome: a prospective epidemiologic study in Rayong, Thailand. I. The 1980 outbreak","volume":"120","author":"Sangkawibha","year":"1984","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.jmii.2017.12.005_bib11","doi-asserted-by":"crossref","first-page":"172","DOI":"10.4269\/ajtmh.1988.38.172","article-title":"A prospective study of dengue infections in Bangkok","volume":"38","author":"Burke","year":"1988","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.jmii.2017.12.005_bib12","first-page":"375","article-title":"Dengue haemorrhagic fever\/dengue shock syndrome: lessons from the Cuban epidemic, 1981","volume":"67","author":"Kouri","year":"1989","journal-title":"Bull World Health Organ"},{"key":"10.1016\/j.jmii.2017.12.005_bib13","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1016\/S0140-6736(07)61687-0","article-title":"Dengue","volume":"370","author":"Halstead","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.jmii.2017.12.005_bib14","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1590\/S0102-311X2005000500002","article-title":"Dengue and dengue hemorrhagic fever epidemics in Brazil: what research is needed based on trends, surveillance, and control experiences?","volume":"21","author":"Teixeira","year":"2005","journal-title":"Cad Sa\u00fade P\u00fablica"},{"key":"10.1016\/j.jmii.2017.12.005_bib15","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.femsim.2004.11.012","article-title":"Altered T helper 1 reaction but not increase of virus load in patients with dengue hemorrhagic fever","volume":"44","author":"Chen","year":"2005","journal-title":"FEMS Immunol Med Microbiol"},{"key":"10.1016\/j.jmii.2017.12.005_bib16","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.jinf.2014.05.013","article-title":"Augmented miR-150 expression associated with depressed SOCS1 expression involved in dengue haemorrhagic fever","volume":"69","author":"Chen","year":"2014","journal-title":"J Infect"},{"key":"10.1016\/j.jmii.2017.12.005_bib17","doi-asserted-by":"crossref","first-page":"965853","DOI":"10.1155\/2013\/965853","article-title":"Increased production of interleukin-4, interleukin-10, and granulocyte-macrophage colony-stimulating factor by type 2 diabetes' mononuclear cells infected with dengue virus, but not increased intracellular viral multiplication","volume":"2013","author":"Lee","year":"2013","journal-title":"BioMed Res Int"},{"key":"10.1016\/j.jmii.2017.12.005_bib18","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/BF02255946","article-title":"Immunopathogenesis of dengue virus infection","volume":"8","author":"Lei","year":"2001","journal-title":"J Biomed Sci"},{"key":"10.1016\/j.jmii.2017.12.005_bib19","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/S0140-6736(14)60572-9","article-title":"Dengue","volume":"385","author":"Guzman","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.jmii.2017.12.005_bib20","doi-asserted-by":"crossref","first-page":"198797","DOI":"10.1155\/2013\/198797","article-title":"The usefulness of clinical-practice-based laboratory data in facilitating the diagnosis of dengue illness","volume":"2013","author":"Liu","year":"2013","journal-title":"BioMed Res Int"},{"key":"10.1016\/j.jmii.2017.12.005_bib21","doi-asserted-by":"crossref","first-page":"370","DOI":"10.4269\/ajtmh.2005.72.370","article-title":"Association between sex, nutritional status, severity of dengue hemorrhagic fever, and immune status in infants with dengue hemorrhagic fever","volume":"72","author":"Nguyen","year":"2005","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.jmii.2017.12.005_bib22","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S1201-9712(03)90057-9","article-title":"Effect of increasing age on the trend of dengue and dengue hemorrhagic fever in Singapore","volume":"7","author":"Ooi","year":"2003","journal-title":"Int J Infect Dis"},{"key":"10.1016\/j.jmii.2017.12.005_bib23","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/0035-9203(87)90041-1","article-title":"Why dengue haemorrhagic fever in Cuba? 1. Individual risk factors for dengue haemorrhagic fever\/dengue shock syndrome (DHF\/DSS)","volume":"81","author":"Bravo","year":"1987","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"10.1016\/j.jmii.2017.12.005_bib24","doi-asserted-by":"crossref","first-page":"e699","DOI":"10.1371\/journal.pntd.0000699","article-title":"Allergies and diabetes as risk factors for dengue hemorrhagic fever: results of a case control study","volume":"4","author":"Figueiredo","year":"2010","journal-title":"PLoS Neglected Trop Dis"},{"key":"10.1016\/j.jmii.2017.12.005_bib25","doi-asserted-by":"crossref","first-page":"e1641","DOI":"10.1371\/journal.pntd.0001641","article-title":"Diabetes with hypertension as risk factors for adult dengue hemorrhagic fever in a predominantly dengue serotype 2 epidemic: a case control study","volume":"6","author":"Pang","year":"2012","journal-title":"PLoS Neglected Trop Dis"},{"key":"10.1016\/j.jmii.2017.12.005_bib26","doi-asserted-by":"crossref","first-page":"213","DOI":"10.3132\/dvdr.2008.034","article-title":"Apoptosis, vascular leakage and increased risk of severe dengue in a type 2 diabetes mellitus patient","volume":"5","author":"Limonta","year":"2008","journal-title":"Diabetes Vasc Dis Res"},{"key":"10.1016\/j.jmii.2017.12.005_bib27","doi-asserted-by":"crossref","first-page":"e0003741","DOI":"10.1371\/journal.pntd.0003741","article-title":"Is diabetes a risk factor for a severe clinical presentation of dengue? - review and meta-analysis","volume":"9","author":"Htun","year":"2015","journal-title":"PLoS Neglected Trop Dis"},{"key":"10.1016\/j.jmii.2017.12.005_bib28","series-title":"Definition, diagnosis and classification of diabetes mellitus and its complications","author":"World Health Organization","year":"1999"},{"key":"10.1016\/j.jmii.2017.12.005_bib29","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.2337\/dc15-S003","article-title":"Standards of medical care in diabetes \u2013 2015: summary of revisions","volume":"38","author":"American Diabetes Association","year":"2015","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jmii.2017.12.005_bib30","doi-asserted-by":"crossref","first-page":"2560","DOI":"10.1001\/jama.289.19.2560","volume":"289","author":"Chobanian","year":"2003","journal-title":"JAMA"},{"key":"10.1016\/j.jmii.2017.12.005_bib31","doi-asserted-by":"crossref","first-page":"651","DOI":"10.4269\/ajtmh.2009.80.651","article-title":"Clinical characteristics, risk factors, and outcomes in adults experiencing dengue hemorrhagic fever complicated with acute renal failure","volume":"80","author":"Lee","year":"2009","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.jmii.2017.12.005_bib32","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1056\/NEJM197011122832001","article-title":"Pattern of necrosis in acute viral hepatitis. Prognostic value of bridging (subacute hepatic necrosis)","volume":"283","author":"Boyer","year":"1970","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jmii.2017.12.005_bib33","doi-asserted-by":"crossref","first-page":"2788","DOI":"10.1056\/NEJMcp052699","article-title":"Clinical practice. Acute pulmonary edema","volume":"353","author":"Ware","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jmii.2017.12.005_bib34","first-page":"9","article-title":"Dengue haemorrhagic fever in Taiwan","volume":"27","author":"Liu","year":"2003","journal-title":"Dengue Bull"},{"key":"10.1016\/j.jmii.2017.12.005_bib35","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.1574-695X.2000.tb01474.x","article-title":"Cytokine cascade in dengue haemorrhagic fever: implications for pathogenesis","volume":"28","author":"Chaturvedi","year":"2000","journal-title":"FEMS Immunol Med Microbiol"},{"key":"10.1016\/j.jmii.2017.12.005_bib36","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/sj.icb.7100008","article-title":"Of cascades and perfect storms: the immunopathogenesis of dengue hemorrhagic fever-dengue shock syndrome (DHF\/DSS)","volume":"85","author":"Pang","year":"2007","journal-title":"Immunol Cell Biol"},{"key":"10.1016\/j.jmii.2017.12.005_bib37","doi-asserted-by":"crossref","first-page":"8709","DOI":"10.1371\/journal.pone.0008709","article-title":"Clinical findings and pro-inflammatory cytokines in dengue patients in Western India: a facility-based study","volume":"5","author":"Priyadarshini","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.jmii.2017.12.005_bib38","doi-asserted-by":"crossref","first-page":"e2194","DOI":"10.1371\/journal.pntd.0002194","article-title":"Review of dengue hemorrhagic fever fatal cases seen among adults: a retrospective study","volume":"7","author":"Sam","year":"2013","journal-title":"PLoS Neglected Trop Dis"},{"key":"10.1016\/j.jmii.2017.12.005_bib39","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1136\/bmj.317.7160.703","article-title":"Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38","volume":"317","author":"UK Prospective Diabetes Study Group","year":"1998","journal-title":"BMJ"},{"key":"10.1016\/j.jmii.2017.12.005_bib40","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1136\/bmj.321.7258.405","article-title":"Association of glycaemia with macrovascular and microvascular complications of Type 2 diabetes (UKPDS 35): prospective observational study","volume":"321","author":"Stratton","year":"2000","journal-title":"BMJ"},{"key":"10.1016\/j.jmii.2017.12.005_bib41","doi-asserted-by":"crossref","first-page":"9","DOI":"10.2337\/diab.23.1.9","article-title":"Impaired leukocyte function in patients with poorly controlled diabetes","volume":"23","author":"Bagdade","year":"1974","journal-title":"Diabetes"},{"key":"10.1016\/j.jmii.2017.12.005_bib42","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.trstmh.2010.05.003","article-title":"Comparison of the effects of oral hydration and intravenous fluid replacement in adult patients with non-shock dengue hemorrhagic fever in Taiwan","volume":"104","author":"Lee","year":"2010","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"10.1016\/j.jmii.2017.12.005_bib43","doi-asserted-by":"crossref","first-page":"4738","DOI":"10.1128\/JVI.73.6.4738-4747.1999","article-title":"Dengue virus structural differences that correlate with pathogenesis","volume":"73","author":"Leitmeyer","year":"1999","journal-title":"J Virol"},{"key":"10.1016\/j.jmii.2017.12.005_bib44","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1086\/315215","article-title":"Dengue viremia titer, antibody response pattern, and virus serotype correlate with disease severity","volume":"181","author":"Vaughn","year":"2000","journal-title":"J Infect Dis"}],"container-title":["Journal of Microbiology, Immunology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1684118218300069?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1684118218300069?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T13:25:16Z","timestamp":1761657916000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1684118218300069"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["S1684118218300069"],"URL":"https:\/\/doi.org\/10.1016\/j.jmii.2017.12.005","relation":{},"ISSN":["1684-1182"],"issn-type":[{"value":"1684-1182","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Diabetic patients suffering dengue are at risk for development of dengue shock syndrome\/severe dengue: Emphasizing the impacts of co-existing comorbidity(ies) and glycemic control on dengue severity","name":"articletitle","label":"Article Title"},{"value":"Journal of Microbiology, Immunology and Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jmii.2017.12.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Taiwan Society of Microbiology. Published by Elsevier Taiwan LLC.","name":"copyright","label":"Copyright"}]}}