{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T15:55:04Z","timestamp":1778601304979,"version":"3.51.4"},"reference-count":35,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,8,29]],"date-time":"2018-08-29T00:00:00Z","timestamp":1535500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009947","name":"Merck Sharp and Dohme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009947","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Microbiology, Immunology and Infection"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.jmii.2018.07.008","type":"journal-article","created":{"date-parts":[[2018,8,31]],"date-time":"2018-08-31T18:54:03Z","timestamp":1535741643000},"page":"328-335","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["Fast track SSTI management program based on a rapid molecular test (GeneXpert\u00ae MRSA\/SA SSTI) and antimicrobial stewardship"],"prefix":"10.1016","volume":"53","author":[{"given":"Emilio","family":"Bouza","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raffaella","family":"Onori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Auxiliadora","family":"Semiglia-Chong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"\u00c1lvarez-Ur\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Alcal\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2545-4204","authenticated-orcid":false,"given":"Almudena","family":"Burillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jmii.2018.07.008_bib1","doi-asserted-by":"crossref","first-page":"E377","DOI":"10.1111\/1469-0691.12235","article-title":"Current management of patients hospitalized with complicated skin and soft tissue infections across Europe (2010-2011): assessment of clinical practice patterns and real-life effectiveness of antibiotics from the REACH study","volume":"19","author":"Garau","year":"2013","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.jmii.2018.07.008_bib2","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1093\/cid\/ciu444","article-title":"Practice guidelines for the diagnosis and management of skin and soft tissue infections: 2014 update by the infectious diseases society of America","volume":"59","author":"Stevens","year":"2014","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jmii.2018.07.008_bib3","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1155\/2008\/846453","article-title":"Bacterial skin and soft tissue infections in adults: a review of their epidemiology, pathogenesis, diagnosis, treatment and site of care","volume":"19","author":"Ki","year":"2008","journal-title":"Can J Infect Dis Med Microbiol"},{"key":"10.1016\/j.jmii.2018.07.008_bib4","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1186\/1471-2334-14-476","article-title":"Influence of real-world characteristics on outcomes for patients with methicillin-resistant Staphylococcal skin and soft tissue infections: a multi-country medical chart review in Europe","volume":"14","author":"Nathwani","year":"2014","journal-title":"BMC Infect Dis"},{"issue":"Suppl 2","key":"10.1016\/j.jmii.2018.07.008_bib5","first-page":"ii37","article-title":"Impact of methicillin-resistant Staphylococcus aureus infections on key health economic outcomes: does reducing the length of hospital stay matter?","volume":"51","author":"Nathwani","year":"2003","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.jmii.2018.07.008_bib6","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.diagmicrobio.2014.02.013","article-title":"Economic outcomes of inappropriate initial antibiotic treatment for complicated skin and soft tissue infections: a multicenter prospective observational study","volume":"79","author":"Lipsky","year":"2014","journal-title":"Diagn Microbiol Infect Dis"},{"key":"10.1016\/j.jmii.2018.07.008_bib7","doi-asserted-by":"crossref","first-page":"719","DOI":"10.3111\/13696998.2014.940423","article-title":"Resource use in patients hospitalized with complicated skin and soft tissue infections in Europe and analysis of vulnerable groups: the REACH study","volume":"17","author":"Ostermann","year":"2014","journal-title":"J Med Econ"},{"key":"10.1016\/j.jmii.2018.07.008_bib8","doi-asserted-by":"crossref","first-page":"e51","DOI":"10.1093\/cid\/ciw118","article-title":"Implementing an antibiotic stewardship program: guidelines by the infectious diseases society of America and the society for healthcare epidemiology of America","volume":"62","author":"Barlam","year":"2016","journal-title":"Clin Infect Dis"},{"issue":"Suppl 3","key":"10.1016\/j.jmii.2018.07.008_bib9","doi-asserted-by":"crossref","first-page":"S134","DOI":"10.1093\/cid\/ciu547","article-title":"Review of rapid diagnostic tests used by antimicrobial stewardship programs","volume":"59","author":"Bauer","year":"2014","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jmii.2018.07.008_bib10","series-title":"Cumitech 7B, lower respiratory tract infections","author":"Sharp","year":"2004"},{"key":"10.1016\/j.jmii.2018.07.008_bib11","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1128\/JCM.44.5.1869-1872.2006","article-title":"Evaluation of the Q score and Q234 systems for cost-effective and clinically relevant interpretation of wound cultures","volume":"44","author":"Matkoski","year":"2006","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.jmii.2018.07.008_bib12","doi-asserted-by":"crossref","first-page":"4225","DOI":"10.1128\/JCM.00334-11","article-title":"Direct detection of Staphylococcus osteoarticular infections by use of Xpert MRSA\/SA SSTI real-time PCR","volume":"49","author":"Dubouix-Bourandy","year":"2011","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.jmii.2018.07.008_bib13","series-title":"Clinical microbiology procedures handbook","article-title":"Gram stain","author":"Chan","year":"2016"},{"key":"10.1016\/j.jmii.2018.07.008_bib14","series-title":"Clinical microbiology procedures handbook","article-title":"Wound cultures","author":"Carson","year":"2016"},{"key":"10.1016\/j.jmii.2018.07.008_bib15","first-page":"378","article-title":"Treatment guide for skin and soft tissue infections. Spanish Chemotherapy society, Spanish internal medicine society, Spanish association of surgeons","volume":"19","author":"Sociedad Espanola de Quimioterapia","year":"2006","journal-title":"Rev Espa\u00f1ola Quimioter"},{"key":"10.1016\/j.jmii.2018.07.008_bib16","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/0895-4356(94)90129-5","article-title":"Validation of a combined comorbidity index","volume":"47","author":"Charlson","year":"1994","journal-title":"J Clin Epidemiol"},{"key":"10.1016\/j.jmii.2018.07.008_bib17","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1001\/archinte.1962.03620240029006","article-title":"Gram-negative bacteremia. I. Etiology and ecology","volume":"110","author":"McCabe","year":"1962","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.jmii.2018.07.008_bib18","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1086\/526444","article-title":"Clinical and economic consequences of failure of initial antibiotic therapy for hospitalized patients with complicated skin and skin-structure infections","volume":"29","author":"Edelsberg","year":"2008","journal-title":"Infect Control Hosp Epidemiol"},{"key":"10.1016\/j.jmii.2018.07.008_bib19","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s40121-015-0085-7","article-title":"Impact of antimicrobial stewardship program (ASP) on outcomes in patients with acute bacterial skin and skin structure infections (ABSSSIs) in an acute-tertiary care hospital","volume":"4","author":"Loo","year":"2015","journal-title":"Infect Dis Ther"},{"key":"10.1016\/j.jmii.2018.07.008_bib20","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1097\/QCO.0000000000000239","article-title":"Epidemiology and microbiology of skin and soft tissue infections","volume":"29","author":"Esposito","year":"2016","journal-title":"Curr Opin Infect Dis"},{"key":"10.1016\/j.jmii.2018.07.008_bib21","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1086\/656431","article-title":"Skin and soft-tissue infections requiring hospitalization at an academic medical center: opportunities for antimicrobial stewardship","volume":"51","author":"Jenkins","year":"2010","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jmii.2018.07.008_bib22","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1111\/j.1468-3083.2011.04416.x","article-title":"Bacterial skin and soft tissue infections: review of the epidemiology, microbiology, aetiopathogenesis and treatment: a collaboration between dermatologists and infectivologists","volume":"26","author":"Tognetti","year":"2012","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.jmii.2018.07.008_bib23","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.diagmicrobio.2013.02.020","article-title":"Microbiology of skin and soft tissue infections in the age of community-acquired methicillin-resistant Staphylococcus aureus","volume":"76","author":"Ray","year":"2013","journal-title":"Diagn Microbiol Infect Dis"},{"key":"10.1016\/j.jmii.2018.07.008_bib24","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/s12879-015-0822-2","article-title":"Early response to antibiotic treatment in European patients hospitalized with complicated skin and soft tissue infections: analysis of the REACH study","volume":"15","author":"Garau","year":"2015","journal-title":"BMC Infect Dis"},{"key":"10.1016\/j.jmii.2018.07.008_bib25","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1186\/1471-2334-13-252","article-title":"Incidence, microbiology, and patient characteristics of skin and soft-tissue infections in a U.S. population: a retrospective population-based study","volume":"13","author":"Ray","year":"2013","journal-title":"BMC Infect Dis"},{"key":"10.1016\/j.jmii.2018.07.008_bib26","doi-asserted-by":"crossref","first-page":"e52722","DOI":"10.1371\/journal.pone.0052722","article-title":"Epidemics of community-associated methicillin-resistant Staphylococcus aureus in the United States: a meta-analysis","volume":"8","author":"Dukic","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jmii.2018.07.008_bib27","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.diagmicrobio.2013.10.008","article-title":"Resistance surveillance program report for selected European nations (2011)","volume":"78","author":"Jones","year":"2014","journal-title":"Diagn Microbiol Infect Dis"},{"key":"10.1016\/j.jmii.2018.07.008_bib28","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1111\/1469-0691.12632","article-title":"Pan-European early switch\/early discharge opportunities exist for hospitalized patients with methicillin-resistant Staphylococcus aureus complicated skin and soft tissue infections","volume":"20","author":"Nathwani","year":"2014","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.jmii.2018.07.008_bib29","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1093\/jac\/dkq362","article-title":"Severity assessment of skin and soft tissue infections: cohort study of management and outcomes for hospitalized patients","volume":"66","author":"Marwick","year":"2011","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.jmii.2018.07.008_bib30","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1128\/JCM.01884-08","article-title":"Rapid detection of Staphylococcus aureus and methicillin-resistant S. aureus (MRSA) in wound specimens and blood cultures: multicenter preclinical evaluation of the Cepheid Xpert MRSA\/SA skin and soft tissue and blood culture assays","volume":"47","author":"Wolk","year":"2009","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.jmii.2018.07.008_bib31","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1097\/CCM.0000000000000330","article-title":"Empiric antibiotic treatment reduces mortality in severe sepsis and septic shock from the first hour: results from a guideline-based performance improvement program","volume":"42","author":"Ferrer","year":"2014","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jmii.2018.07.008_bib32","doi-asserted-by":"crossref","first-page":"e129","DOI":"10.1093\/cid\/ciu039","article-title":"Introduction of rapid methicillin-resistant Staphylococcus aureus polymerase chain reaction testing and antibiotic selection among hospitalized patients with purulent skin infections","volume":"58","author":"Terp","year":"2014","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jmii.2018.07.008_bib33","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1017\/ice.2015.202","article-title":"A randomized clinical trial comparing use of rapid molecular testing for Staphylococcus aureus for patients with cutaneous abscesses in the emergency department with standard of care","volume":"36","author":"May","year":"2015","journal-title":"Infect Control Hosp Epidemiol"},{"key":"10.1016\/j.jmii.2018.07.008_bib34","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1128\/CMR.00066-16","article-title":"Antimicrobial stewardship: how the microbiology laboratory can right the ship","volume":"30","author":"Morency-Potvin","year":"2017","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.jmii.2018.07.008_bib35","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1128\/CMR.00053-14","article-title":"Effectiveness of practices to increase timeliness of providing targeted therapy for inpatients with bloodstream infections: a laboratory medicine best practices systematic review and meta-analysis","volume":"29","author":"Buehler","year":"2016","journal-title":"Clin Microbiol Rev"}],"container-title":["Journal of Microbiology, Immunology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1684118218303384?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1684118218303384?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T13:24:14Z","timestamp":1761657854000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1684118218303384"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["S1684118218303384"],"URL":"https:\/\/doi.org\/10.1016\/j.jmii.2018.07.008","relation":{},"ISSN":["1684-1182"],"issn-type":[{"value":"1684-1182","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fast track SSTI management program based on a rapid molecular test (GeneXpert\u00ae MRSA\/SA SSTI) and antimicrobial stewardship","name":"articletitle","label":"Article Title"},{"value":"Journal of Microbiology, Immunology and Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jmii.2018.07.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Taiwan Society of Microbiology. Published by Elsevier Taiwan LLC.","name":"copyright","label":"Copyright"}]}}