{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T18:57:41Z","timestamp":1781031461029,"version":"3.54.1"},"reference-count":32,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,12,13]],"date-time":"2018-12-13T00:00:00Z","timestamp":1544659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004738","name":"E-Da Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007750","name":"National Cheng Kung University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007750","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Microbiology, Immunology and Infection"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1016\/j.jmii.2018.12.001","type":"journal-article","created":{"date-parts":[[2018,12,14]],"date-time":"2018-12-14T21:12:50Z","timestamp":1544821970000},"page":"561-568","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["High correlation between human rhinovirus type C and children with asthma exacerbations in Taiwan"],"prefix":"10.1016","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9302-3196","authenticated-orcid":false,"given":"Yu-Tsun","family":"Su","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8945-3924","authenticated-orcid":false,"given":"Yen-Ting","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Chi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shang-Shyue","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiu-Yao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Ling","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting-I.","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsun-Mei","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Cheng","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Ren","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Chung","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Chun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jmii.2018.12.001_bib1","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1136\/thx.2008.099051","article-title":"Induced sputum in the diagnosis of childhood community-acquired pneumonia","volume":"64","author":"Lahti","year":"2009","journal-title":"Thorax"},{"key":"10.1016\/j.jmii.2018.12.001_bib2","doi-asserted-by":"crossref","first-page":"29","DOI":"10.3345\/kjp.2014.57.1.29","article-title":"Prevalence of respiratory viral infection in children hospitalized for acute lower respiratory tract diseases, and association of rhinovirus and influenza virus with asthma exacerbations","volume":"57","author":"Kwon","year":"2014","journal-title":"Korean J Pediatr"},{"key":"10.1016\/j.jmii.2018.12.001_bib3","doi-asserted-by":"crossref","first-page":"46","DOI":"10.4103\/prcm.prcm_2_17","article-title":"Viruses and hospitalization for childhood lower respiratory tract infection in Malaysia \u2013 A prospective study","volume":"1","author":"Nathan","year":"2017","journal-title":"Pediatr Respirol Crit Care Med"},{"key":"10.1016\/j.jmii.2018.12.001_bib4","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1136\/thx.2006.070169","article-title":"Worldwide trends in the prevalence of asthma symptoms: phase III of the international study of asthma and allergies in childhood (ISAAC)","volume":"62","author":"Pearce","year":"2007","journal-title":"Thorax"},{"key":"10.1016\/j.jmii.2018.12.001_bib5","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1136\/bmj.310.6989.1225","article-title":"Community study of role of viral infections in exacerbations of asthma in 9-11 year old children","volume":"310","author":"Johnston","year":"1995","journal-title":"BMJ"},{"key":"10.1016\/j.jmii.2018.12.001_bib6","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1183\/09031936.00092410","article-title":"Association between human rhinovirus C and severity of acute asthma in children","volume":"37","author":"Bizzintino","year":"2011","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jmii.2018.12.001_bib7","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.jaci.2012.05.023","article-title":"Innate immune responses to rhinovirus are reduced by the high-affinity IgE receptor in allergic asthmatic children","volume":"130","author":"Durrani","year":"2012","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jmii.2018.12.001_bib8","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1186\/1471-2334-11-168","article-title":"A molecular epidemiological study of respiratory viruses detected in Japanese children with acute wheezing illness","volume":"11","author":"Fujitsuka","year":"2011","journal-title":"BMC Infect Dis"},{"key":"10.1016\/j.jmii.2018.12.001_bib9","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1097\/INF.0b013e31821b8c71","article-title":"Clinical spectrum of human rhinovirus infections in hospitalized Hong Kong children","volume":"30","author":"Mak","year":"2011","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.jmii.2018.12.001_bib10","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.jinf.2009.05.009","article-title":"High prevalence of human rhinovirus C infection in Thai children with acute lower respiratory tract disease","volume":"59","author":"Linsuwanon","year":"2009","journal-title":"J Infect"},{"key":"10.1016\/j.jmii.2018.12.001_bib11","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1097\/INF.0000000000000879","article-title":"Impact of human rhinovirus types and viral load on the severity of illness in hospitalized children with lower respiratory tract infections","volume":"34","author":"Xiao","year":"2015","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.jmii.2018.12.001_bib12","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1084\/jem.20041901","article-title":"Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus","volume":"201","author":"Wark","year":"2005","journal-title":"J Exp Med"},{"key":"10.1016\/j.jmii.2018.12.001_bib13","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1136\/thorax.57.4.328","article-title":"A defective type 1 response to rhinovirus in atopic asthma","volume":"57","author":"Papadopoulos","year":"2002","journal-title":"Thorax"},{"key":"10.1016\/j.jmii.2018.12.001_bib14","doi-asserted-by":"crossref","first-page":"3655","DOI":"10.1128\/JCM.01254-07","article-title":"Clinical features and complete genome characterization of a distinct human rhinovirus (HRV) genetic cluster, probably representing a previously undetected HRV species, HRV-C, associated with acute respiratory illness in children","volume":"45","author":"Lau","year":"2007","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.jmii.2018.12.001_bib15","doi-asserted-by":"crossref","first-page":"944","DOI":"10.3201\/eid1406.080271","article-title":"Global distribution of novel rhinovirus genotype","volume":"14","author":"Briese","year":"2008","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.jmii.2018.12.001_bib16","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1099\/jmm.0.049072-0","article-title":"Genetic analysis of the VP4-VP2 coding region in human rhinovirus species C in patients with acute respiratory infection in Japan","volume":"62","author":"Kiyota","year":"2013","journal-title":"J Med Microbiol"},{"key":"10.1016\/j.jmii.2018.12.001_bib17","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.3201\/eid1508.090321","article-title":"Sugrue Human rhinovirus group C in hospitalized children, Singapore","volume":"15","author":"Tan","year":"2009","journal-title":"Emerg Infec Dis"},{"key":"10.1016\/j.jmii.2018.12.001_bib18","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1128\/CMR.00077-12","article-title":"Human rhinoviruses","volume":"26","author":"Jacobs","year":"2013","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.jmii.2018.12.001_bib19","first-page":"e2","article-title":"Human rhinovirus C: a newly discovered human rhinovirus species","volume":"3","author":"Lau","year":"2010","journal-title":"Emerg Health Threats J"},{"key":"10.1016\/j.jmii.2018.12.001_bib20","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1128\/JCM.01739-07","article-title":"Real-time reverse transcription\u2013PCR assay for comprehensive detection of human rhinoviruses","volume":"46","author":"Lu","year":"2008","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.jmii.2018.12.001_bib21","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1086\/511829","article-title":"Rhinovirus: more than just a common cold virus","volume":"195","author":"Turner","year":"2007","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jmii.2018.12.001_bib22","doi-asserted-by":"crossref","first-page":"13562","DOI":"10.1073\/pnas.0804181105","article-title":"Rhinovirus-induced lower respiratory illness is increased in asthma and related to virus load and Th1\/2 cytokine and IL-10 production","volume":"105","author":"Message","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jmii.2018.12.001_bib23","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1164\/rccm.201104-0660OC","article-title":"Evidence for a causal relationship between allergic sensitization and rhinovirus wheezing in early life","volume":"185","author":"Jackson","year":"2012","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jmii.2018.12.001_bib24","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1164\/rccm.200802-309OC","article-title":"Wheezing rhinovirus illnesses in early life predict asthma development in high-risk children","volume":"178","author":"Jackson","year":"2008","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jmii.2018.12.001_bib25","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.coviro.2012.03.008","article-title":"Pathogenesis of rhinovirus infection","volume":"2","author":"Kennedy","year":"2012","journal-title":"Curr Opin Virol"},{"key":"10.1016\/j.jmii.2018.12.001_bib26","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.jaci.2014.01.029","article-title":"Effects of rhinovirus species on viral replication and cytokine production","volume":"134","author":"Nakagome","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jmii.2018.12.001_bib27","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jaci.2014.03.014","article-title":"Comparison of rhinovirus antibody titers in children with asthma exacerbations and species-specific rhinovirus infection","volume":"134","author":"Iwasaki","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jmii.2018.12.001_bib28","doi-asserted-by":"crossref","first-page":"7418","DOI":"10.1128\/JVI.02290-09","article-title":"The ABCs of rhinoviruses, wheezing, and asthma","volume":"84","author":"Gern","year":"2010","journal-title":"J Virol"},{"key":"10.1016\/j.jmii.2018.12.001_bib29","doi-asserted-by":"crossref","first-page":"3251","DOI":"10.1007\/s10096-012-1692-9","article-title":"Circulation of different rhinovirus groups among children with lower respiratory tract infection in Kiremba, Burundi","volume":"31","author":"Esposito","year":"2012","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"10.1016\/j.jmii.2018.12.001_bib30","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.jaci.2008.10.007","article-title":"A novel group of rhinoviruses is associated with asthma hospitalizations","volume":"123","author":"Miller","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jmii.2018.12.001_bib31","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1128\/CVI.00414-15","article-title":"Understanding the association of human rhinovirus with asthma","volume":"23","author":"Stone","year":"2015","journal-title":"Clin Vaccine Immunol"},{"key":"10.1016\/j.jmii.2018.12.001_bib32","first-page":"206","article-title":"Age-dependent distribution of the atopic phenotype and allergen sensitization among asthmatic children in southern Taiwan","volume":"34","author":"Su","year":"2016","journal-title":"Asian Pac J Allergy Immunol"}],"container-title":["Journal of Microbiology, Immunology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S168411821830536X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S168411821830536X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T13:25:20Z","timestamp":1761657920000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S168411821830536X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["S168411821830536X"],"URL":"https:\/\/doi.org\/10.1016\/j.jmii.2018.12.001","relation":{},"ISSN":["1684-1182"],"issn-type":[{"value":"1684-1182","type":"print"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"High correlation between human rhinovirus type C and children with asthma exacerbations in Taiwan","name":"articletitle","label":"Article Title"},{"value":"Journal of Microbiology, Immunology and Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jmii.2018.12.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Taiwan Society of Microbiology. Published by Elsevier Taiwan LLC.","name":"copyright","label":"Copyright"}]}}