{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T22:55:12Z","timestamp":1790463312941,"version":"4.1.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,5,16]],"date-time":"2019-05-16T00:00:00Z","timestamp":1557964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005762","name":"National Taiwan University Hospital","doi-asserted-by":"publisher","award":["NTUH 104-002627"],"award-info":[{"award-number":["NTUH 104-002627"]}],"id":[{"id":"10.13039\/501100005762","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005762","name":"National Taiwan University Hospital","doi-asserted-by":"publisher","award":["NTUH 108-N4093"],"award-info":[{"award-number":["NTUH 108-N4093"]}],"id":[{"id":"10.13039\/501100005762","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 105-2320-B-002-016"],"award-info":[{"award-number":["MOST 105-2320-B-002-016"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Microbiology, Immunology and Infection"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1016\/j.jmii.2019.04.010","type":"journal-article","created":{"date-parts":[[2019,5,21]],"date-time":"2019-05-21T02:45:27Z","timestamp":1558406727000},"page":"858-864","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Manifestations of enterovirus D68 and high seroconversion among children attending a kindergarten"],"prefix":"10.1016","volume":"52","author":[{"given":"Ya-Li","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Min","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Yi","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsui-Yen","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ai-Ling","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2632-1956","authenticated-orcid":false,"given":"Luan-Yin","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jmii.2019.04.010_bib1","doi-asserted-by":"crossref","first-page":"e64","DOI":"10.1016\/S1473-3099(15)00543-5","article-title":"Global emergence of enterovirus D68: a systematic review","volume":"6","author":"Holm-Hansen","year":"2016","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.jmii.2019.04.010_bib2","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/S2213-2600(15)00335-5","article-title":"Severe respiratory illness associated with a nationwide outbreak of enterovirus D68 in the USA (2014): a descriptive epidemiological investigation","volume":"3","author":"Midgley","year":"2015","journal-title":"Lancet Respir Med"},{"key":"10.1016\/j.jmii.2019.04.010_bib3","first-page":"30","article-title":"Case series: enterovirus D68 infection with severe neurological complications in Taiwan, 2016\u20132017","volume":"34","author":"Wei","year":"2018","journal-title":"Taiwan Epidemiol Bull"},{"key":"10.1016\/j.jmii.2019.04.010_bib4","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1080\/23744235.2017.1400176","article-title":"Clinical characteristics of children infected with enterovirus D68 in an outpatient clinic and the association with bronchial asthma","volume":"50","author":"Itagaki","year":"2018","journal-title":"Infect Dis"},{"key":"10.1016\/j.jmii.2019.04.010_bib5","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.1002\/jmv.21894","article-title":"Cellular tropism of human enterovirus D species serotypes EV-94, EV-70, and EV-68 in\u00a0vitro: implications for pathogenesis","volume":"82","author":"Smura","year":"2010","journal-title":"J Med Virol"},{"key":"10.1016\/j.jmii.2019.04.010_bib6","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.jfma.2017.02.020","article-title":"Incidence of respiratory viral infections and associated factors among children attending a public kindergarten in Taipei City","volume":"117","author":"Lu","year":"2018","journal-title":"J Formos Med Assoc"},{"key":"10.1016\/j.jmii.2019.04.010_bib7","doi-asserted-by":"crossref","first-page":"2698","DOI":"10.1128\/JCM.00542-06","article-title":"Sensitive, seminested PCR amplification of VP1 sequences for direct identification of all enterovirus serotypes from original clinical specimens","volume":"44","author":"Nix","year":"2006","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.jmii.2019.04.010_bib8","doi-asserted-by":"crossref","first-page":"e0184335","DOI":"10.1371\/journal.pone.0184335","article-title":"Distinct genetic clades of enterovirus D68 detected in 2010, 2013, and 2015 in Osaka City, Japan","volume":"12","author":"Kaida","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.jmii.2019.04.010_bib9","first-page":"406","article-title":"The neighbor-joining method: a new method for reconstructing phylogenetic trees","volume":"4","author":"Saitou","year":"1987","journal-title":"Mol Biol Evol"},{"key":"10.1016\/j.jmii.2019.04.010_bib10","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1093\/molbev\/msw054","article-title":"MEGA7: molecular evolutionary genetics analysis version 7.0 for bigger datasets","volume":"33","author":"Kumar","year":"2016","journal-title":"Mol Biol Evol"},{"key":"10.1016\/j.jmii.2019.04.010_bib11","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1099\/vir.0.043935-0","article-title":"Worldwide emergence of multiple clades of enterovirus 68","volume":"93","author":"Tokarz","year":"2012","journal-title":"J Gen Virol"},{"key":"10.1016\/j.jmii.2019.04.010_bib12","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1159\/000065866","article-title":"Human rhinovirus 87 identified as human enterovirus 68 by VP4-based molecular diagnosis","volume":"45","author":"Ishiko","year":"2002","journal-title":"Intervirology"},{"key":"10.1016\/j.jmii.2019.04.010_bib13","doi-asserted-by":"crossref","first-page":"2577","DOI":"10.1099\/vir.0.79925-0","article-title":"Enterovirus 68 is associated with respiratory illness and shares biological features with both the enteroviruses and the rhinoviruses","volume":"85","author":"Oberste","year":"2004","journal-title":"J Gen Virol"},{"key":"10.1016\/j.jmii.2019.04.010_bib14","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.jinf.2018.02.003","article-title":"Seroepidemiology of enterovirus D68 infection in infants and children in Jiangsu, China","volume":"76","author":"Sun","year":"2018","journal-title":"J Infect"},{"key":"10.1016\/j.jmii.2019.04.010_bib15","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1513\/AnnalsATS.201412-592FR","article-title":"Enterovirus d68. A focused review and clinical highlights from the 2014 U.S. Outbreak","volume":"2","author":"Oermann","year":"2015","journal-title":"Ann Am Thorac Soc"},{"key":"10.1016\/j.jmii.2019.04.010_bib16","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.virol.2011.11.021","article-title":"Emergence and epidemic occurrence of enterovirus 68 respiratory infections in The Netherlands in 2010","volume":"423","author":"Meijer","year":"2012","journal-title":"Virology"},{"key":"10.1016\/j.jmii.2019.04.010_bib17","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/irv.12300","article-title":"High frequency of enterovirus D68 in children hospitalised with respiratory illness in Norway, autumn 2014","volume":"9","author":"Bragstad","year":"2015","journal-title":"Influenza Other Respir Viruses"},{"key":"10.1016\/j.jmii.2019.04.010_bib18","first-page":"20935","article-title":"Continued seasonal circulation of enterovirus D68 in The Netherlands, 2011\u20132014","volume":"9","author":"Meijer","year":"2014","journal-title":"Euro Surveill"},{"key":"10.1016\/j.jmii.2019.04.010_bib19","doi-asserted-by":"crossref","first-page":"e4416","DOI":"10.1097\/MD.0000000000004416","article-title":"Molecular evolution and the global reemergence of enterovirus D68 by genome-wide analysis","volume":"95","author":"Gong","year":"2016","journal-title":"Medicine"},{"key":"10.1016\/j.jmii.2019.04.010_bib20","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.jmii.2015.07.015","article-title":"Molecular and epidemiological study of enterovirus D68 in Taiwan","volume":"50","author":"Huang","year":"2017","journal-title":"J Microbiol Immunol Infect"},{"key":"10.1016\/j.jmii.2019.04.010_bib21","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.jmii.2017.12.001","article-title":"Updates on the molecular epidemiology of enterovirus D68 after installation of screening test among acute flaccid paralysis patients in Taiwan","volume":"51","author":"Wei","year":"2018","journal-title":"J Microbiol Immunol Infect"},{"key":"10.1016\/j.jmii.2019.04.010_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0065-2776(01)79001-3","article-title":"Neutralizing antiviral antibody responses","volume":"79","author":"Zinkernagel","year":"2001","journal-title":"Adv Immunol"},{"key":"10.1016\/j.jmii.2019.04.010_bib23","doi-asserted-by":"crossref","first-page":"916","DOI":"10.3201\/eid2105.150036","article-title":"Enterovirus D68-associated severe pneumonia, China 2004","volume":"21","author":"Zhang","year":"2015","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.jmii.2019.04.010_bib24","doi-asserted-by":"crossref","first-page":"16639","DOI":"10.1038\/srep16639","article-title":"Prevalence and molecular characterizations of enterovirus D68 among children with acute respiratory infection in China between 2012 and 2014","volume":"5","author":"Xiao","year":"2015","journal-title":"Sci Rep"},{"key":"10.1016\/j.jmii.2019.04.010_bib25","doi-asserted-by":"crossref","first-page":"e0144208","DOI":"10.1371\/journal.pone.0144208","article-title":"Analysis of enterovirus 68 strains from the 2014 North American outbreak reveals a new clade, indicating viral evolution","volume":"10","author":"Du","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jmii.2019.04.010_bib26","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.jcv.2011.06.019","article-title":"Upsurge of human enterovirus 68 infections in patients with severe respiratory tract infections","volume":"52","author":"Rahamat-Langendoen","year":"2011","journal-title":"J Clin Virol"},{"key":"10.1016\/j.jmii.2019.04.010_bib27","doi-asserted-by":"crossref","first-page":"S120","DOI":"10.1093\/infdis\/jiu232","article-title":"Sex differences in pediatric infectious disease","volume":"209","author":"Muenchhoff","year":"2014","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jmii.2019.04.010_bib28","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1385\/IR:34:3:177","article-title":"Sexual dimorphism in innate immune responses to infectious organisms","volume":"34","author":"Marriott","year":"2006","journal-title":"Immunol Res"},{"key":"10.1016\/j.jmii.2019.04.010_bib29","doi-asserted-by":"crossref","first-page":"e32","DOI":"10.1038\/emi.2017.14","article-title":"Seroepidemiology of enterovirus D68 infection in China","volume":"6","author":"Xiang","year":"2017","journal-title":"Emerg Microbes Infect"},{"key":"10.1016\/j.jmii.2019.04.010_bib30","doi-asserted-by":"crossref","DOI":"10.1128\/genomeA.00579-16","article-title":"Complete genome sequence of enterovirus D68 detected in classroom air and on environmental surfaces","volume":"4","author":"Lednicky","year":"2016","journal-title":"Genome Announc"}],"container-title":["Journal of Microbiology, Immunology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1684118219300477?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1684118219300477?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T13:23:36Z","timestamp":1761657816000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1684118219300477"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["S1684118219300477"],"URL":"https:\/\/doi.org\/10.1016\/j.jmii.2019.04.010","relation":{},"ISSN":["1684-1182"],"issn-type":[{"value":"1684-1182","type":"print"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Manifestations of enterovirus D68 and high seroconversion among children attending a kindergarten","name":"articletitle","label":"Article Title"},{"value":"Journal of Microbiology, Immunology and Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jmii.2019.04.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Taiwan Society of Microbiology. Published by Elsevier Taiwan LLC.","name":"copyright","label":"Copyright"}]}}