{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T01:45:55Z","timestamp":1792201555862,"version":"4.4.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,8,4]],"date-time":"2020-08-04T00:00:00Z","timestamp":1596499200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Microbiology, Immunology and Infection"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.jmii.2020.07.022","type":"journal-article","created":{"date-parts":[[2020,8,11]],"date-time":"2020-08-11T02:47:16Z","timestamp":1597114036000},"page":"1147-1153","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Matrix metalloproteinases activation in Toxocara canis induced pulmonary pathogenesis"],"prefix":"10.1016","volume":"54","author":[{"given":"Cheng-You","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Chan","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsiu-Hsiung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Tan","family":"Chien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuang-Pin","family":"Lan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke-Min","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jmii.2020.07.022_bib1","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.vetpar.2005.06.022","article-title":"Influence of murine Toxocara canis infection on plasma and bronchoalveolar lavage fluid eosinophil numbers and its correlation with cytokine levels","volume":"134","author":"Pecinali","year":"2005","journal-title":"Vet Parasitol"},{"key":"10.1016\/j.jmii.2020.07.022_bib2","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1542\/peds.9.1.7","article-title":"Chronic eosinophilia due to visceral larva migrans; report of three cases","volume":"9","author":"Beaver","year":"1952","journal-title":"Pediatrics"},{"key":"10.1016\/j.jmii.2020.07.022_bib3","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1093\/infdis\/162.6.1418","article-title":"Serologic differentiation between Toxocara canis and Toxocara cati","volume":"162","author":"Nagakura","year":"1990","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jmii.2020.07.022_bib4","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1542\/peds.12.5.491","article-title":"Persistence and distribution of Toxocara larvae in the tissues of children and mice","volume":"12","author":"Smith","year":"1953","journal-title":"Pediatrics"},{"key":"10.1016\/j.jmii.2020.07.022_bib5","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/S0020-7519(83)80017-4","article-title":"The accumulation of Toxocara canis larvae in the brains of mice","volume":"13","author":"Dunsmore","year":"1983","journal-title":"Int J Parasitol"},{"key":"10.1016\/j.jmii.2020.07.022_bib6","first-page":"99","article-title":"Human toxocariasis and the visceral larva migrans syndrome: correlative immunopathology","volume":"66","author":"Kayes","year":"1997","journal-title":"Chem Immunol"},{"key":"10.1016\/j.jmii.2020.07.022_bib7","first-page":"157","article-title":"Histology in diagnosis of parasitic diseases","volume":"46","author":"Papparella","year":"2004","journal-title":"Parassitologia"},{"key":"10.1016\/j.jmii.2020.07.022_bib8","doi-asserted-by":"crossref","first-page":"974","DOI":"10.4269\/ajtmh.1986.35.974","article-title":"Tissue localization of excretory-secretory antigens of larval Toxocara canis in acute and chronic murine toxocariasis","volume":"35","author":"Parsons","year":"1986","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.jmii.2020.07.022_bib9","doi-asserted-by":"crossref","first-page":"455","DOI":"10.3233\/JND-160183","article-title":"Matrix metalloproteinases and tissue inhibitor of metalloproteinases in inflammation and fibrosis of skeletal muscles","volume":"3","author":"Alameddine","year":"2016","journal-title":"J Neuromuscul Dis"},{"key":"10.1016\/j.jmii.2020.07.022_bib10","series-title":"Matrix metalloproteinases","first-page":"115","article-title":"Gelatinase B: structure, regulation and function","author":"Vu","year":"1998"},{"key":"10.1016\/j.jmii.2020.07.022_bib11","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1182\/blood.V100.4.1160.h81602001160_1160_1167","article-title":"Matrix metalloproteinase processing of monocyte chemoattractant proteins generates CC chemokine receptor antagonists with anti-inflammatory properties in\u00a0vivo","volume":"100","author":"McQuibban","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.jmii.2020.07.022_bib12","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s00436-004-1271-9","article-title":"Induction of matrix metalloproteinase-9 in mice during Toxocara canis larvae migration","volume":"95","author":"Lai","year":"2005","journal-title":"Parasitol Res"},{"key":"10.1016\/j.jmii.2020.07.022_bib13","doi-asserted-by":"crossref","first-page":"781","DOI":"10.2307\/3279492","article-title":"In\u00a0vitro maintenance of Toxocara canis larvae and a simple method for the production of Toxocara ES antigen for use in serodiagnostic tests for visceral larva migrans","volume":"61","author":"Savigny","year":"1975","journal-title":"J Parasitol"},{"key":"10.1016\/j.jmii.2020.07.022_bib14","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.2214\/AJR.04.1507","article-title":"Pulmonary lesions associated with visceral larva migrans due to Ascaris suum or Toxocara canis imaging of six cases","volume":"186","author":"Sakai","year":"2006","journal-title":"Am J Roentgenol"},{"key":"10.1016\/j.jmii.2020.07.022_bib15","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.vetpar.2018.01.026","article-title":"Endocrine immune interactions during chronic Toxocariasis caused by Toxocara canis in a murine model: new insights into the pathophysiology of an old infection","volume":"252","author":"Del R\u00edo-Araiza","year":"2018","journal-title":"Vet Parasitol"},{"key":"10.1016\/j.jmii.2020.07.022_bib16","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/0304-4017(84)90066-9","article-title":"The migration of larval Toxocara canis in mice II. Post-intestinal migration in primary infections","volume":"17","author":"Abo-Shehada","year":"1984","journal-title":"Vet Parasitol"},{"key":"10.1016\/j.jmii.2020.07.022_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.exppara.2009.01.010","article-title":"Toxocara canis: larval migration dynamics, detection of antibody reactivity to larval excretory-secretory antigens and clinical findings during experimental infection of gerbils (Meriones unguiculatus)","volume":"122","author":"Alba-Hurtado","year":"2009","journal-title":"Exp Parasitol"},{"key":"10.1016\/j.jmii.2020.07.022_bib18","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1128\/CMR.16.2.265-272.2003","article-title":"Toxocariasis: clinical aspects, epidemiology, medical ecology, and molecular aspects","volume":"16","author":"Despommier","year":"2003","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.jmii.2020.07.022_bib19","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1111\/j.1365-3024.2012.01381.x","article-title":"Comparative ultrastructural studies of the alterations to mouse lung parenchyma during Trichinella Spiralis or Toxocara canis infection","volume":"34","author":"Dabrowska","year":"2012","journal-title":"Parasite Immunol"},{"key":"10.1016\/j.jmii.2020.07.022_bib20","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1016\/S0002-9440(10)64831-6","article-title":"The role of up-regulated serine proteases and matrix metalloproteinases in the pathogenesis of a murine model of colitis","volume":"157","author":"Tarlton","year":"2000","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jmii.2020.07.022_bib21","doi-asserted-by":"crossref","first-page":"591","DOI":"10.3109\/13550289909021288","article-title":"Molecular and cellular mechanisms for microbial entry into the CNS","volume":"5","author":"Zhang","year":"1999","journal-title":"J Neurovirol"},{"key":"10.1016\/j.jmii.2020.07.022_bib22","doi-asserted-by":"crossref","first-page":"6511","DOI":"10.1128\/IAI.68.12.6511-6518.2000","article-title":"Host-pathogen interactions: basic concepts of microbial commensalism, colonization, infection, and disease","volume":"68","author":"Casadevall","year":"2000","journal-title":"Infect Immun"},{"key":"10.1016\/j.jmii.2020.07.022_bib23","first-page":"821","article-title":"Differential expression of extracellular matrix remodeling genes in a murine model of bleomycin-induced pulmonary fibrosis","volume":"152","author":"Swiderski","year":"1998","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jmii.2020.07.022_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0165-5728(98)00241-0","article-title":"Plasminogen activators and matrix metalloproteases, mediators of extracellular proteolysis in inflammatory demyelination of the central nervous system","volume":"94","author":"Cuzner","year":"1999","journal-title":"J Neuroimmunol"},{"key":"10.1016\/j.jmii.2020.07.022_bib25","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1055\/s-0037-1615841","article-title":"The plasminogen (fibrinolytic) system","volume":"82","author":"Collen","year":"1999","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jmii.2020.07.022_bib26","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1096\/fasebj.9.14.7589989","article-title":"Stimulation of matrix metalloproteinase-dependent migration of T cells by eicosanoids","volume":"9","author":"Leppert","year":"1995","journal-title":"FASEB J"},{"key":"10.1016\/j.jmii.2020.07.022_bib27","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1165\/ajrcmb.16.3.9070604","article-title":"Eosinophils as a source of matrix metalloproteinase-9 in asthmatic airway inflammation","volume":"16","author":"Ohno","year":"1997","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.jmii.2020.07.022_bib28","first-page":"95","article-title":"An active zymogen: unravelling the mystery of tissue-type plasminogen activator","volume":"379","author":"Stubbs","year":"1998","journal-title":"Biol Chem"},{"key":"10.1016\/j.jmii.2020.07.022_bib29","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1080\/01902148.2018.1493551","article-title":"LPS-induced MMP-9 expression is mediated through the MAPKs-AP-1 dependent mechanism in BEAS-2B and U937 cells","volume":"44","author":"Tian","year":"2018","journal-title":"Exp Lung Res"},{"key":"10.1016\/j.jmii.2020.07.022_bib30","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/1471-2466-13-36","article-title":"Association of genes of protease-antiprotease balance pathway to lung function and emphysema subtypes","volume":"13","author":"Kukkonen","year":"2013","journal-title":"BMC Pulm Med"},{"key":"10.1016\/j.jmii.2020.07.022_bib31","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1172\/JCI115405","article-title":"The plasminogen activator\/plasmin system","volume":"88","author":"Vassalli","year":"1991","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jmii.2020.07.022_bib32","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1183\/09031936.04.00140703","article-title":"Disturbed alveolar fibrin turnover during pneumonia is restricted to the site of infection","volume":"24","author":"Choi","year":"2004","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jmii.2020.07.022_bib33","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1097\/01.CCM.0000201882.23917.B8","article-title":"Pulmonary coagulopathy as a new target in therapeutic studies of acute lung injury or pneumonia-a review","volume":"34","author":"Schultz","year":"2006","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jmii.2020.07.022_bib34","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1164\/ajrccm\/141.1.218","article-title":"Bronchial epithelial cells produce chemotactic activity for bronchial epithelial cells. Possible role for fibronectin in airway repair","volume":"141","author":"Shoji","year":"1990","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.jmii.2020.07.022_bib35","doi-asserted-by":"crossref","first-page":"280","DOI":"10.3390\/pathogens8040280","article-title":"A dual role for macrophages in modulating lung tissue damage\/repair during L2 Toxocara canis infection","volume":"8","author":"Faz-L\u00f3pez","year":"2019","journal-title":"Pathogens"},{"key":"10.1016\/j.jmii.2020.07.022_bib36","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.pupt.2012.02.001","article-title":"Elastin in asthma","volume":"25","author":"Reddel","year":"2012","journal-title":"Pulm Pharmacol Ther"},{"key":"10.1016\/j.jmii.2020.07.022_bib37","doi-asserted-by":"crossref","first-page":"e0166433","DOI":"10.1371\/journal.pone.0166433","article-title":"Alternatively activated (M2) macrophage phenotype is inducible by endothelin-1 in cultured human macrophages","volume":"11","author":"Soldano","year":"2016","journal-title":"PloS One"},{"key":"10.1016\/j.jmii.2020.07.022_bib38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/bs.pmbts.2017.04.004","article-title":"The role of matrix metalloproteinases in development, repair, and destruction of the lungs","volume":"148","author":"Hendrix","year":"2017","journal-title":"Prog Mol Biol Trans Sci"}],"container-title":["Journal of Microbiology, Immunology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1684118220301791?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1684118220301791?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T13:27:55Z","timestamp":1761658075000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1684118220301791"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":38,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["S1684118220301791"],"URL":"https:\/\/doi.org\/10.1016\/j.jmii.2020.07.022","relation":{},"ISSN":["1684-1182"],"issn-type":[{"value":"1684-1182","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Matrix metalloproteinases activation in Toxocara canis induced pulmonary pathogenesis","name":"articletitle","label":"Article Title"},{"value":"Journal of Microbiology, Immunology and Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jmii.2020.07.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Taiwan Society of Microbiology. Published by Elsevier Taiwan LLC.","name":"copyright","label":"Copyright"}]}}