{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T15:46:20Z","timestamp":1793202380947,"version":"4.5.0"},"reference-count":47,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,3,24]],"date-time":"2021-03-24T00:00:00Z","timestamp":1616544000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008903","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["MOHW107-TDU-B-211-123003"],"award-info":[{"award-number":["MOHW107-TDU-B-211-123003"]}],"id":[{"id":"10.13039\/100008903","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Microbiology, Immunology and Infection"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1016\/j.jmii.2021.03.010","type":"journal-article","created":{"date-parts":[[2021,4,9]],"date-time":"2021-04-09T02:40:02Z","timestamp":1617936002000},"page":"207-214","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["Causes of death among dengue patients causes of death among hospitalized adults with dengue fever in Tainan, 2015: Emphasis on cardiac events and bacterial infections"],"prefix":"10.1016","volume":"55","author":[{"given":"Jen-Chieh","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1552-1082","authenticated-orcid":false,"given":"Cong-Tat","family":"Cia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan-Yao","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nai-Ying","family":"Ko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po-Lin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Chien","family":"Ko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jmii.2021.03.010_bib1","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1136\/bmj.324.7353.1563","article-title":"Dengue: an escalating problem","volume":"324","author":"Gibbons","year":"2002","journal-title":"Br Med J"},{"key":"10.1016\/j.jmii.2021.03.010_bib2","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1016\/S0140-6736(07)61687-0","article-title":"Dengue","volume":"370","author":"Halstead","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.jmii.2021.03.010_bib3","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1128\/CMR.11.3.480","article-title":"Dengue and dengue hemorrhagic fever","volume":"11","author":"Gubler","year":"1998","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.jmii.2021.03.010_bib4","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1080\/14787210.2017.1358610","article-title":"Dengue in the elderly: a review","volume":"15","author":"Lin","year":"2017","journal-title":"Expert Rev Anti Infect Ther"},{"key":"10.1016\/j.jmii.2021.03.010_bib5","doi-asserted-by":"crossref","first-page":"731","DOI":"10.4269\/ajtmh.2010.09-0549","article-title":"Characteristic of dengue disease in Taiwan: 2002-2007","volume":"82","author":"Lin","year":"2010","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.jmii.2021.03.010_bib6","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.ijid.2016.11.008","article-title":"Trend and geographic analysis of the prevalence of dengue in Taiwan, 2010-2015","volume":"54","author":"Hsu","year":"2017","journal-title":"Int J Infect Dis"},{"key":"10.1016\/j.jmii.2021.03.010_bib7","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1186\/s12879-020-4942-y","article-title":"Epidemiological analysis of the Kaohsiung city strategy for dengue fever quarantine and epidemic prevention","volume":"20","author":"Pan","year":"2020","journal-title":"BMC Infect Dis"},{"key":"10.1016\/j.jmii.2021.03.010_bib8","doi-asserted-by":"crossref","first-page":"e123","DOI":"10.1038\/emi.2016.124","article-title":"Consecutive large dengue outbreaks in Taiwan in 2014-2015","volume":"5","author":"Wang","year":"2016","journal-title":"Emerg Microb Infect"},{"key":"10.1016\/j.jmii.2021.03.010_bib9","author":"Center of Disease Control"},{"key":"10.1016\/j.jmii.2021.03.010_bib10","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0005270","article-title":"A cohort study of adult patients with severe dengue in Taiwanese intensive care units: the elderly and APTT prolongation matter for prognosis","volume":"11","author":"Hsieh","year":"2017","journal-title":"PLoS Neglected Trop Dis"},{"key":"10.1016\/j.jmii.2021.03.010_bib11","article-title":"The outcomes of patients with severe dengue admitted to intensive care units","volume":"95","author":"Chen","year":"2016","journal-title":"Medicine (Baltim)"},{"key":"10.1016\/j.jmii.2021.03.010_bib12","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.ajem.2013.01.011","article-title":"Atypical presentations of dengue disease in the elderly visiting the ED","volume":"31","author":"Lee","year":"2013","journal-title":"Am J Emerg Med"},{"key":"10.1016\/j.jmii.2021.03.010_bib13","article-title":"Symptoms associated with adverse dengue fever prognoses at the time of reporting in the 2015 dengue outbreak in Taiwan","volume":"11","author":"Yeh","year":"2017","journal-title":"PLoS Negl Trop Di"},{"key":"10.1016\/j.jmii.2021.03.010_bib14","series-title":"Dengue: guidelines for diagnosis, treatment, prevention and control","author":"World Health Organization","year":"2009"},{"key":"10.1016\/j.jmii.2021.03.010_bib15","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/0895-4356(94)90129-5","article-title":"Validation of a combined comorbidity index","volume":"47","author":"Charlson","year":"1994","journal-title":"J Clin Epidemiol"},{"key":"10.1016\/j.jmii.2021.03.010_bib16","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1097\/00003246-199811000-00016","article-title":"Use of the SOFA score to assess the incidence of organ dysfunction\/failure in intensive care units: results of a multicenter, prospective study. Working group on \"sepsis-related problems\" of the European Society of Intensive Care Medicine","volume":"26","author":"Vincent","year":"1998","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jmii.2021.03.010_bib17","doi-asserted-by":"crossref","first-page":"ii1","DOI":"10.1136\/thoraxjnl-2015-208209","article-title":"BTS\/ICS guideline for the ventilatory management of acute hypercapnic respiratory failure in adults","volume":"71","author":"Davidson","year":"2016","journal-title":"Thorax"},{"key":"10.1016\/j.jmii.2021.03.010_bib18","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0140-6736(74)91639-0","article-title":"Assessment of coma and impaired consciousness. A practical scale","volume":"2","author":"Teasdale","year":"1974","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.jmii.2021.03.010_bib19","first-page":"19","article-title":"Section 2: AKI definition","volume":"2012","year":"2011","journal-title":"Kidney Int Suppl"},{"key":"10.1016\/j.jmii.2021.03.010_bib20","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0004575","article-title":"A two-year review on epidemiology and clinical characteristics of dengue deaths in Malaysia, 2013-2014","volume":"10","author":"Woon","year":"2016","journal-title":"PLoS Neglected Trop Dis"},{"key":"10.1016\/j.jmii.2021.03.010_bib21","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.ijid.2006.02.012","article-title":"Fatal dengue hemorrhagic fever in adults during a dengue epidemic in Singapore","volume":"11","author":"Ong","year":"2007","journal-title":"Int J Infect Dis"},{"key":"10.1016\/j.jmii.2021.03.010_bib22","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0002194","article-title":"Review of dengue hemorrhagic fever fatal cases seen among adults: a retrospective study","volume":"7","author":"Sam","year":"2013","journal-title":"PLoS Neglected Trop Dis"},{"key":"10.1016\/j.jmii.2021.03.010_bib23","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.annemergmed.2009.11.026","article-title":"New York Clinical Information Exchange, et\u00a0al. Health information exchange, biosurveillance efforts, and emergency department crowding during the spring 2009 H1N1 outbreak in New York City","volume":"55","author":"Shapiro","year":"2010","journal-title":"Ann Emerg Med"},{"key":"10.1016\/j.jmii.2021.03.010_bib24","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1186\/cc2981","article-title":"Clinical review: emergency department overcrowding and the potential impact on the critically ill","volume":"9","author":"Cowan","year":"2005","journal-title":"Crit Care"},{"key":"10.1016\/j.jmii.2021.03.010_bib25","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.annemergmed.2003.12.008","article-title":"Community influenza outbreaks and emergency department ambulance diversion","volume":"44","author":"Schull","year":"2004","journal-title":"Ann Emerg Med"},{"key":"10.1016\/j.jmii.2021.03.010_bib26","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1097\/MEJ.0b013e328358fa40","article-title":"The role of an emergency department short-stay ward in the management of dengue fever: a case-control study in a university hospital","volume":"20","author":"Nasarudin","year":"2013","journal-title":"Eur J Emerg Med"},{"key":"10.1016\/j.jmii.2021.03.010_bib27","doi-asserted-by":"crossref","first-page":"e2777","DOI":"10.1371\/journal.pntd.0002777","article-title":"Challenges in dengue fever in the elderly: atypical presentation and risk of severe dengue and hospital-acquired infection","volume":"8","author":"Rowe","year":"2014","journal-title":"PLoS Neglected Trop Dis"},{"key":"10.1016\/j.jmii.2021.03.010_bib28","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0006258","article-title":"Evaluation of the WHO 2009 classification for diagnosis of acute dengue in a large cohort of adults and children in Sri Lanka during a dengue-1 epidemic","volume":"12","author":"Bodinayake","year":"2018","journal-title":"PLoS Neglected Trop Dis"},{"key":"10.1016\/j.jmii.2021.03.010_bib29","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0001191","article-title":"The early clinical features of dengue in adults: challenges for early clinical diagnosis","volume":"5","author":"Low","year":"2011","journal-title":"PLoS Neglected Trop Dis"},{"key":"10.1016\/j.jmii.2021.03.010_bib30","article-title":"The associations between the religious background, social supports, and do-not-resuscitate orders in Taiwan: an observational study","volume":"95","author":"Lin","year":"2016","journal-title":"Medicine (Baltim)"},{"key":"10.1016\/j.jmii.2021.03.010_bib31","article-title":"High mortality in severe sepsis and septic shock patients with do-not-resuscitate orders in East Asia","volume":"11","author":"Huang","year":"2016","journal-title":"PloS One"},{"key":"10.1016\/j.jmii.2021.03.010_bib32","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000005394","article-title":"Trends of Do-Not-Resuscitate consent and hospice care utilization among noncancer decedents in a tertiary hospital in Taiwan between 2010 and 2014: a Hospital-based observational study","volume":"95","author":"Chang","year":"2016","journal-title":"Medicine (Baltim)"},{"key":"10.1016\/j.jmii.2021.03.010_bib33","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.2147\/IJGM.S285795","article-title":"The Clinical application of the tracheostomy decision-making program in respiratory care center prolonged mechanical ventilation patients in Taiwan","volume":"13","author":"Huang","year":"2020","journal-title":"Int J Gen Med"},{"key":"10.1016\/j.jmii.2021.03.010_bib34","doi-asserted-by":"crossref","first-page":"e1614","DOI":"10.1371\/journal.pntd.0001614","article-title":"Dengue deaths in Puerto Rico: lessons learned from the 2007 epidemic","volume":"6","author":"Tomashek","year":"2012","journal-title":"PLoS Neglected Trop Dis"},{"key":"10.1016\/j.jmii.2021.03.010_bib35","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1186\/s12879-015-1058-x","article-title":"Why are people with dengue dying? A scoping review of determinants for dengue mortality","volume":"15","author":"Carabali","year":"2015","journal-title":"BMC Infect Dis"},{"key":"10.1016\/j.jmii.2021.03.010_bib36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s15010-016-0927-6","article-title":"Bacterial coinfections in dengue virus disease: what we know and what is still obscure about an emerging concern","volume":"45","author":"Trunfio","year":"2017","journal-title":"Infection"},{"key":"10.1016\/j.jmii.2021.03.010_bib37","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.jmii.2018.11.003","article-title":"Bloodstream infections in hospitalized adults with dengue fever: clinical characteristics and recommended empirical therapy","volume":"52","author":"Syue","year":"2019","journal-title":"J Microbiol Immunol Infect"},{"key":"10.1016\/j.jmii.2021.03.010_bib38","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.jmii.2015.06.008","article-title":"Risk factors for concurrent bacteremia in adult patients with dengue","volume":"50","author":"Thein","year":"2017","journal-title":"J Microbiol Immunol Infect"},{"key":"10.1016\/j.jmii.2021.03.010_bib39","doi-asserted-by":"crossref","first-page":"221","DOI":"10.4269\/ajtmh.2005.72.221","article-title":"Clinical characteristics and risk factors for concurrent bacteremia in adults with dengue hemorrhagic fever","volume":"72","author":"Lee","year":"2005","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.jmii.2021.03.010_bib40","doi-asserted-by":"crossref","first-page":"804","DOI":"10.4269\/ajtmh.13-0197","article-title":"Identification of concurrent bacterial infection in adult patients with dengue","volume":"89","author":"See","year":"2013","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.jmii.2021.03.010_bib41","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1099\/jmm.0.000388","article-title":"The exploration of risk factors of concurrent bacteraemia in patients critically ill with severe dengue","volume":"65","author":"Chen","year":"2016","journal-title":"J Med Microbiol"},{"key":"10.1016\/j.jmii.2021.03.010_bib42","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.jinf.2016.03.013","article-title":"Diagnostic performance of procalcitonin for bacteremia in patients with severe dengue infection in the intensive care unit","volume":"73","author":"Chen","year":"2016","journal-title":"J Infect"},{"key":"10.1016\/j.jmii.2021.03.010_bib43","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.2169\/internalmedicine.46.6354","article-title":"Dengue hemorrhagic shock and disseminated candidiasis","volume":"46","author":"Suzuki","year":"2007","journal-title":"Intern Med"},{"key":"10.1016\/j.jmii.2021.03.010_bib44","doi-asserted-by":"crossref","first-page":"338","DOI":"10.3855\/jidc.6200","article-title":"Cardiac involvement in dengue infection","volume":"9","author":"Shivanthan","year":"2015","journal-title":"J Infect Dev Ctries"},{"key":"10.1016\/j.jmii.2021.03.010_bib45","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1097\/CCM.0b013e318232d966","article-title":"Cardiac function in Vietnamese patients with different dengue severity grades","volume":"40","author":"Yacoub","year":"2012","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jmii.2021.03.010_bib46","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/nrcardio.2014.40","article-title":"Cardiovascular manifestations of the emerging dengue pandemic","volume":"11","author":"Yacoub","year":"2014","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.jmii.2021.03.010_bib47","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.ijcard.2020.09.034","article-title":"Spectrum of cardiac involvement in patients with dengue fever","volume":"324","author":"Shah","year":"2021","journal-title":"Int J Cardiol"}],"container-title":["Journal of Microbiology, Immunology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1684118221000621?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1684118221000621?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T13:27:44Z","timestamp":1761658064000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1684118221000621"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":47,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["S1684118221000621"],"URL":"https:\/\/doi.org\/10.1016\/j.jmii.2021.03.010","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/507137","asserted-by":"object"}]},"ISSN":["1684-1182"],"issn-type":[{"value":"1684-1182","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Causes of death among dengue patients causes of death among hospitalized adults with dengue fever in Tainan, 2015: Emphasis on cardiac events and bacterial infections","name":"articletitle","label":"Article Title"},{"value":"Journal of Microbiology, Immunology and Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jmii.2021.03.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Taiwan Society of Microbiology. Published by Elsevier Taiwan LLC.","name":"copyright","label":"Copyright"}]}}