{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T19:12:44Z","timestamp":1791400364231,"version":"4.3.3"},"reference-count":42,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,6,28]],"date-time":"2022-06-28T00:00:00Z","timestamp":1656374400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005762","name":"National Taiwan University Hospital","doi-asserted-by":"publisher","award":["111-A152"],"award-info":[{"award-number":["111-A152"]}],"id":[{"id":"10.13039\/501100005762","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Microbiology, Immunology and Infection"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1016\/j.jmii.2022.06.005","type":"journal-article","created":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T13:18:48Z","timestamp":1657113528000},"page":"130-138","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Clinical features and outcomes of patients with chronic granulomatous disease in Taiwan"],"prefix":"10.1016","volume":"56","author":[{"given":"Ting-Sheng","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyh-Hong","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Chieh","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6266-9864","authenticated-orcid":false,"given":"Yao-Hsu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Lung","family":"Lau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-I","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Tsan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bor-Luen","family":"Chiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2611-5175","authenticated-orcid":false,"given":"Hsin-Hui","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jmii.2022.06.005_bib1","first-page":"388","article-title":"Hypergammaglobulinemia associated with severe recurrent and chronic nonspecific infection","volume":"88","author":"Janeway","year":"1954","journal-title":"Am J Dis Child"},{"key":"10.1016\/j.jmii.2022.06.005_bib2","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0005234","article-title":"Chronic granulomatous disease: the European experience","volume":"4","author":"van den Berg","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.jmii.2022.06.005_bib3","doi-asserted-by":"crossref","first-page":"2600","DOI":"10.1056\/NEJMoa1007097","article-title":"Residual NADPH oxidase and survival in chronic granulomatous disease","volume":"363","author":"Kuhns","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jmii.2022.06.005_bib4","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/s10875-020-00750-5","article-title":"Genetic, immunological, and clinical features of the first Mexican cohort of patients with chronic granulomatous disease","volume":"40","author":"Blancas-Galicia","year":"2020","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.jmii.2022.06.005_bib5","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/cei.12202","article-title":"Molecular diagnosis of chronic granulomatous disease","volume":"175","author":"Roos","year":"2014","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.jmii.2022.06.005_bib6","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1093\/jpids\/piy008","article-title":"Chronic granulomatous disease: epidemiology, pathophysiology, and genetic basis of disease","volume":"7","author":"Rider","year":"2018","journal-title":"J Pediatric Infect Dis Soc"},{"key":"10.1016\/j.jmii.2022.06.005_bib7","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s12016-020-08800-x","article-title":"Chronic granulomatous disease: a comprehensive review","volume":"61","author":"Yu","year":"2021","journal-title":"Clin Rev Allergy Immunol"},{"key":"10.1016\/j.jmii.2022.06.005_bib8","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.jaci.2018.09.019","article-title":"EROS\/CYBC1 mutations: Decreased NADPH oxidase function and chronic granulomatous disease","volume":"143","author":"Thomas","year":"2019","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jmii.2022.06.005_bib9","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.gendis.2019.07.010","article-title":"Recent advances in chronic granulomatous disease","volume":"7","author":"Anjani","year":"2020","journal-title":"Genes Dis"},{"key":"10.1016\/j.jmii.2022.06.005_bib10","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1097\/INF.0b013e31815b494c","article-title":"Susceptibility to mycobacterial infections in children with X-linked chronic granulomatous disease: a review of 17 patients living in a region endemic for tuberculosis","volume":"27","author":"Lee","year":"2008","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.jmii.2022.06.005_bib11","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1111\/pai.13033","article-title":"Clinical and genetic characteristics of Chinese pediatric patients with chronic granulomatous disease","volume":"30","author":"Gao","year":"2019","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1016\/j.jmii.2022.06.005_bib12","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1016\/j.imbio.2011.06.002","article-title":"Distribution, clinical features and treatment in Taiwanese patients with symptomatic primary immunodeficiency diseases (PIDs) in a nationwide population-based study during 1985\u20132010","volume":"216","author":"Lee","year":"2011","journal-title":"Immunobiology"},{"key":"10.1016\/j.jmii.2022.06.005_bib13","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1111\/pai.12814","article-title":"Inflammatory bowel disease in chronic granulomatous disease: an emerging problem over a twenty years' experience","volume":"28","author":"Angelino","year":"2017","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1016\/j.jmii.2022.06.005_bib14","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1097\/INF.0b013e3182309ec0","article-title":"Successful treatment of Aspergillus flavus spondylodiscitis with epidural abscess in a patient with chronic granulomatous disease","volume":"31","author":"Chang","year":"2012","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.jmii.2022.06.005_bib15","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.anai.2010.05.013","article-title":"A new autosomal recessive, heterozygous pair of mutations of CYBA in a patient with chronic granulomatous disease","volume":"105","author":"Chang","year":"2010","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jmii.2022.06.005_bib16","first-page":"189","article-title":"Therapeutic effect of interferon-gamma for prevention of severe infection in X-linked chronic granulomatous disease","volume":"102","author":"Ma","year":"2003","journal-title":"J Formos Med Assoc"},{"key":"10.1016\/j.jmii.2022.06.005_bib17","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.pedneo.2013.04.001","article-title":"Successful unrelated cord blood stem cell transplantation in an X-linked chronic granulomatous disease patient with disseminated BCG-induced infection","volume":"56","author":"Lin","year":"2015","journal-title":"Pediatr Neonatol"},{"key":"10.1016\/j.jmii.2022.06.005_bib18","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.diagmicrobio.2005.04.015","article-title":"Successful treatment of Paecilomyces variotii splenic abscesses: a rare complication in a previously unrecognized chronic granulomatous disease child","volume":"53","author":"Wang","year":"2005","journal-title":"Diagn Microbiol Infect Dis"},{"key":"10.1016\/j.jmii.2022.06.005_bib19","doi-asserted-by":"crossref","first-page":"S12","DOI":"10.1093\/jpids\/piy013","article-title":"Infectious complications in patients with chronic granulomatous disease","volume":"7","author":"Bennett","year":"2018","journal-title":"J Pediatric Infect Dis Soc"},{"key":"10.1016\/j.jmii.2022.06.005_bib20","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1006\/bcmd.2000.0274","article-title":"Genomic structure of the human p47-phox (NCF1) gene","volume":"26","author":"Chanock","year":"2000","journal-title":"Blood Cells Mol Dis"},{"key":"10.1016\/j.jmii.2022.06.005_bib21","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0925-4439(01)00106-5","article-title":"Molecular quality control machinery contributes to the leukocyte NADPH oxidase deficiency in chronic granulomatous disease","volume":"1586","author":"Lin","year":"2002","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jmii.2022.06.005_bib22","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0005234","article-title":"Chronic granulomatous disease: the European experience","volume":"4","author":"van den Berg","year":"2009","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.jmii.2022.06.005_bib23","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1097\/00005792-200005000-00003","article-title":"Chronic granulomatous disease. Report on a national registry of 368 patients","volume":"79","author":"Winkelstein","year":"2000","journal-title":"Medicine"},{"key":"10.1016\/j.jmii.2022.06.005_bib24","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1093\/cid\/ciu1154","article-title":"Common severe infections in chronic granulomatous disease","volume":"60","author":"Marciano","year":"2015","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jmii.2022.06.005_bib25","doi-asserted-by":"crossref","first-page":"15","DOI":"10.3390\/jof2020015","article-title":"Aspergillosis in chronic granulomatous disease","volume":"2","author":"King","year":"2016","journal-title":"J Fungi (Basel)"},{"key":"10.1016\/j.jmii.2022.06.005_bib26","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jinf.2005.08.008","article-title":"Mycobacterium tuberculosis in Taiwan","volume":"52","author":"Hsueh","year":"2006","journal-title":"J Infect"},{"key":"10.1016\/j.jmii.2022.06.005_bib27","doi-asserted-by":"crossref","first-page":"e2538","DOI":"10.1093\/cid\/ciaa1049","article-title":"Bacillus calmette-gu\u00e9rin (BCG) infections at high frequency in both AR-CGD and X-CGD patients following BCG vaccination","volume":"73","author":"Ishikawa","year":"2021","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jmii.2022.06.005_bib28","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1086\/318457","article-title":"Nontyphoidal salmonellosis","volume":"32","author":"Hohmann","year":"2001","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jmii.2022.06.005_bib29","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.jinf.2009.01.002","article-title":"Epidemiology of hospital-treated Salmonella infection; data from a national cohort over a ten-year period","volume":"58","author":"Gil Prieto","year":"2009","journal-title":"J Infect"},{"key":"10.1016\/j.jmii.2022.06.005_bib30","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1093\/aje\/kwf155","article-title":"Epidemiology of salmonellosis in California, 1990-1999: morbidity, mortality, and hospitalization costs","volume":"157","author":"Trevejo","year":"2003","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.jmii.2022.06.005_bib31","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.1017\/S0950268812000088","article-title":"Epidemiology, disease spectrum and economic burden of non-typhoidal Salmonella infections in Taiwan, 2006\u20132008","volume":"140","author":"Chen","year":"2012","journal-title":"Epidemiol Infect"},{"key":"10.1016\/j.jmii.2022.06.005_bib32","doi-asserted-by":"crossref","first-page":"657","DOI":"10.7326\/0003-4819-99-5-657","article-title":"NIH conference. Recent advances in chronic granulomatous disease","volume":"99","author":"Gallin","year":"1983","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.jmii.2022.06.005_bib33","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1093\/infdis\/162.3.723","article-title":"Trimethoprim-sulfamethoxazole prophylaxis in the management of chronic granulomatous disease","volume":"162","author":"Margolis","year":"1990","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jmii.2022.06.005_bib34","doi-asserted-by":"crossref","first-page":"e159","DOI":"10.1093\/cid\/cir731","article-title":"Invasive mold infections in chronic granulomatous disease: a 25-year retrospective survey","volume":"53","author":"Blumental","year":"2011","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jmii.2022.06.005_bib35","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.clim.2007.09.008","article-title":"Clinical features, long-term follow-up and outcome of a large cohort of patients with Chronic Granulomatous Disease: an Italian multicenter study","volume":"126","author":"Martire","year":"2008","journal-title":"Clin Immunol"},{"key":"10.1016\/j.jmii.2022.06.005_bib36","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1007\/s10875-019-00635-2","article-title":"Role of allogeneic hematopoietic stem cell transplant for chronic granulomatous disease (CGD): a report of the United States immunodeficiency Network","volume":"39","author":"Yonkof","year":"2019","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.jmii.2022.06.005_bib37","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1097\/MOH.0000000000000097","article-title":"Chronic granulomatous disease - conventional treatment vs. hematopoietic stem cell transplantation: an update","volume":"22","author":"\u00c5hlin","year":"2015","journal-title":"Curr Opin Hematol"},{"key":"10.1016\/j.jmii.2022.06.005_bib38","doi-asserted-by":"crossref","first-page":"S31","DOI":"10.1093\/jpids\/piy015","article-title":"Allogeneic hematopoietic cell transplantation for chronic granulomatous disease: controversies and state of the art","volume":"7","author":"Connelly","year":"2018","journal-title":"J Pediatric Infect Dis Soc"},{"key":"10.1016\/j.jmii.2022.06.005_bib39","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1182\/blood.V87.5.1663.1663","article-title":"Mutations in the X-linked and autosomal recessive forms of chronic granulomatous disease","volume":"87","author":"Roos","year":"1996","journal-title":"Blood"},{"key":"10.1016\/j.jmii.2022.06.005_bib40","doi-asserted-by":"crossref","first-page":"E132","DOI":"10.1002\/humu.20820","article-title":"Molecular epidemiology of chronic granulomatous disease in a series of 80 kindreds: identification of 31 novel mutations","volume":"29","author":"Kannengiesser","year":"2008","journal-title":"Hum Mutat"},{"key":"10.1016\/j.jmii.2022.06.005_bib41","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.bcmd.2010.07.012","article-title":"Hematologically important mutations: X-linked chronic granulomatous disease (third update)","volume":"45","author":"Roos","year":"2010","journal-title":"Blood Cells Mol Dis"},{"key":"10.1016\/j.jmii.2022.06.005_bib42","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.1182\/blood.V95.6.2150","article-title":"Recombination events between the p47-phox gene and its highly homologous pseudogenes are the main cause of autosomal recessive chronic granulomatous disease","volume":"95","author":"Roesler","year":"2000","journal-title":"Blood"}],"container-title":["Journal of Microbiology, Immunology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1684118222000962?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1684118222000962?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T13:29:50Z","timestamp":1761658190000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1684118222000962"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["S1684118222000962"],"URL":"https:\/\/doi.org\/10.1016\/j.jmii.2022.06.005","relation":{},"ISSN":["1684-1182"],"issn-type":[{"value":"1684-1182","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical features and outcomes of patients with chronic granulomatous disease in Taiwan","name":"articletitle","label":"Article Title"},{"value":"Journal of Microbiology, Immunology and Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jmii.2022.06.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Taiwan Society of Microbiology. Published by Elsevier Taiwan LLC.","name":"copyright","label":"Copyright"}]}}