{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T23:10:11Z","timestamp":1793661011473,"version":"4.5.1"},"reference-count":37,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,8,30]],"date-time":"2022-08-30T00:00:00Z","timestamp":1661817600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100017480","name":"Chang Bing Show Chwan Memorial Hospital","doi-asserted-by":"publisher","award":["103037"],"award-info":[{"award-number":["103037"]}],"id":[{"id":"10.13039\/501100017480","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017480","name":"Chang Bing Show Chwan Memorial Hospital","doi-asserted-by":"publisher","award":["RD103032"],"award-info":[{"award-number":["RD103032"]}],"id":[{"id":"10.13039\/501100017480","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Microbiology, Immunology and Infection"],"published-print":{"date-parts":[[2023,4]]},"DOI":"10.1016\/j.jmii.2022.08.013","type":"journal-article","created":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T06:00:49Z","timestamp":1662703249000},"page":"282-291","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Clinical characteristics and differential cytokine expression in hospitalized Taiwanese children with respiratory syncytial virus and rhinovirus bronchiolitis"],"prefix":"10.1016","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4210-206X","authenticated-orcid":false,"given":"Chun Yi","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia Hsin","family":"Sung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1666-3883","authenticated-orcid":false,"given":"Meng Che","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu Chuan","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jih Chin","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu Ping","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy M.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teh Ying","family":"Chou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu Jiun","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jmii.2022.08.013_bib1","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0140-6736(16)30951-5","article-title":"Viral bronchiolitis","volume":"389","author":"Florin","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.jmii.2022.08.013_bib2","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1097\/INF.0000000000000293","article-title":"Multicenter study of viral etiology and relapse in hospitalized children with bronchiolitis","volume":"33","author":"Hasegawa","year":"2014","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.jmii.2022.08.013_bib3","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1111\/all.13624","article-title":"Bronchiolitis needs a revisit: distinguishing between virus entities and their treatments","volume":"74","author":"Jartti","year":"2019","journal-title":"Allergy"},{"key":"10.1016\/j.jmii.2022.08.013_bib4","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1111\/all.13347","article-title":"Risk factors for asthma after infant bronchiolitis","volume":"73","author":"Tormanen","year":"2018","journal-title":"Allergy"},{"key":"10.1016\/j.jmii.2022.08.013_bib5","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1136\/thoraxjnl-2016-208535","article-title":"A clustering approach to identify severe bronchiolitis profiles in children","volume":"71","author":"Dumas","year":"2016","journal-title":"Thorax"},{"key":"10.1016\/j.jmii.2022.08.013_bib6","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1097\/01.inf.0000143642.72480.53","article-title":"Rhinovirus-associated wheezing in infancy: comparison with respiratory syncytial virus bronchiolitis","volume":"23","author":"Korppi","year":"2004","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.jmii.2022.08.013_bib7","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.jpeds.2016.01.041","article-title":"Children hospitalized with rhinovirus bronchiolitis have asthma-like characteristics","volume":"172","author":"Mansbach","year":"2016","journal-title":"J Pediatr"},{"key":"10.1016\/j.jmii.2022.08.013_bib8","doi-asserted-by":"crossref","first-page":"e437","DOI":"10.1097\/INF.0b013e3182a14407","article-title":"Novel inflammatory markers, clinical risk factors and virus type associated with severe respiratory syncytial virus infection","volume":"32","author":"Tabarani","year":"2013","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.jmii.2022.08.013_bib9","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1164\/rccm.201711-2348OC","article-title":"Infant viral respiratory infection nasal immune-response patterns and their association with subsequent childhood recurrent wheeze","volume":"198","author":"Turi","year":"2018","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jmii.2022.08.013_bib10","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1086\/515575","article-title":"Immunopathogenesis of respiratory syncytial virus bronchiolitis","volume":"195","author":"Bennett","year":"2007","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jmii.2022.08.013_bib11","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1164\/ajrccm.161.5.9904078","article-title":"Monocyte IL-10 production during respiratory syncytial virus bronchiolitis is associated with recurrent wheezing in a one-year follow-up study","volume":"161","author":"Bont","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jmii.2022.08.013_bib12","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1164\/rccm.200210-1148OC","article-title":"Type 1 and type 2 cytokine imbalance in acute respiratory syncytial virus bronchiolitis","volume":"168","author":"Legg","year":"2003","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jmii.2022.08.013_bib13","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.4049\/jimmunol.1700216","article-title":"The innate cytokines IL-25, IL-33, and TSLP cooperate in the induction of type 2 innate lymphoid cell expansion and mucous metaplasia in rhinovirus-infected immature mice","volume":"199","author":"Han","year":"2017","journal-title":"J Immunol"},{"key":"10.1016\/j.jmii.2022.08.013_bib14","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.jaci.2014.04.020","article-title":"Neonatal rhinovirus induces mucous metaplasia and airways hyperresponsiveness through IL-25 and type 2 innate lymphoid cells","volume":"134","author":"Hong","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jmii.2022.08.013_bib15","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1164\/rccm.201406-1039OC","article-title":"IL-33-dependent type 2 inflammation during rhinovirus-induced asthma exacerbations in\u00a0vivo","volume":"190","author":"Jackson","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jmii.2022.08.013_bib16","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1097\/INF.0b013e31822dc8c1","article-title":"Decreased innate immune cytokine responses correlate with disease severity in children with respiratory syncytial virus and human rhinovirus bronchiolitis","volume":"31","author":"Garcia","year":"2012","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.jmii.2022.08.013_bib17","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1128\/JCM.00075-14","article-title":"Improved molecular typing assay for rhinovirus species A, B, and C","volume":"52","author":"Bochkov","year":"2014","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.jmii.2022.08.013_bib18","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1097\/INF.0b013e31823345bf","article-title":"Equal virulence of rhinovirus and respiratory syncytial virus in infants hospitalized for lower respiratory tract infection","volume":"31","author":"Van Leeuwen","year":"2012","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.jmii.2022.08.013_bib19","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1080\/22221751.2020.1770129","article-title":"Profiling serum cytokines in COVID-19 patients reveals IL-6 and IL-10 are disease severity predictors","volume":"9","author":"Han","year":"2020","journal-title":"Emerg Microb Infect"},{"key":"10.1016\/j.jmii.2022.08.013_bib20","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1038\/s41591-020-1051-9","article-title":"An inflammatory cytokine signature predicts COVID-19 severity and survival","volume":"26","author":"Del Valle","year":"2020","journal-title":"Nat Med"},{"key":"10.1016\/j.jmii.2022.08.013_bib21","doi-asserted-by":"crossref","first-page":"e326","DOI":"10.1097\/INF.0000000000001299","article-title":"Viral bronchiolitis is associated with altered cytokine gene expression and lymphocyte activation status","volume":"35","author":"Leahy","year":"2016","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.jmii.2022.08.013_bib22","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/1465-9921-10-85","article-title":"Systemic T-helper and T-regulatory cell type cytokine responses in rhinovirus vs. respiratory syncytial virus induced early wheezing: an observational study","volume":"10","author":"Jartti","year":"2009","journal-title":"Respir Res"},{"key":"10.1016\/j.jmii.2022.08.013_bib23","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1097\/INF.0b013e3181a3ea71","article-title":"Impaired immune response in severe human lower tract respiratory infection by respiratory syncytial virus","volume":"28","author":"Larranaga","year":"2009","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.jmii.2022.08.013_bib24","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1093\/infdis\/jiw191","article-title":"Robust cytokine and chemokine response in nasopharyngeal secretions: association with decreased severity in children with physician diagnosed bronchiolitis","volume":"214","author":"Nicholson","year":"2016","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jmii.2022.08.013_bib25","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1164\/rccm.201712-2567OC","article-title":"Reduced nasal viral load and IFN responses in infants with respiratory syncytial virus bronchiolitis and respiratory failure","volume":"198","author":"Thwaites","year":"2018","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jmii.2022.08.013_bib26","first-page":"201","article-title":"Protective Role of TNF-alpha in respiratory syncytial virus infection in\u00a0vitro and in\u00a0vivo","volume":"311","author":"Neuzil","year":"1996","journal-title":"Am J Med Sci"},{"key":"10.1016\/j.jmii.2022.08.013_bib27","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1111\/j.1365-2249.2004.02582.x","article-title":"Severe respiratory syncytial virus infections and reduced interferon-gamma generation in\u00a0vitro","volume":"138","author":"Schauer","year":"2004","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.jmii.2022.08.013_bib28","doi-asserted-by":"crossref","DOI":"10.1111\/pai.13668","article-title":"Prednisolone for the first rhinovirus induced wheezing reduces use of respiratory medication","volume":"33","author":"Erkkola","year":"2022","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1016\/j.jmii.2022.08.013_bib29","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1111\/j.1399-3038.2007.00512.x","article-title":"Efficacy of prednisolone in children hospitalized for recurrent wheezing","volume":"18","author":"Jartti","year":"2007","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1016\/j.jmii.2022.08.013_bib30","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/pai.12046","article-title":"Prednisolone reduces recurrent wheezing after first rhinovirus wheeze: a 7-year follow-up","volume":"24","author":"Lukkarinen","year":"2013","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1016\/j.jmii.2022.08.013_bib31","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1002\/ppul.23489","article-title":"IL-10 gene polymorphism is associated with preschool atopy and early-life recurrent wheezing after bronchiolitis in infancy","volume":"52","author":"Korppi","year":"2017","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.jmii.2022.08.013_bib32","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1093\/infdis\/jis721","article-title":"Innate immune dysfunction is associated with enhanced disease severity in infants with severe respiratory syncytial virus bronchiolitis","volume":"207","author":"Mella","year":"2013","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jmii.2022.08.013_bib33","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1038\/pr.2015.143","article-title":"The role of Th17 and Treg responses in the pathogenesis of RSV infection","volume":"78","author":"Mangodt","year":"2015","journal-title":"Pediatr Res"},{"key":"10.1016\/j.jmii.2022.08.013_bib34","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.ajpath.2011.03.003","article-title":"IL-17-induced pulmonary pathogenesis during respiratory viral infection and exacerbation of allergic disease","volume":"179","author":"Mukherjee","year":"2011","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jmii.2022.08.013_bib35","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000006787","article-title":"Thymic stromal lymphopoietin, IL-33, and periostin in hospitalized infants with viral bronchiolitis","volume":"96","author":"Garcia-Garcia","year":"2017","journal-title":"Medicine (Baltim)"},{"key":"10.1016\/j.jmii.2022.08.013_bib36","first-page":"156","article-title":"IL-31 and IL-33 circulating levels in allergic contact dermatitis","volume":"47","author":"Guarneri","year":"2015","journal-title":"Eur Ann Allergy Clin Immunol"},{"key":"10.1016\/j.jmii.2022.08.013_bib37","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1016\/j.imbio.2015.02.005","article-title":"IL-33\/ST2 axis controls Th2\/IL-31 and Th17 immune response in allergic airway diseases","volume":"220","author":"Vocca","year":"2015","journal-title":"Immunobiology"}],"container-title":["Journal of Microbiology, Immunology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1684118222001426?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1684118222001426?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T21:51:43Z","timestamp":1778622703000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1684118222001426"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4]]},"references-count":37,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["S1684118222001426"],"URL":"https:\/\/doi.org\/10.1016\/j.jmii.2022.08.013","relation":{},"ISSN":["1684-1182"],"issn-type":[{"value":"1684-1182","type":"print"}],"subject":[],"published":{"date-parts":[[2023,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical characteristics and differential cytokine expression in hospitalized Taiwanese children with respiratory syncytial virus and rhinovirus bronchiolitis","name":"articletitle","label":"Article Title"},{"value":"Journal of Microbiology, Immunology and Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jmii.2022.08.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Taiwan Society of Microbiology. Published by Elsevier Taiwan LLC.","name":"copyright","label":"Copyright"}]}}