{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T22:28:03Z","timestamp":1778624883524,"version":"3.51.4"},"reference-count":27,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,8,30]],"date-time":"2022-08-30T00:00:00Z","timestamp":1661817600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["108-2320-B-006-043-MY3"],"award-info":[{"award-number":["108-2320-B-006-043-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["111-2321-B-006-009"],"award-info":[{"award-number":["111-2321-B-006-009"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["111-2314-B-675-001-MY3"],"award-info":[{"award-number":["111-2314-B-675-001-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["111-2740-B-006-003"],"award-info":[{"award-number":["111-2740-B-006-003"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Microbiology, Immunology and Infection"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.jmii.2022.08.016","type":"journal-article","created":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T23:07:52Z","timestamp":1662419272000},"page":"795-802","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["A brief on new waves of monkeypox and vaccines and antiviral drugs for monkeypox"],"prefix":"10.1016","volume":"55","author":[{"given":"Yuan-Pin","family":"Hung","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ching-Chi","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3332-563X","authenticated-orcid":false,"given":"Jen-Chieh","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun-Wei","family":"Chiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Po-Ren","family":"Hsueh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7497-149X","authenticated-orcid":false,"given":"Wen-Chien","family":"Ko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jmii.2022.08.016_bib1","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1080\/22221751.2022.2095309","article-title":"Monkeypox virus emerges from the shadow of its more infamous cousin: family biology matters","volume":"11","author":"Xiang","year":"2022","journal-title":"Emerg Microb Infect"},{"key":"10.1016\/j.jmii.2022.08.016_bib2","doi-asserted-by":"crossref","DOI":"10.1007\/s11357-022-00611-6","article-title":"Monkeypox: considerations for the understanding and containment of the current outbreak in non-endemic countries","author":"Quarleri","year":"2022","journal-title":"Geroscience"},{"key":"10.1016\/j.jmii.2022.08.016_bib3","article-title":"Re-emerging human monkeypox: a major public-health debacle","author":"Saxena","year":"2022","journal-title":"J Med Virol"},{"key":"10.1016\/j.jmii.2022.08.016_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2022.102855","article-title":"The 2022 outbreak and the pathobiology of the monkeypox virus","author":"Kumar","year":"2022","journal-title":"J Autoimmun"},{"key":"10.1016\/j.jmii.2022.08.016_bib5","article-title":"Epidemiological trends and clinical features of the ongoing monkeypox epidemic: a preliminary pooled data analysis and literature review","author":"Bragazzi","year":"2022","journal-title":"J Med Virol"},{"key":"10.1016\/j.jmii.2022.08.016_bib6","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0010141","article-title":"The changing epidemiology of human monkeypox-A potential threat? A systematic review","volume":"16","author":"Bunge","year":"2022","journal-title":"PLoS Neglected Trop Dis"},{"key":"10.1016\/j.jmii.2022.08.016_bib7","doi-asserted-by":"crossref","first-page":"734","DOI":"10.15585\/mmwr.mm7122e1","article-title":"Use of JYNNEOS (Smallpox and monkeypox vaccine, live, nonreplicating) for preexposure vaccination of persons at risk for occupational exposure to orthopoxviruses: recommendations of the advisory committee on immunization practices - United States, 2022","volume":"71","author":"Rao","year":"2022","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"10.1016\/j.jmii.2022.08.016_bib8","doi-asserted-by":"crossref","first-page":"71","DOI":"10.2147\/DDDT.S3687","article-title":"ACAM2000: the new smallpox vaccine for United States Strategic National Stockpile","volume":"4","author":"Nalca","year":"2010","journal-title":"Drug Des Dev Ther"},{"key":"10.1016\/j.jmii.2022.08.016_bib9","doi-asserted-by":"crossref","first-page":"257","DOI":"10.15585\/mmwr.mm6510a2","article-title":"Use of vaccinia virus smallpox vaccine in laboratory and health care personnel at risk for occupational exposure to orthopoxviruses - recommendations of the Advisory Committee on Immunization Practices (ACIP)","volume":"65","author":"Petersen","year":"2016","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"10.1016\/j.jmii.2022.08.016_bib11","doi-asserted-by":"crossref","first-page":"396","DOI":"10.3390\/vaccines8030396","article-title":"IMVAMUNE\u00ae and ACAM2000\u00ae provide different protection against disease when administered postexposure in an intranasal monkeypox challenge prairie dog model","volume":"8","author":"Keckler","year":"2020","journal-title":"Vaccines (Basel)"},{"key":"10.1016\/j.jmii.2022.08.016_bib12","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.vaccine.2019.10.049","article-title":"Co-administration of tecovirimat and ACAM2000 in non-human primates: effect of tecovirimat treatment on ACAM2000 immunogenicity and efficacy versus lethal monkeypox virus challenge","volume":"38","author":"Russo","year":"2020","journal-title":"Vaccine"},{"key":"10.1016\/j.jmii.2022.08.016_bib13","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1080\/14787210.2020.1819791","article-title":"An overview of tecovirimat for smallpox treatment and expanded anti-orthopoxvirus applications","volume":"19","author":"Russo","year":"2021","journal-title":"Expert Rev Anti Infect Ther"},{"key":"10.1016\/j.jmii.2022.08.016_bib14","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.3390\/v2112409","article-title":"Development of ST-246(R) for treatment of poxvirus infections","volume":"2","author":"Jordan","year":"2010","journal-title":"Viruses"},{"key":"10.1016\/j.jmii.2022.08.016_bib15","doi-asserted-by":"crossref","first-page":"e01683","DOI":"10.1128\/AAC.01683-19","article-title":"Drug development against smallpox: present and future","volume":"64","author":"Delaune","year":"2020","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jmii.2022.08.016_bib16","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.antiviral.2019.06.005","article-title":"The development and approval of tecoviromat (TPOXX\u00ae), the first antiviral against smallpox","volume":"168","author":"Merchlinsky","year":"2019","journal-title":"Antivir Res"},{"key":"10.1016\/j.jmii.2022.08.016_bib17","doi-asserted-by":"crossref","first-page":"707","DOI":"10.3390\/v12070707","article-title":"Conserved Oligomeric Golgi (COG) complex proteins facilitate orthopoxvirus entry, fusion and spread","volume":"12","author":"Realegeno","year":"2020","journal-title":"Viruses"},{"key":"10.1016\/j.jmii.2022.08.016_bib18","doi-asserted-by":"crossref","first-page":"603","DOI":"10.3389\/fmicb.2020.00603","article-title":"Discovery of retro-1 analogs exhibiting enhanced anti-vaccinia virus activity","volume":"11","author":"Priyamvada","year":"2020","journal-title":"Front Microbiol"},{"key":"10.1016\/j.jmii.2022.08.016_bib19","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1093\/infdis\/jiy326","article-title":"Effects of treatment delay on efficacy of tecovirimat following lethal aerosol monkeypox virus challenge in cynomolgus macaques","volume":"218","author":"Russo","year":"2018","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jmii.2022.08.016_bib20","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1128\/AAC.01303-07","article-title":"Single-dose safety and pharmacokinetics of ST-246, a novel orthopoxvirus egress inhibitor","volume":"52","author":"Jordan","year":"2008","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jmii.2022.08.016_bib21","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1056\/NEJMoa1705688","article-title":"Oral tecovirimat for the treatment of smallpox","volume":"379","author":"Grosenbach","year":"2018","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jmii.2022.08.016_bib22","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.3390\/v2102213","article-title":"Synthesis and early development of hexadecyloxypropylcidofovir: an oral antipoxvirus nucleoside phosphonate","volume":"2","author":"Hostetler","year":"2010","journal-title":"Viruses"},{"key":"10.1016\/j.jmii.2022.08.016_bib23","first-page":"e00927","article-title":"Pharmacokinetics and efficacy of a potential smallpox therapeutic, brincidofovir, in a lethal monkeypox virus animal model","volume":"6","author":"Hutson","year":"2021","journal-title":"mSphere"},{"key":"10.1016\/j.jmii.2022.08.016_bib24","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.antiviral.2017.01.009","article-title":"Short-term clinical safety profile of brincidofovir: a favorable benefit-risk proposition in the treatment of smallpox","volume":"143","author":"Chittick","year":"2017","journal-title":"Antivir Res"},{"key":"10.1016\/j.jmii.2022.08.016_bib25","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1038\/323464a0","article-title":"A novel selective broad-spectrum anti-DNA virus agent","volume":"323","author":"De Clercq","year":"1986","journal-title":"Nature"},{"key":"10.1016\/j.jmii.2022.08.016_bib26","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.3390\/v2122803","article-title":"Cidofovir activity against poxvirus infections","volume":"2","author":"Andrei","year":"2010","journal-title":"Viruses"},{"key":"10.1016\/j.jmii.2022.08.016_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.antiviral.2021.105179","article-title":"A human recombinant analogue to plasma-derived vaccinia immunoglobulin prophylactically and therapeutically protects against lethal orthopoxvirus challenge","volume":"195","author":"Parker","year":"2021","journal-title":"Antivir Res"},{"key":"10.1016\/j.jmii.2022.08.016_bib28","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.antiviral.2007.06.005","article-title":"Efficacy of N-methanocarbathymidine in treating mice infected intranasally with the IHD and WR strains of vaccinia virus","volume":"76","author":"Smee","year":"2007","journal-title":"Antivir Res"}],"container-title":["Journal of Microbiology, Immunology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1684118222001451?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1684118222001451?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T21:51:33Z","timestamp":1778622693000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1684118222001451"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":27,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["S1684118222001451"],"URL":"https:\/\/doi.org\/10.1016\/j.jmii.2022.08.016","relation":{},"ISSN":["1684-1182"],"issn-type":[{"value":"1684-1182","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A brief on new waves of monkeypox and vaccines and antiviral drugs for monkeypox","name":"articletitle","label":"Article Title"},{"value":"Journal of Microbiology, Immunology and Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jmii.2022.08.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Taiwan Society of Microbiology. Published by Elsevier Taiwan LLC.","name":"copyright","label":"Copyright"}]}}