{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T22:55:21Z","timestamp":1762556121195,"version":"build-2065373602"},"reference-count":44,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["113-2321-B-006-007","111-2321-B-006-009","113-2622-E-007-019","110-2923-B-006-001-MY4","113-2314-B-006-102-MY3"],"award-info":[{"award-number":["113-2321-B-006-007","111-2321-B-006-009","113-2622-E-007-019","110-2923-B-006-001-MY4","113-2314-B-006-102-MY3"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Microbiology, Immunology and Infection"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.jmii.2024.12.009","type":"journal-article","created":{"date-parts":[[2025,1,5]],"date-time":"2025-01-05T01:11:26Z","timestamp":1736039486000},"page":"294-303","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["BNT162b2 mRNA vaccine elicits robust virus-specific antibodies but poor cross-protective CD8+ memory T cell responses in adolescents with type 1 diabetes"],"prefix":"10.1016","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5926-0462","authenticated-orcid":false,"given":"Ching-Fen","family":"Shen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei-De","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yen-Yin","family":"Chou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shih-Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5469-0364","authenticated-orcid":false,"given":"Yu-Wen","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chih-An","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ching-Wei","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7122-4752","authenticated-orcid":false,"given":"Bo-Yang","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3370-9839","authenticated-orcid":false,"given":"Pei-Jane","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ching-Chuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao-Min","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Chien","family":"Ko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8245-9602","authenticated-orcid":false,"given":"Chi-Chang","family":"Shieh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jmii.2024.12.009_bib1","article-title":"Diabetes and deaths of COVID-19 patients: systematic review of meta-analyses","volume":"7","author":"Garg","year":"2023","journal-title":"Health Sci Rev (Oxf)"},{"key":"10.1016\/j.jmii.2024.12.009_bib2","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/s41574-020-00435-4","article-title":"COVID-19 and diabetes mellitus: from pathophysiology to clinical management","volume":"17","author":"Lim","year":"2021","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.jmii.2024.12.009_bib3","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/S2213-8587(20)30271-0","article-title":"Risk factors for COVID-19-related mortality in people with type 1 and type 2 diabetes in England: a population-based cohort study","volume":"8","author":"Holman","year":"2020","journal-title":"Lancet Diabetes Endocrinol"},{"key":"10.1016\/j.jmii.2024.12.009_bib4","first-page":"442","article-title":"Type 2 diabetes and its impact on the immune system","volume":"16","author":"Berbudi","year":"2020","journal-title":"Curr Diabetes Rev"},{"key":"10.1016\/j.jmii.2024.12.009_bib5","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.amjms.2015.11.011","article-title":"The effect of short-term hyperglycemia on the innate immune system","volume":"351","author":"Jafar","year":"2016","journal-title":"AJMS"},{"key":"10.1016\/j.jmii.2024.12.009_bib6","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1111\/j.1574-695X.1999.tb01397.x","article-title":"Immune dysfunction in patients with diabetes mellitus (DM)","volume":"26","author":"Geerlings","year":"1999","journal-title":"FEMS Immunol Med Microbiol"},{"key":"10.1016\/j.jmii.2024.12.009_bib7","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1002\/(SICI)1096-9136(199701)14:1<29::AID-DIA300>3.0.CO;2-V","article-title":"Impaired leucocyte functions in diabetic patients","volume":"14","author":"Delamaire","year":"1997","journal-title":"Diabet Med"},{"key":"10.1016\/j.jmii.2024.12.009_bib8","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/s41586-023-06803-0","article-title":"Lung dendritic-cell metabolism underlies susceptibility to viral infection in diabetes","volume":"624","author":"Nobs","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.jmii.2024.12.009_bib9","doi-asserted-by":"crossref","first-page":"513","DOI":"10.2337\/dc17-2131","article-title":"Risk of infection in type 1 and type 2 diabetes compared with the general population: a matched cohort study","volume":"41","author":"Carey","year":"2018","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jmii.2024.12.009_bib10","doi-asserted-by":"crossref","DOI":"10.3390\/antiox10050752","article-title":"Type 1 diabetes mellitus in the SARS-CoV-2 pandemic: oxidative stress as a major pathophysiological mechanism linked to adverse clinical outcomes","volume":"10","author":"Kountouri","year":"2021","journal-title":"Antioxidants"},{"key":"10.1016\/j.jmii.2024.12.009_bib11","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1016\/S0140-6736(23)00223-4","article-title":"Type 1 diabetes","volume":"401","author":"Quattrin","year":"2023","journal-title":"Lancet"},{"key":"10.1016\/j.jmii.2024.12.009_bib12","article-title":"Type 1 diabetes mellitus","volume":"3","author":"Katsarou","year":"2017","journal-title":"Nat Rev Dis Prim"},{"key":"10.1016\/j.jmii.2024.12.009_bib13","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.amjms.2015.11.011","article-title":"The effect of short-term hyperglycemia on the innate immune system","volume":"351","author":"Jafar","year":"2016","journal-title":"AJMS"},{"key":"10.1016\/j.jmii.2024.12.009_bib14","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1111\/j.1574-695X.1999.tb01397.x","article-title":"Immune dysfunction in patients with diabetes mellitus (DM)","volume":"26","author":"Geerlings","year":"1999","journal-title":"FEMS Immunol Med Microbiol"},{"key":"10.1016\/j.jmii.2024.12.009_bib15","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1002\/(SICI)1096-9136(199701)14:1<29::AID-DIA300>3.0.CO;2-V","article-title":"Impaired leucocyte functions in diabetic patients","volume":"14","author":"Delamaire","year":"1997","journal-title":"Diabet Med"},{"key":"10.1016\/j.jmii.2024.12.009_bib16","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1086\/431587","article-title":"Increased risk of common infections in patients with type 1 and type 2 diabetes mellitus","volume":"41","author":"Muller","year":"2005","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jmii.2024.12.009_bib17","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1111\/j.1365-2249.2008.03720.x","article-title":"Impaired CD4 and CD8 T cell phenotype and reduced chemokine secretion in recent-onset type 1 diabetic children","volume":"153","author":"Hedman","year":"2008","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.jmii.2024.12.009_bib18","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.966344","article-title":"Infectious diseases associated with pediatric type 1 diabetes mellitus: a narrative review","volume":"13","author":"Piccolo","year":"2022","journal-title":"Front Endocrinol"},{"key":"10.1016\/j.jmii.2024.12.009_bib19","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1128\/CVI.00400-16","article-title":"Antibody responses to immunizations in children with type I diabetes mellitus: a case-control study","volume":"23","author":"Eisenhut","year":"2016","journal-title":"Clin Vaccine Immunol"},{"key":"10.1016\/j.jmii.2024.12.009_bib20","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/S0264-410X(00)00268-1","article-title":"Long term persistence of anti-HBs protective levels in young patients with type 1 diabetes after recombinant hepatitis B vaccine","volume":"19","author":"Marseglia","year":"2000","journal-title":"Vaccine"},{"key":"10.1016\/j.jmii.2024.12.009_bib21","article-title":"Innate immune responses of vaccinees determine early neutralizing antibody production after ChAdOx1nCoV-19 vaccination","volume":"13","author":"Shen","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.jmii.2024.12.009_bib22","doi-asserted-by":"crossref","DOI":"10.1126\/science.abm0829","article-title":"mRNA vaccines induce durable immune memory to SARS-CoV-2 and variants of concern","volume":"374","author":"Goel","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.jmii.2024.12.009_bib23","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1016\/j.immuni.2022.10.014","article-title":"Innate immune mechanisms of mRNA vaccines","volume":"55","author":"Verbeke","year":"2022","journal-title":"Immunity"},{"key":"10.1016\/j.jmii.2024.12.009_bib24","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/s43856-022-00083-x","article-title":"BNT162b2 vaccination enhances interferon-JAK-STAT-regulated antiviral programs in COVID-19 patients infected with the SARS-CoV-2 Beta variant","volume":"2","author":"Knabl","year":"2022","journal-title":"Commun Med"},{"key":"10.1016\/j.jmii.2024.12.009_bib25","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.163347","article-title":"Consecutive BNT162b2 mRNA vaccination induces short-term epigenetic memory in innate immune cells","volume":"7","author":"Yamaguchi","year":"2022","journal-title":"JCI Insight"},{"key":"10.1016\/j.jmii.2024.12.009_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.imbio.2023.152393","article-title":"Complement and COVID-19: three years on, what we know, what we don't know, and what we ought to know","volume":"228","author":"Zelek","year":"2023","journal-title":"Immunobiology"},{"key":"10.1016\/j.jmii.2024.12.009_bib27","doi-asserted-by":"crossref","first-page":"4539","DOI":"10.1038\/s41467-022-32232-0","article-title":"A public antibody class recognizes an S2 epitope exposed on open conformations of SARS-CoV-2 spike","volume":"13","author":"Claireaux","year":"2022","journal-title":"Nat Commun"},{"key":"10.1016\/j.jmii.2024.12.009_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111650","article-title":"Molecular analysis of a public cross-neutralizing antibody response to SARS-CoV-2","volume":"41","author":"Yuan","year":"2022","journal-title":"Cell Rep"},{"issue":"suppl 2","key":"10.1016\/j.jmii.2024.12.009_bib29","doi-asserted-by":"crossref","DOI":"10.1186\/ar1917","article-title":"Interleukin-6 and chronic inflammation","volume":"8","author":"Gabay","year":"2006","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.jmii.2024.12.009_bib30","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/s41590-022-01163-9","article-title":"Mechanisms of innate and adaptive immunity to the Pfizer-BioNTech BNT162b2 vaccine","volume":"23","author":"Li","year":"2022","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jmii.2024.12.009_bib31","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.837524","article-title":"Trained immunity: an overview and the impact on COVID-19","volume":"13","author":"Brueggeman","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.jmii.2024.12.009_bib32","doi-asserted-by":"crossref","first-page":"7905","DOI":"10.1007\/s00253-022-12256-8","article-title":"Dual activation profile of monocytes is associated with protection in Mexican patients during SARS-CoV-2 disease","volume":"106","author":"Acosta-Altamirano","year":"2022","journal-title":"Appl Microbiol Biotechnol"},{"key":"10.1016\/j.jmii.2024.12.009_bib33","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1038\/s41586-021-03791-x","article-title":"Systems vaccinology of the BNT162b2 mRNA vaccine in humans","volume":"596","author":"Arunachalam","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.jmii.2024.12.009_bib34","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.947320","article-title":"Innate immune responses to three doses of the BNT162b2 mRNA SARS-CoV-2 vaccine","volume":"13","author":"Saresella","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.jmii.2024.12.009_bib35","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.2337\/db22-0053","article-title":"Immunogenicity and safety of SARS-CoV-2 mRNA vaccines in a cohort of patients with type 1 diabetes","volume":"71","author":"D'Addio","year":"2022","journal-title":"Diabetes"},{"key":"10.1016\/j.jmii.2024.12.009_bib36","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1111\/dom.14643","article-title":"Humoral immune response to COVID-19 vaccination in diabetes is age-dependent but independent of type of diabetes and glycaemic control: the prospective COVAC-DM cohort study","volume":"24","author":"Sourij","year":"2022","journal-title":"Diabetes Obes Metabol"},{"key":"10.1016\/j.jmii.2024.12.009_bib37","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/BF00292541","article-title":"Humoral immune response and delayed type hypersensitivity to influenza vaccine in patients with diabetes mellitus","volume":"30","author":"Diepersloot","year":"1987","journal-title":"Diabetologia"},{"key":"10.1016\/j.jmii.2024.12.009_bib38","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1007\/BF00870139","article-title":"The immune response to influenza vaccination in diabetic patients","volume":"29","author":"Pozzilli","year":"1986","journal-title":"Diabetologia"},{"key":"10.1016\/j.jmii.2024.12.009_bib39","doi-asserted-by":"crossref","first-page":"e474","DOI":"10.1210\/clinem\/dgad001","article-title":"Prevaccination glucose time in range correlates with antibody response to SARS-CoV-2 vaccine in type 1 diabetes","volume":"108","author":"Alhamar","year":"2023","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jmii.2024.12.009_bib40","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.940357","article-title":"Immunogenicity of COVID-19 vaccines in patients with diabetes mellitus: a systematic review","volume":"13","author":"Boroumand","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.jmii.2024.12.009_bib41","doi-asserted-by":"crossref","first-page":"451","DOI":"10.4093\/dmj.2021.0018","article-title":"Identification of key genes and pathways in peripheral blood mononuclear cells of type 1 diabetes mellitus by integrated bioinformatics analysis","volume":"46","author":"Xing Li","year":"2022","journal-title":"Diabetes Metab J"},{"key":"10.1016\/j.jmii.2024.12.009_bib42","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1038\/s41591-019-0675-0","article-title":"Chronic inflammation in the etiology of disease across the life span","volume":"25","author":"Furman","year":"2019","journal-title":"Nat Med"},{"key":"10.1016\/j.jmii.2024.12.009_bib43","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.trsl.2015.04.011","article-title":"Innate inflammation in type 1 diabetes","volume":"167","author":"Cabrera","year":"2016","journal-title":"Transl Res"},{"key":"10.1016\/j.jmii.2024.12.009_bib44","doi-asserted-by":"crossref","first-page":"2748","DOI":"10.1098\/rstb.2011.0106","article-title":"Innate immunity and adjuvants","volume":"366","author":"Akira","year":"2011","journal-title":"Philos Trans R Soc Lond B Biol Sci"}],"container-title":["Journal of Microbiology, Immunology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1684118225000015?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1684118225000015?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T22:51:46Z","timestamp":1762555906000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1684118225000015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":44,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["S1684118225000015"],"URL":"https:\/\/doi.org\/10.1016\/j.jmii.2024.12.009","relation":{},"ISSN":["1684-1182"],"issn-type":[{"type":"print","value":"1684-1182"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"BNT162b2 mRNA vaccine elicits robust virus-specific antibodies but poor cross-protective CD8+ memory T cell responses in adolescents with type 1 diabetes","name":"articletitle","label":"Article Title"},{"value":"Journal of Microbiology, Immunology and Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jmii.2024.12.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Taiwan Society of Microbiology. Published by Elsevier Taiwan LLC.","name":"copyright","label":"Copyright"}]}}